Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30
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The mitochondrial deubiquitinase ubiquitin-specific protease (USP) 30 negatively regulates PINK1-parkin-driven mitophagy. Whether enhanced mitochondrial quality control through inhibition of USP30 can protect dopaminergic neurons is currently being explored in... ...
