Transcription stress causes an inflammatory response via release of IL-1α [0.03%]
转录压力通过释放IL-1α引起炎症反应
Thomas D J Walker,Jessica P Morris,Leonie Unterholzner
Thomas D J Walker
NUB1 traps unfolded FAT10 for ubiquitin-independent degradation by the 26S proteasome [0.03%]
NUB1通过泛素非依赖性途径将未折叠的FAT10蛋白选择性地靶向26S蛋白酶体降解
Connor Arkinson,Ken C Dong,Christine L Gee et al.
Connor Arkinson et al.
The ubiquitin-like modifier FAT10 targets hundreds of proteins in the mammalian immune system to the 26S proteasome for degradation. This degradation pathway requires the cofactor NUB1, yet the underlying mechanisms remain unknown. Here, we...
Structural insights into RNA-guided RNA editing by the Cas13b-ADAR2 complex [0.03%]
Cas13b-ADAR2复合物引导的RNA编辑机制的结构洞察
Junichiro Ishikawa,Kazuki Kato,Soumya Kannan et al.
Junichiro Ishikawa et al.
Cas13 is an RNA-guided RNA endonuclease derived from the type VI CRISPR-Cas system, which has been used in numerous RNA-targeting technologies, such as RNA knockdown, detection and editing. The catalytically inactive Prevotella sp. Cas13b (...
A transcription coupling model for how enhancers communicate with their target genes [0.03%]
增强子与其目标基因通信的转录偶联模型
Elisabeth Altendorfer,Stefan Mundlos,Andreas Mayer
Elisabeth Altendorfer
How enhancers communicate with their target genes to influence transcription is an unresolved question of fundamental importance. Current models of the mechanism of enhancer-target gene or enhancer-promoter (E-P) communication are transcrip...
Irene Serrano
Irene Serrano
Melina Casadio
Melina Casadio
Shigella flexneri evades LPS ubiquitylation through IpaH1.4-mediated degradation of RNF213 [0.03%]
宋内志贺菌通过IpaH1.4介导的RNF213降解来逃避LPS泛素化
Katerina Naydenova,Keith B Boyle,Claudio Pathe et al.
Katerina Naydenova et al.
Pathogens have evolved diverse strategies to counteract host immunity. Ubiquitylation of lipopolysaccharide (LPS) on cytosol-invading bacteria by the E3 ligase RNF213 creates 'eat me' signals for antibacterial autophagy, but whether and how...
Ion-conducting and gating molecular mechanisms of channelrhodopsin revealed by true-atomic-resolution structures of open and closed states [0.03%]
真原子分辨率的通道视紫红质开闭状态结构揭示了其离子传导和闸门分子机制
Dmitrii Zabelskii,Sergey Bukhdruker,Siarhei Bukhalovich et al.
Dmitrii Zabelskii et al.
Channelrhodopsins (ChRs) have emerged as major optogenetics tools, particularly in neuroscience. Despite their importance, the molecular mechanism of ChR opening remains elusive. Moreover, all reported structures of ChRs correspond to eithe...
Charles C Query,Jadwiga Meissner,Maria M Konarska
Charles C Query