Yingying Hu,Joleen Csuka,Presha Rajbhandari et al.
Yingying Hu et al.
Ferroptosis is an iron-dependent form of regulated cell death driven by phospholipid peroxidation, and it has emerged as a potential therapeutic vulnerability of cancer. Here we identify the secretory phospholipase PLA2G2F (phospholipase A2...
Structural and functional basis of antinociceptive action of χ-conotoxin AoIA at the noradrenaline transporter [0.03%]
χ-石房蛤毒素AoIA在去甲肾上腺素转运蛋白水平发挥镇痛作用的结构和功能基础研究
Oliver J V Belleza,Heng Zhang,Helmut Schmidhammer et al.
Oliver J V Belleza et al.
The χ-conotoxins are venom-derived peptides that specifically target the noradrenaline transporter (also known as norepinephrine transporter, NET). Regulation of noradrenergic signaling by NET affects neurophysiological processes, includin...
James Cahill,Kimberly A Hartfield,Stephanie Andrea Heusser et al.
James Cahill et al.
Acid-sensing ion channels (ASICs) are typically activated by acidic environments and contribute to nociception and synaptic plasticity. ASIC1a is the most abundant subunit in the central nervous system and forms homomeric channels permeable...
ESCRT-III assembles around mis-segregated DNA to protect genome stability [0.03%]
ESCRT-III在染色体错分后招募并组装以保护基因组稳定性
James Glover,Nathaniel Talledge,John McCullough et al.
James Glover et al.
Chromosome mis-segregation events that remain unresolved during cytokinesis threaten genome stability. Persistent ultrafine DNA bridges engage the Aurora B-dependent abscission checkpoint (termed NoCut), which delays abscission by phosphory...
Carolina Perdigoto
Carolina Perdigoto
Bridge for lipid delivery [0.03%]
用于脂质递送的桥梁
Katarzyna A Ciazynska
Katarzyna A Ciazynska
CST complex promotes second-strand synthesis in break-induced replication [0.03%]
复制诱导的断裂中CST复合体促进第二链合成
Pilendra Thakre,Jeff Wang,Liping Liu et al.
Pilendra Thakre et al.
Break-induced DNA replication (BIR) is a highly mutagenic recombination pathway used by eukaryotic cells to repair single-ended DNA breaks, mediate mitotic DNA synthesis and promote telomerase-independent telomere maintenance in certain can...
Cytoplasmic lattices store developmentally poised degradative and cytoskeletal complexes in mammalian eggs [0.03%]
胞质晶格存储发育待命的降解和细胞骨架复合物以维持哺乳动物卵母细胞的长寿
Yujie Li,Wei Zheng,Jiyeon Leem et al.
Yujie Li et al.
The cytoplasmic lattice (CPL) in mammalian eggs is essential for early embryonic development but its molecular components, structural organization and functional capacity have remained elusive. Here, using cryo-electron microscopy, we show ...
Promoter reinforcement supports transcriptional resilience in drug-resistant cancer [0.03%]
增强子的强化可支持耐药癌细胞的转录补偿能力
Vasumathi Kameswaran,Sayantanee Paul,Daniel Le et al.
Vasumathi Kameswaran et al.
In mammalian cells, gene-distal regulatory elements enable long-range gene regulation and support cell-type-specific transcriptional programs. This regulatory architecture is frequently perturbed in cancer, particularly when oncogenic trans...