Architecture of the human KICSTOR and GATOR1-KICSTOR complexes [0.03%]
人类KICSTOR和GATOR1-KICSTOR复合物的结构
Fei Teng,Huan Zeng,Xinyi Mai et al.
Fei Teng et al.
The human KICSTOR complex, comprising KPTN, ITFG2, C12orf66 and the scaffolding protein SZT2, anchors the mTORC1 inhibitor GATOR1 to lysosomes. Mutations affecting KICSTOR subunits are associated with severe neurodevelopmental and epileptic...
Structural landscape of the degrading 26S proteasome reveals conformation-specific binding of TXNL1 [0.03%]
结构景观分析降解中的26S蛋白酶体揭示TXNL1的构象特异性结合
Connor Arkinson,Christine L Gee,Zeyuan Zhang et al.
Connor Arkinson et al.
The 26S proteasome targets many cellular proteins for degradation during homeostasis and quality control. Proteasome-interacting cofactors modulate these functions and aid in substrate degradation. Here we solve high-resolution structures o...
Author Correction: SCAF1 drives the compositional diversity of mammalian respirasomes [0.03%]
作者更正：SCAF1驱动哺乳动物呼吸体的组成多样性
Irene Vercellino,Leonid A Sazanov
Irene Vercellino
Published Erratum
Nature structural & molecular biology. 2025 Nov 5. DOI:10.1038/s41594-025-01721-3 2025
High-throughput peptide-centric local stability assay extends protein-ligand identification to membrane proteins, tissues and bacteria [0.03%]
一种基于肽的高通量局部稳定性试验，将蛋白质-配体鉴定扩展到膜蛋白、组织和细菌中
Kejia Li,Clement M Potel,Isabelle Becher et al.
Kejia Li et al.
Systematic mapping of protein-ligand interactions is essential for understanding biological processes and drug mechanisms. Peptide-centric local stability assay (PELSA) is a powerful tool for detecting these interactions and identifying pot...
TRIM21 and OTUD6A orchestrate AKT K27-linked atypical ubiquitination to modulate cancer chemoresistance [0.03%]
TRIM21和OTUD6A通过调节AKT非典型K27位泛素化来调控癌症化疗耐药性
Qiwei Jiang,Peipei Song,Shuishen Zhang et al.
Qiwei Jiang et al.
Ubiquitination regulates various physiological and pathological processes. However, the impact of atypical AKT ubiquitination and its potential role in tumorigenesis remain unclear. Here we show that AKT is modified by K27-linked ubiquitina...
Human DICER1 hotspot mutation induces both loss and gain of miRNA function [0.03%]
人类DICER1热点突变诱导miRNA功能的丢失和获得
David Jee,Seungjae Lee,Dapeng Yang et al.
David Jee et al.
The core miRNA biogenesis enzyme DICER1 sustains recurrent mutations in cancer that compromise its RNase IIIb domain, which cleaves 5p arms of precursor microRNA hairpins. However, the lack of knock-in models has limited fuller understandin...
DICER1 hotspot mutation induces 3p microRNA gain of function via Argonaute strand switch [0.03%]
DICER1热点突变通过Argonaute链转换诱导3p微RNA功能获得性改变
Sharan Malagobadan,Chunmei Shi,Acong Yang et al.
Sharan Malagobadan et al.
Dicer has RNase activity and is an essential enzyme in microRNA (miRNA) biogenesis. Mutations in the DICER1 gene have been linked to various cancers, notably DICER1 syndrome. To investigate the impact of pathogenic hotspot mutations in DICE...
Mechanistic basis for protein conjugation in a diverged bacterial ubiquitination pathway [0.03%]
一个分化出来的细菌泛素化途径中蛋白质连接的机制基础
Qiaozhen Ye,Minheng Gong,Jiaxi Cai et al.
Qiaozhen Ye et al.
Ubiquitination is a fundamental eukaryotic protein post-translational modification pathway, in which ubiquitin or a ubiquitin-like protein (Ubl) is typically conjugated to a lysine of a target protein. Ubiquitination is initiated by adenyla...
James A W Stowell,Conny W H Yu,Zhuo A Chen et al.
James A W Stowell et al.
Shortening of messenger RNA poly(A) tails by the Ccr4-Not complex initiates mRNA decay and is a major determinant of gene regulation. RNA adaptors modulate the specificity of deadenylation by binding to Ccr4-Not through their intrinsically ...