Yukun Wang,Xizi Chen,Maximilian Kümmecke et al.
Yukun Wang et al.
Transcription elongation by RNA polymerase II (Pol II) is an integral step in eukaryotic gene expression. The speed of Pol II is controlled by a multitude of elongation factors, but the exact regulatory mechanisms remain incompletely unders...
TMEM170 proteins are lipid scramblases associated with bridge-type lipid transporters BLTP1/Csf1 [0.03%]
TMEM170蛋白是与桥式脂质转运蛋白BLTP1/CSF1R相关的脂质 scramblase蛋白质
Cristian Rocha-Roa,Paige Chandran Blair,Gurpreet Sidhu et al.
Cristian Rocha-Roa et al.
Bulk lipid transport between organelles has been proposed to involve the partnership between bridge-like lipid transfer proteins (BLTPs) and membrane-embedded lipid scramblases. However, for almost all BLTPs, such physical association has n...
Heterochromatin boundaries maintain centromere position, size and number [0.03%]
异染色质边界维持着着丝粒的位置、大小和数量
Ben L Carty,Danilo Dubocanin,Marina Murillo-Pineda et al.
Ben L Carty et al.
Centromeres are defined by a unique single chromatin domain featuring the histone H3 variant, centromere protein A (CENP-A), and ensure proper chromosome segregation. Centromeric chromatin typically occupies a small subregion of low DNA met...
Heesoo Uhm,Sangsu Bae
Heesoo Uhm
Filament formation and NAD processing by noncanonical human FAM118 sirtuins [0.03%]
非编码型人FAM118 垂延素的丝状形成及NAD+加工能力
Domagoj Baretić,Sophia Missoury,Karishma Patel et al.
Domagoj Baretić et al.
Sirtuins are an ancient family of enzymes with diverse nicotinamide adenine dinucleotide (NAD)-dependent activities. Here we identify family with sequence similarity 118 member B (FAM118B) and FAM118A-two understudied vertebrate proteins-as...
ATG2A-mediated DAG transfer recruits DGAT2 for lipid droplet growth [0.03%]
ATG2A介导的DAG转移募集DGAT2促进脂滴生长
Helin Elhan,Alicia Damm,Justin L Korfhage et al.
Helin Elhan et al.
Lipid droplet (LD) growth mechanisms and the roles of LD-associated lipid transfer proteins remain poorly understood. Here we show that the autophagy lipid transfer protein ATG2A has an anabolic role and promotes LD expansion by transferrin...
Computational design of a high-precision mitochondrial DNA cytosine base editor [0.03%]
高精度线粒体DNA胞嘧啶碱基编辑器的计算设计
Li Mi,Yu-Xuan Li,Xinchen Lv et al.
Li Mi et al.
Bystander editing remains a major limitation of current base editors, hindering their precision and therapeutic potential. Here, we present a de novo protein design strategy that creates a structurally rigid interface between a DNA-binding ...
Baoquan Su,Kun Huang,Zhenling Peng et al.
Baoquan Su et al.
Constructing atomic models from cryogenic electron microscopy (cryo-EM) density maps is essential for interpreting molecular mechanisms. Here we present CryoAtom, an approach for de novo model building for cryo-EM maps, leveraging recent ad...