Structural phylogenetics unravels the evolutionary diversification of communication systems in gram-positive bacteria and their viruses [0.03%]
结构系统发生学解开了革兰氏阳性菌及其病毒通讯系统的进化多样化之谜
David Moi,Charles Bernard,Martin Steinegger et al.
David Moi et al.
Recent advances in artificial-intelligence-based protein structure modeling have yielded remarkable progress in predicting protein structures. Because structures are constrained by their biological function, their geometry tends to evolve m...
Nuclear pore passage of the HIV capsid is driven by its unusual surface amino acid composition [0.03%]
人类免疫缺陷病毒衣壳通过核孔是由其表面氨基酸的特殊组成驱动的
Liran Fu,Shiya Cheng,Dietmar Riedel et al.
Liran Fu et al.
Nuclear transport receptors (NTRs) carry cargo across the permeability barrier of nuclear pore complexes (NPCs)-an FG phase condensed from disordered but cohesive FG-repeat domains. This phase repels inert macromolecules but allows NTR pass...
Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus [0.03%]
报告基因CRISPR筛选揭示Xist位点的顺式调控和反式调控原则
Till Schwämmle,Gemma Noviello,Eleni Kanata et al.
Till Schwämmle et al.
Developmental genes are controlled by an ensemble of cis-acting regulatory elements (REs), which in turn respond to multiple trans-acting transcription factors (TFs). Understanding how a cis-regulatory landscape integrates information from ...
Mayra Furlan-Magaril
Mayra Furlan-Magaril
Karim Housseini B Issa,Muyang Ren,Bradley Burnet et al.
Karim Housseini B Issa et al.
Multiciliogenesis requires large-scale biosynthesis of motility-powering axonemal inner and outer dynein arm motors (IDAs and ODAs) before their intraflagellar transport (IFT) into cilia. ODAs are inhibited by the packaging chaperone Shulin...
Derek A Pratt,Scott J Dixon
Derek A Pratt
Cryo-EM structures reveal the molecular mechanism of SUMO E1-E2 thioester transfer [0.03%]
cryo-EM结构揭示SUMO E1-E2硫酯转移的分子机制
Anindita Nayak,Digant Nayak,Lijia Jia et al.
Anindita Nayak et al.
Post-translational modification of proteins by SUMO (small ubiquitin-like modifier) regulates fundamental cellular processes and occurs through the sequential interactions and activities of three enzymes: E1, E2 and E3. SUMO E1 activates SU...
A small molecule stabilizer rescues the surface expression of nearly all missense variants in a GPCR [0.03%]
一种小分子稳定剂可修复G蛋白偶联受体错义突变几乎全部的表面表达缺陷
Taylor L Mighell,Ben Lehner
Taylor L Mighell
Reduced protein abundance is the most frequent mechanism by which rare missense variants cause disease. A promising therapeutic avenue for treating reduced abundance variants is pharmacological chaperones (PCs, also known as correctors or s...
The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking [0.03%]
人核糖体通过延迟同延伸_domains_的对接来调节多域蛋白的生物发生
Grant A Pellowe,Tomas B Voisin,Laura Karpauskaite et al.
Grant A Pellowe et al.
Proteins with multiple domains are intrinsically prone to misfold, yet fold efficiently during their synthesis on the ribosome. This is especially important in eukaryotes, where multidomain proteins predominate. Here we sought to understand...
Eli Arama,Katia Cosentino,Peter E Czabotar et al.
Eli Arama et al.