James A W Stowell,Conny W H Yu,Zhuo A Chen et al.
James A W Stowell et al.
Shortening of messenger RNA poly(A) tails by the Ccr4-Not complex initiates mRNA decay and is a major determinant of gene regulation. RNA adaptors modulate the specificity of deadenylation by binding to Ccr4-Not through their intrinsically ...
The Japan autophagy consortium [0.03%]
日本自噬联盟
Miwako Ishido,Yoshiari Shimmyo,Etsuko Tsutsumi et al.
Miwako Ishido et al.
Mechanisms of DNMT3A-3L-mediated de novo DNA methylation on chromatin [0.03%]
DNMT3A-3L介导的染色质上从头DNA甲基化的机制研究
Yan Yan,X Edward Zhou,Stacey L Thomas et al.
Yan Yan et al.
De novo DNA methylation is mediated by DNA methyltransferases DNMT3A and DNMT3B, in cooperation with the catalytically inactive paralogs DNMT3L and DNMT3B3. DNMT3L is predominantly expressed in embryonic stem cells to establish methylation ...
Structural landscape of activation, desensitization and inhibition in the human TRPM4 channel [0.03%]
人TRPM4通道激活、脱敏和抑制的结构景观
Celso M Teixeira-Duarte,Weizhong Zeng,Youxing Jiang
Celso M Teixeira-Duarte
TRPM4 is a member of the transient receptor potential melastatin channel subfamily and functions as a Ca2+-activated monovalent-selective cation channel. It is widely expressed in various cells and tissues, where its activation depolarizes ...
Bing Wang,Renee D Hoffman,Ya-Ming Hou et al.
Bing Wang et al.
Retrons have been recently identified as bacterial defense systems that employ a tripartite of reverse transcriptase, non-coding RNA (ncRNA) and its derived multi-copy single stranded DNA (msDNA) to sequester effector activity. Phage invasi...
Francesca Vallese
Francesca Vallese
RNase MRP subunit composition and role in 40S ribosome biogenesis [0.03%]
核糖核酸酶MRP的亚基组成及其在40S核糖体生成中的作用
Eric M Smith,Jimmy Ly,Sofia Haug et al.
Eric M Smith et al.
RNase MRP and RNase P are evolutionarily related complexes that facilitate rRNA and tRNA biogenesis, respectively. The two enzymes share nearly all protein subunits and have evolutionarily related catalytic RNAs. Notably, RNase P includes a...
Structural basis for agonist and heat activation of nociceptor TRPM3 [0.03%]
TRPM3热敏离子通道被激动剂活化及高温活化的分子机制
Sushant Kumar,Fei Jin,Sung Jin Park et al.
Sushant Kumar et al.
Detecting noxious heat is vital for survival, triggering protective pain responses. The TRPM3 channel is a key nociceptor and a promising therapeutic target for pain and neurological disorders. Here we show that the rabbit TRPM3 is intrinsi...
Epigenetic priming promotes tyrosine kinase inhibitor resistance and oncogene amplification [0.03%]
表观遗传学预处理促进酪氨酸激酶抑制剂耐药性和癌基因扩增
Rebecca M Starble,Eric G Sun,Rana Gbyli et al.
Rebecca M Starble et al.
In mammalian cells, gene copy number is controlled to maintain gene expression and genome stability. However, a common molecular feature across cancer types is oncogene amplification, increasing the copy number and expression of tumor-promo...
Global analysis of translocon remodeling during protein synthesis at the ER [0.03%]
对蛋白质在内质网上合成时转位体重塑的全球分析
Arunkumar Sundaram,Qianru Li,Yu Wan et al.
Arunkumar Sundaram et al.
Protein biogenesis at the endoplasmic reticulum requires translocons comprising the Sec61 protein-conducting channel and several dynamically associated accessory factors. Here we used transcriptome-wide selective ribosome profiling in human...