Checking in on proteostasis [0.03%]
检查蛋白质稳态
Eri Sakata,Ramanujan S Hegde,Yan G Zhao et al.
Eri Sakata et al.
Kirandeep K Deol,Cynthia A Harris,Sydney J Tomlinson et al.
Kirandeep K Deol et al.
Ferroptosis, a regulated form of cell death driven by excessive lipid peroxidation, has emerged as a promising therapeutic target in cancer. Ferroptosis suppressor protein 1 (FSP1) is a critical regulator of ferroptosis resistance, yet the ...
Sara M Ambjørn,Bob Meeusen,Johanna Kliche et al.
Sara M Ambjørn et al.
Short linear motifs (SLiMs) are the most ubiquitous protein interaction motifs within unstructured regions of the human proteome, yet their contribution to cellular homeostasis remains poorly understood. Here, to systematically assess SLiM ...
Diego Detrés,Francisco J Sánchez-Rivera
Diego Detrés
Edith Heard,Gitte Neubauer
Edith Heard
Joshua B Sheetz,Srividya Chandrasekhar,Michael Rapé
Joshua B Sheetz
As mitochondria have crucial roles in metabolism and signaling, their structure and function must be continuously monitored and rapidly adjusted to meet cellular demands. Critical to this regulation is a conserved stress response that detec...
The maternal PADI6-UHRF1-UBE2D complex regulates ubiquitination during oocyte maturation and embryogenesis [0.03%]
母体PADI6-UHRF1-UBE2D复合物在卵子成熟和胚胎发育过程中的泛素化调控中起作用
Jinhong Li,Yuechao Lu,Zhili Xia et al.
Jinhong Li et al.
Proteostasis in mammalian oocytes is vital for successful reproduction. The cytoplasmic lattices (CPLs) of oocytes store essential maternal proteins for early embryo development. Here we show that PADI6, a core component of CPLs, forms a co...