Global reorganization of genome architecture at the transition to gametogenesis [0.03%]
配子发生过渡时期的基因组架构的全球性重新组织
Tien-Chi Huang,Maria Rigau,Valeriya Malysheva et al.
Tien-Chi Huang et al.
Global epigenetic resetting in the gonadal primordial germ cells (PGCs) enables transition from early PGCs to gametogenesis and eventual restoring of totipotency after fertilization. This reprogramming process involves global DNA demethylat...
Tetsuya Kotani,Hitoshi Nakatogawa
Tetsuya Kotani
Autophagy is a conserved intracellular degradation system essential for maintaining cellular homeostasis and adapting to a variety of environmental or metabolic cues. Different types of autophagy are induced in response to various physiolog...
M Jasnauskaitė,J Juozapaitis,T Liegutė et al.
M Jasnauskaitė et al.
Retrons are prokaryotic reverse transcriptase systems that produce multicopy single-stranded DNA (msDNA), yet the principles by which they mediate antiviral defense remain largely unresolved. Here we investigate the mechanism of Escherichia...
Author Correction: Phosphorylation-dependent tuning of mRNA deadenylation rates [0.03%]
作者更正：磷酸化依赖的mrna去多聚腺苷酸化速率调节
James A W Stowell,Conny W H Yu,Zhuo A Chen et al.
James A W Stowell et al.
Published Erratum
Nature structural & molecular biology. 2026 Feb 18. DOI:10.1038/s41594-026-01774-y 2026
Z-DNA formation regulates the totipotent-like state and primes Zscan4-dependent chromatin compartmentalization [0.03%]
Z-DNA形成调控全能性状态并诱导Zscan4依赖的染色质区室化
Shireen Shajahan,Yann Loe-Mie,Laure Asselin et al.
Shireen Shajahan et al.
The progression from the one-cell to the two-cell stage constitutes a remarkable transition, accompanied by the activation of a specific set of embryonic genes, epigenome reprogramming and nuclear architecture reorganization. Some of these ...
Computation and deep-learning-driven advances in CRISPR genome editing [0.03%]
计算与深度学习驱动的CRISPR基因组编辑进展
Chinmai Pindi,Giulia Palermo
Chinmai Pindi
Genome editing with CRISPR-Cas systems is revolutionizing medicine, molecular biology and biotechnology. In this Review, we discuss the contributions of deep learning-based structure prediction algorithms, physics-based simulations, neural ...
Structure and function of the yeast amino acid-sensing SEAC-EGOC supercomplex [0.03%]
酵母氨基酸感应SEAC-EGOC超级复合物的结构与功能
Lucas Tafur,Lenny Bonadei,Yiqiang Zheng et al.
Lucas Tafur et al.
The Seh1-associated complex (SEAC; GATOR in mammals) transduces amino acid signals to the Target of Rapamycin Complex 1 (TORC1), a master regulator of cell growth. The SEAC is composed of two subcomplexes, SEACIT (GATOR1), an inhibitor of T...
Julie Soutourina
Julie Soutourina