ATG2A-mediated DAG transfer recruits DGAT2 for lipid droplet growth [0.03%]
ATG2A介导的DAG转移募集DGAT2促进脂滴生长
Helin Elhan,Alicia Damm,Justin L Korfhage et al.
Helin Elhan et al.
Lipid droplet (LD) growth mechanisms and the roles of LD-associated lipid transfer proteins remain poorly understood. Here we show that the autophagy lipid transfer protein ATG2A has an anabolic role and promotes LD expansion by transferrin...
Computational design of a high-precision mitochondrial DNA cytosine base editor [0.03%]
高精度线粒体DNA胞嘧啶碱基编辑器的计算设计
Li Mi,Yu-Xuan Li,Xinchen Lv et al.
Li Mi et al.
Bystander editing remains a major limitation of current base editors, hindering their precision and therapeutic potential. Here, we present a de novo protein design strategy that creates a structurally rigid interface between a DNA-binding ...
Baoquan Su,Kun Huang,Zhenling Peng et al.
Baoquan Su et al.
Constructing atomic models from cryogenic electron microscopy (cryo-EM) density maps is essential for interpreting molecular mechanisms. Here we present CryoAtom, an approach for de novo model building for cryo-EM maps, leveraging recent ad...
Structural basis of glucose-6-phosphate transport by human SLC37A2 [0.03%]
人类SLC37A2蛋白通过结构基础转运葡萄糖-6-磷酸的原理
Qinxuan Lai,Mengzhen Xu,Yongxiang Gao et al.
Qinxuan Lai et al.
Glucose-6-phosphate (G6P) transporters are crucial for glucose metabolism by mediating G6P transport from the cytoplasm to endoplasmic reticulum (ER). However, their transport mechanisms remain poorly understood. Here, we elucidate the stru...
Structural basis of G6P/Pi transport and inhibition in SLC37A4 [0.03%]
SLC37A4蛋白中G6P/Pi的转运及抑制机制的结构基础研究
Dong Zhou,Yang Zhang,Nanhao Chen et al.
Dong Zhou et al.
Glycogen storage disease type Ib (GSD-Ib), caused by loss-of-function mutations in the endoplasmic reticulum transporter SLC37A4, disrupts glucose homeostasis through impaired glucose-6-phosphate (G6P)/phosphate (Pi) antiport. Despite its c...
AlphaSync is an enhanced AlphaFold structure database synchronized with UniProt [0.03%]
AlphaSync是一个与UniProt同步的增强型AlphaFold结构数据库
Benjamin Lang,Bálint Mészáros,Besian I Sejdiu et al.
Benjamin Lang et al.
Accurate prediction of protein structures is essential for understanding biological functions and guiding biomedical research. However, maintaining synchronization between structure models and rapidly expanding, continuously evolving protei...
Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms [0.03%]
亲水性降糖药二甲双胍和疏水性氨基糖通过不同的机制抑制复合物I
Zhaoxiang He,Fei Teng,Yanqing Yang et al.
Zhaoxiang He et al.
Metformin is the only antihyperglycemic biguanide targeting type 2 diabetes mellitus with proven safety. Although a mechanism of action involving tight inhibition of the respiratory complex I has been proposed for hydrophobic biguanides, it...
Architecture of the human KICSTOR and GATOR1-KICSTOR complexes [0.03%]
人类KICSTOR和GATOR1-KICSTOR复合物的结构
Fei Teng,Huan Zeng,Xinyi Mai et al.
Fei Teng et al.
The human KICSTOR complex, comprising KPTN, ITFG2, C12orf66 and the scaffolding protein SZT2, anchors the mTORC1 inhibitor GATOR1 to lysosomes. Mutations affecting KICSTOR subunits are associated with severe neurodevelopmental and epileptic...