Dynamic TOM-TIM23 supercomplex directs mitochondrial protein translocation and sorting [0.03%]
动态的TOM-TIM23超级复合体指导线粒体蛋白转运和分类
Yuqi Yang,Shanshan Wang,Guopeng Wang et al.
Yuqi Yang et al.
The mitochondrial translocase of the outer membrane (TOM) and translocase of the inner membrane 23 (TIM23) complexes are coupled to control protein import across the outer and inner membranes, respectively. However, the mechanisms of protei...
Author Correction: Structural basis of the histone ubiquitination read-write mechanism of RYBP-PRC1 [0.03%]
作者更正：RYBP-PRC1阅读和编写组蛋白泛素化的结构基础
Maria Ciapponi,Elena Karlukova,Sven Schkölziger et al.
Maria Ciapponi et al.
Published Erratum
Nature structural & molecular biology. 2025 Aug 27. DOI:10.1038/s41594-025-01674-7 2025
Author Correction: A critical period of translational control during brain development at codon resolution [0.03%]
作者更正：在脑发育过程中，在密码子分辨率的 critical period 的转译控制
Dermot Harnett,Mateusz C Ambrozkiewicz,Ulrike Zinnall et al.
Dermot Harnett et al.
Published Erratum
Nature structural & molecular biology. 2025 Aug 27. DOI:10.1038/s41594-025-01675-6 2025
Structural basis for lipid transport at membrane contact sites by the IST2-OSH6 complex [0.03%]
IST2-OSH6复合体在质膜接触位点上通过结构基础运输脂类
Melanie Arndt,Angela Schweri,Raimund Dutzler
Melanie Arndt
Membrane contact sites are hubs for interorganellar lipid transport within eukaryotic cells. As a principal tether bridging the endoplasmic reticulum (ER) and the plasma membrane in Saccharomyces cerevisiae, the protein IST2 has a major rol...
Evolutionary analysis reveals the origin of sodium coupling in glutamate transporters [0.03%]
进化分析揭示谷氨酸转运蛋白中钠耦合的起源
Krishna D Reddy,Burha Rasool,Farideh Badichi Akher et al.
Krishna D Reddy et al.
Secondary active membrane transporters harness the energy of ion gradients to concentrate their substrates. Homologous transporters evolved to couple transport to different ions in response to changing environments and needs. The bases of s...
A scaffold for quinone channeling between membrane and soluble bacterial oxidoreductases [0.03%]
在细菌氧化还原酶之间递送醌的支架
M Broc,M V Cherrier,A Uzel et al.
M Broc et al.
Redox processes are at the heart of energetic metabolism that drives life on earth. By extension, complex and efficient electron transfer wires are necessary to connect the various metabolic pathways that are often located in distinct cellu...
Samuel P Berry,Rachelle Gaudet
Samuel P Berry
Luca Mariani,Xiao Liu,Kwangwoon Lee et al.
Luca Mariani et al.
Cell fates are controlled by 'pioneers', sequence-specific transcription factors (TFs) that bind recognition motifs on nucleosomes ('pioneer binding'). Pioneers occupy a minority of their recognition sequences in the genome, suggesting that...
Masahiro Nagano,Bo Hu,Kosuke Ogata et al.
Masahiro Nagano et al.
Germ cells are unique in that they tailor chromatin toward generating totipotency. Accordingly, mammalian spermatogonia, including spermatogonial stem cells that constitute the source for male gametes, acquire distinctive chromatin organiza...
Adel Atari,Haoyang Jiang,Roger A Greenberg
Adel Atari
DNA double-strand breaks (DSBs) are a severe threat to genome stability, as DSB-repair mechanisms with low fidelity contribute to loss of genome integrity. Break-induced replication (BIR) is a crucial DSB-repair pathway when classical homol...