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Structural and functional basis of antinociceptive action of χ-conotoxin AoIA at the noradrenaline transporter

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The χ-conotoxins are venom-derived peptides that specifically target the noradrenaline transporter (also known as norepinephrine transporter, NET). Regulation of noradrenergic signaling by NET affects neurophysiological processes, including pain. Therefore, t... ...