Microglia promote inflammatory cell death upon neuronal mitochondrial impairment during neurodegeneration [0.03%]
小胶质细胞在神经退行性病变期间促进神经元线粒体损伤引起的炎症性细胞死亡
Guangyan Miao,Tina M Fortier,Haibo Liu et al.
Guangyan Miao et al.
The failure to clear dysfunctional mitochondria, cell death and inflammation have been linked in neurodegenerative disease, but their relationship and role in these conditions is not fully understood. Loss of Vps13d prevents clearance of mi...
The PURB-HOTAIR complex regulates p53-dependent promoter-specific transcriptional activation [0.03%]
PURB-HOTAIR复合物调控p53依赖的启动子特异性转录激活
Zhangchuan Xia,Ning Kon,Zhenyi Su et al.
Zhangchuan Xia et al.
p53 executes its diverse functions through different transcriptional targets but the precise mechanism of promoter-specific regulation by p53 remains largely unknown. Through biochemical purification, we identify purine-rich element binding...
Structure of fungal tRNA ligase Trl1 with RNA reveals conserved substrate-binding principles [0.03%]
结构研究：具有RNA的真菌tRNA连接酶Trl1揭示了保守的底物结合原理
Sandra Köhler,Jürgen Kopp,Satyabrata Maiti et al.
Sandra Köhler et al.
RNA ligases play a vital role in RNA processing and maturation, including tRNA splicing, RNA repair and the unfolded protein response (UPR). In fungi and plants, the tripartite tRNA ligase Trl1 catalyzes the joining of TSEN-cleaved pre-tRNA...
PEX14 condensates recruit receptor and cargo pairs for peroxisomal protein import [0.03%]
肽聚糖识别蛋白家族成员NRPP1通过募集受体-配体对促进内质网膜接触点的形成和功能
Jianguo Wu,Shupei Lv,Peng Xu et al.
Jianguo Wu et al.
Peroxisomal proteins are imported into peroxisomes as folded proteins bound to the receptor peroxisomal biogenesis factor 5 (PEX5) through a biomolecular condensate mainly formed by the tyrosine-glycine (YG) repeats in PEX13. PEX14, another...
Rilee Zeinert,Fei Zhou,Pedro Franco et al.
Rilee Zeinert et al.
Magnesium (Mg2+) uptake systems are present in all domains of life, consistent with the vital role of this ion. P-type ATPase Mg2+ importers are required for bacterial growth when Mg2+ is limiting or during pathogenesis. However, insights i...
ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism [0.03%]
ACAD10和ACAD11使哺乳动物能够代谢4-羟基酸类脂质
Edrees H Rashan,Abigail K Bartlett,Daven B Khana et al.
Edrees H Rashan et al.
Fatty acid β-oxidation is a central catabolic pathway with broad health implications. However, various fatty acids, including 4-hydroxy acids (4-HAs), are largely incompatible with β-oxidation machinery before being modified. Here we reve...
Binding of heterochromatin protein Rhino to a subset of piRNA clusters depends on a combination of two histone marks [0.03%]
组蛋白标记的组合决定了异染色质蛋白Rhino与部分piRNA基因簇的结合
Abdou Akkouche,Emma Kneuss,Susanne Bornelöv et al.
Abdou Akkouche et al.
Animal germ cells deploy a specialized small RNA-based silencing system, called the PIWI-interacting RNA (piRNA) pathway, to prevent unwanted expression of transposable elements (TEs) and maintain genome integrity. In Drosophila melanogaste...
Arantxa M L Rojas,Germano Cecere
Arantxa M L Rojas
DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation [0.03%]
TRPML1激活后DMXL1促进V1-ATP酶募集到溶酶体中
Chan Lee,Matthew J G Eldridge,Miguel A Gonzalez-Lozano et al.
Chan Lee et al.
Lysosomes, central hydrolytic organelles, are regulated by ion flow, including calcium and protons, via transporters and channels to maintain an acidified lumen for hydrolytic activity. TRPML1, a lysosomal ion channel, effluxes cations upon...