Global analysis of translocon remodeling during protein synthesis at the ER [0.03%]
对蛋白质在内质网上合成时转位体重塑的全球分析
Arunkumar Sundaram,Qianru Li,Yu Wan et al.
Arunkumar Sundaram et al.
Protein biogenesis at the endoplasmic reticulum requires translocons comprising the Sec61 protein-conducting channel and several dynamically associated accessory factors. Here we used transcriptome-wide selective ribosome profiling in human...
Dynamics of microcompartment formation at the mitosis-to-G1 transition [0.03%]
有丝分裂向G1期过渡过程中微区室的形成动力学研究
Viraat Y Goel,Nicholas G Aboreden,James M Jusuf et al.
Viraat Y Goel et al.
As cells exit mitosis and enter G1, chromosomes decompact and transcription is reestablished. Hi-C studies have indicated that all interphase three-dimensional genome features, including A/B compartments, topologically associating domains a...
Hugo Sepulveda
Hugo Sepulveda
Structure and activation mechanism of a Lamassu phage and plasmid defense system [0.03%]
一种拉玛苏噬菌体和质粒防御系统的结构及激活机制
Yan Li,David W Adams,Hon Wing Liu et al.
Yan Li et al.
Lamassu is a diverse family of defense systems that protect bacteria, including seventh-pandemic strains of Vibrio cholerae, against both plasmids and phage infection. During phage infection, Lamassu targets essential cellular processes, th...
Author Correction: Recruitment of Atg1 to the phagophore by Atg8 orchestrates autophagy machineries [0.03%]
作者更正：Atg8通过招募Atg1至吞噬体来协调自噬机器人的运作
Jing-Zhen Song,Hui Li,Haiyan Yang et al.
Jing-Zhen Song et al.
Published Erratum
Nature structural & molecular biology. 2025 Oct 13. DOI:10.1038/s41594-025-01700-8 2025
Structural phylogenetics unravels the evolutionary diversification of communication systems in gram-positive bacteria and their viruses [0.03%]
结构系统发生学解开了革兰氏阳性菌及其病毒通讯系统的进化多样化之谜
David Moi,Charles Bernard,Martin Steinegger et al.
David Moi et al.
Recent advances in artificial-intelligence-based protein structure modeling have yielded remarkable progress in predicting protein structures. Because structures are constrained by their biological function, their geometry tends to evolve m...
Nuclear pore passage of the HIV capsid is driven by its unusual surface amino acid composition [0.03%]
人类免疫缺陷病毒衣壳通过核孔是由其表面氨基酸的特殊组成驱动的
Liran Fu,Shiya Cheng,Dietmar Riedel et al.
Liran Fu et al.
Nuclear transport receptors (NTRs) carry cargo across the permeability barrier of nuclear pore complexes (NPCs)-an FG phase condensed from disordered but cohesive FG-repeat domains. This phase repels inert macromolecules but allows NTR pass...
Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus [0.03%]
报告基因CRISPR筛选揭示Xist位点的顺式调控和反式调控原则
Till Schwämmle,Gemma Noviello,Eleni Kanata et al.
Till Schwämmle et al.
Developmental genes are controlled by an ensemble of cis-acting regulatory elements (REs), which in turn respond to multiple trans-acting transcription factors (TFs). Understanding how a cis-regulatory landscape integrates information from ...
Mayra Furlan-Magaril
Mayra Furlan-Magaril