Jianwei Zeng,Yong Fu,Pengge Qian et al.
Jianwei Zeng et al.
Apicomplexan parasites, responsible for toxoplasmosis, cryptosporidiosis and malaria, invade host cells through a unique gliding motility mechanism powered by actomyosin motors and a dynamic organelle called the conoid. Here, using cryo-ele...
Tao Li,Ji Chen,Hao Li et al.
Tao Li et al.
Cryo-electron microscopy (cryo-EM) has become the mainstream technique for macromolecular structure determination. However, because of intrinsic resolution heterogeneity, accurate modeling of all-atom structure from cryo-EM maps remains cha...
Author Correction: A small molecule stabilizer rescues the surface expression of nearly all missense variants in a GPCR [0.03%]
作者更正：一种小分子稳定剂可挽救G蛋白偶联受体几乎所有错义变异的表面表达
Taylor L Mighell,Ben Lehner
Taylor L Mighell
Published Erratum
Nature structural & molecular biology. 2025 Dec 7. DOI:10.1038/s41594-025-01734-y 2025
UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6 [0.03%]
UBA6对泛素E2连接酶的特异性揭示了BIRC6的优先作用机制
Carlos Riechmann,Cara J Ellison,Jake W Anderson et al.
Carlos Riechmann et al.
In mammals, ubiquitylation is orchestrated by the canonical ubiquitin-activating E1 enzyme UBA1 and the orthogonal E1 UBA6. Growing evidence underscores the essentiality of both E1s, which differentiate between 29 active ubiquitin-conjugati...
Editorial Expression of Concern: Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis [0.03%]
表达关注的编辑评论：Munc13 C2B 域是一种依赖活性的Ca2+，可调节突触胞外分泌作用
Ok-Ho Shin,Jun Lu,Jeong-Seop Rhee et al.
Ok-Ho Shin et al.
Elizabeth T Abshire,Lynne E Maquat
Elizabeth T Abshire
The exon junction complex (EJC) begins to assemble on the spliceosome, which deposits EJCs upstream of most exon-exon junctions during pre-messenger RNA (mRNA) splicing. EJCs acquire additional alternative modules that define heterogeneous ...
Translational activators align mRNAs at the small mitoribosomal subunit for translation initiation [0.03%]
转录激活因子在小线粒体核糖体亚基上使mRNA定向以启动翻译
Joseph B Bridgers,Andreas Carlström,Dawafuti Sherpa et al.
Joseph B Bridgers et al.
Mitochondrial gene expression is essential for oxidative phosphorylation. Mitochondrial-encoded mRNAs are translated by dedicated mitochondrial ribosomes (mitoribosomes), whose regulation remains elusive. In Saccharomyces cerevisiae, nuclea...
DNA topoisomerase I acts as supercoiling sensor for bacterial transcription elongation [0.03%]
拓扑异构酶I充当细菌转录延伸的超螺旋传感器
Vita Vidmar,Céline Borde,Lisa Bruno et al.
Vita Vidmar et al.
During transcription, RNA polymerase (RNAP) continuously unwinds and rewinds DNA, generating negative and positive supercoils upstream and downstream, respectively. Using single-particle cryo-EM, we elucidated how bacterial RNAP and DNA top...
Yukun Wang,Xizi Chen,Maximilian Kümmecke et al.
Yukun Wang et al.
Transcription elongation by RNA polymerase II (Pol II) is an integral step in eukaryotic gene expression. The speed of Pol II is controlled by a multitude of elongation factors, but the exact regulatory mechanisms remain incompletely unders...