Ancient hybridization underlies tuberization and radiation of the potato lineage [0.03%]
古老的杂交作用构成了 Potato 这条进化线中块茎形成及多样化的基础
Zhiyang Zhang,Pingxian Zhang,Yiyuan Ding et al.
Zhiyang Zhang et al.
Interspecific hybridization may trigger species radiation by creating allele combinations and traits. Cultivated potato and its 107 wild relatives from the Petota lineage all share the distinctive trait of underground tubers, but the underl...
Quantifying the varying harvest of fermentation products from the human gut microbiota [0.03%]
量化人类肠道微生物群发酵产物的收获量
Markus Arnoldini,Richa Sharma,Claudia Moresi et al.
Markus Arnoldini et al.
Fermentation products released by the gut microbiota provide energy and regulatory functions to the host. Yet, little is known about the magnitude of this metabolic flux and its quantitative dependence on diet and microbiome composition. He...
DNA mutagenesis driven by transcription factor competition with mismatch repair [0.03%]
转录因子与错配修复的竞争驱动的DNA突变发生率提升现象
Wei Zhu,Yuning Zhang,Harshit Sahay et al.
Wei Zhu et al.
Despite the remarkable fidelity of eukaryotic DNA replication, nucleotide misincorporation errors occur in every replication cycle, generating mutations that drive genetic diseases and genome evolution. Here, we show that transcription fact...
Kiwa is a membrane-embedded defense supercomplex activated at phage attachment sites [0.03%]
黏附在噬菌体附着点的膜整合防御超复合物Kiwa
Zhiying Zhang,Thomas C Todeschini,Yi Wu et al.
Zhiying Zhang et al.
Bacteria and archaea deploy diverse antiviral defense systems, many of which remain mechanistically uncharacterized. Here, we characterize Kiwa, a widespread two-component system composed of the transmembrane sensor KwaA and the DNA-binding...
Cancer immunology data engine reveals secreted AOAH as a potential immunotherapy [0.03%]
癌症免疫数据引擎揭示分泌AOAH作为潜在的免疫疗法
Lanqi Gong,Jie Luo,Emily Yang et al.
Lanqi Gong et al.
Secreted proteins are central mediators of intercellular communications and can serve as therapeutic targets in diverse diseases. The ∼1,903 human genes encoding secreted proteins are difficult to study through common genetic approaches. T...
Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures [0.03%]
全面的人类蛋白质组谱图跨越50年寿命揭示了衰老轨迹和特征
Yingjie Ding,Yuesheng Zuo,Bin Zhang et al.
Yingjie Ding et al.
Proteins are the cornerstone of life. However, the proteomic blueprint of aging across human tissues remains uncharted. Here, we present a comprehensive proteomic and histological analysis of 516 samples from 13 human tissues spanning five ...
Human interpretable grammar encodes multicellular systems biology models to democratize virtual cell laboratories [0.03%]
人类可解释的语法规则编码多细胞系统生物学模型以实现虚拟细胞实验室的大众化
Jeanette A I Johnson,Daniel R Bergman,Heber L Rocha et al.
Jeanette A I Johnson et al.
Cells interact as dynamically evolving ecosystems. While recent single-cell and spatial multi-omics technologies quantify individual cell characteristics, predicting their evolution requires mathematical modeling. We propose a conceptual fr...
Tornike Mamuladze,Tiago H Zaninelli,Leon C D Smyth et al.
Tornike Mamuladze et al.
Cerebrospinal fluid (CSF) flow is essential for brain homeostasis, and its disruption is implicated in neurodegenerative and neuroinflammatory diseases. Arachnoid cuff exit (ACE) points, anatomical discontinuities in the arachnoid mater aro...
A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis [0.03%]
一项关于颅骨-大脑轴的新发现或有助中风后减少大脑炎症反应
Ruchita Kothari,Mostafa W Abdulrahim,Hyun Jong Oh et al.
Ruchita Kothari et al.
The immune environment surrounding the brain plays a fundamental role in monitoring signs of injury. Insults, including ischemic stroke, can disrupt this balance and incite an exaggerated inflammatory response, yet the underlying mechanism ...
Unmasking the Denisovans [0.03%]
揭秘丹尼索瓦人
Vanessa Villalba-Mouco,Arev Pelin Sümer
Vanessa Villalba-Mouco
The Harbin cranium, linked to Denisovans via mitochondrial DNA, broadens their known range and provides the first insights into Denisovan morphology. This discovery highlights the potential of biomolecular analysis from nontraditional sourc...