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期刊名:Signal transduction and targeted therapy

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ISSN:2095-9907

e-ISSN:2059-3635

IF/分区:52.7/Q1

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共收录本刊相关文章索引2819
Clinical Trial Case Reports Meta-Analysis RCT Review Systematic Review
Classical Article Case Reports Clinical Study Clinical Trial Clinical Trial Protocol Comment Comparative Study Editorial Guideline Letter Meta-Analysis Multicenter Study Observational Study Randomized Controlled Trial Review Systematic Review
Junwei Tang,Lu Wang,Sheng Yang et al. Junwei Tang et al.
Neoadjuvant therapy has become a cornerstone in the management of locally advanced rectal cancer (LARC). In this single-arm, open-label phase II study, we evaluated the efficacy and safety of total neoadjuvant chemotherapy (TNT) using a Cap...
Anmbreen Jamroze,Xiaozhuo Liu,Surui Hou et al. Anmbreen Jamroze et al.
BCL-2 has been implicated in prostate cancer (PCa) progression and development of castration-resistant disease (CRPC); however, it remains unclear how the BCL-2- and AR-expressing PCa cell populations evolve across the PCa continuum, how AR...
Wenzhen Gao,Li Zhu,Yali Wei et al. Wenzhen Gao et al.
The mechanisms by which core clock components are spatially organized to ensure robust oscillations in mammals remain unclear. Here, we identify the positive limb factor BMAL1 as a phase-separating protein that forms dynamic biomolecular co...
Aloña Agirre-Lizaso,Maider Huici-Izagirre,Colm J O&#x;Rourke et al. Aloña Agirre-Lizaso et al.
Cholangiocarcinoma (CCA) comprises a heterogeneous group of biliary malignant tumors with poor prognosis and limited therapeutic options. Recent studies have highlighted the role of the immune system in the development and progression of in...
Xiaofan Guo,Yuxiao Liu,Tianchen Li et al. Xiaofan Guo et al.
Tumor-associated macrophages (TAMs) are pivotal in the immunosuppressive tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC). The efficacy of targeting the CSF-1/CSF-1R axis in PDAC remains uncertain. Using single-cell RNA seq...
Jon K Obst,Carmen A Banuelos,Kunzhong Jian et al. Jon K Obst et al.
Androgen receptor (AR) is a therapeutic target for prostate cancer. Despite effectively targeting its folded ligand-binding domain (LBD), resistance ultimately develops by mechanisms involving reactivation of AR signaling. These mechanisms ...
Lin Gui,Haifeng Liu,Huaqing Wang et al. Lin Gui et al.
This phase 2, single-arm, multi-center study (NCT03934567) evaluates the efficacy and safety of abexinostat, a histone deacetylase inhibitor, in patients with relapsed or refractory (r/r) follicular lymphoma (FL). Eligible participants had ...