Antagonistic pleiotropy in disease tolerance: Foxo1-Trim63 axis as double-edged sword in age-dependent sepsis [0.03%]
疾病耐受性的拮抗多效性：Foxo1-Trim63轴在年龄依赖性脓毒症中的双刃剑作用
Unbin Chae,Jin-Man Kim,Young-Ho Park
Unbin Chae
Sintilimab (PD-1 inhibitor) plus lenvatinib as conversion therapy followed by sequential surgery (SILENSES) for advanced unresectable hepatocellular carcinoma: a phase II, expansion trial [0.03%]
sintilimab（pd-1抑制剂）联合仑伐替尼作为新辅助治疗后序贯手术(silenese研究) 治疗不可切除的局部晚期肝细胞癌：一项Ⅱ期、扩展临床试验
Shichun Lu,Wenwen Zhang,Junfeng Li et al.
Shichun Lu et al.
Our previous findings demonstrated the promising antitumor activity and manageable safety of sintilimab-lenvatinib conversion therapy. The current study aimed to evaluate long-term survival outcomes in patients with unresectable hepatocellu...
Low-dose radiotherapy synergizes with PD-1 blockade to achieve durable survival in advanced NSCLC through antitumor neutrophil programming [0.03%]
低剂量放疗通过抗肿瘤中性粒细胞编程与PD-1阻断协同作用以达到晚期非小细胞肺癌的持久生存率
Laiyan Zhou,Yuanxin Liu,Zherui Xing et al.
Laiyan Zhou et al.
The optimal strategy for combining radiotherapy (RT) and immunotherapy remains under intensive investigation. Here we developed TRIDENT (Triple Radio-Immunotherapy-Driven ENhanced Therapy), a novel triple-modality regimen combining immunomo...
Pancreatic ductal adenocarcinoma: integrating molecular insights for targeted interventions [0.03%]
胰腺导管腺癌：整合分子认识以指导靶向治疗
Ganji Purnachandra Nagaraju,Haasita Nellipudi,Chaithanya Ganji et al.
Ganji Purnachandra Nagaraju et al.
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal and aggressive tumor types, with a dismal 5-year survival rate of less than 15%. Despite major advances in understanding PDAC biology, therapeutic progress has been limited. ...
ENO2 drives tumor cell-induced M2 macrophage polarization to promote colorectal cancer liver metastasis [0.03%]
ENO2通过驱动肿瘤细胞源性M2型巨噬细胞极化促进结直肠癌肝转移
Junwei Tang,Zhihao Chen,Dongsheng Zhang et al.
Junwei Tang et al.
Liver metastasis is the primary cause of mortality in colorectal cancer (CRC) patients. To decipher the underlying mechanisms, we performed single-cell RNA sequencing (scRNA-seq) on paired primary colorectal tumors, adjacent tissues and liv...
Total neoadjuvant chemotherapy combined with PD‑1 blockade and IL‑2 in MSS/pMMR locally advanced rectal cancer: short-term results of a prospective, single-arm phase II study [0.03%]
对于MSS/pMMR局部晚期直肠癌，术前新辅助化疗联合PD-1抑制剂和IL-2的短期疗效：一项单臂二期临床试验的初步结果
Junwei Tang,Lu Wang,Sheng Yang et al.
Junwei Tang et al.
Neoadjuvant therapy has become a cornerstone in the management of locally advanced rectal cancer (LARC). In this single-arm, open-label phase II study, we evaluated the efficacy and safety of total neoadjuvant chemotherapy (TNT) using a Cap...
Harnessing pre-existing measles immunity: mRNA-Lipid nanoparticle-mediated measles hemagglutinin expression boosts antitumor CD8⁺ T cell responses [0.03%]
利用既往存在的麻疹病毒免疫性：mRNA-脂质纳米颗粒介导的麻疹血凝素表达增强抗肿瘤CD8⁺T细胞反应
Javier Martínez-Latorre,Paula M Soriano-Teruel,Vicente Candela-Noguera et al.
Javier Martínez-Latorre et al.
Single-cell imaging analysis, therapeutic modeling and a Phase Ib trial validate BCL-2 as a target across heterogeneous castration-resistant prostate cancer [0.03%]
单细胞成像分析、治疗模型及Ⅱb期临床试验验证BCL-2是异质性去势抵抗性前列腺癌的治疗靶点
Anmbreen Jamroze,Xiaozhuo Liu,Surui Hou et al.
Anmbreen Jamroze et al.
BCL-2 has been implicated in prostate cancer (PCa) progression and development of castration-resistant disease (CRPC); however, it remains unclear how the BCL-2- and AR-expressing PCa cell populations evolve across the PCa continuum, how AR...
Bone morphogenetic protein signaling drives rete ridge morphogenesis: a distinct epidermal appendage program [0.03%]
骨形态发生蛋白信号驱动毛囊ridge形态发生：一种独特的皮肤附属器官程序
Dong Gil Lee,Sun-Uk Kim,Young-Ho Park
Dong Gil Lee
BMAL1 regulates circadian rhythms via phase separation-mediated transcriptional hub formation [0.03%]
昼夜节律调节依赖于BMAL1介导的转录调控相分离簇形成
Wenzhen Gao,Li Zhu,Yali Wei et al.
Wenzhen Gao et al.
The mechanisms by which core clock components are spatially organized to ensure robust oscillations in mammals remain unclear. Here, we identify the positive limb factor BMAL1 as a phase-separating protein that forms dynamic biomolecular co...