Nuclear mitochondrial acetyl-CoA acetyltransferase 1 orchestrates natural killer cell-dependent antitumor immunity in colorectal cancer [0.03%]
结直肠癌中线粒体源性乙酰辅酶A乙酰转移酶1通过调节自然杀伤细胞的抗肿瘤免疫作用促进癌症发展
Chen Wei,Kun Liao,Hao-Jie Chen et al.
Chen Wei et al.
Tumor metabolism often interferes with the immune microenvironment. Although natural killer (NK) cells play pivotal roles in antitumor immunity, the connection between NK cells and tumor metabolism remains unclear. Our systematic analysis o...
N-deglycosylation targeting chimera (DGlyTAC): a strategy for immune checkpoint proteins inactivation by specifically removing N-glycan [0.03%]
N-去糖基化靶向嵌合体(DGlyTAC)：通过特异性去除N-聚糖失活免疫检查点蛋白的新策略
Li Li,Jiajia Wu,Weiqian Cao et al.
Li Li et al.
Among the leading methods for triggering therapeutic anti-cancer immunity is the inhibition of immune checkpoint pathways. N-glycosylation is found to be essential for the function of various immune checkpoint proteins, playing a critical r...
A20 attenuates oxidized self-DNA-mediated inflammation in acute kidney injury [0.03%]
A20通过抑制氧化的自身DNA介导的炎症在急性肾损伤中的作用研究
Hanwen Li,Yongyao Wu,Lisha Xiang et al.
Hanwen Li et al.
The ubiquitin-editing enzyme A20 is known to regulate inflammation and maintain homeostasis, but its role in self-DNA-mediated inflammation in acute kidney injury (AKI) is not well understood. Here, our study demonstrated that oxidized self...
Bio-barrier-adaptable biomimetic nanomedicines combined with ultrasound for enhanced cancer therapy [0.03%]
结合超声波的仿生纳米药物用于癌症治疗
Juan Guo,Xueting Pan,Qingyuan Wu et al.
Juan Guo et al.
Addressing the critical biological barriers of targeted accumulation and deep tumor penetration remains essential for the clinical translation of nanomedicines. However, existing nanomedicines often face challenges during in vivo transporta...
Yang Yang,Bing Zhao,Yuanzhe Wang et al.
Yang Yang et al.
Diabetic neuropathy (DN) is a prevalent and debilitating complication of diabetes mellitus, significantly impacting patient quality of life and contributing to morbidity and mortality. Affecting approximately 50% of patients with diabetes, ...
STING aggravates ferroptosis-dependent myocardial ischemia-reperfusion injury by targeting GPX4 for autophagic degradation [0.03%]
STING通过靶向GPX4促进其自噬降解从而加重心肌缺血再灌注铁死亡损伤
Xiaohong Wang,Tao Chen,Sizhe Chen et al.
Xiaohong Wang et al.
Despite advancements in interventional coronary reperfusion technologies following myocardial infarction, a notable portion of patients continue to experience elevated mortality rates as a result of myocardial ischemia-reperfusion (MI/R) in...
Tumor immunology: a short IL18 cleavage product promotes cancer immunosurveillance [0.03%]
肿瘤免疫学：一种较短的IL18裂解产物促进癌症免疫监视
Emma Guilbaud,Lorenzo Galluzzi
Emma Guilbaud
Rapavir, a novel inhibitor of sodium taurocholate cotransporting polypeptide, potently blocks hepatitis B virus entry [0.03%]
新型胆盐摄取抑制剂雷帕韦强力阻断乙肝病毒入侵钠离子通道
Jia He,Haibo Yu,Kunling Song et al.
Jia He et al.
Glucosidase alpha neutral C promotes influenza virus replication by inhibiting proteosome-dependent degradation of hemagglutinin [0.03%]
α-中性糖苷酶C通过抑制血凝素的蛋白酶体依赖性降解促进流感病毒复制
Xinzhong Liao,Qian Xie,Minqi Liang et al.
Xinzhong Liao et al.
The H7N9 influenza virus poses a significant threat to human health, and the mechanism by which it infects humans remains incompletely understood. Our investigation has unveiled significant insights into the role of glucosidase alpha, neutr...
Conversion of Ku80 K568 crotonylation to SUMOylation facilitates DNA non-homologous end joining and cancer radioresistance [0.03%]
Ku80位点的乙酰化修饰转换为SUMO修饰促进DNA非同源末端连接及肿瘤细胞放疗抵抗作用
Hongling Zhao,Shanshan Gao,Yang Han et al.
Hongling Zhao et al.
Chemo-/radioresistance of malignant tumors hampers cancer control and increases patient mortality. Efficient repair of damaged DNA is critical for the maintenance of genomic integrity and fidelity of genetic information. In reverse, increas...