Distinct metabolomic and proteomic signatures in Parkinson's disease patients with REM sleep behavior disorder [0.03%]
伴有快动眼睡眠行为障碍的帕金森病患者特有的代谢组和蛋白质组特征
Yaping Shao,Jing Wang,Yaping Liu et al.
Yaping Shao et al.
Rapid eye movement sleep behavior disorder (RBD) is the most specific prodromal marker of Parkinson's disease (PD), affecting 40-50% of PD patients. PD with RBD (RBD-PD) represents a clinically aggressive subtype characterized by more sever...
PRIME-HFrEF Trial: a randomized, double-blind, multi-dose umbilical cord-derived mesenchymal stem cell regimen for heart failure [0.03%]
关于脐带间充质干细胞治疗心力衰竭的随机、双盲、多剂量PRIME-HFREF试验
Wei Han,Yuheng Jiao,Wei Chen et al.
Wei Han et al.
The safety of multi-dose mesenchymal stem cell (MSC) regimens has seldom been systematically investigated. The PRIME-HFrEF (Prospective Randomized Controlled Study of Multiple Intravenous Infusions of Umbilical Cord-derived MSCs in Patients...
Randomized Controlled Trial
Signal transduction and targeted therapy. 2026 Mar 26;11(1):112. DOI:10.1038/s41392-026-02678-5 2026
Short-chain acyl-CoA dehydrogenase initiates mtDNA demethylation and leakage to fuel antitumor immunity in colorectal cancer [0.03%]
结直肠癌中短链酰基辅酶a脱氢酶触发线粒体DNA去甲基化和释放以促进抗肿瘤免疫反应
Fang Yang,Meng Wang,Shaofan Hu et al.
Fang Yang et al.
Reprogramming of lipid metabolism and cyclic GMP‒AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling is associated with cancer development. However, whether and how fatty acid metabolism regulates the cGAS‒STING pathway i...
Hailong Duan,Xin Peng,Sha Qin et al.
Hailong Duan et al.
Micronuclei are small, independent cytoplasmic structures containing nuclear material. They typically form during cell division due to DNA damage or division abnormalities, serve as biomarkers of genetic damage, and are closely associated w...
Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications [0.03%]
活性氧在癌症中的作用：从机制到治疗意义
Sharmin Akter,Rajesh Madhuvilakku,Anik Kumar Kar et al.
Sharmin Akter et al.
Reactive oxygen species (ROS) act as critical secondary messengers in various intracellular signaling pathways that regulate cellular proliferation, differentiation, and survival under normal physiological conditions. However, dysregulation...
Oligodendrocyte precursor cells-microglia crosstalk via BMP4 drives microglial neuroprotective response and mitigates Alzheimer's disease [0.03%]
少突前体细胞-小胶质细胞通过BMP4相互作用驱动小胶质细胞神经保护反应并缓解阿尔茨海默病
Soonbong Baek,Jaemyung Jang,Seungeun Yeo et al.
Soonbong Baek et al.
Oligodendrocyte precursor cells (OPCs) rapidly respond to neural injury, becoming activated to preserve myelin homeostasis and interacting with diverse cell types in the central nervous system (CNS). However, the molecular basis of OPC comm...
Arterial inflammation after myocardial infarction: regulating the immune system [0.03%]
心肌梗死后动脉炎症：调节免疫系统
Christos P Kotanidis,Charalambos Antoniades
Christos P Kotanidis
Visinin-like protein 1 disrupts calcium homeostasis and promotes atrial fibrillation in human and rodent models [0.03%]
VISN-like蛋白1通过扰乱钙稳态促进人类及小鼠房颤发生
Ke Xiong,Guanghua Wang,Desheng Li et al.
Ke Xiong et al.
Atrial fibrillation (AF), the most prevalent sustained cardiac arrhythmia, is closely linked to disturbed intracellular Ca2+ homeostasis. Visinin-like protein 1 (VILIP-1), newly identified in cardiomyocytes, has been implicated in modulatin...
Potent and selective LSD1 inhibitor DC551040 reveals a promising combination therapy for AML with insight into epigenetic dysregulation [0.03%]
potent和选择性LSD1抑制剂DC551040显示了针对AML组合疗法的希望，揭示了表观遗传失调的见解
Jiang Wang,Hanlin Wang,Runhua Du et al.
Jiang Wang et al.
Epigenetic dysregulation is a fundamental cancer hallmark, and lysine demethylase 1 (LSD1) is a central target for cancer intervention. Developing novel LSD1 inhibitors with high selectivity, favorable bioavailability, and safety for acute ...