Targeting tumor-specific T cells with LAG3-directed interleukin-2 prevents T-cell exhaustion and reinvigorates antitumor immunity [0.03%]
LAG3定向白细胞介素-2可靶向肿瘤特异性T细胞，防止T细胞衰竭并重新激发抗肿瘤免疫反应
Xiaohong Yu,Huiping Liao,Jiaoyun Lv et al.
Xiaohong Yu et al.
LAG3 is a critical inhibitory receptor that is highly enriched on exhausted T cells within the tumor microenvironment (TME), where it acts as a key driver of T-cell exhaustion-an archetypal barrier to robust antitumor immunity. In a colon c...
Elongation of spinal cord reactive astrocytes via LRP1/TRK signaling [0.03%]
LRP1/TRK信号调控脊髓星形胶质细胞反应性增生
Francisco Javier Rodriguez-Jimenez,Francisca Selles,Pavla Jendelova et al.
Francisco Javier Rodriguez-Jimenez et al.
Necroptosis triggers inflammatory interferon signatures in patient-derived metastatic breast cancer organoids [0.03%]
患者衍生的转移性乳腺癌类器官中坏死性凋亡触发炎症干扰素特征
Kaja Nicole Wächtershäuser,Jana V Schneider,Alec Gessner et al.
Kaja Nicole Wächtershäuser et al.
Breast cancer (BC) is the most common type of cancer among women worldwide and underlies relapse, disease progression, and metastasis. Resistance to chemotherapy and programmed cell death (PCD), including apoptosis, strongly affects BC ther...
Insights into the therapeutic strategies for aging and aging-associated diseases [0.03%]
衰老及老年相关疾病的治疗策略新见解
Ruifang Dong,Qiming Wu,Juntao Kan et al.
Ruifang Dong et al.
Aging is a complex biological process characterized by progressive functional decline, driving the incidence of age-related diseases such as neurodegeneration, metabolic disorders, and cardiovascular diseases. Therapeutic strategies targeti...
Sintilimab plus concurrent chemoradiotherapy for treatment of locally advanced small cell lung cancer (SINCE-01): a phase II clinical trial [0.03%]
sintilla单抗联合同期放化疗治疗局部晚期小细胞肺癌(SINCE-01):一项II期临床试验
Qian Zhao,Yintao Li,Hongjiao Zhang et al.
Qian Zhao et al.
Patients diagnosed with limited-stage small cell lung cancer (LS-SCLC) face dismal long-term outcomes, as relapse occurs frequently even after standard concurrent chemoradiotherapy. Integrating immune checkpoint blockade into chemoradiother...
Haoyi Yang,Huafeng Zhang,Ni Xia et al.
Haoyi Yang et al.
As immunoregulatory cells, regulatory T cells (Tregs) play pivotal roles in maintaining immune tolerance and preventing autoimmunity. However, Tregs exhibit distinct functions across different diseases. In cancer, Tregs are most likely to s...
Dual epitope anti-LILRB4 synthetic T-cell receptor and antigen receptor (STAR)-T-cell therapy for relapsed/refractory acute myeloid leukemia [0.03%]
用于复发/难治性急性髓系白血病的双表位抗LILRB4合成T细胞受体和抗原受体（STAR）-T细胞疗法
Meng Lv,Hongli Zheng,Xuying Pei et al.
Meng Lv et al.
Acute myeloid leukemia (AML) is a rapidly progressive malignancy with poor prognosis. To date, chimeric antigen receptor (CAR) T-cell therapy in AML has been limited by the lack of antigens with high specificity for AML cells. Here, we deve...
Combating small extracellular vesicle-mediated immunological barriers in the tumor microenvironment via strategically activatable PEGylated peptides [0.03%]
利用策略性激活型聚乙二醇化肽对抗肿瘤微环境中由小型细胞外囊泡介导的免疫屏障
Chan Ho Kim,Hyewon Ko,Jae Ah Lee et al.
Chan Ho Kim et al.
Tumor cell-derived small extracellular vesicles (TDEs) play a critical role in immune evasion, including the establishment of an immunosuppressive tumor microenvironment (TME), and form a substantial barrier to effective cancer immunotherap...
PRELP negatively regulates IL-17A-mediated proliferation and the inflammatory response in psoriasis [0.03%]
PRELP通过抑制IL-17A介导的增殖和炎症反应负向调控银屑病病变进展
Cong-Cong He,Ming-Xing Lei,Jing-Wei Jiang et al.
Cong-Cong He et al.
Psoriasis is a common immune-mediated skin disease driven largely by interleukin-17A (IL-17A). Although IL-17A plays a key role in disease pathogenesis, the underlying mechanisms remain incompletely understood. Through bioinformatic analysi...
Phosphoproteomics distinguishes disease-specific mechanisms for human phospholamban cardiomyopathy reversible by RNA therapy [0.03%]
磷酸蛋白质组学区分人类磷蛋白 lamana 心肌病的疾病特异性机制，可通过 RNA 疗法逆转
Frederik E Deiman,Nils Bömer,Pia Davidsson et al.
Frederik E Deiman et al.
Phospholamban (PLN) p.Arg14del (R14Δ/+, also known as R14del) is a pathogenic variant that causes inherited cardiomyopathy. RNA therapy improves cardiac function and survival in murine PLN R14Δ/+. However, the molecular disease mechanisms...