Glioblastoma at the crossroads: current understanding and future therapeutic horizons [0.03%]
胶质母细胞瘤的现状与未来治疗前景
Shilpi Singh,Devanjan Dey,Debashis Barik et al.
Shilpi Singh et al.
Glioblastoma (GBM) remains the most aggressive and lethal brain tumor in adults and poses significant challenges to patient survival. This review provides a comprehensive exploration of the molecular and genetic landscape of GBM, focusing o...
A novel peptide 66CTG stabilizes Myc proto-oncogene protein to promote triple-negative breast cancer growth [0.03%]
一种新型肽66CTG可稳定Myc原癌基因蛋白以促进三阴性乳腺癌生长
Huichun Liang,Fubing Li,Huan Fang et al.
Huichun Liang et al.
Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer that lacks reliable targets for diagnosis and therapy. Non-coding RNA (ncRNA)-encoded products hold promise for addressing this unmet need. By analyzing the...
Transferrin receptor 1 nuclear translocation facilitates tumor progression via p53-mediated chromatin interactions and genome-wide alterations [0.03%]
转铁蛋白受体1核转移通过p53介导的染色质相互作用和全基因组变化促进肿瘤进展
Yaxin Hou,Guoheng Tang,Qizhi Wang et al.
Yaxin Hou et al.
Transferrin receptor 1 (TfR1), a widely expressed type II transmembrane glycoprotein located on the plasma membrane, is well known for its established role in cellular iron uptake. Nevertheless, emerging evidence implies that TfR1 exhibits ...
Acevaltrate as a novel ferroptosis inducer with dual targets of PCBP1/2 and GPX4 in colorectal cancer [0.03%]
靶向PCBP1/2和GPX4的新型铁死亡诱导剂Acevaltrate在结直肠癌中的作用
Dianping Yu,Hongmei Hu,Qing Zhang et al.
Dianping Yu et al.
Ferroptosis induced by ferrous ions (Fe2+) and lipid peroxidation accumulation is a novel form of regulated cell death that has become a hot topic in tumor therapy research. Identifying small-molecule drugs that can induce ferroptosis in tu...
Tislelizumab (anti-PD-1) plus chemotherapy as neoadjuvant therapy for patients with stage IB3/IIA2 cervical cancer (NATIC): a prospective, single-arm, phase II study [0.03%]
替雷利珠单抗（抗PD-1）联合化疗作为IB3/IIA2期宫颈癌新辅助治疗的疗效和安全性：一项前瞻性、单臂、Ⅱ期临床试验（NATIC研究）
Jindong Sheng,Haitao Luo,Xiangyu Liu et al.
Jindong Sheng et al.
The clinical benefit of neoadjuvant immunochemotherapy in locally advanced cervical cancer (LACC) remains unclear. This single-arm, phase II study (Chinese Clinical Trial Registry, ChiCTR2200065392) aimed to evaluate the efficacy and safety...
CAR-T cell therapy for cancer: current challenges and future directions [0.03%]
癌症的CAR-T细胞治疗：当前挑战与未来发展方向
Inés Zugasti,Lady Espinosa-Aroca,Klaudyna Fidyt et al.
Inés Zugasti et al.
Chimeric antigen receptor T (CAR-T) cell therapies have transformed the treatment of relapsed/refractory (R/R) B-cell malignancies and multiple myeloma by redirecting activated T cells to CD19- or BCMA-expressing tumor cells. However, this ...
Oleic acid restores the impaired antitumor immunity of γδ-T cells induced by palmitic acid [0.03%]
油酸可恢复棕榈酸诱导的γδT细胞抗肿瘤免疫受损的作用
Yanmei Zhang,Zheng Xiang,Yan Xu et al.
Yanmei Zhang et al.
Dietary fatty acids (FAs) are associated with the therapeutic intervention under various health conditions. Human γδ-T cells are indispensable for immunosurveillance toward malignant cells. However, their impact on γδ-T cell metabolism ...
Safety and immunogenicity of an HIV vaccine trial with DNA prime and replicating vaccinia boost [0.03%]
DNA联合复制型痘苗病毒艾滋病疫苗的安全性和免疫原性临床研究
Ying Liu,Wei Lv,Pu Shan et al.
Ying Liu et al.
Developing a safe and effective vaccine remains a global priority for ending the human immunodeficiency virus (HIV) pandemic. All HIV vaccine trials with protein, DNA, non-replication vector or their combinations failed in the past. We cons...
Tailoring a novel colorectal cancer stem cell-targeted therapy by inhibiting the SMYD3/c-MYC axis [0.03%]
通过抑制SMYD3/c-MYC轴靶向新型结直肠癌干细胞治疗
Martina Lepore Signorile,Elisabetta Di Nicola,Giovanna Forte et al.
Martina Lepore Signorile et al.
Cancer stem cells (CSCs) are responsible for colorectal cancer (CRC) chemoresistance, recurrence, and metastasis. Therefore, identifying molecular stemness targets that are involved in tumor growth is crucial for effective treatment. Here, ...
Serine/threonine/tyrosine kinase 1 drives pancreatic carcinogenesis via GSK3β sequestration-mediated Wnt/β-catenin pathway hyperactivation [0.03%]
丝氨酸/苏氨酸/酪氨酸蛋白激酶1通过GSK3β捕获介导的Wnt/β-连环蛋白信号过度活化驱动胰腺癌发生
Cefan Zhou,Xueying Dong,Shi Li et al.
Cefan Zhou et al.
The Wnt/β-catenin pathway is strongly relevant to pancreatic cancer progression, poor prognostic outcomes, and elevated cancer-related mortality. However, the mechanism underlying continuously activated Wnt/β-catenin signaling in pancreat...