Protein lactylation in health and diseases: molecular mechanisms, biological significance, and clinical implications [0.03%]
蛋白质乳酰化在健康与疾病中的作用：分子机制、生物意义及临床意义
Yue Yang,Ying He,Ziyi Zhang et al.
Yue Yang et al.
Protein lysine lactylation (Kla) is a newly identified post-translational modification (PTM), in which lactyl groups are transferred to specific lysine residues in proteins. As a crucial intermediary between cellular metabolism and epigenet...
Orelabrutinib versus chemoimmunotherapy in treatment-naïve chronic lymphocytic leukemia/small lymphocytic lymphoma: a randomized, phase 3 trial [0.03%]
奥雷布替尼与化疗免疫疗法在初治慢性淋巴细胞白血病/小淋巴细胞淋巴瘤中的疗效比较：一项随机III期临床试验
Fei Li,Keshu Zhou,Wei Xu et al.
Fei Li et al.
Orelabrutinib is a potent, irreversible, and highly-selective BTK inhibitor that has been approved for the treatment of relapsed/refractory chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL). This randomized, phase 3 study (...
Neoadjuvant tislelizumab (anti-PD-1 antibody) plus chemotherapy in patients with advanced epithelial ovarian cancer: the exploratory NAIVE trial [0.03%]
替雷利珠单抗（PD-1抗体）联合化疗新辅助治疗晚期卵巢上皮癌的Ⅱ期NAIVE研究
Zhigang Zhang,Jing Fei,Sangting Lao et al.
Zhigang Zhang et al.
The clinical efficacy and immune modulation of neoadjuvant immunochemotherapy for epithelial ovarian cancer (EOC) remain uncertain. To clarify these effects, the NAIVE trial (NCT04815408), a prospective phase II study, evaluated the efficac...
Next-generation chemogenetic inhibition using a brain-permeant non-prescription agent [0.03%]
一种可通过血脑屏障的非处方药物化学遗传学抑制方法
Steven O Devenish,Sahil D Patel,Laura V Ussingkær et al.
Steven O Devenish et al.
Chemogenetics allows the controllable manipulation of brain circuits upon delivery of a selective activating ligand, and has been invaluable in dissecting brain circuits underlying many behaviours. The Gαi/o-coupled designer muscarinic rec...
Osimertinib-induced cardiotoxicity is driven by HDAC-dependent epigenetic repression and rescued by vorinostat [0.03%]
柳氮替尼诱导的心脏毒性由组蛋白脱乙酰酶依赖的表观遗传抑制驱动，并可通过伏立诺他逆转
Angelica Toro Cora,Arvind Singh Bhati,Allen Sam Titus et al.
Angelica Toro Cora et al.
Osimertinib, a third-generation EGFR tyrosine kinase inhibitor (TKI), has improved outcomes in non-small cell lung cancer (NSCLC) patients harboring the T790M mutation; however, emerging clinical evidence indicates a risk of cardiotoxicity....
Partial downregulation of platelet glycoprotein VI by low affinity antibodies confers sustained and safe antithrombotic protection [0.03%]
部分下调血小板糖蛋白VI的低亲和力抗体可提供持续且安全的抗血栓保护作用
Stefano Navarro,Sarah Beck,Sabrina I Bonfiglio et al.
Stefano Navarro et al.
Glycoprotein (GP) VI is a platelet-specific activating receptor for collagen and fibrin(ogen), and a promising target for antithrombotic therapy. Inhibitory Fab fragments against GPVI provide robust protection in mouse models of arterial th...
Extracellular RNA dimension in alternative medicine: processing-dependent integrity and bioactivity of honeysuckle miRNA MIR2911 [0.03%]
外泌rna视角下的替代医学：忍冬miRNA MIR2911的处理依赖性完整性及生物活性
Jieqiong Lei,Yangchao Dong,Yiting Wu et al.
Jieqiong Lei et al.
What's past is prologue: epigenetic memory links transient inflammation to future disease [0.03%]
往事不忘──表观遗传记忆链接短暂的炎症和未来的疾病
Samuel T Keating,Assam El-Osta
Samuel T Keating
Advances and prospects in cell therapy for cancer: explorations from T cells to stem cells [0.03%]
肿瘤细胞治疗进展与前景——从T细胞到干细胞探索
Guisha Zi,Lei Zhang,Ling Zhou et al.
Guisha Zi et al.
The increasing global burden of cancer necessitates innovative therapeutic strategies. Cell therapy represents a major breakthrough in oncology, evolving rapidly from the successful application of chimeric antigen receptor T (CAR-T) cells i...
Tetrahedral DNA nano-PROTACs enable enhanced ocular penetration and efficient nucleolin degradation for choroidal neovascularization therapy [0.03%]
四面体DNA纳米分子胶降解核糖核酸结合蛋白核糖核酸酶，治疗脉络膜新生血管病
Jiayi Song,Xu Wei,Kai He et al.
Jiayi Song et al.
Despite the paradigm shift brought about by anti-VEGF therapy against neovascular age-related macular degeneration, significant challenges persist, including the risk of intraocular infection and retinal structural damage caused by frequent...