Glycolytic heterogeneity drives metabolic-targeted therapy in pancreatic ductal adenocarcinoma [0.03%]
糖酵解异质性驱动胰腺导管腺癌代谢靶向治疗
Ugo Chianese,Chiara Papulino,Gerardo Saggese et al.
Ugo Chianese et al.
Pancreatic ductal adenocarcinoma is traditionally characterized as a glycolytic tumor. However, the extent and clinical relevance of its metabolic heterogeneity remain poorly understood. In this study, we investigated whether glycolytic act...
Correction: Circulating tumor DNA refines consolidation immunotherapy for limited-stage small cell lung cancer patients [0.03%]
纠正：循环肿瘤DNA可优化有限期小细胞肺癌患者的免疫巩固治疗
Yin Yang,Yuqi Wu,Jingjing Zhao et al.
Yin Yang et al.
Diabetes and its complications: molecular mechanisms, prevention and treatment [0.03%]
糖尿病及其并发症的分子机制、预防和治疗措施
Lijun Zhao,Jiamin Yuan,Qing Yang et al.
Lijun Zhao et al.
Diabetic complications represent a formidable clinical challenge characterized by hyperglycemia-induced multiorgan dysfunction and dysregulated intercellular signaling networks. Advances in spatial multiomics and single-cell transcriptomic ...
Astrocytic noncanonical WNT5B signaling modulates extracellular matrix remodeling and neuropathology in Huntington's disease [0.03%]
astrocyte非经典WNT5B信号通路调节亨廷顿病中的细胞外基质重塑及神经病理学变化
Phuong Thi Thanh Nguyen,Ali Yousefian-Jazi,Seung Jae Hyeon et al.
Phuong Thi Thanh Nguyen et al.
Huntington's disease (HD) is a fatal neurodegenerative disorder characterized by a triad of behavioral symptoms: involuntary movement, emotional change, and cognitive dysfunction. Although alterations in WNT signaling have been reported in ...
A microbiota-dependent bile acid reprograms alveolar macrophages to control lung inflammation [0.03%]
一种依赖微生物群的胆汁酸重新编程肺泡巨噬细胞以控制肺部炎症
Magdalena Wolska,Pilar Rodríguez-Viso,Anna Świątkowska et al.
Magdalena Wolska et al.
Metabolic dysfunction-associated steatotic liver disease accelerates pancreatic cancer progression and metastasis via the macrophage migration inhibitory factor-CD44 axis [0.03%]
代谢功能紊乱相关脂肪性肝病通过巨噬细胞迁移抑制因子-CD44轴加速胰腺癌的进展和转移
Qian Yu,Hui Song,Xiao-Ya Shi et al.
Qian Yu et al.
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a poor prognosis, particularly in the presence of liver metastases. The mechanisms by which metabolic dysfunction-associated steatotic liver disease (MASLD), for...
Vertical RAS pathway inhibition in pancreatic cancer drives therapeutically exploitable mitochondrial alterations [0.03%]
胰腺癌中的垂直RAS通路抑制驱动了可药物利用的线粒体改变
Philipp Hafner,Steffen J Keller,Xun Chen et al.
Philipp Hafner et al.
Oncogenic KRAS mutations drive metabolic reprogramming in pancreatic ductal adenocarcinoma (PDAC). Src-homology 2 domain-containing phosphatase 2 (SHP2) is essential for full KRAS activity, and promising dual SHP2/mitogen-activated protein ...
Extracellular vesicle-derived miRNA-182-5p educates macrophages towards an immunosuppressive phenotype in pancreatic cancer [0.03%]
胰腺癌中细胞外小泡衍生的miRNA-182-5p使巨噬细胞向免疫抑制表型分化
Baldev Singh,Pankaj Gaur,Pritha Bose et al.
Baldev Singh et al.
Reprogramming the immunosuppressive milieu in pancreatic cancer (PaCa) remains an important yet unmet therapeutic goal. Although tumor-associated macrophages (TAMs) are known to promote tumor growth and metastasis, little is known about the...
Perioperative penpulimab-based combination therapy in patients with resectable non-small cell lung cancer (ALTER-L043): an open-label, multicenter, randomized, phase II trial [0.03%]
可切除非小细胞肺癌患者围手术期派安普利单抗联合治疗：一项开放性、多中心、随机II期试验（ALTER-L043）
Meng Wang,Weiran Liu,Hongbo Guo et al.
Meng Wang et al.
Although perioperative immunotherapy combined with neoadjuvant chemotherapy has improved the clinical outcomes of patients with resectable non-small cell lung cancer (NSCLC), the optimal combination strategy remains unknown. This multicente...
The aryl hydrocarbon receptor: structure, signaling, physiology and pathology [0.03%]
芳烃受体：结构、信号转导及其生理和病理作用
Xavier Coumoul,Robert Barouki,Charlotte Esser et al.
Xavier Coumoul et al.
The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor of the bHLH/PAS protein family. In this review, we explore the multifaceted roles of AHR in both health and disease, tracing its recognition as a xenobiotic sens...