Francesca Vallese
Francesca Vallese
RNase MRP subunit composition and role in 40S ribosome biogenesis [0.03%]
核糖核酸酶MRP的亚基组成及其在40S核糖体生成中的作用
Eric M Smith,Jimmy Ly,Sofia Haug et al.
Eric M Smith et al.
RNase MRP and RNase P are evolutionarily related complexes that facilitate rRNA and tRNA biogenesis, respectively. The two enzymes share nearly all protein subunits and have evolutionarily related catalytic RNAs. Notably, RNase P includes a...
Structural basis for agonist and heat activation of nociceptor TRPM3 [0.03%]
TRPM3热敏离子通道被激动剂活化及高温活化的分子机制
Sushant Kumar,Fei Jin,Sung Jin Park et al.
Sushant Kumar et al.
Detecting noxious heat is vital for survival, triggering protective pain responses. The TRPM3 channel is a key nociceptor and a promising therapeutic target for pain and neurological disorders. Here we show that the rabbit TRPM3 is intrinsi...
Epigenetic priming promotes tyrosine kinase inhibitor resistance and oncogene amplification [0.03%]
表观遗传学预处理促进酪氨酸激酶抑制剂耐药性和癌基因扩增
Rebecca M Starble,Eric G Sun,Rana Gbyli et al.
Rebecca M Starble et al.
In mammalian cells, gene copy number is controlled to maintain gene expression and genome stability. However, a common molecular feature across cancer types is oncogene amplification, increasing the copy number and expression of tumor-promo...
Global analysis of translocon remodeling during protein synthesis at the ER [0.03%]
对蛋白质在内质网上合成时转位体重塑的全球分析
Arunkumar Sundaram,Qianru Li,Yu Wan et al.
Arunkumar Sundaram et al.
Protein biogenesis at the endoplasmic reticulum requires translocons comprising the Sec61 protein-conducting channel and several dynamically associated accessory factors. Here we used transcriptome-wide selective ribosome profiling in human...
Dynamics of microcompartment formation at the mitosis-to-G1 transition [0.03%]
有丝分裂向G1期过渡过程中微区室的形成动力学研究
Viraat Y Goel,Nicholas G Aboreden,James M Jusuf et al.
Viraat Y Goel et al.
As cells exit mitosis and enter G1, chromosomes decompact and transcription is reestablished. Hi-C studies have indicated that all interphase three-dimensional genome features, including A/B compartments, topologically associating domains a...
Hugo Sepulveda
Hugo Sepulveda
Structure and activation mechanism of a Lamassu phage and plasmid defense system [0.03%]
一种拉玛苏噬菌体和质粒防御系统的结构及激活机制
Yan Li,David W Adams,Hon Wing Liu et al.
Yan Li et al.
Lamassu is a diverse family of defense systems that protect bacteria, including seventh-pandemic strains of Vibrio cholerae, against both plasmids and phage infection. During phage infection, Lamassu targets essential cellular processes, th...
Author Correction: Recruitment of Atg1 to the phagophore by Atg8 orchestrates autophagy machineries [0.03%]
作者更正：Atg8通过招募Atg1至吞噬体来协调自噬机器人的运作
Jing-Zhen Song,Hui Li,Haiyan Yang et al.
Jing-Zhen Song et al.
Published Erratum
Nature structural & molecular biology. 2025 Oct 13. DOI:10.1038/s41594-025-01700-8 2025