piRNA gene density and SUMOylation organize piRNA transcriptional condensate formation [0.03%]
piRNA基因密度和SUMO化组织piRNA转录凝聚体形成
Chengming Zhu,Xiaoyue Si,Xinhao Hou et al.
Chengming Zhu et al.
Piwi-interacting RNAs (piRNAs) are essential for maintaining genome integrity and fertility in various organisms. In flies and nematodes, piRNA genes are encoded in heterochromatinized genomic clusters. The molecular mechanisms of piRNA tra...
Xiangyun Fang,Haichao Jin,Jin Wang et al.
Xiangyun Fang et al.
TWIK-related halothane-inhibited potassium channel (THIK1) maintains the resting membrane potential and regulates potassium efflux in microglia. It is a potential therapeutic target for neurodegenerative disorders, neuropathic pain and infl...
Author Correction: Reconstruction of diploid higher-order human 3D genome interactions from noisy Pore-C data using Dip3D [0.03%]
作者更正：使用Dip3D从嘈杂的Pore-C数据重建二倍体高阶人类三维基因组相互作用
Ying Chen,Zhuo-Bin Lin,Shao-Kai Wang et al.
Ying Chen et al.
Published Erratum
Nature structural & molecular biology. 2025 Apr 28. DOI:10.1038/s41594-025-01571-z 2025
Recruitment of Atg1 to the phagophore by Atg8 orchestrates autophagy machineries [0.03%]
Atg8介导的Atg1招募调控自噬机器聚集组装
Jing-Zhen Song,Hui Li,Haiyan Yang et al.
Jing-Zhen Song et al.
Autophagy-related (Atg) proteins catalyze autophagosome formation at the phagophore assembly site (PAS). The assembly of Atg proteins at the PAS follows a semihierarchical order, in which Atg8 is thought to be quite downstream but still abl...
Design of PROTACs utilizing the E3 ligase GID4 for targeted protein degradation [0.03%]
利用E3连接酶GID4设计PROTAC以降解目标蛋白
Yanran Li,Kaiwen Bao,Jiyue Sun et al.
Yanran Li et al.
Proteolysis targeting chimeras (PROTACs) hijack E3 ligases and the ubiquitin-proteasome system to achieve selective degradation of neo-substrates. Their ability to target otherwise intractable substrates has rendered them a valuable modalit...
Hijai R Shin,Roberto Zoncu
Hijai R Shin
Pengxin Chai,Jun Yang,Indigo C Geohring et al.
Pengxin Chai et al.
Dynein-driven cargo transport has a pivotal role in diverse cellular activities, central to which is dynein's mechanochemical cycle. Here, we performed a systematic cryo-electron microscopic investigation of the conformational landscape of ...
Cryo-EM structures of PP2A:B55 with p107 and Eya3 define substrate recruitment [0.03%]
低温电子显微镜下的PP2A:B55与p107和Eya3复合物结构确定底物募集机制
Sathish K R Padi,Rachel J Godek,Wolfgang Peti et al.
Sathish K R Padi et al.
Phosphoprotein phosphatases (PPPs) achieve specificity by binding substrates and regulators using PPP-specific short motifs. Protein phosphatase 2A (PP2A) is a highly conserved phosphatase that regulates cell signaling and is a tumor suppre...
The subcortical maternal complex safeguards mouse oocyte-to-embryo transition by preventing nuclear entry of SPIN1 [0.03%]
次皮层母细胞复合体通过阻止SPIN1进入核内来保障小鼠卵母细胞到胚胎的转换
Chengpeng Xu,Dandan Qin,Xukun Lu et al.
Chengpeng Xu et al.
How cytoplasmic regulators control nuclear events in mammalian oocytes and early embryos remains largely enigmatic. We previously identified a subcortical maternal complex (SCMC) that specifically resides in the cytoplasm of mammalian oocyt...
Author Correction: Structure of the human K2P13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site [0.03%]
作者更正：人K2P13.1通道的结构揭示了亲水性孔道限制和脂质辅因子位点
Shatabdi Roy-Chowdhury,Seil Jang,Fayal Abderemane-Ali et al.
Shatabdi Roy-Chowdhury et al.
Published Erratum
Nature structural & molecular biology. 2025 Apr 15. DOI:10.1038/s41594-025-01553-1 2025