Soma-to-germline miRNA inheritance through yolk promotes stress resilience in progeny [0.03%]
卵黄促进体细胞来源的miRNA继承以增强子代抗逆性
Névé Aupérin,Meetali Singh,Loan Bourdon et al.
Névé Aupérin et al.
At the onset of reproduction, oviparous animals synthesize large amounts of yolk in somatic tissues to provide lipids and other nutrients to their progeny. However, whether the yolk transports other molecules, such as RNAs with gene-regulat...
Rap1-mediated steric hindrance protects telomeres from MRX sensing [0.03%]
Rap1通过立体位阻介导的机制保护端粒免于MRX的感受作用
Stefano Mattarocci,Giordano Reginato,Elda Cannavo et al.
Stefano Mattarocci et al.
Telomere capping largely depends on telomere length. Abnormally short telomeres are prone to activate DNA damage checkpoint, undergo unscheduled chromosomal fusions through nonhomologous end-joining (NHEJ) and be resected. All these process...
Structural basis of PTH1R-β-arrestin core engagement reveals design principles for G-protein-biased therapeutics [0.03%]
甲状旁腺激素受体与β-arrestin复合物的结构基础揭示了偏向型G蛋白药物的设计原理
Li-Hua Zhao,Qian He,Qingning Yuan et al.
Li-Hua Zhao et al.
G-protein-coupled receptors (GPCRs) transmit cellular signals through both G protein and arrestin pathways and biased signaling offers potential therapeutic advantages through selective activation. Although GPCR-G protein complexes are well...
How ligands tune the parathyroid hormone receptor's grip on β-arrestin [0.03%]
配体如何调节甲状旁腺激素受体与β-arrestin的结合力
Jakob Höppner,Thomas J Gardella
Jakob Höppner
Peter Škrinjar,Jérôme Eberhardt,Gabriel Studer et al.
Peter Škrinjar et al.
Deep learning has driven major breakthroughs in protein structure prediction; however, one of the next critical steps forward is accurately predicting how proteins interact with small-molecule ligands, to enable real-world applications such...
Membrane insertion of mitochondrial-encoded proteins regulates ribosome decoding speed [0.03%]
线粒体编码蛋白的膜插入调节核糖体解码速度
Thomas Schöndorf,Valentyn Petrychenko,Ilgin Kotan et al.
Thomas Schöndorf et al.
The human mitochondrial genome encodes 13 subunits of the oxidative phosphorylation system essential for energy metabolism to drive cellular activities. Translation of 11 mRNAs by membrane-bound ribosomes is coupled to insertion of the nasc...
Michele Brischigliaro,Antoni Barrientos
Michele Brischigliaro
Structural basis for recognition of diverse localizing mRNAs by Egl-BicD [0.03%]
Egl和BicD识别多种定位mRNA的分子机制
Kashish Singh,Sabila Chilaeva,Mark A McClintock et al.
Kashish Singh et al.
Localization of mRNAs is a widespread mechanism for dictating where proteins operate in cells and underpins many fundamental processes, from embryonic patterning to synaptic plasticity. This spatial control is mediated by the interaction of...
Florence Besse,Andres Ramos
Florence Besse
Integrated MINFLUX tracking reveals two distinct chromatin dynamics classes across cell types [0.03%]
整合的MINFLUX追踪在细胞类型间揭示了两种不同的染色质动态类别
Matteo Mazzocca,Domenic N Narducci,Simon Grosse-Holz et al.
Matteo Mazzocca et al.
Chromatin dynamics control the timescales of essential biological processes and reflect how chromatin is organized in the nucleus. Previous studies have reported widely varying degrees of chromatin subdiffusion without consensus. For robust...