Phase separation promotes Atg8 lipidation and vesicle condensation for autophagy progression [0.03%]
相分离通过促进自噬相关脂化和囊泡浓缩来促进自噬体发育
Yuko Fujioka,Takuma Tsuji,Tetsuya Kotani et al.
Yuko Fujioka et al.
Upon starvation, the autophagy-initiating Atg1 complex undergoes phase separation to organize the preautophagosomal structure (PAS) in Saccharomyces cerevisiae, from which autophagosome formation is considered to proceed. However, the physi...
GluA4 AMPA receptor gating mechanisms and modulation by auxiliary proteins [0.03%]
GluA4型AMPA受体的激活机制及其辅助蛋白调节作用
Carlos Vega-Gutiérrez,Javier Picañol-Párraga,Irene Sánchez-Valls et al.
Carlos Vega-Gutiérrez et al.
AMPA-type glutamate receptors, fundamental ion channels for fast excitatory neurotransmission and synaptic plasticity, contain a GluA tetrameric core surrounded by auxiliary proteins such as transmembrane AMPA receptor regulatory proteins (...
Activation of Arp2/3 complex by a SPIN90 dimer in linear actin-filament nucleation [0.03%]
SPIN90二聚体在直线状肌动蛋白核生成中的Arp2/3复合体活化作用
Justus Francis,Achyutha Krishna Pathri,Kankipati Teja Shyam et al.
Justus Francis et al.
Arp2/3 complex is a key nucleator of actin filaments. It requires activation by nucleation-promoting factors (NPFs). WISH/DIP1/SPIN90 (WDS) proteins represent a unique class of NPFs that activate the Arp2/3 complex independently of preexist...
Arp2/3-mediated bidirectional actin assembly by SPIN90 dimers [0.03%]
SPIN90二聚体介导的由Arp2/3活化双向成肌动蛋白组装
Tianyang Liu,Luyan Cao,Miroslav Mladenov et al.
Tianyang Liu et al.
Branched actin networks nucleated by the Arp2/3 complex have critical roles in various cellular processes, from cell migration to intracellular transport. However, when activated by WISH/DIP/SPIN90-family proteins, Arp2/3 nucleates linear a...
Cameron J Glasscock,Robert J Pecoraro,Ryan McHugh et al.
Cameron J Glasscock et al.
Sequence-specific DNA-binding proteins (DBPs) have critical roles in biology and biotechnology and there has been considerable interest in the engineering of DBPs with new or altered specificities for genome editing and other applications. ...
Dimitris Typas
Dimitris Typas
m6A and the NEXT complex direct Xist RNA turnover and X-inactivation dynamics [0.03%]
m6A和NEXT复合体通过直接调控XistRNA的周转来影响X染色体失活的动态过程
Guifeng Wei,Heather Coker,Lisa Rodermund et al.
Guifeng Wei et al.
X-chromosome inactivation (XCI) in mammals is orchestrated by the noncoding RNA X-inactive-specific transcript (Xist) that, together with specific interacting proteins, functions in cis to silence an entire X chromosome. Defined sites on Xi...