Melina Casadio
Melina Casadio
Structural basis of ClC-3 transporter inhibition by TMEM9 and PtdIns(3,5)P2 [0.03%]
TMEM9和PtdIns(3,5)P2抑制ClC-3转运蛋白的结构基础
Marina Schrecker,Yeeun Son,Rosa Planells-Cases et al.
Marina Schrecker et al.
The trafficking and activity of endosomes relies on the exchange of chloride ions and protons by members of the CLC family of chloride channels and transporters; mutations of the genes encoding these transporters are associated with numerou...
A conserved coupling of transcriptional ON and OFF periods underlies bursting dynamics [0.03%]
一个保守的转录ON和OFF期耦合构成了爆发动力学现象的基础
Po-Ta Chen,Michal Levo,Benjamin Zoller et al.
Po-Ta Chen et al.
Transcription commonly occurs in bursts, with alternating productive (ON) and quiescent (OFF) periods determining mRNA production rates. However, how bursting dynamics regulate transcription is not well understood. Here, we conduct real-tim...
Joel Cyrille Brenner,Linda Charlotte Zirden,Lana Buzuk et al.
Joel Cyrille Brenner et al.
Hsp70 and Hsp90 chaperones and their regulatory cochaperones are critical for maintaining protein homeostasis. Glucose-regulated protein 94 (GRP94), the sole Hsp90 chaperone in the secretory pathway of mammalian cells, is essential for the ...
Author Correction: The importance of physiological and disease contexts in capturing mRNA modifications [0.03%]
作者更正：在捕捉mRNA修饰时考虑生理和疾病背景的重要性
Audrey Penning,Jana Jeschke,François Fuks
Audrey Penning
Published Erratum
Nature structural & molecular biology. 2025 Jul 11. DOI:10.1038/s41594-025-01637-y 2025
Yuqi Wang,Xi Wang,Charles J David et al.
Yuqi Wang et al.
Alf Håkon Lystad
Alf Håkon Lystad
Comparative CRISPRi screens reveal a human stem cell dependence on mRNA translation-coupled quality control [0.03%]
比较CRISPR干扰筛选揭示了人类干细胞依赖于与翻译偶联的质控体系
Geraldine Rodschinka,Sergio Forcelloni,Felix M Kühner et al.
Geraldine Rodschinka et al.
The translation of mRNA into proteins in multicellular organisms needs to be carefully tuned to changing proteome demands in development and differentiation, while defects in translation often have a disproportionate impact in distinct cell...