RNase MRP subunit composition and role in 40S ribosome biogenesis [0.03%]
核糖核酸酶MRP的亚基组成及其在40S核糖体生成中的作用
Eric M Smith,Jimmy Ly,Sofia Haug et al.
Eric M Smith et al.
RNase MRP and RNase P are evolutionarily related complexes that facilitate rRNA and tRNA biogenesis, respectively. The two enzymes share nearly all protein subunits and have evolutionarily related catalytic RNAs. Notably, RNase P includes a...
Structural basis for agonist and heat activation of nociceptor TRPM3 [0.03%]
TRPM3热敏离子通道被激动剂活化及高温活化的分子机制
Sushant Kumar,Fei Jin,Sung Jin Park et al.
Sushant Kumar et al.
Detecting noxious heat is vital for survival, triggering protective pain responses. The TRPM3 channel is a key nociceptor and a promising therapeutic target for pain and neurological disorders. Here we show that the rabbit TRPM3 is intrinsi...
Epigenetic priming promotes tyrosine kinase inhibitor resistance and oncogene amplification [0.03%]
表观遗传学预处理促进酪氨酸激酶抑制剂耐药性和癌基因扩增
Rebecca M Starble,Eric G Sun,Rana Gbyli et al.
Rebecca M Starble et al.
In mammalian cells, gene copy number is controlled to maintain gene expression and genome stability. However, a common molecular feature across cancer types is oncogene amplification, increasing the copy number and expression of tumor-promo...
Global analysis of translocon remodeling during protein synthesis at the ER [0.03%]
对蛋白质在内质网上合成时转位体重塑的全球分析
Arunkumar Sundaram,Qianru Li,Yu Wan et al.
Arunkumar Sundaram et al.
Protein biogenesis at the endoplasmic reticulum requires translocons comprising the Sec61 protein-conducting channel and several dynamically associated accessory factors. Here we used transcriptome-wide selective ribosome profiling in human...
Dynamics of microcompartment formation at the mitosis-to-G1 transition [0.03%]
有丝分裂向G1期过渡过程中微区室的形成动力学研究
Viraat Y Goel,Nicholas G Aboreden,James M Jusuf et al.
Viraat Y Goel et al.
As cells exit mitosis and enter G1, chromosomes decompact and transcription is reestablished. Hi-C studies have indicated that all interphase three-dimensional genome features, including A/B compartments, topologically associating domains a...
Hugo Sepulveda
Hugo Sepulveda
Structure and activation mechanism of a Lamassu phage and plasmid defense system [0.03%]
一种拉玛苏噬菌体和质粒防御系统的结构及激活机制
Yan Li,David W Adams,Hon Wing Liu et al.
Yan Li et al.
Lamassu is a diverse family of defense systems that protect bacteria, including seventh-pandemic strains of Vibrio cholerae, against both plasmids and phage infection. During phage infection, Lamassu targets essential cellular processes, th...
Author Correction: Recruitment of Atg1 to the phagophore by Atg8 orchestrates autophagy machineries [0.03%]
作者更正：Atg8通过招募Atg1至吞噬体来协调自噬机器人的运作
Jing-Zhen Song,Hui Li,Haiyan Yang et al.
Jing-Zhen Song et al.
Published Erratum
Nature structural & molecular biology. 2025 Oct 13. DOI:10.1038/s41594-025-01700-8 2025
Structural phylogenetics unravels the evolutionary diversification of communication systems in gram-positive bacteria and their viruses [0.03%]
结构系统发生学解开了革兰氏阳性菌及其病毒通讯系统的进化多样化之谜
David Moi,Charles Bernard,Martin Steinegger et al.
David Moi et al.
Recent advances in artificial-intelligence-based protein structure modeling have yielded remarkable progress in predicting protein structures. Because structures are constrained by their biological function, their geometry tends to evolve m...