Structural basis of G6P/Pi transport and inhibition in SLC37A4 [0.03%]
SLC37A4蛋白中G6P/Pi的转运及抑制机制的结构基础研究
Dong Zhou,Yang Zhang,Nanhao Chen et al.
Dong Zhou et al.
Glycogen storage disease type Ib (GSD-Ib), caused by loss-of-function mutations in the endoplasmic reticulum transporter SLC37A4, disrupts glucose homeostasis through impaired glucose-6-phosphate (G6P)/phosphate (Pi) antiport. Despite its c...
AlphaSync is an enhanced AlphaFold structure database synchronized with UniProt [0.03%]
AlphaSync是一个与UniProt同步的增强型AlphaFold结构数据库
Benjamin Lang,Bálint Mészáros,Besian I Sejdiu et al.
Benjamin Lang et al.
Accurate prediction of protein structures is essential for understanding biological functions and guiding biomedical research. However, maintaining synchronization between structure models and rapidly expanding, continuously evolving protei...
Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms [0.03%]
亲水性降糖药二甲双胍和疏水性氨基糖通过不同的机制抑制复合物I
Zhaoxiang He,Fei Teng,Yanqing Yang et al.
Zhaoxiang He et al.
Metformin is the only antihyperglycemic biguanide targeting type 2 diabetes mellitus with proven safety. Although a mechanism of action involving tight inhibition of the respiratory complex I has been proposed for hydrophobic biguanides, it...
Architecture of the human KICSTOR and GATOR1-KICSTOR complexes [0.03%]
人类KICSTOR和GATOR1-KICSTOR复合物的结构
Fei Teng,Huan Zeng,Xinyi Mai et al.
Fei Teng et al.
The human KICSTOR complex, comprising KPTN, ITFG2, C12orf66 and the scaffolding protein SZT2, anchors the mTORC1 inhibitor GATOR1 to lysosomes. Mutations affecting KICSTOR subunits are associated with severe neurodevelopmental and epileptic...
Structural landscape of the degrading 26S proteasome reveals conformation-specific binding of TXNL1 [0.03%]
结构景观分析降解中的26S蛋白酶体揭示TXNL1的构象特异性结合
Connor Arkinson,Christine L Gee,Zeyuan Zhang et al.
Connor Arkinson et al.
The 26S proteasome targets many cellular proteins for degradation during homeostasis and quality control. Proteasome-interacting cofactors modulate these functions and aid in substrate degradation. Here we solve high-resolution structures o...
Author Correction: SCAF1 drives the compositional diversity of mammalian respirasomes [0.03%]
作者更正：SCAF1驱动哺乳动物呼吸体的组成多样性
Irene Vercellino,Leonid A Sazanov
Irene Vercellino
Published Erratum
Nature structural & molecular biology. 2025 Nov 5. DOI:10.1038/s41594-025-01721-3 2025
High-throughput peptide-centric local stability assay extends protein-ligand identification to membrane proteins, tissues and bacteria [0.03%]
一种基于肽的高通量局部稳定性试验，将蛋白质-配体鉴定扩展到膜蛋白、组织和细菌中
Kejia Li,Clement M Potel,Isabelle Becher et al.
Kejia Li et al.
Systematic mapping of protein-ligand interactions is essential for understanding biological processes and drug mechanisms. Peptide-centric local stability assay (PELSA) is a powerful tool for detecting these interactions and identifying pot...
TRIM21 and OTUD6A orchestrate AKT K27-linked atypical ubiquitination to modulate cancer chemoresistance [0.03%]
TRIM21和OTUD6A通过调节AKT非典型K27位泛素化来调控癌症化疗耐药性
Qiwei Jiang,Peipei Song,Shuishen Zhang et al.
Qiwei Jiang et al.
Ubiquitination regulates various physiological and pathological processes. However, the impact of atypical AKT ubiquitination and its potential role in tumorigenesis remain unclear. Here we show that AKT is modified by K27-linked ubiquitina...
Human DICER1 hotspot mutation induces both loss and gain of miRNA function [0.03%]
人类DICER1热点突变诱导miRNA功能的丢失和获得
David Jee,Seungjae Lee,Dapeng Yang et al.
David Jee et al.
The core miRNA biogenesis enzyme DICER1 sustains recurrent mutations in cancer that compromise its RNase IIIb domain, which cleaves 5p arms of precursor microRNA hairpins. However, the lack of knock-in models has limited fuller understandin...