Masahiro Nagano,Bo Hu,Kosuke Ogata et al.
Masahiro Nagano et al.
Germ cells are unique in that they tailor chromatin toward generating totipotency. Accordingly, mammalian spermatogonia, including spermatogonial stem cells that constitute the source for male gametes, acquire distinctive chromatin organiza...
Adel Atari,Haoyang Jiang,Roger A Greenberg
Adel Atari
DNA double-strand breaks (DSBs) are a severe threat to genome stability, as DSB-repair mechanisms with low fidelity contribute to loss of genome integrity. Break-induced replication (BIR) is a crucial DSB-repair pathway when classical homol...
Shanti Pal Gangwar,Maria V Yelshanskaya,Laura Y Yen et al.
Shanti Pal Gangwar et al.
Kainate receptors (KARs) are tetrameric, ligand-gated ion channels of the ionotropic glutamate receptor family that mediate excitatory neurotransmission and modulate neuronal circuits and synaptic plasticity during development of the centra...
Masihuz Zaman,Shu Yang,Ya Huang et al.
Masihuz Zaman et al.
Proteomic profiling of Alzheimer disease (AD) brains has identified numerous understudied proteins, including midkine (MDK), that are highly upregulated and correlated with amyloid-β (Aβ) from the early disease stage but their roles in di...
Publisher Correction: Cytoplasmic PXR regulates glucose metabolism by binding mRNAs and modulating their stability [0.03%]
出版更正：细胞质PXR通过结合mRNA并调节其稳定性来调控葡萄糖代谢
Xiaofei Wang,Zehua Wang,Sihan Li et al.
Xiaofei Wang et al.
Published Erratum
Nature structural & molecular biology. 2025 Aug 18. DOI:10.1038/s41594-025-01668-5 2025
Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug [0.03%]
疟原虫天然翻译机制的综合结构生物学研究及其抗疟药物抑制作用机理分析
Leonie Anton,Wenjing Cheng,Meseret T Haile et al.
Leonie Anton et al.
Our understanding of cellular events is hampered by the gap between the resolution at which we can observe events inside cells and our ability to replicate physiological conditions in test tubes. Here, we show in Plasmodium falciparum, a no...
Cytoplasmic PXR regulates glucose metabolism by binding mRNAs and modulating their stability [0.03%]
胞质PXR通过结合mRNA并调节其稳定性来调控葡萄糖代谢
Xiaofei Wang,Zehua Wang,Sihan Li et al.
Xiaofei Wang et al.
Pregnane X receptor (PXR) is a nuclear receptor considered to be a master transcription factor of xenobiotic metabolism. Here, using enhanced ultraviolet crosslinking and immunoprecipitation, we show that PXR can bind mRNAs in different can...
Structural analyses define the molecular basis of clusterin chaperone function [0.03%]
结构分析定义了clusterin分子伴侣功能的分子基础
Patricia Yuste-Checa,Alonso I Carvajal,Chenchen Mi et al.
Patricia Yuste-Checa et al.
Clusterin (apolipoprotein J), a conserved glycoprotein abundant in blood and cerebrospinal fluid, functions as a molecular chaperone and apolipoprotein. Dysregulation of clusterin is linked to late-onset Alzheimer disease. Despite its promi...
Core splicing architecture and early spliceosomal recognition determine microexon sensitivity to SRRM3/4 [0.03%]
核心拼接结构和早期拼接识别决定了微小外显子对SRRM3/4的敏感性
Sophie Bonnal,Simon Bajew,Rosa Martinez-Corral et al.
Sophie Bonnal et al.
Microexons are essential for the proper operation of neurons and pancreatic endocrine cells, in which their inclusion depends on the splicing factors SRRM3 and SRRM4 (SRRM3/4). However, in pancreatic cells, lower expression of these regulat...