Reciprocal stabilization of CtBP and TRIM28 represses autophagy to promote metastasis [0.03%]
CTBP和TRIM28的互惠稳定抑制自噬促进转移
Lixin Tai,Dongliang Zhu,Ping Tang et al.
Lixin Tai et al.
Deciphering the processes through which cancer cells overcome stress, escape a repressive microenvironment and metastasize remains a challenge. Autophagy has been demonstrated to regulate cancer metastasis and C-terminal binding protein (Ct...
Pietro De Camilli,Karin M Reinisch
Pietro De Camilli
Katarzyna Marcinkiewicz
Katarzyna Marcinkiewicz
Katarzyna A Ciazynska
Katarzyna A Ciazynska
CTCF depletion decouples enhancer-mediated gene activation from chromatin hub formation [0.03%]
CTCF缺失解耦增强子介导的基因激活和染色质聚集体形成
Magdalena A Karpinska,Yi Zhu,Zahra Fakhraei Ghazvini et al.
Magdalena A Karpinska et al.
Enhancers and promoters interact in three-dimensional (3D) chromatin structures to regulate gene expression. Here we characterize the mechanisms that drive the formation and function of these structures in a lymphoid-to-myeloid transdiffere...
Darío G Lupiáñez
Darío G Lupiáñez
Flexing protein assemblies [0.03%]
可变形的蛋白质组装体
Yang Li,Yang Zhang
Yang Li
Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30 [0.03%]
嵌合型去泛素酶工程揭示线粒体自噬调节因子USP30特异性抑制的结构基础
Nafizul Haque Kazi,Nikolas Klink,Kai Gallant et al.
Nafizul Haque Kazi et al.
The mitochondrial deubiquitinase ubiquitin-specific protease (USP) 30 negatively regulates PINK1-parkin-driven mitophagy. Whether enhanced mitochondrial quality control through inhibition of USP30 can protect dopaminergic neurons is current...
Slow awakening of the silent X chromosome in female primordial germ cells [0.03%]
原始生殖细胞中静默的X染色体缓慢激活
Christine M Disteche,Xinxian Deng
Christine M Disteche