Structural insights into OSTα/β-mediated transport of bile acids and steroid conjugates [0.03%]
OSTα/β介导的胆汁酸和类固醇结合物转运的结构见解
Xicheng Sun,Taikun Tian,Minying Low et al.
Xicheng Sun et al.
Mammalian organic solute transporter α/β (OSTα/β) is crucial for the enterohepatic circulation of bile acids and the homeostasis of steroid conjugates, mediating their movement across membranes as an obligate heterodimer. Here we presen...
Sammy H S Chan,Julian O Streit,Tomasz Włodarski et al.
Sammy H S Chan et al.
The ribosome biases the conformations sampled by nascent polypeptide chains along folding pathways toward biologically active states. A hallmark of the cotranslational folding (coTF) of many proteins constitutes highly stable folding interm...
A single-vesicle fluorescence microscopy platform to quantify phospholipid scrambling [0.03%]
一种单脂质体荧光显微镜平台用于量化磷脂打乱现象
Sarina Veit,Grace I Dearden,Kartikeya M Menon et al.
Sarina Veit et al.
Scramblases are physiologically important proteins that translocate phospholipids bidirectionally across cell membranes. For example, scrambling facilitated by dimers of the voltage-dependent anion channel 1 (VDAC1) enables endoplasmic reti...
Semirandom DNA adducts regulate a filamentous defense-associated reverse transcriptase [0.03%]
半随机DNA加合物调节丝状抗病相关逆转录酶
Nolan Neville,Nicole V Johnson,Edwin E Escobar et al.
Nolan Neville et al.
Retrons and several defense-associated reverse transcriptases (DRTs) synthesize non-genomic DNA for bacteriophage immunity. In some instances, this non-genomic DNA is of undefined, semirandom sequence. How undefined DNA sequences impart ant...
Jinhong Hu,Sofia Ievleva,Sung Jin Park et al.
Jinhong Hu et al.
Proteins operate in dynamic environments where ions, lipids and temperature collectively define their properties, yet most studies rely on simplified conditions that overlook these intrinsic variables. Here we show two such factors-temperat...
Vanessa Borges Pires,Boris Pfander
Vanessa Borges Pires
Distinct repair outcomes from single and convergent replication fork collapse [0.03%]
单一和汇聚复制叉崩溃产生不同的修复结果
Sara C Conwell,Khushi V N Patel,Savannah J Weeks-Pollenz et al.
Sara C Conwell et al.
Replication fork collapse at single-strand DNA breaks threatens genome stability but how such forks are repaired and resolved has remained unclear. Here we replicate site-specific nicks with single or converging replication forks in Xenopus...
Dynamic regulation of H3K9 dimethylation drives mouse minor zygotic genome activation [0.03%]
H3K9二甲基化动力调节驱动小鼠次要合子基因组激活
Ryo Maeda,Shunsuke Kuroki,Hiromi Shimojo et al.
Ryo Maeda et al.
Minor zygotic genome activation (ZGA) is crucial for early development and totipotency acquisition; however, the regulatory mechanisms controlling minor ZGA gene expression remain elusive. Here, we show that mouse minor ZGA is driven by spa...
Author Correction: Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex [0.03%]
作者更正：巴贝斯虫属周氏堡型呼吸链超级复合物的结构、组装与抑制
Andrew E MacLean,Shikha Shikha,Mariana Ferreira Silva et al.
Andrew E MacLean et al.
Published Erratum
Nature structural & molecular biology. 2026 May 22. DOI:10.1038/s41594-026-01824-5 2026