Jinhong Hu,Sofia Ievleva,Sung Jin Park et al.
Jinhong Hu et al.
Proteins operate in dynamic environments where ions, lipids and temperature collectively define their properties, yet most studies rely on simplified conditions that overlook these intrinsic variables. Here we show two such factors-temperat...
Vanessa Borges Pires,Boris Pfander
Vanessa Borges Pires
Distinct repair outcomes from single and convergent replication fork collapse [0.03%]
单一和汇聚复制叉崩溃产生不同的修复结果
Sara C Conwell,Khushi V N Patel,Savannah J Weeks-Pollenz et al.
Sara C Conwell et al.
Replication fork collapse at single-strand DNA breaks threatens genome stability but how such forks are repaired and resolved has remained unclear. Here we replicate site-specific nicks with single or converging replication forks in Xenopus...
Dynamic regulation of H3K9 dimethylation drives mouse minor zygotic genome activation [0.03%]
H3K9二甲基化动力调节驱动小鼠次要合子基因组激活
Ryo Maeda,Shunsuke Kuroki,Hiromi Shimojo et al.
Ryo Maeda et al.
Minor zygotic genome activation (ZGA) is crucial for early development and totipotency acquisition; however, the regulatory mechanisms controlling minor ZGA gene expression remain elusive. Here, we show that mouse minor ZGA is driven by spa...
Author Correction: Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex [0.03%]
作者更正：巴贝斯虫属周氏堡型呼吸链超级复合物的结构、组装与抑制
Andrew E MacLean,Shikha Shikha,Mariana Ferreira Silva et al.
Andrew E MacLean et al.
Published Erratum
Nature structural & molecular biology. 2026 May 22. DOI:10.1038/s41594-026-01824-5 2026
Soma-to-germline miRNA inheritance through yolk promotes stress resilience in progeny [0.03%]
卵黄促进体细胞来源的miRNA继承以增强子代抗逆性
Névé Aupérin,Meetali Singh,Loan Bourdon et al.
Névé Aupérin et al.
At the onset of reproduction, oviparous animals synthesize large amounts of yolk in somatic tissues to provide lipids and other nutrients to their progeny. However, whether the yolk transports other molecules, such as RNAs with gene-regulat...
Rap1-mediated steric hindrance protects telomeres from MRX sensing [0.03%]
Rap1通过立体位阻介导的机制保护端粒免于MRX的感受作用
Stefano Mattarocci,Giordano Reginato,Elda Cannavo et al.
Stefano Mattarocci et al.
Telomere capping largely depends on telomere length. Abnormally short telomeres are prone to activate DNA damage checkpoint, undergo unscheduled chromosomal fusions through nonhomologous end-joining (NHEJ) and be resected. All these process...
Structural basis of PTH1R-β-arrestin core engagement reveals design principles for G-protein-biased therapeutics [0.03%]
甲状旁腺激素受体与β-arrestin复合物的结构基础揭示了偏向型G蛋白药物的设计原理
Li-Hua Zhao,Qian He,Qingning Yuan et al.
Li-Hua Zhao et al.
G-protein-coupled receptors (GPCRs) transmit cellular signals through both G protein and arrestin pathways and biased signaling offers potential therapeutic advantages through selective activation. Although GPCR-G protein complexes are well...
How ligands tune the parathyroid hormone receptor's grip on β-arrestin [0.03%]
配体如何调节甲状旁腺激素受体与β-arrestin的结合力
Jakob Höppner,Thomas J Gardella
Jakob Höppner