Hana Polasek-Sedlackova
Hana Polasek-Sedlackova
Shengchun Zhang,Ran Yi,Linfeng An et al.
Shengchun Zhang et al.
RNA-only complexes adopt intricate three-dimensional structures to fulfill diverse functions independently of protein partners. Although multimeric RNA-only structures have been engineered in synthetic RNA nanomaterials, naturally occurring...
Jingjing Gao,Christopher Nardone,Matthew C J Yip et al.
Jingjing Gao et al.
Proteasomes degrade diverse proteins in different cellular contexts through incompletely defined regulatory mechanisms. Here we report the cryo-EM structure of human thioredoxin-like protein 1 (TXNL1) bound to the 19S regulatory particle of...
GAGA zinc finger transcription factor searches chromatin by 1D-3D facilitated diffusion [0.03%]
GAGA锌指转录因子通过一维-三维促扩散在染色质中搜索
Xinyu A Feng,Maryam Yamadi,Yiben Fu et al.
Xinyu A Feng et al.
The search for target sites on chromatin by eukaryotic sequence-specific transcription factors (TFs) is integral to the regulation of gene expression but the mechanism of nuclear exploration has remained obscure. Here we use multicolor sing...
Baihui Wang,Rafael Kronenberg-Tenga,Valentina Rosti et al.
Baihui Wang et al.
In the cell nucleus, chromatin is anchored to the nuclear lamina, a network of lamin filaments and binding proteins that underly the inner nuclear membrane. The nuclear lamina is involved in chromatin organization through the interaction of...
Stephanie Webb,Katerina Toropova,Aakash G Mukhopadhyay et al.
Stephanie Webb et al.
Members of the kinesin-2 family coordinate with other motors to power diverse physiological processes, but the structural mechanisms regulating kinesin-2 activity have been unknown. Distinctively, kinesin-2s canonically function as heterotr...
Lidia Wrobel
Lidia Wrobel
eIF1 and eIF5 dynamically control translation start site fidelity [0.03%]
EIF1和EIF5对翻译起始密码子选择的动态调节作用
Rosslyn Grosely,Carlos Alvarado,Ivaylo P Ivanov et al.
Rosslyn Grosely et al.
Human translation initiation requires accurate recognition of translation start sites. While AUG codons are canonical start sites, non-AUG codons are also used, typically with lower efficiency. The initiator tRNA and initiation factors eIF1...
Structural basis for mTORC1 regulation by the CASTOR1-GATOR2 complex [0.03%]
CASTOR1-GATOR2复合物调节mTORC1的结构基础
Rachel M Jansen,Clément Maghe,Karla Tapia et al.
Rachel M Jansen et al.
Mechanistic target of rapamycin complex 1 (mTORC1) is a nutrient-responsive master regulator of metabolism. Amino acids control the recruitment and activation of mTORC1 at the lysosome through the nucleotide loading state of the heterodimer...
A structural switch reveals how to disarm USP30 and unlock mitophagy [0.03%]
结构转换揭示了如何使USP30失活以及如何解锁线粒体自噬
Julia C Fitzgerald,Anja Bremm
Julia C Fitzgerald