TRIM21 and OTUD6A orchestrate AKT K27-linked atypical ubiquitination to modulate cancer chemoresistance [0.03%]
TRIM21和OTUD6A通过调节AKT非典型K27位泛素化来调控癌症化疗耐药性
Qiwei Jiang,Peipei Song,Shuishen Zhang et al.
Qiwei Jiang et al.
Ubiquitination regulates various physiological and pathological processes. However, the impact of atypical AKT ubiquitination and its potential role in tumorigenesis remain unclear. Here we show that AKT is modified by K27-linked ubiquitina...
Human DICER1 hotspot mutation induces both loss and gain of miRNA function [0.03%]
人类DICER1热点突变诱导miRNA功能的丢失和获得
David Jee,Seungjae Lee,Dapeng Yang et al.
David Jee et al.
The core miRNA biogenesis enzyme DICER1 sustains recurrent mutations in cancer that compromise its RNase IIIb domain, which cleaves 5p arms of precursor microRNA hairpins. However, the lack of knock-in models has limited fuller understandin...
DICER1 hotspot mutation induces 3p microRNA gain of function via Argonaute strand switch [0.03%]
DICER1热点突变通过Argonaute链转换诱导3p微RNA功能获得性改变
Sharan Malagobadan,Chunmei Shi,Acong Yang et al.
Sharan Malagobadan et al.
Dicer has RNase activity and is an essential enzyme in microRNA (miRNA) biogenesis. Mutations in the DICER1 gene have been linked to various cancers, notably DICER1 syndrome. To investigate the impact of pathogenic hotspot mutations in DICE...
Mechanistic basis for protein conjugation in a diverged bacterial ubiquitination pathway [0.03%]
一个分化出来的细菌泛素化途径中蛋白质连接的机制基础
Qiaozhen Ye,Minheng Gong,Jiaxi Cai et al.
Qiaozhen Ye et al.
Ubiquitination is a fundamental eukaryotic protein post-translational modification pathway, in which ubiquitin or a ubiquitin-like protein (Ubl) is typically conjugated to a lysine of a target protein. Ubiquitination is initiated by adenyla...
James A W Stowell,Conny W H Yu,Zhuo A Chen et al.
James A W Stowell et al.
Shortening of messenger RNA poly(A) tails by the Ccr4-Not complex initiates mRNA decay and is a major determinant of gene regulation. RNA adaptors modulate the specificity of deadenylation by binding to Ccr4-Not through their intrinsically ...
The Japan autophagy consortium [0.03%]
日本自噬联盟
Miwako Ishido,Yoshiari Shimmyo,Etsuko Tsutsumi et al.
Miwako Ishido et al.
Mechanisms of DNMT3A-3L-mediated de novo DNA methylation on chromatin [0.03%]
DNMT3A-3L介导的染色质上从头DNA甲基化的机制研究
Yan Yan,X Edward Zhou,Stacey L Thomas et al.
Yan Yan et al.
De novo DNA methylation is mediated by DNA methyltransferases DNMT3A and DNMT3B, in cooperation with the catalytically inactive paralogs DNMT3L and DNMT3B3. DNMT3L is predominantly expressed in embryonic stem cells to establish methylation ...
Structural landscape of activation, desensitization and inhibition in the human TRPM4 channel [0.03%]
人TRPM4通道激活、脱敏和抑制的结构景观
Celso M Teixeira-Duarte,Weizhong Zeng,Youxing Jiang
Celso M Teixeira-Duarte
TRPM4 is a member of the transient receptor potential melastatin channel subfamily and functions as a Ca2+-activated monovalent-selective cation channel. It is widely expressed in various cells and tissues, where its activation depolarizes ...
Bing Wang,Renee D Hoffman,Ya-Ming Hou et al.
Bing Wang et al.
Retrons have been recently identified as bacterial defense systems that employ a tripartite of reverse transcriptase, non-coding RNA (ncRNA) and its derived multi-copy single stranded DNA (msDNA) to sequester effector activity. Phage invasi...
Francesca Vallese
Francesca Vallese