Structure and function of the yeast amino acid-sensing SEAC-EGOC supercomplex [0.03%]
酵母氨基酸感应SEAC-EGOC超级复合物的结构与功能
Lucas Tafur,Lenny Bonadei,Yiqiang Zheng et al.
Lucas Tafur et al.
The Seh1-associated complex (SEAC; GATOR in mammals) transduces amino acid signals to the Target of Rapamycin Complex 1 (TORC1), a master regulator of cell growth. The SEAC is composed of two subcomplexes, SEACIT (GATOR1), an inhibitor of T...
Julie Soutourina
Julie Soutourina
Mingxu Fang,Yajie Gu,Miron Leanca et al.
Mingxu Fang et al.
Circadian biological clocks evolved across kingdoms of life as an adaptation to predictable cycles of sunrise and sunset. In the cyanobacterium Synechococcus elongatus, a protein-based clock precisely controls when different genes are turne...
The filamentous ultrastructure of the PopZ condensate is required for its cellular function [0.03%]
丝状超结构对PopZ凝聚体的细胞功能是必不可少的
Daniel Scholl,Tumara Boyd,Andrew P Latham et al.
Daniel Scholl et al.
Biomolecular condensates have key roles in regulating cellular processes. Yet, the relationship between atomic features and condensate function remains poorly understood. We studied this relationship using the polar organizing protein Z (Po...
Naoto Nagahata,Kazuki Kato,Sota Yamada et al.
Naoto Nagahata et al.
RNA-guided DNA nucleases Cas9 and IscB (insertion sequences Cas9-like OrfB) are components of type II CRISPR-Cas adaptive immune systems and transposon-associated OMEGA (obligate mobile element-guided activity) systems, respectively. Sequen...
Xiaogen Zhou,Xiangyu Xu,Guijun Zhang
Xiaogen Zhou
Nataliya Petryk
Nataliya Petryk
Author Correction: Heterochromatin boundaries maintain centromere position, size and number [0.03%]
作者更正：异染色质边界维持着异染色质的位置、大小和数量
Ben L Carty,Danilo Dubocanin,Marina Murillo-Pineda et al.
Ben L Carty et al.
Published Erratum
Nature structural & molecular biology. 2026 Jan 21. DOI:10.1038/s41594-026-01748-0 2026
Cereblon induces G3BP2 neosubstrate degradation using molecular surface mimicry [0.03%]
分子表面模拟诱导 cereblon 降解 G3BP2 新底物
Stefano Annunziato,Chao Quan,Etienne J Donckele et al.
Stefano Annunziato et al.
Molecular glue degraders (MGDs) are small-molecule compounds that divert E3 ligases to degrade nonnatural substrates called neosubstrates. Clinically effective MGDs bind cereblon (CRBN), a substrate receptor of the Cullin 4-RING E3 ubiquiti...