Determinants of drug efficacy and the dynamics of G protein activation [0.03%]
药物疗效的影响因素及G蛋白激活的动力学研究
Henrik G Dohlman
Henrik G Dohlman
Hypervariable loop profiling decodes sequence determinants of antibody stability [0.03%]
超变环谱分析解码抗体稳定性的序列决定因素
Yue Wan,Jiahao Liang,Yile Dai et al.
Yue Wan et al.
Antibody folding and aggregation are major challenges in the development of relevant reagents and therapeutics. Antibodies face a biophysical trade-off; the immense diversity in complementarity-determining regions (CDRs), which is crucial f...
Structural mechanism for noncanonical GPCR signaling in the Hedgehog pathway [0.03%]
刺猬信号通路非典型G蛋白偶联受体信号机制的结构基础
William P Steiner,Nathan Iverson,Guibing Liu et al.
William P Steiner et al.
The Hedgehog (Hh) pathway is fundamental to embryogenesis, tissue homeostasis and cancer. Hh signals are transduced through an unusual mechanism; upon agonist-induced phosphorylation, the noncanonical G-protein-coupled receptor (GPCR) Smoot...
Elena Lopez-Jimenez,Cristina González-Aguilera
Elena Lopez-Jimenez
MTCH2 promotes BAX and BAK self-assembly and apoptotic pore growth [0.03%]
MTCH2促进BAX和BAK的自我组装及凋亡孔道生长
Hector Flores-Romero,Aida Pena-Blanco,Jonas Aufdermauer et al.
Hector Flores-Romero et al.
During apoptosis, the BCL-2 family members BAX and BAK oligomerize and form a pore to mediate the decisive step of mitochondrial outer membrane permeabilization. However, the contribution of additional cellular components to apoptotic pore ...
Matthew McCallum,James Brett Case,Jack T Brown et al.
Matthew McCallum et al.
The protease TMPRSS2 facilitates coronavirus infections, yet its mechanism of viral glycoprotein recognition remains unclear. Here we show that, following ACE2 engagement of the SARS-CoV-2 spike (S) inducing the early fusion intermediate co...
Structural insight into how RAD51 paralog exchange regulates RAD51 filament formation [0.03%]
RAD51旁系同源物交换调节RAD51丝状结构形成的机制见解
Yashpal Rawal,Youngho Kwon,Lijia Jia et al.
Yashpal Rawal et al.
Homologous recombination (HR) repairs DNA double-strand breaks and stabilizes stressed replication forks, and HR deficiency promotes genome instability and cancer. HR requires assembly of RAD51 nucleoprotein filaments on single-stranded DNA...
Cracking the code of native amyloid fibrils: advances and next steps to enable pathology-informed therapeutic and diagnostic [0.03%]
破解天然淀粉样纤维的密码：推进以病理学为导向的治疗和诊断方法的研究进展与下一步措施
Hilal A Lashuel
Hilal A Lashuel
Cryo-electron microscopy studies on amyloid fibrils formed by different proteins and isolated from the brains of persons with neurodegenerative diseases have consistently shown that their core structure is distinct from that of fibrils form...
Sara Osman
Sara Osman
Structural insights into coffee bitter taste perception by TAS2R43 receptor [0.03%]
咖啡苦味感知TAS2R43受体结构的见解
Yoojoong Kim,Ryan H Gumpper,Yuxuan Zhuang et al.
Yoojoong Kim et al.
Bitter taste functions as a means of both protection against potentially toxic compounds and savoring bitter tasting foods and beverages. Among the 26 bitter taste receptors, taste receptor type 2 member 43 (TAS2R43) has been identified as ...