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期刊名:Nature structural & molecular biology

缩写:NAT STRUCT MOL BIOL

ISSN:1545-9993

e-ISSN:1545-9985

IF/分区:10.1/Q1

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共收录本刊相关文章索引3771
Clinical Trial Case Reports Meta-Analysis RCT Review Systematic Review
Classical Article Case Reports Clinical Study Clinical Trial Clinical Trial Protocol Comment Comparative Study Editorial Guideline Letter Meta-Analysis Multicenter Study Observational Study Randomized Controlled Trial Review Systematic Review
Shengchun Zhang,Ran Yi,Linfeng An et al. Shengchun Zhang et al.
RNA-only complexes adopt intricate three-dimensional structures to fulfill diverse functions independently of protein partners. Although multimeric RNA-only structures have been engineered in synthetic RNA nanomaterials, naturally occurring...
Jingjing Gao,Christopher Nardone,Matthew C J Yip et al. Jingjing Gao et al.
Proteasomes degrade diverse proteins in different cellular contexts through incompletely defined regulatory mechanisms. Here we report the cryo-EM structure of human thioredoxin-like protein 1 (TXNL1) bound to the 19S regulatory particle of...
Xinyu A Feng,Maryam Yamadi,Yiben Fu et al. Xinyu A Feng et al.
The search for target sites on chromatin by eukaryotic sequence-specific transcription factors (TFs) is integral to the regulation of gene expression but the mechanism of nuclear exploration has remained obscure. Here we use multicolor sing...
Baihui Wang,Rafael Kronenberg-Tenga,Valentina Rosti et al. Baihui Wang et al.
In the cell nucleus, chromatin is anchored to the nuclear lamina, a network of lamin filaments and binding proteins that underly the inner nuclear membrane. The nuclear lamina is involved in chromatin organization through the interaction of...
Stephanie Webb,Katerina Toropova,Aakash G Mukhopadhyay et al. Stephanie Webb et al.
Members of the kinesin-2 family coordinate with other motors to power diverse physiological processes, but the structural mechanisms regulating kinesin-2 activity have been unknown. Distinctively, kinesin-2s canonically function as heterotr...
Rosslyn Grosely,Carlos Alvarado,Ivaylo P Ivanov et al. Rosslyn Grosely et al.
Human translation initiation requires accurate recognition of translation start sites. While AUG codons are canonical start sites, non-AUG codons are also used, typically with lower efficiency. The initiator tRNA and initiation factors eIF1...
Rachel M Jansen,Clément Maghe,Karla Tapia et al. Rachel M Jansen et al.
Mechanistic target of rapamycin complex 1 (mTORC1) is a nutrient-responsive master regulator of metabolism. Amino acids control the recruitment and activation of mTORC1 at the lysosome through the nucleotide loading state of the heterodimer...