Cecilia Xi Zhang,Ruby Yun-Ju Huang,Guojun Sheng et al.
Cecilia Xi Zhang et al.
Epithelial-mesenchymal transition (EMT) is a fundamental mechanism involved in the morphogenesis of metazoans. Through this evolutionarily conserved multi-stage process, cells acquire quasi-epithelial to multiple intermediate morphologies w...
Decoding Alzheimer's disease at the cellular level reveals promising combination therapy [0.03%]
从细胞层面解读阿尔茨海默病表明联合疗法颇具前景
Kyle Coleman,Nicholas P Tatonetti
Kyle Coleman
Alzheimer's disease (AD) has long resisted effective treatments due to its pathological heterogeneity and cell-type-specific regulatory changes. In this issue of Cell, Li et al. leverage single-cell RNA sequencing and drug repurposing to pr...
Genomic atlas of 8,105 accessions reveals stepwise domestication, global dissemination, and improvement trajectories in soybean [0.03%]
基于8,105份大豆种质资源的基因组图谱揭示了大豆渐进式驯化、全球传播和改良过程
Zhou Zhu,Yalin Wang,Shulin Liu et al.
Zhou Zhu et al.
After millennia of domestication, dissemination, and improvement, soybean has evolved into a globally significant leguminous crop. Addressing how soybeans adapt to diverse planting environments and breeding objectives will facilitate future...
Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution [0.03%]
无需测序的单分子分辨率全基因组空间转录组学
Yubao Cheng,Shengyuan Dang,Yuan Zhang et al.
Yubao Cheng et al.
Recent breakthroughs in spatial transcriptomics technologies have enhanced our understanding of diverse cellular identities, spatial organizations, and functions. Yet existing spatial transcriptomics tools are still limited in either transc...
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis [0.03%]
免疫蛋白酶体扰乱神经元代谢并驱动多发性硬化症中的神经退行性病变
Marcel S Woo,Johannes Brand,Lukas C Bal et al.
Marcel S Woo et al.
Published Erratum
Cell. 2025 Sep 30:S0092-8674(25)01087-6. DOI:10.1016/j.cell.2025.09.019 2025
Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance [0.03%]
结核分枝杆菌转录调控的进化与传播增强和耐药相关
Peter H Culviner,Abigail M Frey,Qingyun Liu et al.
Peter H Culviner et al.
Mycobacterium tuberculosis (Mtb) has co-evolved with humans for thousands of years and is characterized by variation in virulence, transmissibility, and disease phenotypes. To identify bacterial contributors to phenotypic diversity, we deve...
Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons [0.03%]
功能RNA切割驱动了V型CRISPR-Cas系统从转座子中进化出现
Shuai Jin,Zixu Zhu,Yunjia Li et al.
Shuai Jin et al.
Transposon-encoded TnpB nucleases gave rise to type V CRISPR-Cas12 effectors through multiple independent domestication events. These systems use different RNA molecules as guides for DNA targeting: transposon-derived right-end RNAs (reRNAs...
Single-cell nascent transcription reveals sparse genome usage and plasticity [0.03%]
单细胞新生转录揭示了稀疏的基因组利用和可塑性
Shaoqian Ma,Yantao Hong,Junhan Chen et al.
Shaoqian Ma et al.
Understanding cell diversification from a common genome in metazoans requires single-cell transcriptional analysis. We introduce single-cell full-length EU-labeled nascent RNA sequencing (scFLUENT-seq), a single-cell nascent RNA sequencing ...
Multiscale proteomic modeling reveals protein networks driving Alzheimer's disease pathogenesis [0.03%]
多尺度蛋白质组学建模揭示了驱动阿尔茨海默病发病机制的蛋白质网络
Erming Wang,Kaiwen Yu,Jiqing Cao et al.
Erming Wang et al.
The molecular mechanisms underlying the pathogenesis of Alzheimer's disease (AD), the most common form of dementia, remain poorly understood. Proteomics offers a crucial approach to elucidating AD pathogenesis, as alterations in protein exp...
Safe immunosuppression-resistant pan-cancer immunotherapeutics by velcro-like density-dependent targeting of tumor-associated carbohydrate antigens [0.03%]
类似胶带的糖基抗原密度依赖性靶向实现安全有效的广谱免疫治疗
Raymond W Zhou,Paresh Kumar Purohit,Jai Hyun Kim et al.
Raymond W Zhou et al.
Bispecific antibodies and chimeric antigen receptor T cells are some of the most potent cancer immunotherapeutics in clinical use, yet most cancers remain poorly targetable. High-affinity antibodies required to maximize killing detect low a...