The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment [0.03%]
揭示顶体虫生存所需的宿主基因组及其代谢依赖性以寻求治疗手段
N Bishara Marzook,Ok-Ryul Song,Lotta Baumgärtel et al.
N Bishara Marzook et al.
Cryptosporidium is a leading cause of diarrheal disease, yet little is known regarding the infection cell biology of this intracellular intestinal parasite. To this end, we implemented an arrayed genome-wide CRISPR-Cas9 knockout screen to m...
Structure of gut microbial glycolipid modulates host inflammatory response [0.03%]
肠道微生物甘油糖脂结构调节宿主炎症反应
Hyoung-Soo Cho,Ji-Sun Yoo,Xinyang Song et al.
Hyoung-Soo Cho et al.
Commensals are constantly shaping the host's immunological landscape. Lipopolysaccharides found in gram-negative microbes have a terminal lipid A in their outer membrane. Here, we report that structural variations in symbiotic lipid A lead ...
SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress [0.03%]
SPIDR 实现了RNA-蛋白质相互作用的多重映射，并揭示了细胞应激条件下选择性翻译抑制的机制
Erica Wolin,Jimmy K Guo,Mario R Blanco et al.
Erica Wolin et al.
RNA-binding proteins (RBPs) regulate all stages of the mRNA life cycle, yet current methods generally map RNA targets of RBPs one protein at a time. To overcome this limitation, we developed SPIDR (split-and-pool identification of RBP targe...
Procr+ chondroprogenitors sense mechanical stimuli to govern articular cartilage maintenance and regeneration [0.03%]
力学生物学感应在关节软骨维持和再生中的作用
Qiaoling Zhu,Feng Yin,Jiachen Qin et al.
Qiaoling Zhu et al.
Protein C receptor+ (Procr+) cells were identified as stem or progenitor cells in multiple adult tissues. However, whether mechanical stimuli fine-tune their activation and differentiation remain unknown. Here, we found rare Procr+ cells in...
Daniela C Soto,José M Uribe-Salazar,Gulhan Kaya et al.
Daniela C Soto et al.
Duplicated genes expanded in the human lineage likely contributed to brain evolution, yet challenges exist in their discovery due to sequence-assembly errors. We used a complete telomere-to-telomere genome sequence to identify 213 human-spe...
Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia [0.03%]
功能性的肝脏基因组学鉴定出癌症恶病质消耗肝细胞激素促进作用
Doris Kaltenecker,Søren Fisker Schmidt,Peter Weber et al.
Doris Kaltenecker et al.
In cancer cachexia, the presence of a tumor triggers systemic metabolic disruption that leads to involuntary body weight loss and accelerated mortality in affected patients. Here, we conducted transcriptomic and epigenomic profiling of the ...
Identification and application of cell-type-specific enhancers for the macaque brain [0.03%]
识别和应用恒河猴大脑中细胞类型特异性增强子
Ling Li,Yiming Huang,Dengyu Lu et al.
Ling Li et al.
Published Erratum
Cell. 2025 Jul 21:S0092-8674(25)00815-3. DOI:10.1016/j.cell.2025.07.026 2025
In vivo prime editing rescues alternating hemiplegia of childhood in mice [0.03%]
体内prime编辑技术可拯救小鼠的儿童交替性偏瘫症状
Alexander A Sousa,Markus Terrey,Holt A Sakai et al.
Alexander A Sousa et al.
Alternating hemiplegia of childhood (AHC) is a neurodevelopmental disorder with no disease-modifying treatment. Mutations in ATP1A3, encoding an Na+/K+ ATPase subunit, cause 70% of AHC cases. Here, we present prime editing (PE) and base edi...
Cell-type-directed network-correcting combination therapy for Alzheimer's disease [0.03%]
针对阿尔茨海默病的细胞类型导向网络纠正型联合治疗
Yaqiao Li,Carlota Pereda Serras,Jessica Blumenfeld et al.
Yaqiao Li et al.
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by heterogeneous molecular changes across diverse cell types, posing significant challenges for treatment development. To address this, we introduced a ce...
Small RNAs are modified with N-glycans and displayed on the surface of living cells [0.03%]
小RNAs具有N-聚糖修饰并以细胞表面蛋白形式展示
Ryan A Flynn,Kayvon Pedram,Stacy A Malaker et al.
Ryan A Flynn et al.
Published Erratum
Cell. 2025 Jul 21:S0092-8674(25)00808-6. DOI:10.1016/j.cell.2025.07.019 2025