Selective requirement of glycosphingolipid synthesis for natural killer and cytotoxic T cells [0.03%]
固有杀伤细胞和细胞毒性T细胞对糖脂合成的选择性需求
Tasha A Morrison,Jaelyn Vigee,Kevin A Tovar et al.
Tasha A Morrison et al.
Cell identity genes that exhibit complex regulation are marked by super-enhancer (SE) architecture. Assessment of SEs in natural killer (NK) cells identified Ugcg, encoding the enzyme responsible for glycosphingolipid (GSL) synthesis. Condi...
Macrophages direct location-dependent recall of B cell memory to vaccination [0.03%]
巨噬细胞定位决定B细胞对疫苗接种的免疫记忆反应
Rama Dhenni,Alexandra Carey Hoppé,Arnold Reynaldi et al.
Rama Dhenni et al.
Vaccines generate long-lived plasma cells and memory B cells (Bmems) that may re-enter secondary germinal centers (GCs) to further mutate their B cell receptor upon boosting and re-exposure to antigen. We show in mouse models that lymph nod...
Alzheimer's disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons [0.03%]
老年痴呆患者来源的高分子量tau损害海马神经元簇状放电
Samuel S Harris,Robert Ellingford,Jana Hartmann et al.
Samuel S Harris et al.
Tau accumulation is closely related to cognitive symptoms in Alzheimer's disease (AD). However, the cellular drivers of tau-dependent decline of memory-based cognition remain elusive. Here, we employed in vivo Neuropixels and patch-clamp re...
Regional differences in progenitor metabolism shape brain growth during development [0.03%]
发育过程中祖细胞代谢的区域差异塑造大脑生长
Natalia Baumann,Robin J Wagener,Awais Javed et al.
Natalia Baumann et al.
Mammals have particularly large forebrains compared with other brain parts, yet the developmental mechanisms underlying this regional expansion remain poorly understood. Here, we provide a single-cell-resolution birthdate atlas of the mouse...
Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumors [0.03%]
肿瘤中的细胞外染色体DNA复制和维持与DNA损伤通路偶联
Xing Kang,Xinran Li,Jiaqi Zhou et al.
Xing Kang et al.
Extrachromosomal DNA (ecDNA) drives the evolution of cancer cells. However, the functional significance of ecDNA and the molecular components involved in its replication and maintenance remain largely unknown. Here, using CRISPR-C technolog...
Tomotsune Ameku,Anna Laddach,Hannah Beckwith et al.
Tomotsune Ameku et al.
Published Erratum
Cell. 2025 Apr 26:S0092-8674(25)00459-3. DOI:10.1016/j.cell.2025.04.023 2025
Menghan Liu,Sydney B Blattman,Mai Takahashi et al.
Menghan Liu et al.
Published Erratum
Cell. 2025 Apr 25:S0092-8674(25)00453-2. DOI:10.1016/j.cell.2025.04.018 2025
RNA polymerase II partitioning is a shared feature of diverse oncofusion condensates [0.03%]
RNA聚合酶II分区是多种致癌融合凝聚体的共同特征
Heankel Lyons,Prashant Pradhan,Gopinath Prakasam et al.
Heankel Lyons et al.
Condensates regulate transcription by selectively compartmentalizing biomolecules, yet the rules of specificity and their relationship to function remain enigmatic. To identify rules linked to function, we leverage the genetic selection bia...
Nan Zhou,Jingzhi Chen,Meiqin Hu et al.
Nan Zhou et al.
Lysosomes maintain an acidic pH of 4.5-5.0, optimal for macromolecular degradation. Whereas proton influx is produced by a V-type H+ ATPase, proton efflux is mediated by a fast H+ leak through TMEM175 channels, as well as an unidentified sl...
Neuron-astrocyte coupling in lateral habenula mediates depressive-like behaviors [0.03%]
外侧缰核神经元-星形胶质细胞偶联介导类似抑郁的行为反应
Qianqian Xin,Junying Wang,Jinkun Zheng et al.
Qianqian Xin et al.
The lateral habenula (LHb) neurons and astrocytes have been strongly implicated in depression etiology, but it was not clear how the two dynamically interact during depression onset. Here, using multi-brain-region calcium photometry recordi...