RNA Pol II inhibition activates cell death independently from the loss of transcription [0.03%]
RNA聚合酶II抑制独立于转录丢失激活细胞死亡
Nicholas W Harper,Gavin A Birdsall,Megan E Honeywell et al.
Nicholas W Harper et al.
RNA Pol II-mediated transcription is essential for eukaryotic life. Although loss of transcription is thought to be universally lethal, the associated mechanisms promoting cell death are not yet known. Here, we show that death following the...
Daoming Chen,Zhou Yu,Wenbo Wu et al.
Daoming Chen et al.
Hair loss affects millions globally, significantly impacting quality of life and psychological well-being. Despite its prevalence, effective strategies for promoting human hair growth remain elusive. By investigating congenital generalized ...
Aarti Krishnan,Melis N Anahtar,Jacqueline A Valeri et al.
Aarti Krishnan et al.
The antimicrobial resistance crisis necessitates structurally distinct antibiotics. While deep learning approaches can identify antibacterial compounds from existing libraries, structural novelty remains limited. Here, we developed a genera...
Prevalent mesenchymal drift in aging and disease is reversed by partial reprogramming [0.03%]
广泛存在的衰老和疾病间充质转移可由部分重编程逆转
Jinlong Y Lu,William B Tu,Ronghui Li et al.
Jinlong Y Lu et al.
The loss of cellular and tissue identity is a hallmark of aging and numerous diseases, but the underlying mechanisms are not well understood. Our analysis of gene expression data from over 40 human tissues and 20 diseases reveals a pervasiv...
Inner speech in motor cortex and implications for speech neuroprostheses [0.03%]
运动皮层中的内部言语及其对言语神经假体的启示
Erin M Kunz,Benyamin Abramovich Krasa,Foram Kamdar et al.
Erin M Kunz et al.
Speech brain-computer interfaces (BCIs) show promise in restoring communication to people with paralysis but have also prompted discussions regarding their potential to decode private inner speech. Separately, inner speech may be a way to b...
Systematic profiling reveals betaine as an exercise mimetic for geroprotection [0.03%]
系统性分析发现甘氨酸是一种类运动的抗衰老物质
Lingling Geng,Jiale Ping,Ruochen Wu et al.
Lingling Geng et al.
Published Erratum
Cell. 2025 Aug 12:S0092-8674(25)00852-9. DOI:10.1016/j.cell.2025.07.030 2025
Engineering crop flower morphology facilitates robotization of cross-pollination and speed breeding [0.03%]
工程改造作物花的形态可促进异交授粉和速繁育的机器人化
Yue Xie,Tinghao Zhang,Minghao Yang et al.
Yue Xie et al.
Artificial intelligence (AI) and robots offer vast opportunities in shifting toward precision agriculture to enhance crop yields, reduce costs, and promote sustainable practices. However, many crop traits obstruct the application of AI-base...
Bronze Age Yersinia pestis genome from sheep sheds light on hosts and evolution of a prehistoric plague lineage [0.03%]
羊青铜时代的耶尔森氏鼠疫菌基因组揭示了史前鼠疫菌系的宿主及其进化过程
Ian Light-Maka,Taylor R Hermes,Raffaela Angelina Bianco et al.
Ian Light-Maka et al.
Most human pathogens are of zoonotic origin. Many emerged during prehistory, coinciding with domestication providing more opportunities for spillover into human populations. However, we lack direct DNA evidence linking animal and human infe...
Zikun Zhu,Saurav Mallik,Taylor A Stevens et al.
Zikun Zhu et al.
Nearly all mitochondrial proteins are translated on cytosolic ribosomes. How these proteins are subsequently delivered to mitochondria remains poorly understood. Using selective ribosome profiling, we show that nearly 20% of mitochondrial p...
NRT1.1B acts as an abscisic acid receptor in integrating compound environmental cues for plants [0.03%]
NRT1.1B充当植物整合复合环境信号的脱落酸受体
Xiaojun Ma,Wei Wang,Jingyi Zhang et al.
Xiaojun Ma et al.
Abscisic acid (ABA) is the most crucial phytohormone for plants in adapting to environmental conditions. While the ABA signaling network in plants has been extensively explored, our understanding of the diverse ABA sensing systems remains l...