Environmental tuning of thyroid hormone signaling drives developmental plasticity [0.03%]
环境调节甲状腺素信号通路促进发育可塑性
Marcela Herrera,Saori Miura,Zoé Chamot et al.
Marcela Herrera et al.
Vertebrate developmental transitions unfold in environments increasingly altered by global change. Thyroid hormones, a deeply conserved endocrine axis, coordinate post-embryonic transformations, yet the effects of natural ecological variati...
Submillennial timescales of eruptible rhyolite magma: Converging evidence from Aira Caldera, Japan [0.03%]
日本AIRA火口地带可喷发英安岩熔岩的亚千年时间尺度：来自日本AIRA火山区的证据收敛性分析
Bradley W Pitcher,Guilherme A R Gualda,Nobuo Geshi
Bradley W Pitcher
Recent studies debate whether caldera-forming silicic magma is primarily stored in a crystal-poor, eruptible state for >100,000 years (kyr) ("warm storage") or exists as a crystal-rich "mush" with defrosting events causing brief periods (
Glacier retreat shapes organic nutrient availability across lake succession [0.03%]
glacier retreat 形成湖泊演替过程中有机营养物的变化规律
Grégoire Saboret,Elliot Lewis,Nicolaj Krog Larsen et al.
Grégoire Saboret et al.
Glacier retreat is rapidly transforming landscapes, creating thousands of new lakes that act as natural laboratories of ecological succession. In these newly formed ecosystems, colonizing animals must meet their requirements for essential o...
Thierry Mourer,Mohamad Harastani,Celine Cuche et al.
Thierry Mourer et al.
Capsid stabilization, induced by low-nanomolar concentrations of Lenacapavir (LEN)-a first-in-class capsid inhibitor-impedes HIV-1 replication in macrophages without disrupting reverse transcription or nuclear import. In LEN-treated cells, ...
Monolithically integrating polarization-doped InGaN p-FET and GaN n-FET for complementary logic circuitry [0.03%]
单片集成电荷极化调控p沟道InGaN增强型晶体管与氮化镓n沟道耗尽型晶体管的互补逻辑电路
Jingjing Yu,Teng Li,Yunhong Lao et al.
Jingjing Yu et al.
Low-efficiency p-type impurity doping has long impeded the practical adoption of wide-bandgap semiconductors in integrated circuits (ICs). In wide-bandgap III-nitride semiconductors, the inherent polarization effects provide an alternative ...
Łukasz Niezabitowski,Róisín Long,Anthony K Redmond et al.
Łukasz Niezabitowski et al.
Whole-genome duplications (WGDs) profoundly shaped early vertebrate evolution. The set of paralogs retained from these events-"ohnologs"-has had lasting impacts on genome structure and function, including disease gene enrichment. Despite th...
ZPY-CpG-Ch, a broad coverage vaccine against Streptococcus pneumoniae [0.03%]
针对肺炎链球菌的广谱疫苗ZPY-CpG-Ch
Teerawit Audshasai,Stavros Panagiotou,Lisa Crossman et al.
Teerawit Audshasai et al.
Existing licensed pneumococcal vaccines, including Prevnar-13 and its higher-valency successors, have played a major role in reducing invasive pneumococcal disease worldwide. However, their effectiveness is increasingly threatened by the ri...
Two contrasting atmospheric circulation patterns linked to Kuroshio Extension variability [0.03%]
与黑潮延伸体变异相联系的两种不同的大气环流模态
Se-Yong Song,Samantha Stevenson,Emanuele Di Lorenzo et al.
Se-Yong Song et al.
The influence of Kuroshio Extension (KE) variability on North Pacific atmospheric circulation has been increasingly recognized in high-resolution observations and models. While the role of fine-scale air-sea interactions has been highlighte...
Biomimetic hierarchical heterogeneity endows layered nanocomposite with excellent mechanical and electrical insulating properties [0.03%]
仿生多层次异质性使层状纳米复合材料具有优异的力学和电学绝缘性能
Guan-Hua Yu,Xiao-Feng Pan,Wen-Long Xu et al.
Guan-Hua Yu et al.
Aramid-based nanopapers with high mechanical and electrical insulating properties, together with high-temperature stability, are urgently desired for electrical safety but are challenging to be constructed. Notably, biological materials can...
Transposable elements and homotypic niches drive immune dynamics and resistance in melanoma epigenetic-based immunotherapy [0.03%]
转座元件和同型生态位驱动黑色素瘤表观遗传学免疫治疗中的免疫反应动态及抗性
Erika Ciervo,Francesco Ceccarelli,Anna Maria Di Giacomo et al.
Erika Ciervo et al.
Melanoma plasticity drives immune evasion and therapy resistance through dynamic cell-state transitions beyond genetic alterations. Although epigenetic remodeling is central to this process, its impact under therapeutic pressure remains unc...