Climate differentially impacts ticks infected and uninfected with Borrelia burgdorferi [0.03%]
气候差异性影响携带和不携带伯氏疏螺旋体的Ixodes栖息地分布
Heather Broughton,Arielle Crews,Marie Lilly et al.
Heather Broughton et al.
Climate change continues to alter the behavior and distribution of species worldwide, with major ramifications for the transmission and risk of infectious diseases, including those caused by zoonotic vector-borne pathogens. This study explo...
Multiomic identification of senescent stem cell populations critical for osteoarthritis progression and therapy in subchondral bones [0.03%]
多组学鉴定软骨下骨中对骨关节炎进展和治疗起关键作用的衰老干细胞群
Pei Lin Li,Jie Tang,Xiao Tong Li et al.
Pei Lin Li et al.
Osteoarthritis (OA) is a challenging degenerative joint disease with limited treatment options. Subchondral bone plays a critical role in maintaining joint homeostasis and influencing OA progression. Here, we investigated the role of senesc...
Pablo Díaz-Núñez,Christian Lanza,Ziwei Wang et al.
Pablo Díaz-Núñez et al.
Low-symmetry crystals have emerged as a platform for exploring unique light-matter interactions in the form of hyperbolic shear polaritons. These excitations exhibit unique properties such as frequency-dispersive optical axes and asymmetric...
Haiqi Huang,Zhuochen Du,Kun Liao et al.
Haiqi Huang et al.
Reconfigurable high-dimensional synthetic photonic lattices offer a promising platform for exploring the dynamic evolution of complex physical systems in high-dimensional spaces. However, the realization of reconfigurable high-dimensional s...
Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology [0.03%]
内源性逆转录病毒样蛋白募集UBQLN2到应激颗粒并影响其功能生物学
Harihar M Mohan,Martin G Fernandez,Camellia Huang et al.
Harihar M Mohan et al.
The human genome is replete with sequences derived from foreign elements including endogenous retrovirus-like proteins of unknown function. Here, we show that UBQLN2, a ubiquitin-proteasome shuttle factor implicated in neurodegenerative dis...
Baixu Zhu,Jun Chen,Ruipeng Li et al.
Baixu Zhu et al.
Superlattices of polyhedral nanocrystals exhibit emergent properties defined by their structural arrangements, but native nanocrystal ligands often limit their programmability. Polymeric ligands address this limitation by enabling tunable n...
Present-day Earth mantle structure set up by crustal pollution of the basal magma ocean [0.03%]
现今地幔结构由底辟玄武洋污染形成的壳层所控制
Maxim D Ballmer,Rob J Spaargaren,Ananya Mallik et al.
Maxim D Ballmer et al.
The crystallization of a global magma ocean during early terrestrial planet evolution and the subsequent segregation of a longer-lived "basal magma ocean" (BMO) atop the core set up the evolution of the mantle-atmosphere system. Although se...
Ultrastrong and ductile precipitation-hardened alloy via high antiphase boundary energy [0.03%]
通过高反相畴界能量实现超高强度和延展性的沉淀硬化合金
Shuai Dai,Yunzhu Shi,Junyang He et al.
Shuai Dai et al.
Coherent precipitation-hardened alloys often struggle to achieve both ultrahigh strength and exceptional ductility due to their limited resistance to dislocation motion and vulnerability to glide plane softening. Here, we tackle these chall...
Is sex at birth a biological coin toss? Insights from a longitudinal and GWAS analysis [0.03%]
出生性别真的是随机的吗？来自纵向和基因组关联分析的新见解
Siwen Wang,Bernard A Rosner,Hongyan Huang et al.
Siwen Wang et al.
Some families consistently have offspring of only one sex, raising questions about whether sex at birth is truly random. This study investigated whether offspring sex follows a simple binomial distribution within families and identified mat...
A wearable device for continuous immunoassay-based monitoring of C-peptide in interstitial fluid [0.03%]
一种用于连续免疫测定法监测组织液中C肽的可穿戴设备
Shengbo Chen,Ziyu Guo,Boxi Lu et al.
Shengbo Chen et al.
C-peptide is a critical biomarker for evaluating pancreatic β cell function and managing diabetes. However, conventional methods such as enzyme-linked immunosorbent assay are limited by lengthy processing times and the necessity for invasi...