Cell surface engineering with a pseudofibrotic ECM reprograms the antifibrotic activity of mesenchymal stromal cells [0.03%]
具有假纤维化基质的细胞表面工程学重新编程了间充质基质细胞的抗纤维化活性
Xianghua Zhong,Xinchao Liu,Jiajia Luo et al.
Xianghua Zhong et al.
Fibrotic diseases, which impair tissue function and contribute to organ failure, remain a major clinical challenge with limited treatment options. Mesenchymal stromal cells (MSCs) offer promise for antifibrotic therapy via paracrine signali...
Manipulating metal growth in hollow ionic-electronic conductor for anode-free lithium metal batteries [0.03%]
用于无负极锂金属电池的空心离子电子导体的金属生长调控
Lianqiang Peng,Xiaotian Wang,Xu Liu et al.
Lianqiang Peng et al.
Anode-free lithium metal batteries (AFLMBs) demonstrate promising high energy density yet suffer from irregular Li deposition, parasitic reactions, and severe volume expansion. The current anode modulation strategies such as tailored solid ...
Plasmonic tuning of dark-exciton radiation dynamics and far-field emission directionality in monolayer WSe2 [0.03%]
单层WSe2中暗 exciton辐射动力学和远场发射方向性的等离子体调谐
Shuaiyu Jin,Feihong Liu,Ilya Razdolski et al.
Shuaiyu Jin et al.
Manipulation of excitonic emission properties is important for numerous photonic applications. Of particular interest are developing easy-to-implement yet effective approaches for controlling the radiation dynamics and directionality of spi...
Cooperativity and communication between the active sites of the dimeric SARS-CoV-2 main protease [0.03%]
SARS-CoV-2主要蛋白酶二聚体活性位点之间的协作和通讯
Sarah N Zvornicanin,Ala M Shaqra,Julia Flynn et al.
Sarah N Zvornicanin et al.
The coronaviral main protease (Mpro) has been the subject of various biochemical and structural studies and a drug target against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. SARS-CoV-2 Mpro is active as a dimer,...
Artificial intelligence-enabled "inherited noninvasive intracellular recording" for prolonged monitoring of cardiac action potentials [0.03%]
人工智能驱动的“非侵入性细胞内记录遗传”用于心脏动作电位的长期监测
Suhang Liu,Xingyuan Xu,Yijing Cai et al.
Suhang Liu et al.
Intracellular action potential (AP) recording that allows long-term monitoring is challenging because permanent membrane penetration is impossible due to cell death or resealing of perforated cell membrane. Herein, an "inherited noninvasive...
Perovskite nanocrystals-in-glass hierarchical structures enable stable continuous-wave random lasers [0.03%]
钙钛矿纳米晶-玻璃分层结构实现稳定的连续波随机激光发射
Xinkuo Li,Chenduan Chen,Ke Sun et al.
Xinkuo Li et al.
Encapsulating perovskite nanocrystals (PNCs) in glass enables enhanced stability of PNCs and numerous applications such as random lasers. However, preparing PNCs and tuning their properties in glass is energy consuming because of high proce...
Dual-mode microfluidic immunostaining device for diagnostic biomarkers detection and tumor microenvironment evaluation [0.03%]
用于诊断生物标志物检测和肿瘤微环境评估的双模式微流体免疫染色设备
Yu Zhang,Yanhua Huang,Jing Jia et al.
Yu Zhang et al.
The limited availability of tissue samples from rare tumors poses a major barrier to advances in precise diagnosis, prognostic evaluation, and therapeutic research-challenges exemplified by primary central nervous system diffuse large B cel...
Maëlle Lerebourg,Floris P de Lange,Marius V Peelen
Maëlle Lerebourg
Efficient behavior requires the rapid attentional selection of task-relevant objects. Preparatory activity of target-selective neurons in visual cortex is thought to support attentional selection, guiding spatial attention and favoring proc...
Consecutive phase transformations of inorganic-organic assembly in the synthesis of single-walled zeolitic nanotube [0.03%]
单壁分子筛纳米管合成过程中无机-有机复合物的连续相变过程研究
Zhaoning Song,Hanlin Wang,Zhenyuan Zhao et al.
Zhaoning Song et al.
Single-walled zeolitic nanotube features a one-dimensional, hollow tubular structure with double-layered zeolitic walls, which represents a unique type of open framework materials. The formation mechanism underlying this characteristic stru...
Cryo-EM of autoantibody-bound NMDA receptors reveals antigenic hotspots in an active immunization model of anti-NMDAR encephalitis [0.03%]
抗NMDAR脑炎主动免疫模型中，与自身抗体结合的NMDA受体的冷冻电镜揭示了抗原热点区域
Junhoe Kim,Farzad Jalali-Yazdi,Brian E Jones et al.
Junhoe Kim et al.
Autoantibodies targeting synaptic membrane proteins are associated with autoimmune encephalitis manifested by seizures, psychosis, and memory dysfunction. Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis, a prototype of these autoimm...