Dasatinib reversibly disrupts T cell motility and activation in lymph nodes [0.03%]
Dasatinib可逆地破坏淋巴结T细胞的运动和活化
Daniela Claudino Carvoeiro,Ana Marcos-Jiménez,Ilya Tsukalov et al.
Daniela Claudino Carvoeiro et al.
The tyrosine kinase inhibitor dasatinib is prescribed as a first-line treatment for Philadelphia chromosome-positive leukemias and is increasingly used in other clinical settings. While dasatinib is effective and generally well tolerated, p...
Intermediate stages in the origin of metabolism at a phosphorylating hydrothermal vent [0.03%]
含磷酸化热液喷口代谢起源的中间阶段
Natalia Mrnjavac,Nadja K Hoffmann,Manon L Schlikker et al.
Natalia Mrnjavac et al.
The origin of life required the emergence of metabolism, an autocatalytic network of enzymatic reactions that synthesize amino acids, nucleotides, and cofactors. At the origin of metabolism, there were no enzymes-how did it start? Empirical...
A temporal differentiation program after birth delineates γδ T cell immunity [0.03%]
出生后的时序分化程序确定了γδ T细胞免疫功能
Maria V Baglioni,Marcelo G F Fares da Silva,Andrea Sonnenholzner et al.
Maria V Baglioni et al.
Type 1 and type 3 γδ T cells develop in the embryonic thymus, yet it is not known whether they continue to differentiate after birth in tissues. Here, we show that in the first week of life, intestinal γδ T cells up-regulated many T cel...
Artificial Neptune balls: Superadhesive biomimetic networks for broad-size microplastics capture and removal [0.03%]
仿人造海神球：广谱微塑料捕获与移除的超粘附仿生网络
Haeleen Hong,Byeunggon Kim,Mesbah Ahmad et al.
Haeleen Hong et al.
The cleanup of persistent microplastics (MPs) from aquifers requires the capture and removal of a broad range of MP sizes and shapes. Conventional methods such as filtration and centrifugation are inefficient in removing such a broad range ...
RTF2 and CLASPIN localize CHK1 to the replication fork to control S-phase progression [0.03%]
RTF2和CLASPIN通过在复制叉处定位CHK1来控制S期进程
Cayla Broton,Catherine L W Miller,Penelope D Ruiz et al.
Cayla Broton et al.
The essential kinase ataxia telangiectasia and Rad3-related (ATR) monitors the replicative (S) phase of the cell cycle to ensure faithful propagation of genetic material. While much is known about the mechanisms governing ATR activity at re...
Assessing pedestrian responses to autonomous and personal mobility robots in crowded public spaces [0.03%]
评估拥挤公共场所中行人对自主移动机器人和个人移动机器人的反应
Dominik Wojcikiewicz,Aude Billard,Diego Paez-Granados
Dominik Wojcikiewicz
Robots increasingly share spaces with people, supporting delivery services and mobility for the aging populations, yet their ability to share space comfortably lacks understanding and benchmarks for designers and policy-makers. We compared ...
Elevating cerebellar theta oscillations boosts noninvasively induced motor plasticity [0.03%]
通过非侵入性方法增强小脑θ振荡以提高运动可塑性
Danny Adrian Spampinato,Valentina Pezzopane,Alex Martino Cinnera et al.
Danny Adrian Spampinato et al.
Matching brain stimulation to the brain's natural rhythms can drive plasticity, yet this principle has rarely been tested in humans. We targeted the cerebellum, a key hub for motor coordination and learning, using a rhythm-tuned protocol th...
Poly(A)-binding proteins act as a thermosensory switch to control flowering via cytoplasmic retention of RNA-binding protein 45C [0.03%]
多聚腺苷酸结合蛋白通过细胞质滞留RNA结合蛋白45C控制开花以充当热感受器开关
An Yan,Ximing Gong,Songyao Zhang et al.
An Yan et al.
Poly(A)-binding proteins (PABPs) are canonically recognized for their roles in mRNA-dependent processes through binding to the poly(A) tail of mRNA. However, whether PABPs possess functions distinct from their action on mRNA, particularly i...
Mechanistic insights into water transport in electrified desalination: Osmosis and electroosmosis decoupled [0.03%]
电脱盐中水传输的机制见解：解耦渗透和电渗作用
Lijing Xu,Zhiwei Wang,Menachem Elimelech et al.
Lijing Xu et al.
High-salinity wastewaters pose a serious challenge for conventional desalination technologies that are fundamentally constrained by the high osmotic pressure. Electrified desalination can overcome this limitation as it is driven by an elect...
Cryo-EM structures of apo, agonist- and antagonist-bound heteromeric kainate receptors [0.03%]
无配体、激动剂和拮抗剂结合的异源二聚体烟碱受体的冷冻电镜结构
Changping Zhou,Guadalupe Segura-Covarrubias,Ashlee M&#x;Kay Hoffman et al.
Changping Zhou et al.
Kainate receptors (KARs) mediate excitatory synaptic transmission and regulate neurotransmitter release. In the central nervous system, KARs predominantly exist as heterotetramers comprising low-affinity (GluK1-3) and high-affinity (GluK4-5...