Single-cell epigenetic profiling reveals a tumor-intrinsic interferon response program in ccRCC tied to poor prognosis and BAP1 loss [0.03%]
单细胞表观基因组分析揭示了ccRCC中的肿瘤内在干扰素反应程序与预后不良和BAP1丢失相关性
Sabrina Y Camp,Meng Xiao He,Michael S Cuoco et al.
Sabrina Y Camp et al.
Transcriptional programs in renal cell carcinoma (RCC) have been linked to tumor heterogeneity and clinical outcomes, but analogous efforts to define chromatin programs shaping disease biology have been limited. Here, we generated single-ce...
Electroluminescent perovskite QD-based neural networks for energy-efficient and accelerate multitasking learning [0.03%]
用于节能和加速多任务学习的钙钛矿量子点电致发光神经网络
Young Ran Park,Gunuk Wang
Young Ran Park
The ability of multitasking (MT) learning in neuro-inspired artificial intelligence (AI) systems offers promise for energy-efficient deployment in robotics, health care, and autonomous vehicles. Here, an MT learning framework is established...
Hemizygous loss of helicases promotes genomic instability and cancer development [0.03%]
解旋酶单倍体缺失通过促进基因组不稳定性和肿瘤发生来驱动癌症发展
Karolin Voßgröne,Francesco Favero,Krushanka Kashyap et al.
Karolin Voßgröne et al.
Cancer mutations perturb key processes, driving uncontrolled cell proliferation. With critical roles of enzymes in cell function and growth, we hypothesized that cancer driver mutations alter specific and recurrent enzymatic functions. Leve...
Intratumoral Parvimonas micra promotes esophageal squamous cell carcinoma via p-cresol-induced Treg differentiation [0.03%]
帕微单胞菌通过对羟基苯甲醇诱导调节性T细胞分化促进食管鳞癌生长
Guoyu Cheng,Xuan Jiang,Lingxuan Zhu et al.
Guoyu Cheng et al.
Intratumoral microbiota has emerged as a notable factor influencing cancer initiation and progression. However, its composition and functional impact in esophageal squamous cell carcinoma (ESCC) remain largely unexplored. Here, we performed...
cPLA2α targeting to exosomes connects nuclear deformation to LTB4-signaling during neutrophil chemotaxis [0.03%]
靶向exosome的cPLA2α在中性粒细胞趋化过程中将核变形与LTB4信号传导相连
Subhash B Arya,Fatima Jordan-Javed,Kristen Loesel et al.
Subhash B Arya et al.
Efficient neutrophil chemotaxis requires the integration of mechanical forces and lipid-mediated signaling. While the signaling lipid leukotriene B4 (LTB4) reinforces cellular polarity, how mechanical cues regulate its production remains un...
Covalent capture and genetic code expansion enables chemoproteomic profiling and functional characterization of lysine acetoacetylation [0.03%]
共价捕获和遗传密码扩张技术使赖氨酸乙酰丙酰化的化学蛋白质组学分析及功能表征成为可能
Xiaohan Song,Yuhan Lu,Xinlong Guo et al.
Xiaohan Song et al.
Lysine acetoacetylation (Kacac) driven by metabolite acetoacetic acid represents a molecular mechanism by which ketone bodies regulate cellular functions beyond energy provision. However, comprehensive characterization of Kacac has been hin...
Haiyan Chu,Huilin Zhang,Dahua Ren et al.
Haiyan Chu et al.
With increasing understanding of cadmium (Cd) exposure levels and toxicity mechanisms, the adequacy of current Cd limit standards for protecting public health requires comprehensive evaluation. Here, we found that 39.04% of rice Cd content ...
Glomerular routing of tumor-derived extracellular vesicles substantiates urinary biopsy [0.03%]
肿瘤源性细胞外囊泡的肾小球路由证实了尿液活检的作用
Shota Kawaguchi,Taiga Ajiri,Rina Mitsuya et al.
Shota Kawaguchi et al.
Urinary small extracellular vesicles (sEVs), which can reflect systemic conditions, hold great promise for noninvasive cancer diagnostics, yet the mechanism by which tumor-derived sEVs reach urine remains unclear. Here, we demonstrate that ...
Selective attention to auditory and visual modalities converges onto noncholinergic basal forebrain neurons [0.03%]
听觉和视觉的感觉门控汇聚于胆碱能基底前脑神经元之外的神经元上
Sz-Wen Liu,Shih-Chieh Lin
Sz-Wen Liu
Selective attention enables animals and humans to prioritize behaviorally relevant stimuli among competing sensory inputs. Although the basal forebrain (BF) is known to modulate cortical activity and support attention, it remains unclear wh...
12R-HETE acts as an endogenous ligand for Nur77 in the intestines and regulates NKp46+ ILC3 development [0.03%]
12-羟基二十碳四烯酸作为Nur77在肠道内的内源性配体，调节NKp46+ ILC3的发育
Ningning Huang,Zhipeng Yang,Yaojie You et al.
Ningning Huang et al.
How intestinal immunity develops during early life remains a key question in understanding defense against infections. Group 3 innate lymphoid cells (ILC3s) are critical for this defense, and their developmental progression and subset balan...