Targeting mitocytosis potentiates mitochondria drug delivery for antimetastasis therapy [0.03%]
线粒体靶向降解技术增强抗转移药物疗效的机制研究
Yudi Deng,Yunhui Zhang,Fuya Jia et al.
Yudi Deng et al.
Mitocytosis is a compensatory pathway responding to mitochondria stress in migratory cells, which expels damaged mitochondria through migrasomes, preserving mitochondrial homeostasis and cellular viability. We found distinct responses to mi...
Experimental data reuploading with provable enhanced learning capabilities [0.03%]
具备增强学习能力的实验性数据重新上传
Martin F X Mauser,Solène Four,Lena Marie Predl et al.
Martin F X Mauser et al.
The past decades have seen the development of quantum machine learning, stemming from the intersection of quantum computing and machine learning. This field is particularly promising for the design of alternative quantum (or quantum inspire...
Dissection of the T cell infiltrate in mouse pancreatic tumors reveals an extensive and diverse tumor-reactive T cell repertoire [0.03%]
小鼠胰腺肿瘤T细胞浸润的解析揭示了广泛且多样的肿瘤反应性T细胞库
Hannes Kehm,Stefan Zens,Daniel Baumann et al.
Hannes Kehm et al.
Although pancreatic cancer is generally refractory to immune checkpoint blockade, recent studies of tumor-infiltrating T cells in human tumor samples demonstrated the presence of in vivo expanded, tumor-reactive T cell receptor (TCR) clonot...
Miniaturized optically generated Bessel beam ultrasound for volumetric transcranial brain stimulation [0.03%]
一种微型光学生成的贝塞尔束超声波用于体积颅内脑刺激
Yueming Li,Guo Chen,Tiago R Oliveira et al.
Yueming Li et al.
Noninvasive stimulation of small, variably shaped brain subregions is crucial for advancing our understanding of brain functions. Current ultrasound neuromodulation faces two major trade-offs when targeting brain subregions: miniaturization...
Polymer-Sensitized Hybrid Design Strategy for High-Efficiency Blue Hyperfluorescent OLEDs [0.03%]
高效蓝色超荧光OLED的聚合物敏化杂化设计策略
Junwon Jeon,Hyung Jin Cheon,Joo Yoon Woo et al.
Junwon Jeon et al.
Achieving efficient and color-pure-blue emission in solution-processed organic light-emitting diodes (SOLEDs) remains a challenge due to poor triplet utilization and interfacial energy loss. We report high-efficiency blue hyperfluorescent (...
SRC-mediated phosphorylation of UBC9 regulates inflammatory and metabolic signaling in alcohol-associated liver disease [0.03%]
SRC介导的UBC9磷酸化调节酒精性肝病中的炎症和代谢信号转导
Swati Chandla,Youngyi Lim,Andrea Floris et al.
Swati Chandla et al.
Alcohol-associated liver disease (ALD) remains a major public health challenge with limited treatment options. NF-κB-driven inflammation in Kupffer cells (KCs) plays a central role in ALD, but the upstream regulators remain poorly understo...
Innate immune sensing of dietary alcohol ignites inflammation to drive alcohol-related disease [0.03%]
固有免疫感应膳食酒精引发炎症以驱动酒精相关疾病
Yeonseo Jang,Hoeun Bae,SuHyeon Oh et al.
Yeonseo Jang et al.
Alcohol consumption has short- and long-term impacts on physical and mental health. Although multiple host and environmental factors contribute to alcohol-related disease, the innate immune sensors that detect toxic signals from alcohol rem...
Acoustoelectric control of optoelectronic anisotropy for reconfigurable polarimetry [0.03%]
声光调控光电各向异性实现可重构偏振检测
Chang Jiang,Jiaming Gu,Hanlin Lu et al.
Chang Jiang et al.
Harnessing light polarization provides a powerful degree of freedom for optical communications, imaging, and sensing. Two-dimensional (2D) anisotropic semiconductors have emerged as a promising platform for miniaturized on-chip polarimetry;...
RNA binding protein Pcbp1 maintains mitochondria integrity to promote antibody production and germinal center response [0.03%]
RNA结合蛋白Pcbp1通过维持线粒体完整性促进抗体产生和生发中心反应
Lizhen Zhu,Li Lin,Tuan Qi et al.
Lizhen Zhu et al.
B cells are crucial for adaptive immunity, orchestrating humoral responses by producing antibodies essential for pathogen clearance. Here, we show that Poly(rC) binding protein 1 (Pcbp1), a multifunctional RNA binding protein, is a key regu...
Qing Li,Zhe-Ning Xiang,Bin-Bin Zhang et al.
Qing Li et al.
The recently found spin-triplet superconductor candidate UTe2 has attracted enormous attention. Here, we report the finding of superconductivity up to Tc ≈ 4 K in one of its siblings, i.e., UAs2 under pressure. UAs2 shows metallic behavior...