Decoding the chemical space of fast-ion conductors via a descriptor-guided transfer learning framework [0.03%]
基于描述符引导的迁移学习框架探索快速离子导体化学空间
Zhilong Wang,Fengqi You
Zhilong Wang
Fast-ion conductors (FICs) are key components for next-generation high-performance batteries, yet predicting ion mobility remains challenging because of the unclear transport mechanisms. This difficulty is further compounded by experimental...
Holly V Moeller,Erica Lasek-Nesselquist,Zachary L Reitz et al.
Holly V Moeller et al.
Stable acquisitions of metabolism, such as the endosymbiotic incorporation of eukaryotic chloroplasts, are thought to proceed through mechanisms that increase the genetic repertoire of the host and allow for vertical integration of new meta...
Ribosomal protein bL27 protects translating ribosomes from tmRNA-SmpB [0.03%]
核糖体蛋白bL27保护翻译中的核糖体免受tmRNA-SmpB的影响
Divyasorubini Seerpatham,George Wanes,Chathuri Pathirage et al.
Divyasorubini Seerpatham et al.
Bacterial ribosomal protein bL27 is universally conserved, and its amino terminus is adjacent to the peptidyl transfer center, yet its roles in translation remain unclear. Combining genetics, biochemistry, and molecular dynamics, we show th...
Jiaze Li,Michael T Schaub,Leto Peel
Jiaze Li
Extending community detection from pairwise networks to hypergraphs introduces fundamental theoretical challenges. Hypergraphs exhibit structural heterogeneity with no direct graph analog: Hyperedges of varying orders can connect nodes acro...
Continuous contributions of the dorsolateral striatum to movement initiation and execution [0.03%]
背外侧纹状体在运动启动和执行中的持续作用
Jiaming Cao,Yujie Zhao,Jianing Yu
Jiaming Cao
Spikes in the dorsolateral striatum (DLS) of the basal ganglia (BG) correlate with forelimb and whole-body movements, but the extent to which they contribute to movement remains unclear. Using behavior-timed optogenetic inhibition in rats p...
Distributed burst firing mediates optimized cortical encoding of natural self-motion [0.03%]
分散的爆发式放电介导了对自然自我运动的优化皮层编码
Jerome Carriot,Isabelle Mackrous,Kathleen E Cullen et al.
Jerome Carriot et al.
Accurate perception of self-motion requires that vestibular input be transformed into neural representations suitable for integrating multisensory cues to guide action. Here, we demonstrate that vestibular cortical neurons represent the sel...
Ly6d expression delineates two putative postnatal thymus epithelial progenitor cells that are differentially affected by aging [0.03%]
LY6D表达界定了两种假定的产后胸腺上皮干细胞，其衰老程度不同
Irene Calvo-Asensio,Andreas Tarcevski,Fatima Dhalla et al.
Irene Calvo-Asensio et al.
To date, the identity and maintenance of postnatal thymic epithelial progenitor cells (TEPCs) remain unclear, as does the persistence of bipotent TEPCs after birth or whether lineage-restricted progenitors independently maintain separate TE...
Tunable dislocations overcome mechano-functional tradeoff in perovskite oxides [0.03%]
可调式位错克服了钙钛矿氧化物中的力学-功能权衡现象
Jiawen Zhang,Wenjun Lu,Xufei Fang
Jiawen Zhang
Recent advancements in dislocation engineering are reshaping the traditional view towards ceramics being brittle. Here, we use KTaO3 (KTO), a perovskite oxide that is newly discovered with room-temperature bulk plasticity, and demonstrate t...
Deep learning reveals a neurocomputational mechanism predicting depression risk in adolescents [0.03%]
深度学习揭示了预测青少年抑郁风险的神经计算机制
Han Lu,Xiaoqian Yan,Benjamin Becker et al.
Han Lu et al.
Early detection and prevention of psychiatric disorders, particularly depression, remain as major global health challenges, yet reliable tools for identifying individuals before symptom onset are lacking. Here, we combine functional neuroim...
Structural insights into a substrate translocation pathway revealed by the RND efflux pump complex MexJK from Pseudomonas aeruginosa [0.03%]
铜绿假单胞菌RND型外排泵复合物MexJK的结构揭示了其底物转运机制
Zhikun Wu,Ziyue Meng,Wei Huang et al.
Zhikun Wu et al.
Resistance-nodulation-cell division (RND) efflux pumps are the major cause of multidrug resistance in Pseudomonas aeruginosa. The inner membrane protein MexK from P. aeruginosa is a narrow-spectrum RND transporter. It assembles with membran...