Jack J Middelburg
Jack J Middelburg
Increasing hydrostatic pressure induces the release of dissolved organic matter from rapidly settling marine particles and contributes to the depth attenuation of carbon fluxes.
Interface-engineered plasmonic covalent organic framework nanofilms on TiO2 nanotubes for universal mass spectrometry imaging [0.03%]
基于TiO₂纳米管的等离激元共价有机框架纳米膜界面工程用于普适性质谱成像技术
Yizhu Xu,Xinzhou Wu,Weifeng Li et al.
Yizhu Xu et al.
Covalent organic frameworks (COFs) hold promise for surface-assisted laser desorption/ionization mass spectrometry imaging (MSI), yet their integration with plasmonic nanostructured platforms remains unexplored. Here, we report a liquid-liq...
Jinghui Liu,Elisa Nerli,Charlie Duclut et al.
Jinghui Liu et al.
Organ injury triggers nonneuronal electric currents essential for regeneration. However, the mechanisms by which electrical signals are generated, sensed, and transmitted upon damage to promote organ growth remain unclear. Here, we uncover ...
Volcanism-induced collapse and recovery of the Atlantic meridional overturning circulation under glacial conditions [0.03%]
冰川期火山活动诱发大西洋经向翻转环流的崩溃与复苏
Guido Vettoretti,Ruei-Jia Hu,Ingo Bethke et al.
Guido Vettoretti et al.
Volcanic eruptions have considerable impacts on climate across various timescales; however, it remains uncertain if, and how, volcanic activity could drive climate change over multiple millennia. Here we incorporate realistic volcanic forci...
Hydrostatic pressure induces strong leakage of dissolved organic matter from "marine snow" particles [0.03%]
静水压可诱导“海洋雪”颗粒溶解有机物的大量泄漏
Peter Stief,Jutta Niggemann,Margot Bligh et al.
Peter Stief et al.
Marine snow forms at the ocean surface, sinks to depth, and ultimately enables carbon sequestration in the seabed. Fast-sinking marine snow particles, such as diatom aggregates, encounter a rapid increase in hydrostatic pressure during thei...
Stress ensemble in the BNST mediates comorbid anxiety and sleep disruption [0.03%]
BNST中的应激神经元群介导共病焦虑和睡眠障碍
Haiyan Sun,Zhentong Qiu,Xin Liu et al.
Haiyan Sun et al.
Anxiety and insomnia are highly comorbid; however, the underlying brain-circuit mechanisms remain inadequately explored. Here, we identify a dual-functional ensemble within the bed nucleus of the stria terminalis (BNST) that modulates both ...
Noninvasive photoacoustic computed mesoscopy for longitudinal brain imaging [0.03%]
用于纵向脑部成像的非侵入性光声计算介观成像技术
Shijie Ruan,Wei Qin,Linyang Li et al.
Shijie Ruan et al.
Photoacoustic imaging has become a powerful tool for visualizing the brain morphology, function, and metabolism. However, severe optical scattering and high-frequency acoustic attenuation within the brain degrade the performance of photoaco...
Day-to-day fluctuations in cognitive precision predict the domain-general intention-behavior gap [0.03%]
日常认知精度的波动预测领域通用意向-行为差距
Daniel J Wilson,Cendri A Hutcherson
Daniel J Wilson
The idea that better cognitive functioning helps to close the gap between goals and behavior seems self-evident, yet empirical work has found unusually weak interindividual associations between cognitive task performance and real-world, goa...
Single-molecule localization microscopy reveals the molecular organization of endogenous membrane receptors [0.03%]
单分子定位显微镜揭示内源性膜受体的分子组织
Patrick Eiring,Maximilian J Steinhardt,Nele Bauer et al.
Patrick Eiring et al.
Super-resolution microscopy in combination with genetic labeling methods allows imaging of single proteins in cells. However, visualizing endogenous proteins on primary cells remains challenging due to the use of sterically demanding antibo...
In vivo functional profiling and structural characterization of the human GLP1R A316T variant [0.03%]
人GLP1R A316T变异体的体内功能谱分析和结构表征
Liliane El Eid,Yusman Manchanda,Gregory Austin et al.
Liliane El Eid et al.
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are effective therapies for type 2 diabetes (T2D) and obesity, yet patient responses are variable, with GLP1R gene variation potentially linked to therapeutic outcomes. A GLP1R natural mi...