Murine vascular organoids are responsive and adaptable 3D systems with cellular heterogeneity and dynamic plasticity [0.03%]
具细胞异质性和动态可塑性的三维响应型小鼠血管器官模型
Sophie Guelfi,Krish Skandha Gopalan,Pieter Maene et al.
Sophie Guelfi et al.
Blood vascular organoids (BVOs) have emerged as powerful tools for interrogating endothelial heterogeneity, function, and organ-specific cues during development, homeostasis, and disease. Here, we describe the stepwise generation and charac...
Programmed ribosomal frameshifting during PLEKHM2 mRNA decoding generates a constitutively active proteoform that supports myocardial function [0.03%]
PLEKHM2 mRNA解码期间的程序化核糖体框移生成了一种支持心肌功能的组成性活化蛋白型
Gary Loughran,Raffaella De Pace,Ningyu Ding et al.
Gary Loughran et al.
Programmed ribosomal frameshifting is a process where a proportion of ribosomes change their reading frame on an mRNA. While frameshifting is commonly used by viruses, very few phylogenetically conserved examples are known in nuclear encode...
Biosensor-driven strain engineering reveals key cellular processes for maximizing isoprenol production in Pseudomonas putida [0.03%]
基于生物传感器的菌株工程揭示了提高Pseudomonas putida中异戊醇产量的关键细胞过程
Javier Menasalvas,Shawn Kulakowski,Yan Chen et al.
Javier Menasalvas et al.
Synthetic biology generates vast combinatorial designs, yet high-throughput analytical methods to screen them are poorly matched to interrogate this search space. We address this challenge by developing a biosensor-driven, growth-coupled se...
Molecularly tailored dual-interface passivation via solvent-free rub-on transfer for efficient and stable perovskite LEDs [0.03%]
基于溶剂自由的擦取转移实现分子定制化双界面钝化的高效稳定钙钛矿LEDs
Jin Kyoung Park,Jin Hyuck Heo,Hong Seop Jeon et al.
Jin Kyoung Park et al.
Conventional solution-based passivation methods for perovskite light-emitting diodes (PeLEDs) often introduce secondary defects. A molecularly tailored dual-interface passivation strategy is presented using a solvent-free rub-on transfer me...
The hook-like adaptor and cargo-binding (HAC) domain in the kinesin-2 tail enables adaptor assembly and cargo recognition [0.03%]
钩状适配体和货物结合（HAC）结构域使kinesin-2尾部能够组装并识别运输货物
Xuguang Jiang,Radostin Danev,Sotaro Ichinose et al.
Xuguang Jiang et al.
Intracellular transport relies on motor proteins such as kinesins to deliver cargo along microtubules, yet how they recognize cargo remains unclear. Here, we present high-resolution cryo-electron microscopy structures of the heterotrimeric ...
Quantum spin Hall effect in III-V semiconductors at elevated temperatures: Advancing topological electronics [0.03%]
拓扑电子学中III-V族半导体的量子自旋霍尔效应：高温下的进展
Manuel Meyer,Jonas Baumbach,Sergey Krishtopenko et al.
Manuel Meyer et al.
The quantum spin Hall effect (QSHE), a hallmark of topological insulators, enables dissipationless, spin-polarized edge transport and has been predicted in various two-dimensional materials. However, challenges such as limited scalability, ...
Cavity-mediated electron-electron interactions: Renormalizing Dirac states in graphene [0.03%]
空穴介导的电子-电子相互作用：石墨烯中狄拉克态的重正化
Hang Liu,Francesco Troisi,Hannes Hübener et al.
Hang Liu et al.
Embedding materials in optical cavities has emerged as a strategy for tuning material properties. Here, we develop a nonperturbative quantum electrodynamical approach based on a photon-free self-consistent Hartree-Fock framework to model th...
Mendelian randomization study implicates inflammaging biomarkers in retinal vasculature, cardiovascular diseases, and longevity [0.03%]
孟德尔随机化研究揭示了炎症老化生物标志物在视网膜血管、心血管疾病和长寿方面的作用
Ana Villaplana-Velasco,Nicolas Perrot,Yu Hang et al.
Ana Villaplana-Velasco et al.
With the increasing proportion of elderly individuals, understanding biological mechanisms of aging is critical. Retinal vascular complexity, measured as fractal dimension (Df) from fundus photographs, has emerged as a vascular aging indica...
Enhancing cross-organelle coordination to advance plant cytochrome P450 functionality in yeast [0.03%]
增强跨细胞器协调以在酵母中推进植物细胞色素P450功能
Shanhui Xu,Songbo Wei,Yun Xiong et al.
Shanhui Xu et al.
Sustainable production of plant secondary metabolites remains a substantial challenge. Microbial cell factories offer a promising solution, yet reconstituting plant cytochrome P450s, key enzymes in these pathways, remains a major hurdle. In...
Time-resolved Mendelian randomization detects substantial variation in the detrimental effect of obesity throughout life [0.03%]
时间解析的孟德尔随机化检测了肥胖对生命全程的危害效应的显著变化
Torgny Karlsson,Fatemeh Hadizadeh,Mathias Rask-Andersen et al.
Torgny Karlsson et al.
The global burden of disease attributable to obesity continues to rise. The disease incidence is substantially higher in elderly populations, but how obesity affects disease risk across a lifetime is largely unknown. To quantify the long-te...