Keeping the photon in the dark: Enabling quantum dot dark state control by chirped pulses and magnetic fields [0.03%]
利用展宽脉冲和磁场实现量子点暗态控制
Florian Kappe,René Schwarz,Yusuf Karli et al.
Florian Kappe et al.
Dark excitons in quantum dots are not directly optically accessible, which has limited their use in practical applications. Nevertheless, they offer promising features such as substantially longer lifetimes compared to bright excitons, maki...
The human genetic variant rs6190 unveils Foxc1 and Arid5a as novel prometabolic targets of the glucocorticoid receptor in muscle [0.03%]
人类基因变异rs6190揭露Foxc1和Arid5a是肌糖皮质激素受体的新促代谢目标
Ashok Daniel Prabakaran,Fabian Montecino-Morales,Kevin McFarland et al.
Ashok Daniel Prabakaran et al.
The mechanisms segregating positive from negative effects of the glucocorticoid receptor (GR) on metabolic health remain poorly elucidated. Here, we generated mice genocopying the human GR polymorphism rs6190, which was sufficient to increa...
Sensing of extracellular l-proline availability by the integrated stress response determines the outcome of cell competition [0.03%]
整合应激反应通过感应细胞外左旋脯氨酸的可用性决定细胞竞争的结局
Shruthi Krishnan,Ana Lima,Sizhe Tan et al.
Shruthi Krishnan et al.
Cell competition is a conserved fitness quality control that eliminates cells that are less fit than their neighbors. How winner cells induce the elimination of losers is poorly understood. We tackle this question by studying the onset of e...
Alec R Brenner,Aaron J Cavosie,Jasmine Palma-Gomez et al.
Alec R Brenner et al.
North Pole Dome (Pilbara Craton, Western Australia) contains unique geological analogs to early Earth and Mars. Recently discovered shatter cones in 3.47-billion-year-old (Ga) rocks reveal that it is also the site of an ancient meteorite im...
Atomic-resolution structure of a chimeric Powassan tick-borne flavivirus [0.03%]
原子分辨率的Powass安蜱传黄病毒嵌合体结构
Sayan Das,Anoop Narayanan,Anqi Wang et al.
Sayan Das et al.
Powassan virus (POWV) is an emerging tick-borne flavivirus for which no vaccine or antiviral treatment exists. The incidence of human infections of POWV in North America has been increasing because of the expanding distribution of the tick ...
Highly textured metal anodes for stable aqueous batteries: Fabrication and characterization [0.03%]
高度纹理化的金属阳极用于稳定的水系电池：制备与表征
Shifeng Hong,Mingjia Fang,Samuel Baffour et al.
Shifeng Hong et al.
We report a purely mechanical "cold-compression flow" method for fabricating Zn, Sn, and In substrates with tunable crystallographic textures. Using textured Zn as a model system, we investigate Zn electrocrystallization and demonstrate cor...
Single-cell spatial transcriptomics reveals immunotherapy-driven bone marrow niche remodeling in AML [0.03%]
单细胞空间转录组揭示AML免疫治疗驱动的骨髓生态龛重塑
Gege Gui,Molly A Bingham,Julius R Herzog et al.
Gege Gui et al.
Given the graft-versus-leukemia effect observed with allogeneic hematopoietic stem cell transplantation in refractory or relapsed acute myeloid leukemia (AML), immunotherapies have been explored in nontransplant settings. We applied a multi...
Clement Rodier,Ian D Estabrook,Eunice HoYee Chan et al.
Clement Rodier et al.
The sarcomere is the elementary contractile unit of muscles. Adult muscle cells are large and chain thousands of sarcomeres into long periodic myofibrils that attach to the skeleton. During development, muscle cells must increase in length ...
Src/FN1 pathway activation drives tumor cell cluster formation and metastasis in lung cancer: A promising therapeutic target [0.03%]
肺源性肿瘤细胞簇的形成和转移由Src/FN1途径驱动：一个有前景的治疗靶点
Zujun Que,Zhichao Xi,Dan Qi et al.
Zujun Que et al.
Lung cancer remains the leading cause of cancer-related death globally, with metastasis driven by circulating tumor cells (CTCs)-particularly clusters-being a major treatment challenge. Despite their critical role, the biological difference...
High-throughput multiplexed gene and cell doping analysis through CRISPR-Cas12a system integrated with blood direct PCR [0.03%]
基于血液直接PCR的CRISPR-Cas12a系统在高通量多路基因和细胞兴奋剂检测中的应用
Joon-Yeop Yi,Hyomin Choi,Minyoung Kim et al.
Joon-Yeop Yi et al.
Advancements in gene and cell therapies introduce "gene and cell doping," requiring efficient and sensitive detection methods. Here, we report a high-throughput multiplexed gene and cell doping analysis (HiMDA) using CRISPR-Cas12a system in...