Elevating cerebellar theta oscillations boosts noninvasively induced motor plasticity [0.03%]
通过非侵入性方法增强小脑θ振荡以提高运动可塑性
Danny Adrian Spampinato,Valentina Pezzopane,Alex Martino Cinnera et al.
Danny Adrian Spampinato et al.
Matching brain stimulation to the brain's natural rhythms can drive plasticity, yet this principle has rarely been tested in humans. We targeted the cerebellum, a key hub for motor coordination and learning, using a rhythm-tuned protocol th...
Poly(A)-binding proteins act as a thermosensory switch to control flowering via cytoplasmic retention of RNA-binding protein 45C [0.03%]
多聚腺苷酸结合蛋白通过细胞质滞留RNA结合蛋白45C控制开花以充当热感受器开关
An Yan,Ximing Gong,Songyao Zhang et al.
An Yan et al.
Poly(A)-binding proteins (PABPs) are canonically recognized for their roles in mRNA-dependent processes through binding to the poly(A) tail of mRNA. However, whether PABPs possess functions distinct from their action on mRNA, particularly i...
Mechanistic insights into water transport in electrified desalination: Osmosis and electroosmosis decoupled [0.03%]
电脱盐中水传输的机制见解：解耦渗透和电渗作用
Lijing Xu,Zhiwei Wang,Menachem Elimelech et al.
Lijing Xu et al.
High-salinity wastewaters pose a serious challenge for conventional desalination technologies that are fundamentally constrained by the high osmotic pressure. Electrified desalination can overcome this limitation as it is driven by an elect...
Cryo-EM structures of apo, agonist- and antagonist-bound heteromeric kainate receptors [0.03%]
无配体、激动剂和拮抗剂结合的异源二聚体烟碱受体的冷冻电镜结构
Changping Zhou,Guadalupe Segura-Covarrubias,Ashlee M&#x;Kay Hoffman et al.
Changping Zhou et al.
Kainate receptors (KARs) mediate excitatory synaptic transmission and regulate neurotransmitter release. In the central nervous system, KARs predominantly exist as heterotetramers comprising low-affinity (GluK1-3) and high-affinity (GluK4-5...
Electrochemically tailored ion-trapping nanoarchitectures in COF membranes for selective monovalent/divalent ion sieving [0.03%]
用于选择性单/双价离子筛分的COF膜电化学调控离子捕获纳米结构
Jing Wang,Pengrui Jin,Ziwen Dai et al.
Jing Wang et al.
The efficient separation of monovalent and divalent ions remains a core challenge in desalination and ion resource recovery. Here, we propose an electrochemical confinement strategy to spatially organize EDTA into aligned arrays within the ...
Corticosterone-linked microglial activity underpins sexually dimorphic neuroplasticity after ketamine anesthesia [0.03%]
糖皮质激素链联的微胶质细胞活性导致氯胺酮麻醉后的性别差异性神经可塑性
Alessandro Venturino,MohammadAmin Alamalhoda,Thomas Negrello et al.
Alessandro Venturino et al.
Anesthesia recovery is critical for resuming normal physiological and neuronal functions; however, the mechanisms involved remain elusive. Here, we identify a female-selective corticosterone-mediated microglia-neuron interaction during keta...
Adaptive intrathecal nanorobotics in mice and nonhuman primates for navigated CNS therapy [0.03%]
用于导航CNS治疗的适应性鞘内纳米机器人在小鼠和非人灵长类动物中的应用
Yumeng Lu,Xinjian Fan,Chengjuan Fan et al.
Yumeng Lu et al.
Intrathecal delivery for central nervous system (CNS) therapy lacks spatiotemporal control due to spinal canal anatomical constraints, especially at human scale. We developed an adaptive magnetic nanorobotic platform enabling multimode swar...
A motoneuron discharge-driven interface realizing simultaneous and proportional control of prosthetics in end-users [0.03%]
一种基于运动神经元放电的假肢同步比例控制接口系统
Chen Chen,Ruye Guo,Dongxuan Li et al.
Chen Chen et al.
Accurate decoding of movement intent from muscle signals is essential for dexterous prosthetic control. While motoneuron discharge decomposition provides a promising approach, most studies are confined to proof-of-concept demonstrations due...
A NHEJ1 mutator allele influencing germline mutation rates sex-specifically in humans [0.03%]
一个NHEJ1等位基因通过性别特异性影响人类生殖系突变率
Kun Wu,Jiuhong Nan,Haoxuan Liu
Kun Wu
Germline mutations play a pivotal role in evolution and are the primary cause of hereditary diseases in humans. Although interpopulation and interspecific variations in the mutation rate and spectrum are observed, their underlying genetic b...
Transient receptor potential vanilloid 2 functions as a directional driver for hepoxilin A3-mediated neutrophil migration [0.03%]
瞬时受体电位香草素通道2作为白细胞三烯介导的中性粒细胞迁移的方向驱动因素发挥作用
Claudia Feriotti,Regino Mercado-Lubo,Merran Bryford et al.
Claudia Feriotti et al.
Neutrophil migration involves a dynamic balance of chemoattractant and inhibitory signals. We previously identified hepoxilin A3 (HxA3) as a potent chemoattractant that directs neutrophil migration across intestinal epithelia and showed tha...