Martí Galí,María Andrea Orihuela-García,Yohan Ruprich-Robert et al.
Martí Galí et al.
Vertical fluxes of particulate organic carbon (POC) are central to the oceanic carbon cycle, yet the role and interannual variability of convective POC transport remain poorly constrained. Autonomous profilers drifting in the Labrador and I...
A hemispherical latitude-gradient sensor for closed-loop monitoring and management of scoliosis correction [0.03%]
一种半球形纬度梯度传感器用于脊柱侧凸矫正的闭环监测和管理
Hehua Zhang,Yuyu Gao,Xinxin He et al.
Hehua Zhang et al.
Conservative treatment of scoliosis relies on physiotherapy and bracing, yet both approaches lack tools for quantitative, real-time monitoring of corrective forces. Here, we introduce a hemispherical latitude-gradient (HS-LG) sensor as a pr...
Molecular mechanism by which SARS-CoV-2 Orf9b suppresses the Tom70-Hsp90 interaction to evade innate immunity [0.03%]
SARS-CoV-2 Orf9b通过抑制Tom70-Hsp90相互作用来逃避先天免疫的分子机制
Noah Sherer,Abhishek Bastiray,Xiao-Ru Chen et al.
Noah Sherer et al.
The Tom70-Hsp90 interaction is critical for MAVS-mediated interferon (IFN) production. Upon RNA virus infection, cytosolic Hsp90 recruits key innate immune signaling proteins to MAVS on mitochondria through its interaction with Tom70. To ev...
Bidirectional terahertz frequency conversion via structural resonances at a plasma time boundary [0.03%]
等离子体时间边界结构共振的双向太赫兹频谱转换
Yindong Huang,Bin Zhou,Aijun Xuan et al.
Yindong Huang et al.
A time boundary, an abrupt temporal change in material refractive index that conserves wave vector while shifting optical frequency, offers a powerful route to dynamic spectral control. Prior demonstrations of time boundaries in Drude-like ...
Most people who agree with you won't protest: Predictors of marches and demonstrations from six decades of research [0.03%]
六十年研究预测了抗议活动：如果你赞同就不会出来游行了
Shelley Boulianne,Jennifer Earl
Shelley Boulianne
Protest and activism are endemic and potent features of many nations' political life and critical potential counters to democratic backsliding and authoritarianism. In this review article, we meta-analytically examine six decades of researc...
Stiff matrix impairs cytotoxic T lymphocyte function at multiple levels [0.03%]
刚性的基质通过多种途径损害细胞毒T细胞的功能
Mir Hadi Seyedzadeh,M A Tolentino,Newton Gil Peres et al.
Mir Hadi Seyedzadeh et al.
Cytotoxic T lymphocytes (CTLs) play a pivotal role in antitumor immunity via inducing apoptosis in cancer cells. However, their effector functions can be compromised by the perturbations in the tumor microenvironment (TME). Among the divers...
Hongzhao Wu,Xiangwei Su,Cheng Zhang et al.
Hongzhao Wu et al.
A key challenge in visual search is that target objects defined by specific features are often mixed with distractors. This demands intelligent vision systems capable of performing selective feature acquisition instead of randomly or exhaus...
Engineered heart-liver axis nanoregulators synergize autophagy activation and systemic metabolic reprogramming against atherosclerosis [0.03%]
工程化的心肝轴纳米调控剂协同激活自噬和全身代谢重编程对抗动脉粥样硬化
Yiyong Tang,Jiadi Liu,Liya Tian et al.
Yiyong Tang et al.
Atherosclerosis (AS) is the most important pathological basis for cardiovascular diseases worldwide. However, the current mainstream therapeutic strategies for AS only target isolated pathological links, ignoring hepatic steatosis as a rela...
Genetic screening identifies WNT5A/RYK as a determinant of extracellular vesicle fate [0.03%]
基因筛选鉴定出WNT5A/RYK是细胞外囊泡命运的决定因素
Julia Dancourt,Satish Babu Moparthi,Jeanne Lainé et al.
Julia Dancourt et al.
Extracellular vesicles (EVs) are natural mediators of intercellular communication through the transfer of cytoplasmic material from donor to recipient cells. The molecular mechanisms governing EV uptake and cargo delivery in recipient cells...
Ji-Hyung Lee,Kiran Kumar Nakka,Ryan P Calhoun et al.
Ji-Hyung Lee et al.
Stem cell-mediated regeneration is essential for tissue integrity. In skeletal muscle, tissue repair largely depends on muscle stem cells (MuSCs), which undergo dynamic cell-state transitions through making precise fate decisions during reg...