Jiaze Li,Michael T Schaub,Leto Peel
Jiaze Li
Extending community detection from pairwise networks to hypergraphs introduces fundamental theoretical challenges. Hypergraphs exhibit structural heterogeneity with no direct graph analog: Hyperedges of varying orders can connect nodes acro...
Continuous contributions of the dorsolateral striatum to movement initiation and execution [0.03%]
背外侧纹状体在运动启动和执行中的持续作用
Jiaming Cao,Yujie Zhao,Jianing Yu
Jiaming Cao
Spikes in the dorsolateral striatum (DLS) of the basal ganglia (BG) correlate with forelimb and whole-body movements, but the extent to which they contribute to movement remains unclear. Using behavior-timed optogenetic inhibition in rats p...
Distributed burst firing mediates optimized cortical encoding of natural self-motion [0.03%]
分散的爆发式放电介导了对自然自我运动的优化皮层编码
Jerome Carriot,Isabelle Mackrous,Kathleen E Cullen et al.
Jerome Carriot et al.
Accurate perception of self-motion requires that vestibular input be transformed into neural representations suitable for integrating multisensory cues to guide action. Here, we demonstrate that vestibular cortical neurons represent the sel...
Ly6d expression delineates two putative postnatal thymus epithelial progenitor cells that are differentially affected by aging [0.03%]
LY6D表达界定了两种假定的产后胸腺上皮干细胞，其衰老程度不同
Irene Calvo-Asensio,Andreas Tarcevski,Fatima Dhalla et al.
Irene Calvo-Asensio et al.
To date, the identity and maintenance of postnatal thymic epithelial progenitor cells (TEPCs) remain unclear, as does the persistence of bipotent TEPCs after birth or whether lineage-restricted progenitors independently maintain separate TE...
Tunable dislocations overcome mechano-functional tradeoff in perovskite oxides [0.03%]
可调式位错克服了钙钛矿氧化物中的力学-功能权衡现象
Jiawen Zhang,Wenjun Lu,Xufei Fang
Jiawen Zhang
Recent advancements in dislocation engineering are reshaping the traditional view towards ceramics being brittle. Here, we use KTaO3 (KTO), a perovskite oxide that is newly discovered with room-temperature bulk plasticity, and demonstrate t...
Deep learning reveals a neurocomputational mechanism predicting depression risk in adolescents [0.03%]
深度学习揭示了预测青少年抑郁风险的神经计算机制
Han Lu,Xiaoqian Yan,Benjamin Becker et al.
Han Lu et al.
Early detection and prevention of psychiatric disorders, particularly depression, remain as major global health challenges, yet reliable tools for identifying individuals before symptom onset are lacking. Here, we combine functional neuroim...
Structural insights into a substrate translocation pathway revealed by the RND efflux pump complex MexJK from Pseudomonas aeruginosa [0.03%]
铜绿假单胞菌RND型外排泵复合物MexJK的结构揭示了其底物转运机制
Zhikun Wu,Ziyue Meng,Wei Huang et al.
Zhikun Wu et al.
Resistance-nodulation-cell division (RND) efflux pumps are the major cause of multidrug resistance in Pseudomonas aeruginosa. The inner membrane protein MexK from P. aeruginosa is a narrow-spectrum RND transporter. It assembles with membran...
MBNL1 hijacks a structured single-stranded distal DNA element to sustain FLT3 expression in KMT2A-rearranged leukemias [0.03%]
MBNL1劫持结构化单链远端DNA元件以维持KMT2A重排白血病中FLT3的表达
Meixia Che,Shaela Fields,Siqi Yi et al.
Meixia Che et al.
The molecular mechanisms by which KMT2A-rearranged (KMT2A-r) leukemias maintain the oncogenic FLT3 expression remain largely unclear, limiting therapeutic opportunities. Here, we identify the RNA binding protein MBNL1 as an unexpected posit...
High-resolution mapping of embryonic genome activation unveils a decoupling of transcription activation from precocious H3K4me3 removal [0.03%]
高分辨率胚胎基因组激活图谱揭示转录激活与H3K4me3提前去除脱钩现象
Jasmina Al-Mousawi,Luca Michetti,Laura Castaldi et al.
Jasmina Al-Mousawi et al.
The lack of temporal resolution in transcriptomic data during mammalian embryonic genome activation (EGA) has precluded the comprehensive understanding of the functional relationships between the various gene regulatory mechanisms governing...
Language-like statistical structure arises in learned signaling: evidence from birdsong [0.03%]
类似语言的统计结构产生于学习信号：鸣鸟的例子
Simon Kirby,Kazuo Okanoya,Ellen C Garland et al.
Simon Kirby et al.
All languages have statistically coherent subsequences (e.g., words) whose frequency distribution follows a power law. These properties facilitate language learning in humans, making them good candidates for arising through cultural transmi...