Simple mass transfer regulation achieves scaling-free zero liquid discharge of seawater desalination brine without chemical additive [0.03%]
Yang Liu,Yekai Lian,Jinjuan Chen et al.
Yang Liu et al.
Thermal-driven interfacial evaporation crystallization offers a promising path to zero liquid discharge (ZLD) for high-salinity brine. However, cocrystallization of specific minor salt species with major salts forms scaling that causes oper...
Amin Khairoun,Philippe Ciais,Thu Hang Nguyen et al.
Amin Khairoun et al.
Arctic and boreal fires are critical threats to terrestrial carbon reservoirs, particularly peat fires that trigger long-term irrecoverable carbon losses and permafrost thaw. However, the occurrence of peat fires and their associated carbon...
Jagged1 regulates extracellular matrix deposition and remodeling in triple-negative breast cancer [0.03%]
Marjaana Parikainen,Ujjwal Suwal,Pekka Rappu et al.
Marjaana Parikainen et al.
The extracellular matrix (ECM) and tumor microenvironment heterogeneity drive cancer progression and treatment resistance. High Jagged1 expression correlates with poor patient survival and promotes tumor growth and invasion in triple-negati...
Self-inactivating AAV-CRISPR at different ages enables sustained amelioration of Huntington's disease deficits in BAC226Q mice [0.03%]
Yuanyi Dai,Zuliayeti Abudujielili,Yunyi Ding et al.
Yuanyi Dai et al.
Huntington's disease (HD) is a monogenic autosomal dominant neurodegenerative disorder caused by a CAG repeat expansion in exon 1 of the HTT gene, yielding a gain-of-toxic-function mutant Huntingtin protein (mHTT). CRISPR-Cas9 is a potentia...
China's petrochemical plants' CO2 emissions and high-impact contributors for carbon-neutrality production [0.03%]
Xiujing Chen,Tianyang Lei,Weichen Zhao et al.
Xiujing Chen et al.
The petrochemical sector accounted for 15% of global industrial direct CO2 emissions in 2021, with China contributing 43% of global chemical output and therefore being central to climate-change mitigation efforts. However, the lack of China...
KLF5 controls subtype-independent highly interactive enhancers in pancreatic cancer to regulate cell survival [0.03%]
Thomas L Ekstrom,Zhangshuai Dai,Julia Thiel et al.
Thomas L Ekstrom et al.
Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal cancer with a 5-year survival rate of 13%. Despite recent molecular stratification of tumors into distinct classical and basal-like cell states, most tumors are heterogeneous a...
Gary M Feinman,David Stasavage,David M Carballo et al.
Gary M Feinman et al.
This study presents a global, deep-time comparative analysis of governance, questioning entrenched viewpoints about the origins and evolution of democratic institutions. Drawing on archaeological and textual data from 40 case observations a...
Synergistic electronic-topological strategy enables spatiotemporal control of covalent adaptable networks [0.03%]
Hongfei Huang,Lijie Sun,Yalin Zhang et al.
Hongfei Huang et al.
Covalent adaptable networks (CANs) hold considerable promise for combining the advantages of thermosets and thermoplastics. However, their use in high-speed melt spinning is restricted by insufficient dynamic bond reactivity at processing t...
Evidence for chronological diversification of spinal neuron subtypes by a shared sequence of transcription factors [0.03%]
Laia Caudet Segarra,Kevin Sangster,Julia Sagner et al.
Laia Caudet Segarra et al.
Uncovering the mechanisms that generate the immense diversity of neuronal cell types remains a fundamental goal of developmental biology. Different "cardinal classes" of spinal neurons that share a common molecular identity are produced fro...
Applying machine learning to identify unrecognized COVID-19 deaths recorded as other causes of death in the United States [0.03%]
Mathew V Kiang,Zehang Richard Li,Elizabeth Wrigley-Field et al.
Mathew V Kiang et al.
The actual number of US deaths caused by severe acute respiratory syndrome coronavirus 2 infection has been investigated and debated since the start of the COVID-19 pandemic. Here, we use machine learning trained on US death certificates fr...