Metabotissugenic citrate biomaterials orchestrate bone regeneration via citrate-mediated signaling pathways [0.03%]
柠檬酸介导的信号通路引导骨再生的柠檬酸盐生物材料
Hui Xu,Xinyu Tan,Ethan Gerhard et al.
Hui Xu et al.
Bone regeneration requires coordinated anabolic and catabolic signaling, yet the interplay between mammalian target of rapamycin complex 1 (mTORC1) and adenosine monophosphate-activated protein kinase (AMPK) pathways remains unclear. This s...
Jee Hyun Yi,Young Ju Yoon,Huijeong Jeong et al.
Jee Hyun Yi et al.
To gain insights into neural mechanisms enabling behavioral adaptations to complex and multidimensional environmental dynamics, we examined roles of vasoactive intestinal polypeptide (VIP)-expressing neurons in mouse medial prefrontal corte...
Understanding the success and failure of online political debate: Experimental evidence using large language models [0.03%]
理解在线政治辩论的成功与失败：使用大型语言模型的实验证据
Tobias Heide-Jørgensen,Gregory Eady,Anne Rasmussen
Tobias Heide-Jørgensen
Online political debate is frequently lamented for being toxic, partisan, and counterproductive. However, we know little about how core elements of political debate (justification, tone, willingness to compromise, and partisanship) affect i...
Targeting tumor-associated CCR2+ macrophages to inhibit pancreatic cancer recurrence following irreversible electroporation [0.03%]
针对与肿瘤相关的CCR2+巨噬细胞抑制不可逆电穿孔后胰腺癌的复发
Weichen Xu,Shaoyue Li,Xuexia Shan et al.
Weichen Xu et al.
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with pronounced resistance to conventional therapies. Irreversible electroporation (IRE) is a promising therapy for PDAC; however, its clinical efficacy is limited by a h...
A phylogenetic approach uncovers cryptic endogenous retrovirus subfamilies in the primate lineage [0.03%]
系统发育分析揭示了灵长类动物中的隐蔽内源性逆转录病毒亚科
Xun Chen,Zicong Zhang,Yizhi Yan et al.
Xun Chen et al.
Current approaches for classifying and annotating endogenous retroviruses (ERVs) and their long terminal repeats (LTRs) have limited resolution and are inaccurate. Here, we developed an annotation approach based on phylogenetic analysis and...
A shallow mantle source for the Chang'e 5 lavas reveals how top-down heating prolonged lunar magmatism [0.03%]
嫦娥五号玄武岩源自浅部地幔，表明“由上至下”加热延长了月球火山活动期限
Stephen M Elardo,Kim A Cone,Matthew A Siegler et al.
Stephen M Elardo et al.
The 2-billion-year-old basalts collected by the Chang'e 5 mission are younger than any other sampled lunar igneous rock. These lavas provide critical insight into the evolution of the Moon at a time when magmatism was waning and represent a...
Cornel Dillinger,Ahilan Rasaiah,Abigail Vogel et al.
Cornel Dillinger et al.
Visualization and tracking of microrobots in real time pose key challenges for surgical microrobotic systems, as existing imaging modalities like magnetic resonance imaging, computed tomography, and x-ray are unable to monitor microscale it...
Paul Kerner,Rakesh Arul,Damien Thompson et al.
Paul Kerner et al.
Observing and controlling dynamics of single atoms in ambient conditions is challenging when using conventional atomic-scale techniques due to their invasive character. Here, such control is achieved optically, by confining pulses of visibl...
Delivery of a fibrin-binding hemostatic polymer ameliorates neurovascular damage and neural tissue loss after traumatic brain injury [0.03%]
一种纤维蛋白结合的止血聚合物用于改善创伤性脑损伤后的神经血管损害和神经组织丢失
Qinghua Han,David Brenes,Kevin W Bishop et al.
Qinghua Han et al.
Traumatic brain injury (TBI) often induces blood leakage into brain tissues, which causes further tissue loss after the initial injury. To mitigate this secondary injury, we hypothesized that delivery of a fibrin-binding hemostatic polymer,...