Ligand-tuned extracellular domain dynamics are correlated with signaling states in an adhesion GPCR [0.03%]
配体可调的粘附G蛋白偶联受体细胞外结构域动态与信号转导状态相关性研究
Kristina Cechova,Sumit J Bandekar,Szymon P Kordon et al.
Kristina Cechova et al.
Adhesion G protein-coupled receptors (aGPCRs) transduce signals via engagement of their large extracellular regions (ECRs) with adhesion partners. ADGRG6 (GPR126) is an aGPCR vital for the development of multiple organs and myelination. ECR...
Long-term amyloid aggregation kinetic assay and rapid amyloid clustering enabled by programmable microdroplet water extraction [0.03%]
由可编程微滴水提取实现的长期淀粉样蛋白聚集动力学测定及快速淀粉样蛋白簇生成
Da Yeon Cheong,Seokbeom Roh,Jung Bae Seong et al.
Da Yeon Cheong et al.
Amyloids are misfolded protein aggregates linked to neurodegenerative diseases. Their aggregation kinetics are influenced by numerous variables and exhibit autocatalytic and stochastic behavior, prompting the use of microdroplet-based assay...
TAL1 is indispensable in ETV2-primed human endothelial cell fate determination [0.03%]
TAL1在ETV2诱导的人类内皮细胞命运决定中不可或缺
Yun Zhao,Mengze Sun,Zixuan Hong et al.
Yun Zhao et al.
ETS variant transcription factor 2 (ETV2) serves as a foundational transcription factor for endothelial lineage specification. However, the lineage-specific cofactors that orchestrate with ETV2 during endothelial fate commitment remain elus...
Sipin Zhang,Zhenhua Qi,Huoqing Luo et al.
Sipin Zhang et al.
Psychological stress can evoke itch without a peripheral stimulus, yet the underlying mechanism remains undefined. Here, we demonstrate that a peptidergic circuit within the medial prefrontal cortex (mPFC) mediates this phenomenon. In mice ...
Retention of noble gases in the deep Earth: Kinetic trapping or stable bonding? [0.03%]
深地球中稀有气体的保留：动力学捕获还是稳定结合？
Sarah Figowy,Razvan Caracas,Guillaume Avice
Sarah Figowy
The bonding potential of noble gases in high-pressure silica-bearing solids and melts remains debated, yet it is a central question for understanding their retention behavior and evaluating the role of silicate-bearing phases in the transpo...
Retention of noble gases in the deep Earth: Kinetic trapping or stable bonding? [0.03%]
深地球中稀有气体的保留：动力学捕获还是稳定结合？
Sarah Figowy,Razvan Caracas,Guillaume Avice
Sarah Figowy
The bonding potential of noble gases in high-pressure silica-bearing solids and melts remains debated, yet it is a central question for understanding their retention behavior and evaluating the role of silicate-bearing phases in the transpo...
A programmed reset mechanism primes Clostridioides difficile virulence at the onset of infection [0.03%]
预编程的复位机制在艰难梭菌感染初期启动毒力反应
Nicole C Gadda,Jilarie A Santos-Santiago,Rani S Sellers et al.
Nicole C Gadda et al.
Clostridioides difficile is a major cause of antibiotic-associated diarrhea. This pathogen produces toxins essential for disease and flagella that promote intestinal colonization. Flagella and toxins are coregulated in an ON/OFF manner lead...
Direct bacterial transcript visualization illuminates spatiotemporal environmental adaptation of Mycobacterium tuberculosis in the lung [0.03%]
直接细菌转录可视化揭示了结核分枝杆菌在肺部时空环境适应性变迁
Anna-Lisa E Lawrence,Shumin Tan
Anna-Lisa E Lawrence
Spatiotemporal environmental variation results in marked heterogeneity in bacterial infection progression and disease outcome, with vital consequences for treatment success. For the globally important pathogen Mycobacterium tuberculosis (Mt...
Dominik Fahrner,William T Colgan,Joseph A MacGregor et al.
Dominik Fahrner et al.
Petermann Glacier (PG), the largest marine-terminating glacier in northern Greenland based on catchment area and ice discharge, plays a key role in modulating ice export from the Greenland Ice Sheet (GrIS). With an upstream catchment connec...
Single-exposure holographic 3D printing via inverse-designed phase masks [0.03%]
基于相位掩模设计的单次曝光全息三维打印技术
Dajun Lin,Xiaofeng Chen,Connor J O&#x;Dea et al.
Dajun Lin et al.
Additive manufacturing using light is commonly constrained by serial voxel-by-voxel or layer-by-layer processing, which fundamentally limits fabrication speed and scalability. Here, we introduce a single-exposure holographic three-dimension...