Bicarbonate-integrated transarterial chemoembolization (TACE) in real-world hepatocellular carcinoma [0.03%]
碳酸氢钠整合的经动脉化疗栓塞(TACE)治疗肝细胞癌的真实世界研究
Kai Jin,Siying Zeng,Bin Li et al.
Kai Jin et al.
The objective response rate of conventional transarterial chemoembolization (TACE) for locoregional control of hepatocellular carcinoma (HCC) is approximately 50%. We previously developed bicarbonate-integrated TACE, termed TILA-TACE, which...
Focal adhesion kinase/Src family kinase axis-mediated tyrosine phosphorylation of metabolic enzymes facilitates tumor metastasis [0.03%]
黏附斑激酶/Src家族激酶轴介导的代谢酶酪氨酸磷酸化促进肿瘤转移
Jie Chen,Jing Zhang,Yuheng Zhu et al.
Jie Chen et al.
Lymph node metastasis is crucial for esophageal squamous cell carcinoma (ESCC) malignancy. However, the molecular drivers and related mechanisms of lymph node metastasis in ESCC cells are unclear. In the present study, we found that the tyr...
Arterial stiffness and vascular aging: mechanisms, prevention, and therapy [0.03%]
动脉僵硬度与血管衰老：机制、预防和治疗
Maximilian Jonathan Herzog,Patrick Müller,Katharina Lechner et al.
Maximilian Jonathan Herzog et al.
Cardiovascular diseases are the leading cause of morbidity and mortality worldwide. The central underlying mechanisms of cardiovascular diseases are vascular aging and associated arterial stiffness. Arterial stiffness is characterized by st...
Neutrophil-specific targeting of STAT3 impairs tumor progression via the expansion of cytotoxic CD8+ T cells [0.03%]
STAT3特异性中性粒细胞靶向通过增加细胞毒性CD8+T细胞的增殖来抑制肿瘤进展
Irem Ozel,Guanyu Sha,Agnieszka Będzińska et al.
Irem Ozel et al.
Neutrophils have emerged as key players in tumor progression and are often associated with poor prognosis. Despite ongoing efforts to target neutrophil functions in cancer, therapeutic success has been limited. In this study, we addressed t...
Neuronal immunoproteasome and PFKFB3-forced glycolysis: key players in multiple sclerosis [0.03%]
神经免疫蛋白酶体和PFKFB3强制性糖酵解：多发性硬化的关键因素
Claudia Rodríguez-López,Juan P Bolaños,José J Lucas
Claudia Rodríguez-López
Single amino acid substitution in Hendra virus attachment glycoprotein induces cross-neutralizing antibodies against Nipah virus [0.03%]
亨德拉病毒糖蛋白单氨基酸替代诱导尼帕病毒交叉中和抗体产生
Yaohui Li,Xiaoyan Huang,Ruihua Li et al.
Yaohui Li et al.
Nipah virus (NiV) and Hendra virus (HeV) are highly pathogenic henipaviruses within the Paramyxoviridae family, causing severe respiratory and neurological diseases in humans and animals with fatality rates up to 75%, and no licensed human ...
The deacetylases HDAC1/HDAC2 control JAK2V617F-STAT signaling through the ubiquitin ligase SIAH2 [0.03%]
去乙酰化酶HDAC1/HDAC2通过泛素连接酶SIAH2调控JAK2V617F-STAT信号转导
Al-Hassan M Mustafa,Giuseppe Petrosino,Marten A Fischer et al.
Al-Hassan M Mustafa et al.
Epigenetic modulators of the histone deacetylase (HDAC) family control key biological processes and are frequently dysregulated in cancer. There is superior activity of HDAC inhibitors (HDACi) in patients with myeloproliferative neoplasms (...
Transforming acidic coiled-coil-containing protein 3-mediated lipid metabolism reprogramming impairs CD8+ T-cell cytotoxicity in hepatocellular carcinoma [0.03%]
酸性卷曲螺旋结构域含跨膜区蛋白3介导的脂质代谢重组抑制肝细胞癌CD8⁺T细胞的胞毒性作用
Ying Li,Zule Chen,Dongdong Wang et al.
Ying Li et al.
Recent evidence has highlighted immune checkpoint inhibitors as among the most promising immunotherapies for various malignancies. However, a significant proportion of HCC patients exhibit poor responses. Lipid metabolic heterogeneity is co...
Disarming a molecular brake: cAMP-responsive element modulator deletion supercharges CAR-NK cells [0.03%]
解除分子制动:cAMP反应元件调节物的缺失可增强CAR-NK细胞功能
Sudheendra Hebbar Subramanyam,Klaus Tenbrock
Sudheendra Hebbar Subramanyam
Adjuvant icotinib for resected EGFR-mutated stage II-IIIA non-small-cell lung cancer (ICTAN, GASTO1002): a randomized comparison study [0.03%]
术后EGFR突变II至IIIA期非小细胞肺癌患者辅助艾坦治疗研究（ICTAN，GASTO1002）：一项随机对照研究
Ning Li,Wei Ou,Chao Cheng et al.
Ning Li et al.
The efficacy, safety and ideal treatment duration of an adjuvant epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) for patients with resected EGFR-mutated non-small-cell lung cancer (NSCLC) were not known until 2014, whe...