Anlotinib plus sintilimab as first-line treatment for patients with advanced colorectal cancer (APICAL-CRC): an open-label, single-arm, phase II trial [0.03%]
阿帕替尼联合信迪利单抗一线治疗晚期结直肠癌患者的疗效和安全性：一项开放性、单臂、II期临床试验(APICAL-CRC)
Zhan Wang,Bao-Dong Qin,Chen-Yang Ye et al.
Zhan Wang et al.
This is an investigator-initiated, open-label, single-arm, phase II trial that aimed to assess the combination of sintilimab plus anlotinib among patients with treatment-naïve metastatic colorectal cancer (mCRC) (APICAL-CRC ClinicalTrials....
CABIN1 peptide effectively targets MEF2D-fusion protein in B-cell precursor acute lymphoblastic leukemia [0.03%]
肽CABIN1可有效靶向前体B细胞急性淋巴细胞白血病中的MEF2D融合蛋白
Subin Cha,Sangho Lee,Han-Teo Lee et al.
Subin Cha et al.
Coinhibition of the MEK/RTK pathway has high therapeutic efficacy in KRAS-mutant non-small cell lung cancer [0.03%]
MEK/RTK通路联合抑制可高效治疗KRAS突变非小细胞肺癌
Jun Lu,Minjuan Hu,Yikai Zhao et al.
Jun Lu et al.
Oncogenic KRAS mutations are frequently detected in NSCLC. It remains a major challenge to target all KRAS mutants. MEK inhibitors are considered candidates for treating KRAS-mutant NSCLC; however, their easy adaptive resistance precludes f...
Inhibition of salt-inducible kinases resolves autoimmune arthritis by promoting macrophage efferocytosis [0.03%]
盐诱导激酶抑制通过促进巨噬细胞胞葬作用缓解自身免疫性关节炎
Mingyu Lee,Min Kyung Kim,Shenzheng Mo et al.
Mingyu Lee et al.
Mengjie Li,Mengmeng Zhou,Jin Jiang
Mengjie Li
Astrocytic monoamine oxidase B (MAOB)-gamma-aminobutyric acid (GABA) axis as a molecular brake on repair following spinal cord injury [0.03%]
脊髓损伤后的修复过程中的单胺氧化酶B-γ氨基丁酸分子刹车作用机制研究：胶质细胞轴线研究
Hye Yeong Lee,Jung Moo Lee,Hye-Lan Lee et al.
Hye Yeong Lee et al.
Neuroregeneration and remyelination rarely occur in the adult mammalian brain and spinal cord following central nervous system (CNS) injury. The glial scar has been proposed as a major contributor to this failure in the regenerative process...
Loss-of-function variations in solute carrier family 38 member 6 are associated with essential tremor [0.03%]
溶质载体家族38成员6功能缺失变异与原发性震颤相关联
Zhangqi Yuan,Qiying Sun,Junyu Luo et al.
Zhangqi Yuan et al.
Essential tremor (ET) is a common neurological disease that is characterized by 4-12 Hz kinetic tremors of the upper limbs and high genetic heterogeneity. Although numerous candidate genes and loci have been reported, the etiology of ET rem...
Characterization of the extrinsic and intrinsic signatures and therapeutic vulnerability of small cell lung cancers [0.03%]
小细胞肺癌的外在和内在特征及其治疗弱点的鉴定
Gui-Zhen Wang,Zheng Wang,Shi-Hao Bai et al.
Gui-Zhen Wang et al.
Small-cell lung cancer (SCLC), an aggressive neuroendocrine tumor strongly associated with exposure to tobacco carcinogens, is characterized by early dissemination and dismal prognosis with a five-year overall survival of less than 7%. High...
Epidemiological and phylogenetic characteristics of human metapneumovirus in Beijing, China, 2014-2024 [0.03%]
2014-2024年北京市人副流感病毒第三型的流行病学和基因特征研究
Aihua Li,Cheng Gong,Liang Wang et al.
Aihua Li et al.
In November 2024, there was an unusual surge in human metapneumovirus (hMPV) infection cases in Beijing. We performed an epidemiological investigation among cases with acute respiratory tract infection (ARTI). We enrolled ARTI cases from 35...