Glycobiology-driven therapeutic targeting of glycan-binding proteins: mechanisms, diseases, and clinical translation [0.03%]
糖生物学驱动的糖基结合蛋白治疗靶向：机制、疾病和临床转化
Alyanna M Popatia,Ahmad Sharanek,Arezu Jahani-Asl
Alyanna M Popatia
Galectins are glycan-binding proteins that interact with diverse glycoconjugates and protein networks to regulate intracellular and extracellular signaling pathways governing fundamental biological processes. Increasing evidence implicates ...
Histone deacetylase enzyme activity is not the universal anticancer target of HDAC inhibitors [0.03%]
组蛋白去乙酰酶抑制剂的抗癌作用机制并非都是通过抑制组蛋白去乙酰酶的酶活性来实现的
Chaitra Rai,Hang Ruan,Xue Li et al.
Chaitra Rai et al.
Histone deacetylase inhibitors (HDIs) are approved for treating hematologic cancers and are currently being evaluated in hundreds of clinical trials for various cancers and other diseases, although their mechanisms of action remain poorly u...
The Gdf15-xenobiotic receptor axis shapes NK cell maladaptation predicting cold tumors under environmental stress [0.03%]
GDF15-异体受体轴影响自然杀伤细胞的非适应性状态预测环境压力下的冷肿瘤
Juil Kim,Ki-Hyung Kim,Zhimin Du et al.
Juil Kim et al.
Cold tumors, including epithelial ovarian cancer (EOC), mostly arise from sporadic factors, particularly hormonal and environmental influences, and are characterized by limited immune cell infiltration. Growth differentiation factor 15 (Gdf...
Epigenetic control of telomeric RNA maintains heterochromatin in telomerase-driven cancers [0.03%]
表观遗传调控的端粒RNA维持端粒酶驱动癌症中的异染色质
Jared D W Price,Frederick S Vizeacoumar,Omar Abuhussein et al.
Jared D W Price et al.
Tumor heterogeneity presents a major clinical challenge. Reactivation of telomerase (hTERT) is a near-universal hallmark of cancer, yet direct inhibition of hTERT has shown limited therapeutic benefit. To uncover tractable telomerase-relate...
Spatiotemporally programmed nanomedicine engineering to resolve conflicting immunosignals in triple-negative breast cancer [0.03%]
时空程序化纳米药物工程解决三阴性乳腺癌免疫信号冲突问题
Xiuping Guo,Wensheng Zheng,Kaichao Song et al.
Xiuping Guo et al.
In triple-negative breast cancer (TNBC), chemotherapy-induced immunogenic cell death (ICD) often fails to trigger truly effective antitumor immunity. This failure primarily stems from the simultaneous release of damage-associated molecular ...
Transcriptional and epigenetic regulation of autophagy: mechanisms, disease relevance and therapeutic opportunities [0.03%]
自噬的转录和表观遗传调控：机制、病理意义与治疗机会
Jieun Seo,Seo-Young Park,Dong Chul Lee et al.
Jieun Seo et al.
Autophagy is a tightly regulated catabolic process that is essential for cellular homeostasis, stress adaptation, and metabolic balance. Its dysregulation has been implicated in a wide range of diseases, including cancer, neurodegenerative ...
Innovative peptide-loaded hybrid membrane nanovaccine enables precise personalized immunotherapy for HPV-related cervical diseases [0.03%]
创新的肽载杂化膜纳米疫苗能够实现人乳头瘤病毒相关宫颈疾病的精准个性化免疫治疗
Renjie Wang,Jie Wang,Jinghan Ruan et al.
Renjie Wang et al.
Human papillomavirus (HPV)-associated cervical diseases pose significant health risks to women worldwide. Current clinical interventions face challenges in achieving complete viral clearance and controlling disease progression, with limited...
Anti-asthma drug montelukast induces autistic behaviors via disrupting neuronal retinoic acid signaling [0.03%]
抗哮喘药物蒙特鲁卡斯通过干扰神经元视黄酸信号诱导自闭症行为
Zi-Jian Hao,Qiong-Hui Wu,Ya-Li Li et al.
Zi-Jian Hao et al.
Autism spectrum disorders (ASD) affect approximately 1.0% of children worldwide with still increasing global prevalence. The fact that genetic factors contribute to less than 50% of ASD suggests some critical yet enigmatic roles of non-gene...
Macrophage accumulation on the injured pulmonary surface promotes intrathoracic adhesions [0.03%]
肺损伤表面的巨噬细胞积聚促进胸内粘连形成
Yu Mori,Tomohisa Sakaue,Mikio Okazaki et al.
Yu Mori et al.
Multi-omics and artificial intelligence for precision drug discovery and potential clinical applications [0.03%]
多组学与人工智能赋能的精准药物发现及临床应用潜力
Yuqing Liu,Kun Zhu,Weijun Peng et al.
Yuqing Liu et al.
The integration of multiomics technologies with artificial intelligence (AI) has become a transformative force in modern precision medicine, particularly within drug discovery. Multiomics approaches, including genome-wide association studie...