Imane Boutitah-Benyaich,Herena Eixarch,Javier Villacieros-Álvarez et al.
Imane Boutitah-Benyaich et al.
Multiple sclerosis is a chronic immune-mediated disorder of the central nervous system characterized by demyelination, axonal loss, and neuroinflammation, culminating in progressive neurological disability. Despite significant advances in u...
Sodium nitrate protects against metabolic syndrome by sialin-mediated macrophage rebalance [0.03%]
NaNO3通过介导巨噬细胞再平衡的岩藻糖苷酶保护机体免受代谢综合征侵害
Shaorong Li,Yaning Wang,Zihan Zhang et al.
Shaorong Li et al.
Metabolic syndrome, characterized by metabolic dysfunction-associated steatotic liver disease (MASLD) and type 2 diabetes mellitus (T2DM), poses a significant threat to patients' health worldwide; however, efficient treatment is currently u...
Molecular signatures of skeletal muscle insulin resistance: bringing personalised diabetes treatment a step closer [0.03%]
骨骼肌胰岛素抵抗的分子特征：使个性化糖尿病治疗更近一步
Giovanni Levate,Roland H Stimson
Giovanni Levate
Inhibition of long interspersed nuclear element-1 by nucleoside reverse transcriptase inhibitors attenuates vascular calcification [0.03%]
核苷逆转录酶抑制剂通过抑制长散在核元素-1而减轻血管钙化
Jianshuai Ma,Dayu He,Mingxuan Zhang et al.
Jianshuai Ma et al.
Vascular calcification (VC) is a critical vascular pathological event, contributing to the rise in both the prevalence and fatality of cardiovascular diseases. However, the lack of effective therapeutic strategies for VC is attributed prima...
Development of a leucine-rich repeat-containing protein 15-targeted radio-immunotheranostic approach to deplete pro-tumorigenic mechanisms and immunotherapy resistance [0.03%]
开发富含亮氨酸的重复序列蛋白15靶向放射免疫诊疗法以耗尽促肿瘤机制和免疫疗法耐药性
Claire M Storey,Mohamed Altai,Katharina Lückerath et al.
Claire M Storey et al.
Leucine-rich repeat containing 15 (LRRC15) has emerged as an attractive biomarker and target for cancer therapy. Transforming growth factor-β (TGFβ) induces the expression of this plasma membrane protein specifically in aggressive and tre...
A longevity-associated variant of the human BPIFB4 gene prevents diastolic dysfunction in progeria mice [0.03%]
人BPIFB4基因的一个与长寿相关的变异体能够预防早老症小鼠的舒张功能障碍
Yan Qiu,Monica Cattaneo,Anna Maciag et al.
Yan Qiu et al.
Tumor microenvironment delineates differential responders to trastuzumab emtansine in HER2-positive metastatic breast cancer patients previously treated with pyrotinib: an exploratory biomarker analysis of a phase II study (NJMU-BC02) [0.03%]
吡咯替尼治疗后HER2阳性转移性乳腺癌患者T-DM1疗效差异的肿瘤微环境探索性生物标志物分析（南京医科大学BC02二期临床试验）
Hong Pan,Ji Wang,Yue Sun et al.
Hong Pan et al.
Trastuzumab emtansine (T-DM1) has been approved for the treatment of HER2-positive breast cancer. However, the efficacy of T-DM1 for patients after failure of pyrotinib and/or trastuzumab plus pertuzumab has not been clear. Additionally, no...
Consolidative nivolumab versus observation in unresectable stage III non-small cell lung cancer patients following neoadjuvant nivolumab plus chemotherapy and concurrent chemoradiotherapy (CA209-7AL): a randomized clinical trial [0.03%]
NEOSTAR：接受新辅助纳武利尤单抗联合化疗和同期放化疗后的不可切除III期非小细胞肺癌患者的维持治疗——纳武利尤单抗对比观察的一项随机临床试验
Bo Qiu,Yuanyuan Zhao,Wenzhuo He et al.
Bo Qiu et al.
CA209-7AL is a randomized, multicenter, phase 2 trial evaluating the efficacy and safety of consolidative nivolumab (NIVO) versus observation following neoadjuvant NIVO plus chemotherapy and concurrent chemoradiotherapy (CCRT) for unresecta...
Liquid biomarkers associate with TGF-β Type I receptor and hypoxia in kidney cancer [0.03%]
液体生物标志物与肾癌的TGF-βI型受体和缺氧相关
Pramod Mallikarjuna,Cemal Erdem,Ruben Ilundain Beorlegui et al.
Pramod Mallikarjuna et al.
A two-strata energy flux system driven by a stress hormone prioritizes cardiac energetics [0.03%]
一种应激激素驱动的两层能量通量系统优先考虑心脏能量供给
Zhiheng Rao,Zhichao Chen,Yuxuan Bao et al.
Zhiheng Rao et al.
The heart, an organ with a continuously high demand for energy, inherently lacks substantial reserves. The precise mechanisms that prioritize energy allocation to cardiac mitochondria, ensuring steady-state ATP production amidst high-energy...