GSK-3 regulates CD4-CD8 cooperation for super-armed CD8+ cytolytic T cells in immunotherapy against tumors [0.03%]
GSK-3调节CD4-CD8合作以产生超级武装的CD8+细胞毒性T淋巴细胞对抗肿瘤免疫疗法
Bastien Moës,Janna Krueger,Chen Liu et al.
Bastien Moës et al.
Although the efficacy of immune checkpoint blockade (ICB) depends on coordinated activity across progenitor and terminal effector CD4⁺ and CD8⁺ T-cell compartments, the cell-intrinsic pathways that enable this cooperation remain incomplet...
Myeloid Mas drives pyruvate kinase M2-mediated Spi1 lactylation to fuel inflammatory senescence in MASLD [0.03%]
髓系Mas通过驱动Spi1的丙酮酸激酶M2介导的白喉拉克酰化来为MASLD中的炎症衰老供能
Luying Zhao,Shujing Xu,Shikai Qiao et al.
Luying Zhao et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is driven by unresolved inflammation, yet precise mechanisms linking immune metabolism to disease progression remain elusive. Here, we identified myeloid-expressed Mas, a G pr...
VCPIP1 drives diabetic cardiomyopathy by deubiquitinating AMPKγ1 and preventing AMPKα-γ subunit assembly in cardiomyocytes [0.03%]
去泛素化AMPKγ1并阻止心脏肌细胞中AMPKα-γ亚基组装的VCPIP1驱动糖尿病心肌病
Xue Han,Zhuqi Huang,Guoxuan Liu et al.
Xue Han et al.
Protein ubiquitination modifications contribute to cardiomyocyte homeostasis and pathophysiology in diabetic cardiomyopathy (DCM). Yet the roles of deubiquitinating enzymes (DUBs) in DCM remain poorly defined. This study sought to delineate...
Targeting EHMT2 overcomes 5-fluorouracil resistance in colorectal cancer by modulating cell cycle and apoptosis [0.03%]
靶向EHMT2通过调节细胞周期和凋亡克服结直肠癌对氟尿嘧啶的耐药性
In Hwan Tae,Yunsang Kang,Jinkwon Lee et al.
In Hwan Tae et al.
5-Fluorouracil (5-FU) is a first-line chemotherapy commonly used to treat colorectal cancer (CRC). However, the development of acquired resistance to 5-FU remains a significant clinical challenge, and the underlying epigenetic mechanisms ar...
Disrupting SOX2 self-association and condensate formation to overcome chemotherapeutic drug resistance in lung squamous cell carcinoma [0.03%]
干扰SOX2自关联和凝聚物形成以克服肺鳞状细胞癌对化疗药物的耐药性
Juehan Wang,Yulin Wen,Sainan Huang et al.
Juehan Wang et al.
Chemotherapy remains a primary treatment for lung squamous cell carcinoma (LSCC), and its efficacy is limited due to drug resistance; however, the mechanisms involved in drug resistance are still unclear. In this study, we identify a signif...
A nanobody-based proteolysis-targeting chimera offers broad-spectrum protection against diverse influenza virus infections [0.03%]
一种基于纳米抗体的蛋白降解嵌合体可提供广谱保护以抵御各种流感病毒感染
Yichao Zhuang,Lei Chen,Chen Qin et al.
Yichao Zhuang et al.
Influenza A viruses continue to pose a major threat to global public health. In addition to H1N1 and H3N2 subtypes causing seasonal epidemics that result in an estimated 3-5 million severe cases and 290,000-650,000 deaths annually, other su...
Clinical translational research on stem cell products: prospects and challenges [0.03%]
干细胞产品的临床转化研究：前景与挑战
Shuang Chen,Lin Zhang,Yushuang Ren et al.
Shuang Chen et al.
Stem cell therapy has shown significant efficacy as a viable treatment for several resistant diseases. Despite the increasing number of stem cell products on the market worldwide, the clinical translational application of stem cell products...
HILL: the efficacy and safety of hepatic arterial infusion chemotherapy with the FOLFOX regimen combined with lenvatinib and the PD-L1 inhibitor durvalumab in unresectable hepatocellular carcinoma: a prospective, single-arm, phase 2 clinical trial [0.03%]
肝动脉灌注FOLFOX联合仑伐替尼和Durvalumab治疗不可切除的肝细胞癌：一项前瞻性单臂二期临床试验
Shao-Hua Li,Zhi-Jun Zuo,Liang-He Lu et al.
Shao-Hua Li et al.
Despite numerous available treatment options, the overall prognosis for patients with unresectable hepatocellular carcinoma (uHCC) remains poor. This study aimed to evaluate the efficacy and safety of combining hepatic arterial infusion che...
Solid tumors exploit proton-sensing GPR65 for orchestration of an immunosuppressive tumor microenvironment [0.03%]
质子感应GPR65介导的肿瘤免疫抑制微环境的研究
Natalia Truong-Andrievici,Jean-Fred Fontaine,Sebastian Kunz et al.
Natalia Truong-Andrievici et al.
Hypoxia-driven microRNA-27b underlies pathologic cardiac endoreplication in heart disease [0.03%]
缺氧驱动的微小核糖核酸-27b在心脏病理性心肌内倍性中发挥关键作用
Peter Mirtschink,Ting Yuan,Corinne Bischof et al.
Peter Mirtschink et al.
Heart disease is characterized by stress-induced endoreplication preceding pathological cardiomyocyte overgrowth, yet the upstream regulatory mechanisms linking tissue hypoxia to aberrant cellular growth remain incompletely defined. Here, w...