Structural basis of RECQL5-induced RNA polymerase II transcription braking and subsequent reactivation [0.03%]
RECQL5诱导的RNA聚合酶II转录制动及其随后激活的结构基础
Luojia Zhang,Yuliya Gordiyenko,Tomos Morgan et al.
Luojia Zhang et al.
Abnormally fast transcription elongation can lead to detrimental consequences such as transcription-replication collisions, altered alternative splicing patterns and genome instability. Therefore, elongating RNA polymerase II (Pol II) requi...
Single-cell long-read Hi-C, scNanoHi-C2, details 3D genome reorganization in embryonic-stage germ cells [0.03%]
单细胞长读Hi-C技术scNanoHi-C2详细阐述了胚胎期生殖细胞中染色体三维基因组的重新组织
Jiansen Lu,Wen Li,Fuchou Tang
Jiansen Lu
During mouse development, embryonic-stage germ cells (EGCs) make crucial fate decisions, with female EGCs embarking on meiosis whereas male EGCs enter mitotic arrest until birth. Despite increasing understanding of the reprogramming of epig...
Yihu Xie,Yi Ren
Yihu Xie
Structural basis for the synergistic assembly of the snRNA export complex [0.03%]
snRNA输出复合物协同装配的结构基础
Etienne Dubiez,William Garland,Maja Finderup Brask et al.
Etienne Dubiez et al.
The nuclear cap-binding complex (CBC) and its partner Arsenite-Resistance Protein 2 (ARS2) regulate the fate of RNA polymerase II transcripts via mutually exclusive interactions with RNA effectors. One such effector is PHAX, which mediates ...
Sandra M G Dias
Sandra M G Dias
Yousuf A Khan,K Ian White,Richard A Pfuetzner et al.
Yousuf A Khan et al.
SNARE (soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein receptor) proteins drive membrane fusion at different cell compartments as their core domains zipper into a parallel four-helix bundle. After fusion, these bundles ar...
Bruce Stillman,John F X Diffley,Janet H Iwasa
Bruce Stillman
The initiation of DNA replication in eukaryotic cells begins with the assembly of pre-replicative complexes (pre-RCs) at many sites along each chromosome during the G1 phase of the cell cycle. Pre-RCs license each chromosome for duplication...
Structural basis and functional roles for Toll-like receptor binding to Latrophilin in C. elegans development [0.03%]
toll样受体结合_latrophilin在秀丽隐杆线虫发育中的结构基础和功能作用
Gabriel Carmona-Rosas,Jingxian Li,Jayson J Smith et al.
Gabriel Carmona-Rosas et al.
Latrophilins are conserved adhesion-type G-protein-coupled receptors associated with embryonic defects and lethality. However, their mechanistic roles and ligands in embryogenesis remain unknown. Here, we identified TOL-1, the sole Toll-lik...
Chew Theng Lim,Thomas C R Miller,Kang Wei Tan et al.
Chew Theng Lim et al.
Eukaryotic DNA replication initiates from genomic loci known as origins. At budding yeast origins like ARS1, a double hexamer (DH) of the MCM replicative helicase is assembled by origin recognition complex (ORC), Cdc6 and Cdt1 by sequential...
Yanhe Zhao,Kangkang Song,Amirrasoul Tavakoli et al.
Yanhe Zhao et al.
Cilia are microtubule-based organelles that have important roles in cell sensing, signaling and motility. Recent studies have revealed the atomic structures of many multicomponent ciliary complexes, elucidating their mechanisms of action. H...