Resolution of R-loops and transcription-replication conflicts by SETX-BRCA1-BARD1 complex
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Senataxin (SETX), an RNA-DNA helicase, accumulates at transcription pause sites through the tumor suppressor BRCA1. Here, we provide mechanistic insight into how SETX-BRCA1 resolves transcription-associated R-loops to prevent deleterious outcomes. Specifically... ...
