Structural insights into coffee bitter taste perception by TAS2R43 receptor [0.03%]
咖啡苦味感知TAS2R43受体结构的见解
Yoojoong Kim,Ryan H Gumpper,Yuxuan Zhuang et al.
Yoojoong Kim et al.
Bitter taste functions as a means of both protection against potentially toxic compounds and savoring bitter tasting foods and beverages. Among the 26 bitter taste receptors, taste receptor type 2 member 43 (TAS2R43) has been identified as ...
Evgenii Ziaikin,Nitsan Dallal,Masha Y Niv
Evgenii Ziaikin
Qiuxiang Tan,Yu Yu,Xuteng Han et al.
Qiuxiang Tan et al.
Bitter taste receptors (T2Rs) are considered attractive drug targets. However, the ligand recognition and selectivity of these receptors remain elusive, hampering their drug development. Here we present seven structures of human T2R14 and T...
Calcium dependent activation of the TMEM16F scramblase and ion channel [0.03%]
钙离子激活的TMEM16F通道蛋白的翻转酶和离子通道活性
Zhang Feng,Omar E Alvarenga,Eleonora Di Zanni et al.
Zhang Feng et al.
The ubiquitous transmembrane protein 16F (TMEM16F) Ca2+-activated channel and scramblase catalyzes phosphatidylserine externalization to enable blood coagulation, membrane fusion and brain immune surveillance. Despite its importance, the mo...
Comparative characterization of Cas12f orthologs reveals mechanistic features underlying enhanced genome editing efficiency [0.03%]
Cas12f同源物的比较表征揭示了增强基因组编辑效率的机制特征
Kaoling Guan,Rodrigo Fregoso Ocampo,Paula B Matheus Carnevali et al.
Kaoling Guan et al.
Miniature CRISPR-Cas12f nucleases are attractive candidates for therapeutic genome editing because of their compact size and compatibility with adeno-associated virus (AAV) delivery. However, editing efficiencies in mammalian cells are lowe...
Microtubules in the axon are GDP bound but adopt a stable GTP-like expanded state [0.03%]
轴突中的微管结合GDP但处于稳定的GTP样扩展状态
Elena A Zehr,Shufeng Sun,Stephanie L Sarbanes et al.
Elena A Zehr et al.
Microtubules scaffold cells, supporting signaling and cargo transport. They assemble from GTP-tubulin, which hydrolyzes to GDP-tubulin during polymerization. GTP-microtubule lattices are stable; GDP lattices depolymerize rapidly. In vitro, ...
Do-Hwan Ahn,Claudia Alleva,Tom Reichenbach et al.
Do-Hwan Ahn et al.
In mammals, glucose transporters (GLUTs) mediate organism-wide sugar distribution, yet the molecular basis of substrate specificity remains unclear. The bacterial xylose transporter XylE serves as a model for GLUTs. However, although xylose...
Kotaro Tsukada,Yuka Nakazawa,Tomoo Ogi
Kotaro Tsukada