Alf Håkon Lystad
Alf Håkon Lystad
Comparative CRISPRi screens reveal a human stem cell dependence on mRNA translation-coupled quality control [0.03%]
比较CRISPR干扰筛选揭示了人类干细胞依赖于与翻译偶联的质控体系
Geraldine Rodschinka,Sergio Forcelloni,Felix M Kühner et al.
Geraldine Rodschinka et al.
The translation of mRNA into proteins in multicellular organisms needs to be carefully tuned to changing proteome demands in development and differentiation, while defects in translation often have a disproportionate impact in distinct cell...
A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients [0.03%]
一个异三聚体蛋白复合物在质子梯度耗散时组装变形虫V-ATP酶
Christopher Nardone,Julian Mintseris,Dingwei He et al.
Christopher Nardone et al.
Organelles such as lysosomes and synaptic vesicles are acidified by V-ATPases, which consist of a cytosolically oriented V1 complex that hydrolyzes ATP and a membrane-embedded VO complex that pumps protons. In yeast, V1-VO association is fa...
Himanish Basu,Coco Holliday,Isaac M Chiu
Himanish Basu
Antonio R Cerullo
Antonio R Cerullo
Ferlin structures [0.03%]
费林结构
Suhaila Rahman
Suhaila Rahman
A nanobody-based therapeutic targeting Nipah virus limits viral escape [0.03%]
一种靶向 nipah 病毒的纳米抗体治疗性药物可限制病毒逃逸
Ariel Isaacs,Guillermo Valenzuela Nieto,Xinghai Zhang et al.
Ariel Isaacs et al.
Nipah virus (NiV) and Hendra virus (HeV) are highly pathogenic henipaviruses without approved human vaccines or therapies. Here, we report on a highly potent bispecific therapeutic that combines an anti-fusion glycoprotein nanobody with an ...
Glycerol mediates crosstalk between metabolism and trafficking through the golgin Imh1 [0.03%]
甘油通过高尔基体糖蛋白Imh1介导代谢和转运之间的交叉对话
Wan-Yun Chiu,Yi-Hsun Wang,Ming-Chieh Lin et al.
Wan-Yun Chiu et al.
The golgins are long coiled-coil proteins involved in vesicular transport to the Golgi, a process that contributes to Golgi function and integrity. Previous studies have elucidated that their self-interaction and their interaction with smal...
Publisher Correction: ATM and IRAK1 orchestrate two distinct mechanisms of NF-κB activation in response to DNA damage [0.03%]
出版更正：ATM 和 IRAK1 协调对 DNA 损伤产生 NF-κB 激活的两种不同机制
Elodie Bournique,Ambrocio Sanchez,Sunwoo Oh et al.
Elodie Bournique et al.
Published Erratum
Nature structural & molecular biology. 2025 Jul 7. DOI:10.1038/s41594-025-01638-x 2025
Structural insights into transcriptional regulation by the helicase RECQL5 [0.03%]
RECQL5解旋酶转录调控的结构洞察
Alfredo Jose Florez Ariza,Nicholas Z Lue,Patricia Grob et al.
Alfredo Jose Florez Ariza et al.
Transcription poses a major challenge for genome stability. The RECQL5 helicase helps safeguard genome integrity and is the only member of the human RecQ helicase family that directly binds to RNA polymerase II (Pol II) and affects its prog...