K2MODNP: A Lead-Free Initiator with Excellent Thermal Stability and Promising Energetic Performance [0.03%]
具有优异热稳定性和良好性能的无铅启动剂K2MODNP的研究
Prachi Bhatia,Priyanka Das,Meera Khatri et al.
Prachi Bhatia et al.
Researchers in the field of high-energy density materials are actively exploring toxic metal-free alternatives for traditional primary explosive lead azide due to its well-known environmental and health threats. In this work, dianionic N,N'...
Electrochemical 2-Deoxyglycosylation of N-Containing Molecules with β-Stereoselectivity [0.03%]
具有β立体选择性的含氮分子的电化学2-脱氧糖基化反应
Shunzhen Chang,Zeyu Cao,Kaiyin Jiang et al.
Shunzhen Chang et al.
N-Glycosides represent a structurally important class of compounds with various applications in the chemical, biological, and pharmaceutical fields. Conventional N-glycosylation methods typically require acidic conditions and face inherent ...
Glyoxylate Sulfonyl Hydrazone Enables a Scalable Approach to Reformatsky-Type Products from Aliphatic Alcohols via Photocatalytic HAT [0.03%]
通过光催化氢原子转移以醛式硫基水杨腈使脂肪族醇进行reformatsky反应的可扩展方法
Matteo Gasparetto,Stefano Bonciolini,Damiano Diprima et al.
Matteo Gasparetto et al.
Herein, a commercially available ethyl glyoxylate sulfonyl hydrazone engages in a photocatalytic hydrogen atom transfer mechanism with aliphatic alcohols, delivering β-hydroxy ester compounds without relying on transition metal chemistry. ...
Copper-Iron-Catalyzed Cross-Coupling of ortho-Substituted Sulfonamides with Sterically Hindered (Hetero)aryl Chlorides and Alkyl Halides: Synthesis of Sulfonamide Drugs [0.03%]
邻位取代磺酰胺与 sterically hindered（杂）芳基氯化物和烷基卤化物的铜铁催化交叉偶联反应：合成磺酰胺药物
Keya Roy,Anay Saha,Sampa Mondal et al.
Keya Roy et al.
We describe for the first time an effective copper-iron-catalyzed cross-coupling strategy that enables the reaction for a diverse array of ortho-substituted primary (hetero)aryl and aliphatic sulfonamides with challenging sterically hindere...
Lewis Base-Catalyzed Sequential [2 + 3]/[4 + 4] Annulations of α-Allylic Allenoates and Aldimine Esters: Construction of Functionalized Pyrrole-Fused Eight-Membered O-Heterocycles [0.03%]
路易斯碱催化α-烯丙基烯醇亚胺酯与醛亚胺酯的连续[2+3]/[4+4]环化反应合成功能化的吡咯并八元氧杂环化合物
Xuling Pan,You Huang
Xuling Pan
The efficient construction of eight-membered rings has gained significant attention due to their widespread applications in natural products and pharmaceuticals. However, the synthesis of these molecules, especially by organocatalytic strat...
Enantioselective Access to Lactam-Fused Eight-Membered Bridged Biaryls via N-Heterocyclic Carbene-Catalyzed [5 + 3]-Domino Annulation [0.03%]
通过N-杂环卡宾催化[5+3]串联环化反应构建内酰胺并八元桥环茋类化合物的对映选择性合成
Yuanyuan Cheng,Jing Li,Qijian Ni
Yuanyuan Cheng
We disclose herein an efficient asymmetric synthesis of axially chiral lactam-fused bridged biaryls through an N-heterocyclic carbene-catalyzed [5 + 3] annulation of ortho-indolizinyl N-sulfonylanilines with α-bromoenals. This transformati...
Furan Oxidation-Cyclization to Oxazepines: Favoring 7-exo-trig over 6-endo-trig and 5-exo-trig Trajectories [0.03%]
富烯氧化环化合成氧杂庚环：促进7-exo-三键环化路径而非6-endo-和5-exo-三键环化路径
Fatma Albayrak Halac,Busra Nur Aydın Kandemir,Hasan Secen et al.
Fatma Albayrak Halac et al.
The sequential oxidation-cyclization of hydroxyaminoalkylfurans to oxazepines is controlled by a regioselective 7-exo-trig cyclization rather than the usually more favorable, 6-endo-trig and 5-exo-trig cyclizations. The key trajectory deter...
Nickel-Catalyzed Reductive Alkylation and Arylation of Arylallylamines via C-N Bond Cleavage [0.03%]
镍催化通过C-N键断裂的芳烯胺的还原烷基化和芳构化反应
Pei Liu,Muhammad Bilal,Yu-Lei Wei et al.
Pei Liu et al.
Transition-metal-catalyzed C-N bond activation has emerged as a powerful yet underdeveloped strategy in synthetic chemistry, largely constrained by the high bond dissociation energy and intrinsic stability of amines. Here, we report a Ni-ca...
Oxidative α-Amination and Aziridination of Cyclic β-Ketoesters Using Aminobenziodoxolones [0.03%]
cyclic β-酮酸酯的氧化α-胺化和氮丙啶化反应构建氨基醇及氮杂环化合物
Kazuki Kawanaka,Kotaro Muraoka,Kensuke Kiyokawa et al.
Kazuki Kawanaka et al.
The oxidative amination of β-ketoesters with hypervalent iodine reagents bearing transferable amino groups (aminobenziodoxolones) is described. NH2-substituted and alkylamine-derived aminobenziodoxolones enable electrophilic α-amination, ...
Unlocking a Grignard Cascade: Three-Component Access to Complex Polycyclic Architectures from Quinolines [0.03%]
开锁的Grignard级联反应：从喹啉出发构建复杂多环骨架的三组分方法
Liqing Xu,Xuemeng Wang,Yunyun Liu et al.
Liqing Xu et al.
We report a transition-metal-free, three-component reaction for the direct C2/C3 annulation of quinolines with Grignard reagents and enones. This method unveils a new enone reactivity in [4 + 2] cyclizations, enabling efficient dearomatizat...