Enantioselective Access to Lactam-Fused Eight-Membered Bridged Biaryls via N-Heterocyclic Carbene-Catalyzed [5 + 3]-Domino Annulation
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We disclose herein an efficient asymmetric synthesis of axially chiral lactam-fused bridged biaryls through an N-heterocyclic carbene-catalyzed [5 + 3] annulation of ortho-indolizinyl N-sulfonylanilines with α-bromoenals. This transformation proceeds via a Mi... ...
