Unlocking a Grignard Cascade: Three-Component Access to Complex Polycyclic Architectures from Quinolines
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We report a transition-metal-free, three-component reaction for the direct C2/C3 annulation of quinolines with Grignard reagents and enones. This method unveils a new enone reactivity in [4 + 2] cyclizations, enabling efficient dearomatization to construct hex... ...
