Furan Oxidation-Cyclization to Oxazepines: Favoring 7-exo-trig over 6-endo-trig and 5-exo-trig Trajectories
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The sequential oxidation-cyclization of hydroxyaminoalkylfurans to oxazepines is controlled by a regioselective 7-exo-trig cyclization rather than the usually more favorable, 6-endo-trig and 5-exo-trig cyclizations. The key trajectory determinant is the genera... ...
