Deconstructive Alkylation of Unstrained Cyclic Amines via Lewis Base-Boryl Radical-Enabled Spin-Center Shift [0.03%]
Gui-Hao Zhang,Zhong-Ping Cai,Tian Ye et al.
Gui-Hao Zhang et al.
Deconstructive alkylation of unstrained cyclic amines is achieved through a boryl radical-enabled spin-center shift (SCS) strategy. Mechanistic studies, including control experiments and DFT calculations, support a pathway involving boryl r...
Deskarene: Single-Molecule Conductance and Mixed-Valence Character of Diferrocene-Based Ladder-Type Conjugated Molecules [0.03%]
Yanxia Huang,Yuanping Li,Na Huang et al.
Yanxia Huang et al.
Ferrocene-anthracene-fused ladder-type molecules (2Fc-anti and 2Fc-syn) were achieved via a C-H activation/annulation strategy. This design extends the π-conjugated system through molecular ladderization, effectively elongating the molecul...
Synthesis of γ-Carbonyl Aliphatic Sulfoxonium Salts via Site-Selective Ring Opening of In Situ Formed 2-Sulfoxonium Cyclobutanone [0.03%]
Bingyang Han,Zihui Gong,Zhaofeng Wang
Bingyang Han
We report herein a Rh-catalyzed tandem reaction between a pivaloyl-substituted sulfoxonium-iodonium ylide and diverse nucleophiles, enabling the efficient synthesis of γ-sulfoxonium carbonyl compounds, which were previously inaccessible. T...
A Mild Synthetic Protocol for Conversion of Aldehydes to Nitriles Using a Copper Catalyst and LiHMDS as the Nitrogen Source [0.03%]
一种温和的合成方法：利用铜催化剂和LiHMDS作为氮源将醛转化为腈化合物
Joakim Bøgelund Jakobsen,Xinkai Wu,Markus Staudt et al.
Joakim Bøgelund Jakobsen et al.
Interconversion of functional groups in organic chemistry is a key task. Here we have developed an oxidative transformation of aldehydes to nitriles using lithium bis(trimethylsilyl)amide as a nitrogen source and copper iodide as an inexpen...
Direct Access to SCF3-Substituted 2H-Thiopyrans Via a [4 + 2] Annulation with 1,3-Dienes, AgSCF3, and KI [0.03%]
通过[4+2]环化反应直接获得SCF3取代的2H-噻喃杂环化合物
Kang Guo,Bin Chen,Yongchao Lu et al.
Kang Guo et al.
A [4 + 2] annulation with 1,3-dienes, AgSCF3, and KI has been established, affording a variety of CF3S-substituted 2H-thiopyrans with high chemo- and regioselectivities. The intermediate (CF3S)2C═S is generated in situ via the reaction of ...
Electrochemical Radical Addition-Initiated Ring-Opening/Functionalization of 2-Alkylidenecyclobutanols toward γ,δ-Unsaturated Ketone Synthesis [0.03%]
电化学自由基加成引发的2-烯亚甲基 cyclobutanols 开环/官能团化反应制备γ,δ-不饱和酮类化合物
Juan Fan,Huiying Sun,Yanjiang Chen et al.
Juan Fan et al.
γ,δ-Unsaturated carbonyl compounds bearing halogen/sulfonyl groups are valuable in medicinal chemistry, but their efficient synthesis remains a considerable challenge. Here, we report an electrochemical radical addition-initiated ring-ope...
Au(I)/Au(III)-Catalyzed Annulative Addition of Alkynes to Aryl Iodides [0.03%]
金(I)/金(III)催化联芳基碘与末端炔氢的偶联环化反应
Hongyan Liu,Bo Xu
Hongyan Liu
We present a ligand-enabled, gold-catalyzed syn-1,2-carbohetero-functionalization of both internal and terminal alkynes with o-iodo-arylamides. The transformation integrates a tandem oxidative addition and syn-auration, affording a diverse ...
Enantioselective Synthesis of Seven-Membered Bridged Biaryls via Pd-Catalyzed Asymmetric Annulative Allylic Alkylation [0.03%]
钯催化不对称环化偶联反应构建七元桥环茋类化合物
Cong Li,Qijian Ni,Xiaoxiao Song
Cong Li
An enantioselective formal [5+2] annulation strategy for the efficient synthesis of seven-membered bridged biaryls is reported through palladium-catalyzed asymmetric annulative allylic alkylation of o-indolizinyl N-sulfonylanilines with (Z)...
Chemodivergent Multicomponent Reactions of Morita-Baylis-Hillman-Type Yne-allylic Esters with 1,3-Dicarbonyls or Aroylacetonitriles [0.03%]
炔亚甲基马尔科夫尼柯夫烯丙酯与1,3-二羰基化合物或芳基乙腈的化学分化多重组分反应
Chen Huang,Chao-Xu Li,Guang-Jie Wang et al.
Chen Huang et al.
Herein, we introduce Morita-Baylis-Hillman-type yne-allylic esters that serve as novel precursors in a chemodivergent multicomponent reaction platform with carbon-based nucleophiles. SN2″ addition of tertiary amines generates unprecedented...
Palladium-Catalyzed Intramolecular meta-C-H Arylation Assisted by Nitrile Templates Under Microwave-Accelerated Conditions Accessing Fluorene Frameworks [0.03%]
钯催化微波促进条件下氮苷模板化亚胺参与的分子内苯环meta-C-H芳基化反应构建荧蒽框架化合物
Kurella Mounika,Gedu Satyanarayana
Kurella Mounika
Although intermolecular meta-C-H arylation has been thoroughly studied and well established, the intramolecular version of meta-C-H arylation is still largely unexplored and offers exciting opportunities for future research. With these cons...