Synthesis of Nanographene-Fused Carbaporphyrin(2.1.0.1) and Its Organopalladium(II) Complex [0.03%]
亚芳并碳巴_porphin和其金属配合物的合成研究
Zhe Liu,Zhaohui Zong,Ningchao Liu et al.
Zhe Liu et al.
New nanographene ligands are indispensable for expanding the metal-doping chemistry of nanographenes. In this study, by incorporating an o-dipyrrolylbenzene unit into the bay region of an iconic nanographene, hexa-peri-hexabenzocoronene (HB...
Development of a HAT Reagent for the Decarboxylative Thiocyanation of Aliphatic Carboxylic Acids [0.03%]
开发用于脂肪族羧酸脱羧硫氰化的HAT试剂
Jordan Vigier,Tatiana Besset,Hélène Lebel
Jordan Vigier
A novel reagent for the decarboxylative thiocyanation of nonactivated aliphatic carboxylic acids by HAT has been synthesized. The transition metal-free process involved the use of an organic photocatalyst and blue light irradiation. Primary...
Pushing the Performance Boundaries of Highly Energetic Bis(1,2,4-triazoles) through Merging Dual Strategies of C-Azo Bridging and N-Nitramino Functionalization [0.03%]
通过结合C-偶氮桥联和N-硝氨基化的双策略推动高能 bis(1,2,4-三唑)的性能界限
Yangyang Long,Dongshuai Su,Hui Zhang et al.
Yangyang Long et al.
In this work, by combining the energetic -N═N-, -NO2, and N-NH2/N-NHNO2 groups with triazole, N-amino compound 3 and N-nitramino compound 4 were synthesized. Compound 3 has a unique crystal structure, exhibiting enhanced energetic properti...
Analyte-Induced Restriction of Intramolecular Rotation: Turn-On aza-BODIPY Sensor for Biothiol Detection in Aqueous Media [0.03%]
分析物诱导的分子内旋转限制：用于生物硫醇检测的开启型aza-BODIPY传感器
Bleda Can Sadikogullari,Ayse Daut Ozdemir
Bleda Can Sadikogullari
Two alternate aza-BODIPY fluorophores bearing a formyl-functional group were synthesized and evaluated for biothiol sensing. Both provide high binding constants (up to 9800 M-1) and low limits of detection (as low as 1 μM). More importantl...
Construction of Fused Polycyclic Skeletons via Palladium-Catalyzed Dearomatization of Naphthalenes and Benzenes [0.03%]
钯催化萘和苯的脱芳香化反应合成稠合多环骨架化合物
Jiaqi Li,Zhenyue Li,Yuan Yuan et al.
Jiaqi Li et al.
A novel palladium-catalyzed dearomative cyclization of naphthalenes and benzenes has been accomplished for the expedient construction of fused polycyclic skeletons bearing an all-carbon quaternary center. Excellent functional group toleranc...
Kinetically Controlled aza-Michael/Epimerization Cascade Enables a Scalable Total Synthesis of Putative (+)-Fumigaclavine F [0.03%]
动力学控制的aza-迈克尔加成/差向异构化级联反应实现拟(−)-皱柄木蓝素F的可扩展全合成
Adrian O Dukes,Pathum M Weerawarna,Richard B Silverman
Adrian O Dukes
The first total syntheses of putative (+)-fumigaclavine F (seven pots, 16% overall yield, 400 mg scale) and its proposed biosynthetic precursor (seven pots, 21% overall yield, 400 mg scale) have been achieved. The stereochemistry of both wa...
Selective P450BM3 Hydroxylation of the Spiro[3.3]heptane Core as a Route to Potential Drug Fragment Molecules [0.03%]
螺[3.3]庚烷类化合物P450BM3选择性羟化：潜在药物片段分子合成的新策略
Xinxin Zhang,Xiaoning Zhang,Luet L Wong et al.
Xinxin Zhang et al.
Engineered P450BM3 enzyme variants, developed from an initial screening panel of 42 enzymes, convert N-benzyl spiro[3.3]heptane-2-carboxamide into three distally monohydroxylated regioisomers with essentially complete enantioselectivity. Tw...
Photoinduced Asymmetric Dearomative Hydroalkylation of Electron-Deficient Indoles with Alkyltrifluoroborates [0.03%]
电子贫乏吲哚与烷基三氟硼酸酯的光致不对称去芳构化氢官能团化反应
Zitong Zhu,Dong Ye,Yuqiao Zhou et al.
Zitong Zhu et al.
A visible-light-induced catalytic asymmetric dearomative hydroalkylation of electron-deficient indole derivatives with potassium alkyltrifluoroborates was realized under mild reaction conditions. A synergistic catalyst system involving orga...
Cooperative Copper/Eosin Y-Catalyzed Photochemical Oxidative Coupling Reactions of Indolines for the Synthesis of 1,5'-Biindoles [0.03%]
cooperatively catalyzed photochemical oxidative coupling reactions of indolines for the synthesis of 1,5'-biindoles
Yue Lv,Beibei Zhang,Keqi Tang et al.
Yue Lv et al.
An unprecedented copper- and Eosin Y-catalyzed oxidative coupling of indolines is presented. The method provides direct access to 1,5'-biindolyls from the corresponding indolines. The reaction conditions are mild and conducted at room tempe...
Coinage Metal-Catalyzed Divergent Heterocyclizations of Underexplored N-Propargyl Hydrazides [0.03%]
N-炔丙基胲化合物的金属催化发散异环化反应
Daniel Diez-Iriepa,Mireia Toledano-Pinedo,Lorena Herrera-Hernández et al.
Daniel Diez-Iriepa et al.
Herein, we disclose metal-catalyzed tunable annulations of uncharted alkyne-tethered hydrazides for the divergent preparation of diazacyclic frameworks. Cationic gold facilitates the O-cyclization, providing valuable [1,3,4]oxadiazine scaff...