Norbornene and Base-Regulated Divergent Synthesis of Fluorenones and Phenanthrenes from Aryl Halides and 2-Halomandelic Acids [0.03%]
从芳基卤化物和2-卤代扁桃酸合成荧烯酮和以碱为调控剂的异博来烯及[5,5]并苯化合物的汇聚/发散合成法
Ying Fu,Yu Luo,Wenying Yang et al.
Ying Fu et al.
A palladium-catalyzed, norbornene- and norbornadiene-mediated Catellani-type annulation reaction of haloarenes with 2-halomandelic acids prepared 9-fluorenones and phenanthrenes, respectively. Theoretical investigations suggest that, within...
Dual Co/Photoredox-Catalyzed Regio- and Stereoselective Allyl Homocoupling Providing Functionalized 1,5-Dienes [0.03%]
双重光/光促进的区域和立体选择性烯丙基均裂偶联制备含官能团的1,5-二烯烃
Fengyun Gao,Giona Armellin,Stephanie G E Amos et al.
Fengyun Gao et al.
Vinyl cyclic carbonates are productive allyl precursors in the generation of functionalized 1,5-dienes featuring a quaternary center using dual Co/organophotoredox catalysis. A bulky N^P^N ligand is key to the exclusive regio- and stereocon...
Photocatalytic C-3 Acylation of Indoles Using ICF2SO2Ph as Acyl Fluoride Precursor [0.03%]
以ICF2SO2Ph作为酰氟前体的吲哚C-3酰基化光催化反应
Jiarui Liang,Dandan Xia,Huanyi Guo et al.
Jiarui Liang et al.
ICF2SO2Ph represents an important reagent for introducing the CF2SO2Ph functionality into organic scaffolds. Here, we found that ICF2SO2Ph acts as an acyl fluoride precursor, enabling the C-3 acylation of indoles. Under mild visible light p...
Six-Membered N-ANP-Enabled Tandem Catellani/Buchwald Annulation for the Construction of π-Extended Dibenzocarbazoles [0.03%]
六元N-杂环卡宾活化串联Catellani/Buchwald偶联反应构建π扩展的二苯并咔唑类化合物
Xue Gong,Lei Tian,Shilei Liu et al.
Xue Gong et al.
We report a Pd/NBE/Cu-catalyzed tandem Catellani/Buchwald annulation for the direct C-H/N-H [3+4] cyclization of carbazoles with aryl iodonium salts. This protocol provides efficient access to a range of π-extended dibenzocarbazole framewo...
Jordan Y Artzy,Wenbin Liu,Yunyi Wang
Jordan Y Artzy
C-Aryl nucleosides are medicinally valuable due to their enhanced metabolic stability achieved by replacing a labile C-N bond with a C-C bond to nucleobases. Herein, a direct metallaphotoredox deoxygenative arylation to access heteroaryl C-...
Divergent Asymmetric Total Synthesis of (+)-Panduratin I, (+)-Nicolaioidesin B, (+)-Isopanduratin A1, and (+)-2-Hydroxyisopanduratin A via Enantioselective Radical Cation (4 + 2) Cycloaddition [0.03%]
远程不对称发散式全合成：通过立体选择性自由基阳离子（4+2）环加成构建(+)-Panduratin I、(+)-Nicolaioidesin B、(+)-Isopanduratin A1和(+)-2-羟基异panduratin A
Hayato Akao,Shuhei Ohmura,Kazuaki Ishihara
Hayato Akao
The first asymmetric total synthesis of panduratin I, nicolaioidesin B, isopanduratin A1, and 2-hydroxyisopanduratin A has been achieved. The characteristic chiral cyclohexenyl skeleton of these natural products was constructed via enantios...
Construction of Chiral Quaternary Carbons via Enzymatic Epoxidation of Tertiary Allylic Alcohols [0.03%]
利用三级 allylic 酒精的酶促环氧化构建手性季碳原子
Quan Zhang,Jian Li
Quan Zhang
A chemoenzymatic strategy to construct aryl-substituted chiral quaternary carbon centers has been established. Directed evolution of P450BM3 enables highly enantioselective epoxidation of tertiary allylic alcohols (up to 99% ee), which is a...
Low-Energy Photocatalytic C-H Amination of Arenes Enabled by an Orange-Light Organic Photooxidant [0.03%]
一种有机光氧化剂启用的橙光催化芳烃碳氢氨化反应
Ramandeep Kaur,Luke D Fasse,Thomas L Gianetti
Ramandeep Kaur
Direct C-H amination of arenes provides rapid access to C-N bonds in pharmaceuticals, agrochemicals, and functional materials, yet most photoredox approaches require high-energy blue light. Here, we introduce a low-energy orange-light photo...
Protodesilylation as a Stereochemical Switch: Divergent Asymmetric Synthesis from Chiral Skipped Dienes [0.03%]
立体化学开关：从手性缺烯烃出发的发散式不对称合成
Hayato Tanikawa,Rina Hashimoto,Nobuyuki Komine et al.
Hayato Tanikawa et al.
Protodesilylation is demonstrated to function not simply as replacement of a silyl group with hydrogen but as a key switch that triggers divergent skeletal transformations. Enantioenriched silyl-substituted skipped dienes are efficiently pr...
Photoinduced Controllable Synthesis of α-Oximino Ketone and α-Imino Ketones from Nitrostyrene Via NO Radical Migration and Rearrangement [0.03%]
硝基苯乙烯通过NO自由基迁移和重排光控合成α-肟亚胺酮和α-亚氨基酮
Yu Li,Linyu Pu,Yixian Cheng et al.
Yu Li et al.
A photoinduced strategy for the direct and precise construction of α-oximino ketones and α-imino ketones from nitrostyrenes was established. Upon photoexcitation, NO radical was generated from a nitro group, which undergoes intramolecular...