mRNA 3' UTRs chaperone intrinsically disordered regions to control protein activity [0.03%]
mRNA 3'UTR通过分子伴侣作用调控内在无序区以控制蛋白质活性
Yang Luo,Yaofeng Zhong,Sudipto Basu et al.
Yang Luo et al.
More than 2,700 human mRNA 3' UTRs have hundreds of highly conserved nucleotides, but their biological roles are unclear. These mRNAs encode proteins strongly enriched for long intrinsically disordered regions (IDRs) with hydrophobic amino ...
Sicong Wang,Kouta Niizuma,Daniel Dan Liu et al.
Sicong Wang et al.
Organ shortage remains a major challenge in transplantation medicine. Interspecies blastocyst complementation offers a promising strategy to generate human organs in livestock. However, efficient xenogeneic donor cell engraftment remains ch...
William S DeWitt,Ashni A Vora,Tatsuya Araki et al.
William S DeWitt et al.
Darwinian evolution of immunoglobulin genes within germinal centers (GCs) underlies the progressive increase in antibody affinity following antigen exposure. Whereas the cellular mechanics of how competition between B cells increases affini...
Deep-sea megafauna co-opts microbial energy metabolism genes to withstand ultra-long starvation [0.03%]
深海大型动物劫持微生物能量代谢基因以应对极度饥饿事件
Jianbo Yuan,Xiaojun Zhang,Shihao Li et al.
Jianbo Yuan et al.
The deep-sea supergiant isopod is renowned for surviving over 5 years without food, which is a crucial adaptive trait for megafauna inhabiting extreme environments. Here, morphological, physiological, and genomic comparisons of deep-sea iso...
Single-cell mapping of regulatory DNA-protein interactions [0.03%]
单细胞染色质相互作用分析技术mapping of Regulatory DNA-Protein Interactions (MRI)
Wei-Yu Chi,Sang-Ho Yoon,Evrim Goksel et al.
Wei-Yu Chi et al.
Gene expression is controlled by transcription factors (TFs), whose genome binding is shaped by chromatin accessibility and histone modifications, yet mapping these interactions, particularly those with weak affinity or a transient nature, ...
Anita Donlic,Troy J Comi,Sofia A Quinodoz et al.
Anita Donlic et al.
Biomolecular condensates compartmentalize the interior of cells to organize complex functions, yet linking molecular interactions within condensates to their mesoscale organization remains a major challenge. To bridge this gap, we developed...
Tej Pandya,Maria Zagorulya,Michelle M Leung et al.
Tej Pandya et al.
Predicting lung cancer risk would enhance prevention trials. Although the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial demonstrated reduced lung cancer incidence with interleukin (IL)-1β inhibition, the high number...
Paleogenomes reveal the evolutionary relationship between modern and cave lions [0.03%]
古基因组揭示了现代狮和洞穴狮之间的进化关系
David W G Stanton,Anders Bergström,Peter D Heintzman et al.
David W G Stanton et al.
The Eurasian cave lion was abundant across the Northern Hemisphere before the Late Pleistocene megafaunal extinctions. However, the extent of the distinction between cave and modern lions and their adaptive differences have remained unclear...
Plant cell wall-plasma membrane attachments mediate stress resilience through cellulose synthase complexes and remorins [0.03%]
细胞壁-质膜连接通过胞质素复合体和remorin介导胁迫抗逆性
Yue Rui,Magda Zaoralová,William P Dwyer et al.
Yue Rui et al.
The outer cell surface of an organism is the frontline for detecting and responding to environmental stimuli. In plants, this interface consists of the plasma membrane that lies beneath the cell wall and remains associated with it through a...
Explosive cytotoxicity of ruptoblasts bridges hormone surveillance and immune defense [0.03%]
裂细胞爆破解开了激素监视与免疫防御之间的桥梁作用
Chew Chai,Eliya Sultan,Souradeep R Sarkar et al.
Chew Chai et al.
Current understanding of cytotoxic immunity is shaped by hematopoietic-derived cells-T cells, natural killer cells, and neutrophils. Here, we identify "ruptoblasts," a previously unknown cytotoxic glandular cell type in regenerative planari...