A glycolytic shunt via the pentose phosphate pathway is a metabolic checkpoint for nervous system sensory homeostasis and axonal regeneration [0.03%]
糖酵解通路通过磷酸戊糖途径成为感觉稳态和轴突再生的代谢检查点
Yayue Song,Lucia Luengo-Gutierrez,Virag Sagi-Kiss et al.
Yayue Song et al.
Homeostasis and repair in the nervous system are thought to rely on distinct molecular programs. Here, we uncover an unexpected role for the pentose phosphate pathway (PPP) in peripheral sensory axons, where it supports both homeostatic mec...
Structure of pancreatic hIAPP fibrils derived from patients with type 2 diabetes [0.03%]
2型糖尿病患者胰岛素淀粉样多肽纤维的结构
Wenjing Liu,Jianting Han,Wei Gong et al.
Wenjing Liu et al.
Type 2 diabetes (T2D) impacts the quality of life and lifespan of nearly 10% of the global population. Human islet amyloid polypeptide (hIAPP) constitutes a major component of islet amyloid deposition in patients with T2D, with hIAPP fibril...
Butyrolactol A enhances caspofungin efficacy via flippase inhibition in drug-resistant fungi [0.03%]
但anolactone A通过抑制耐药真菌的翻转酶增强卡波芬净的效果
Xuefei Chen,H Diessel Duan,Michael J Hoy et al.
Xuefei Chen et al.
Fungal infections cause millions of deaths annually and are challenging to treat due to limited therapeutic options and rising resistance. Cryptococci are intrinsically resistant to the latest generation of antifungals, echinocandins, while...
FOCAS: Transcriptome-wide screening of individual m6A sites functionally dissects epitranscriptomic control of gene expression in cancer [0.03%]
基于转录组的m6A位点功能筛选解析其对癌症基因表达的表观转录组学调控作用
Xinning Zhang,Yifan Zhang,Xinyu Liu et al.
Xinning Zhang et al.
Although N6-methyladenosine (m6A) is a pervasive RNA modification essential for gene regulation, dissecting the functions of individual m6A sites remains technically challenging. To overcome this, we developed functional m6A sites detection...
Mechanisms of HSV-1 helicase-primase inhibition and replication fork complex assembly [0.03%]
HSV-1解旋酶-原酸酶抑制及复制叉复合物装配的机制研究
Zishuo Yu,Pradeep Sathyanarayana,Cong Liu et al.
Zishuo Yu et al.
Herpesviruses are widespread double-stranded DNA viruses that establish lifelong latency and cause various diseases. Although DNA-polymerase-targeting antivirals are effective, increasing drug resistance underscores the need for alternative...
Neuronal calcium spikes enable vector inversion in the Drosophila brain [0.03%]
果蝇大脑中神经元钙 spike 使向量取反成为可能
Itzel G Ishida,Sachin Sethi,Thomas L Mohren et al.
Itzel G Ishida et al.
A typical neuron signals to downstream cells when it is depolarized and fires sodium spikes. Some neurons, however, also fire calcium spikes when hyperpolarized. The function of such bidirectional signaling remains unclear in most circuits....
Tumor-produced ammonia is metabolized by regulatory T cells to further impede anti-tumor immunity [0.03%]
肿瘤产生的氨被调节性T细胞代谢以进一步阻碍抗肿瘤免疫反应
Jian Gu,Yu Li,Qiuyang Chen et al.
Jian Gu et al.
Mechanisms of adaptation of regulatory T cells (Tregs) to harsh tumor metabolic microenvironments for suppression of anti-tumor immunity remain largely unclear. Here, using spatial metabolomics and transcriptomics, we show that human hepato...
Benjamin P Kay,Muriah D Wheelock,Joshua S Siegel et al.
Benjamin P Kay et al.
Prescription stimulants (e.g., methylphenidate) are thought to improve attention, but evidence from prior fMRI studies is conflicted. We utilized resting-state fMRI data from the Adolescent Brain Cognitive Development Study (n = 11,875; 8-1...
The evolving landscape of Alzheimer's disease therapy: From Aβ to tau [0.03%]
阿尔茨海默病治疗领域的发展：从淀粉样蛋白到tau蛋白质
Jean-Philippe Courade,Henrik Zetterberg,Günter U Höglinger et al.
Jean-Philippe Courade et al.
A marked evolution in Alzheimer's disease (AD) therapy research is ongoing. In this perspective, we highlight emerging outcomes of tau-targeting approaches with disease-modifying potential evidenced by PET-based slowing of tau accumulation ...
Elizabeth V Goldfarb
Elizabeth V Goldfarb
In this issue of Cell, Kay and colleagues show robust and reproducible differences in human brain networks associated with stimulants. Individuals taking stimulants had distinct functional connectivity of a set of brain networks linked to b...