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期刊名:Cell

缩写:CELL

ISSN:0092-8674

e-ISSN:1097-4172

IF/分区:42.5/Q1

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共收录本刊相关文章索引9608
Clinical Trial Case Reports Meta-Analysis RCT Review Systematic Review
Classical Article Case Reports Clinical Study Clinical Trial Clinical Trial Protocol Comment Comparative Study Editorial Guideline Letter Meta-Analysis Multicenter Study Observational Study Randomized Controlled Trial Review Systematic Review
Zhengyu Wang,Bo-Syong Pan,Rajesh Kumar Manne et al. Zhengyu Wang et al.
Passive diffusion does not explain why many drugs are too large and/or too polar for rule-breaking membrane penetration, such as proteolysis-targeting chimeras (PROTACs, generally of a molecular weight > 800 Da). Here, using biotinylated ch...
Marina T Nikolova,Zhisong He,Makiko Seimiya et al. Marina T Nikolova et al.
Human blood vessel organoids (hBVOs) have emerged as a system to model human vascular development and disease. Here, we use single-cell multi-omics together with genetic and signaling pathway perturbations to reconstruct hBVO development. M...
Guido Kroemer,Andrea B Maier,Ana Maria Cuervo et al. Guido Kroemer et al.
Major progress has been made in elucidating the molecular, cellular, and supracellular mechanisms underlying aging. This has spurred the birth of geroscience, which aims to identify actionable hallmarks of aging. Aging can be viewed as a pr...
Gabriella E Martyn,Michael T Montgomery,Hank Jones et al. Gabriella E Martyn et al.
Regulatory DNA provides a platform for transcription factor binding to encode cell-type-specific patterns of gene expression. However, the effects and programmability of regulatory DNA sequences remain difficult to map or predict. Here, we ...
Krista G Freeman,Sudipta Mondal,Lourriel S Macale et al. Krista G Freeman et al.
Mycobacteriophage Bxb1 is a well-characterized virus of Mycobacterium smegmatis with double-stranded DNA and a long, flexible tail. Mycobacteriophages show considerable potential as therapies for Mycobacterium infections, but little is know...
Wen-Bing Jin,Leyi Xiao,Mingeum Jeong et al. Wen-Bing Jin et al.
Microbiota-derived bile acids (BAs) are associated with host biology/disease, yet their causal effects remain largely undefined. Herein, we speculate that characterizing previously undefined microbiota-derived BAs would uncover previously u...
Raquel Martin-Arevalillo,Bruno Guillotin,Jonas Schön et al. Raquel Martin-Arevalillo et al.
How developmental signals program gene expression in space and time is still poorly understood. Here, we addressed this question for the plant master regulator, auxin. Transcriptional responses to auxin rely on a large multigenic transcript...
Shady Saad,Tomek Swigut,Saman Tabatabaee et al. Shady Saad et al.
Polyglutamine (polyQ) expansion is associated with pathogenic protein aggregation in neurodegenerative disorders. However, long polyQ tracts are also found in many transcription factors (TFs), such as FOXP2, a TF implicated in human speech....
Yanyu Zhu,Ashwin Balaji,Mengting Han et al. Yanyu Zhu et al.
Three-dimensional (3D) genome dynamics are crucial for cellular functions and disease. However, real-time, live-cell DNA visualization remains challenging, as existing methods are often confined to repetitive regions, suffer from low resolu...