Tumor transcriptome-wide expression classifiers predict treatment sensitivity in advanced prostate cancers [0.03%]
肿瘤转录组表达分类器可预测晚期前列腺癌的治疗敏感性
Emily Grist,Peter Dutey-Magni,Marina A Parry et al.
Emily Grist et al.
Advanced prostate cancers respond to hormone therapy but outcomes vary and no predictive tests exist for informed treatment selection. To identify novel biomarker-treatment pairings, we examined associations between biological pathways and ...
Molecular impact of antisense oligonucleotide therapy in C9orf72-associated ALS [0.03%]
针对C9orf72相关ALS的反义寡核苷酸治疗的分子影响
Zachary T McEachin,Mingee Chung,Sabrina A Stratton et al.
Zachary T McEachin et al.
C9orf72-associated amyotrophic lateral sclerosis (c9ALS) is caused by an intronic G4C2 repeat expansion that leads to toxic RNA transcripts and dipeptide repeat proteins (DPRs). A clinical trial using the antisense oligonucleotide (ASO) BII...
Raya Faigenbaum-Romm,Noam Yedidi,Orit Gefen et al.
Raya Faigenbaum-Romm et al.
Uncovering phenotypic heterogeneity is fundamental to understanding processes such as development and stress responses. Due to the low mRNA abundance in single bacteria, determining biologically relevant heterogeneity remains a challenge. U...
Structural basis of poxvirus fusion regulation and anti-A16/G9 antibody-mediated neutralization and protection [0.03%]
痘病毒融合调节和抗A16/G9抗体介导的中和与保护的作用机制及其结构基础
Annalisa Meola,Riccardo Vernuccio,Leandro Battini et al.
Annalisa Meola et al.
Monkeypox virus (MPXV) is a poxvirus endemic to Central and West Africa with high epidemic potential. Poxviruses enter host cells via a conserved entry-fusion complex (EFC), which mediates viral fusion to the cell membrane. The EFC is a pro...
Kevin C Allan,Jesse J Zhan,Andrew R Morton et al.
Kevin C Allan et al.
Cellular maturation is a crucial step for tissue formation and function, distinct from the initial steps of differentiation and cell fate specification. In the central nervous system, failure of oligodendrocyte maturation is linked to disea...
Shank3 oligomerization governs material properties of the postsynaptic density condensate and synaptic plasticity [0.03%]
SHANK3寡聚化调控突触后致密带凝聚物的物理特性及突触可塑性
Bowen Jia,Zeyu Shen,Shihan Zhu et al.
Bowen Jia et al.
Cells contain numerous types of membraneless organelles or biological condensates formed via phase separation. Cellular biological condensates have broad material properties ranging from Newtonian fluids to elastic solids. How the material ...
Bacteriophages inhibit and evade cGAS-like immune function in bacteria [0.03%]
噬菌体抑制和逃避细菌中的cGAS样免疫功能
Erin Huiting,Xueli Cao,Jie Ren et al.
Erin Huiting et al.
Published Erratum
Cell. 2025 Aug 22:S0092-8674(25)00923-7. DOI:10.1016/j.cell.2025.08.009 2025
A receptor antagonist counterbalances multiple systemin phytocytokines in tomato [0.03%]
一种受体拮抗剂可抵消番茄中的多种系统素植物细胞生长素的作用
Lei Wang,Louis-Philippe Maier,Nga Pham et al.
Lei Wang et al.
Tight regulation of immune activation is crucial for plant health. How plants control the actions of their immunostimulatory phytocytokines is largely unknown. Here, we identify antiSYS as a natural inhibitor of the tomato cytokine systemin...
Zeguang Wu,Jinhong Shi,Qiezhong Lamao et al.
Zeguang Wu et al.
Despite the success of autologous chimeric antigen receptor (CAR)-T cell therapy, achieving persistence and avoiding rejection in allogeneic settings remains challenging. We showed that signal peptide peptidase-like 3 (SPPL3) deletion enabl...
Imaging high-frequency voltage dynamics in multiple neuron classes of behaving mammals [0.03%]
哺乳动物的行为活动中多类神经元的高频电压动力学成像技术
Simon Haziza,Radosław Chrapkiewicz,Yanping Zhang et al.
Simon Haziza et al.
Published Erratum
Cell. 2025 Aug 21:S0092-8674(25)00924-9. DOI:10.1016/j.cell.2025.08.010 2025