Zhengyu Wang,Bo-Syong Pan,Rajesh Kumar Manne et al.
Zhengyu Wang et al.
Passive diffusion does not explain why many drugs are too large and/or too polar for rule-breaking membrane penetration, such as proteolysis-targeting chimeras (PROTACs, generally of a molecular weight > 800 Da). Here, using biotinylated ch...
Fate and state transitions during human blood vessel organoid development [0.03%]
人类血管器官样组织发育过程中的细胞命运决定及转分化现象
Marina T Nikolova,Zhisong He,Makiko Seimiya et al.
Marina T Nikolova et al.
Human blood vessel organoids (hBVOs) have emerged as a system to model human vascular development and disease. Here, we use single-cell multi-omics together with genetic and signaling pathway perturbations to reconstruct hBVO development. M...
Nutrient-regulated control of lysosome function by signaling lipid conversion [0.03%]
信号脂质转化调控营养控制溶酶体功能
Michael Ebner,Dmytro Puchkov,Orestes López-Ortega et al.
Michael Ebner et al.
Published Erratum
Cell. 2025 Apr 17:S0092-8674(25)00412-X. DOI:10.1016/j.cell.2025.04.009 2025
From geroscience to precision geromedicine: Understanding and managing aging [0.03%]
从中老年医学到精准老年内科学：了解和管理衰老
Guido Kroemer,Andrea B Maier,Ana Maria Cuervo et al.
Guido Kroemer et al.
Major progress has been made in elucidating the molecular, cellular, and supracellular mechanisms underlying aging. This has spurred the birth of geroscience, which aims to identify actionable hallmarks of aging. Aging can be viewed as a pr...
Gabriella E Martyn,Michael T Montgomery,Hank Jones et al.
Gabriella E Martyn et al.
Regulatory DNA provides a platform for transcription factor binding to encode cell-type-specific patterns of gene expression. However, the effects and programmability of regulatory DNA sequences remain difficult to map or predict. Here, we ...
Krista G Freeman,Sudipta Mondal,Lourriel S Macale et al.
Krista G Freeman et al.
Mycobacteriophage Bxb1 is a well-characterized virus of Mycobacterium smegmatis with double-stranded DNA and a long, flexible tail. Mycobacteriophages show considerable potential as therapies for Mycobacterium infections, but little is know...
Microbiota-derived bile acids antagonize the host androgen receptor and drive anti-tumor immunity [0.03%]
胆汁酸拮抗宿主雄激素受体并促进抗肿瘤免疫反应
Wen-Bing Jin,Leyi Xiao,Mingeum Jeong et al.
Wen-Bing Jin et al.
Microbiota-derived bile acids (BAs) are associated with host biology/disease, yet their causal effects remain largely undefined. Herein, we speculate that characterizing previously undefined microbiota-derived BAs would uncover previously u...
Raquel Martin-Arevalillo,Bruno Guillotin,Jonas Schön et al.
Raquel Martin-Arevalillo et al.
How developmental signals program gene expression in space and time is still poorly understood. Here, we addressed this question for the plant master regulator, auxin. Transcriptional responses to auxin rely on a large multigenic transcript...
DNA binding and mitotic phosphorylation protect polyglutamine proteins from assembly formation [0.03%]
DNA结合和有丝分裂磷酸化可防止多聚谷氨酰胺蛋白聚集形成
Shady Saad,Tomek Swigut,Saman Tabatabaee et al.
Shady Saad et al.
Polyglutamine (polyQ) expansion is associated with pathogenic protein aggregation in neurodegenerative disorders. However, long polyQ tracts are also found in many transcription factors (TFs), such as FOXP2, a TF implicated in human speech....
High-resolution dynamic imaging of chromatin DNA communication using Oligo-LiveFISH [0.03%]
基于Oligo-LiveFISH的染色体DNA通讯高分辨率动态成像
Yanyu Zhu,Ashwin Balaji,Mengting Han et al.
Yanyu Zhu et al.
Three-dimensional (3D) genome dynamics are crucial for cellular functions and disease. However, real-time, live-cell DNA visualization remains challenging, as existing methods are often confined to repetitive regions, suffer from low resolu...