Targeting myosin II to alter the disease course of challenging diseases [0.03%]
靶向肌球蛋白II以改变难治性疾病的发展进程
Douglas N Robinson
Douglas N Robinson
In this issue of Cell, Kenchappa et al. and Radnai et al. report the development of selective non-muscle myosin II inhibitors that show therapeutic potential in glioblastoma and methamphetamine use disorder, opening new avenues for targetin...
Adenosine kinase and ADAL coordinate detoxification of modified adenosines to safeguard metabolism [0.03%]
次黄嘌呤核苷酸脱氢酶和ADAL协调清除修饰腺苷以保障代谢安全
Akiko Ogawa,Satoshi Watanabe,Iuliia Ozerova et al.
Akiko Ogawa et al.
RNA contains diverse post-transcriptional modifications, and its catabolic breakdown yields numerous modified nucleosides requiring correct processing, but the mechanisms remain unknown. Here, we demonstrate that three RNA-derived modified ...
A conserved mechanism for the retrieval of polyubiquitinated proteins from cilia [0.03%]
一种从纤毛回收泛素化蛋白的保守机制
Sven M Lange,Jeremy A Bennett,Robyn J Eisert et al.
Sven M Lange et al.
The temporospatial distribution of proteins within cilia is regulated by intraflagellar transport (IFT), wherein molecular trains shuttle between the cell body and cilium. Defects in this process impair various signal-transduction pathways ...
A unified cell atlas of vascular plants reveals cell-type foundational genes and accelerates gene discovery [0.03%]
统一的细胞图谱揭示了血管植物的基本细胞类型和加速基因发现的功能基因
Hao-Chen Xue,Zhou-Geng Xu,Yu-Jie Liu et al.
Hao-Chen Xue et al.
The pace of gene discovery in plants has slowed as forward genetic screens reach saturation. To address this, we built a unified single-cell atlas of shoot apices from six vascular plant species spanning major evolutionary groups. This cros...
Jenny Sachweh,Mandy Börmel,Sven Klumpe et al.
Jenny Sachweh et al.
Nuclear pore complexes (NPCs) bridge across the nuclear envelope and mediate nucleocytoplasmic exchange. They consist of hundreds of nucleoporin building blocks and exemplify the structural complexity of macromolecular assemblies. To ensure...
De novo design of a peptide modulator to reverse sodium channel dysfunction linked to cardiac arrhythmias and epilepsy [0.03%]
从头设计肽类调制剂以逆转与心律失常和癫痫相关的心脏钠通道功能障碍
Ryan Mahling,Bence Hegyi,Erin R Cullen et al.
Ryan Mahling et al.
Ion channels orchestrate electrical signaling in excitable cells. In nature, ion channel function is customized by modulatory proteins that have evolved to fulfill distinct physiological needs. Yet, engineering synthetic modulators that pre...
Chengtao Xu,Xiaolin Niu,Haifeng Sun et al.
Chengtao Xu et al.
RNA-guided RNA editing represents an attractive alternative to DNA editing. However, the prevailing tool, CRISPR-Cas13, has collateral RNA cleavage activity that causes undesirable cytotoxicity in human cells. Here, we report an ultracompac...
RNA Pol II inhibition activates cell death independently from the loss of transcription [0.03%]
RNA聚合酶II抑制独立于转录丢失激活细胞死亡
Nicholas W Harper,Gavin A Birdsall,Megan E Honeywell et al.
Nicholas W Harper et al.
RNA Pol II-mediated transcription is essential for eukaryotic life. Although loss of transcription is thought to be universally lethal, the associated mechanisms promoting cell death are not yet known. Here, we show that death following the...
Daoming Chen,Zhou Yu,Wenbo Wu et al.
Daoming Chen et al.
Hair loss affects millions globally, significantly impacting quality of life and psychological well-being. Despite its prevalence, effective strategies for promoting human hair growth remain elusive. By investigating congenital generalized ...
Aarti Krishnan,Melis N Anahtar,Jacqueline A Valeri et al.
Aarti Krishnan et al.
The antimicrobial resistance crisis necessitates structurally distinct antibiotics. While deep learning approaches can identify antibacterial compounds from existing libraries, structural novelty remains limited. Here, we developed a genera...