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The critical role of the endogenous immune compartment after CAR T cell therapy in recurrent GBM

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Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, with a median survival of under 15 months and no effective treatment after recurrence. A recent phase 1 trial of intracerebroventricular bivalent chimeric antigen receptor (CAR) T c... ...