Gut-to-brain signaling restricts dietary protein intake during recovery from catabolic states [0.03%]
肠-脑信号在机体从消耗状态下恢复期间限制饮食蛋白摄入量的作用机制研究
Nikolai P Jaschke,Joseph R Luchsinger,Zuojia Chen et al.
Nikolai P Jaschke et al.
Dietary needs are dynamic, with optimal ranges for nutrients varying over time and across physiological states. How optimal nutrient set points are established and why they are adjusted remains largely unknown. In our efforts to understand ...
Disparate leukemia mutations converge on nuclear phase-separated condensates [0.03%]
不同的白血病突变汇聚到细胞核相分离凝聚物中
Gandhar K Datar,Elmira Khabusheva,Archish Anand et al.
Gandhar K Datar et al.
During cancer development, mutations promote changes in gene expression that cause transformation. Leukemia associated with aberrant HOXA expression is driven by translocations of nucleoporin genes or KMT2A as well as mutations in NPM1. The...
Generation of antigen-specific paired-chain antibodies using large language models [0.03%]
使用大型语言模型生成抗原特异性配对链抗体
Perry T Wasdin,Nicole V Johnson,Alexis K Janke et al.
Perry T Wasdin et al.
The traditional process of antibody discovery is limited by inefficiency, high costs, and low success rates. Recent approaches employing artificial intelligence (AI) have been developed to optimize existing antibodies and generate antibody ...
Chiara Fornetto,Thomas Euler,Tom Baden
Chiara Fornetto
Vision first evolved in the water, where the spectral content of light informs about viewing distance. However, whether and how aquatic visual systems exploit this "fact of physics" remains unknown. Here, we show that zebrafish use "color" ...
Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer [0.03%]
人高级别浆液性卵巢癌蛋白质基因组综合特征分析
Hui Zhang,Tao Liu,Zhen Zhang et al.
Hui Zhang et al.
Published Erratum
Cell. 2025 Nov 3:S0092-8674(25)01248-6. DOI:10.1016/j.cell.2025.10.043 2025
Usha Nair,Anjali Jotwani,Jiefei Geng et al.
Usha Nair et al.
Published Erratum
Cell. 2025 Nov 1:S0092-8674(25)01190-0. DOI:10.1016/j.cell.2025.10.018 2025
Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans [0.03%]
疫苗诱导人类异种HIV-1中和抗体B细胞谱系
Wilton B Williams,S Munir Alam,Gilad Ofek et al.
Wilton B Williams et al.
Published Erratum
Cell. 2025 Nov 1:S0092-8674(25)01195-X. DOI:10.1016/j.cell.2025.10.023 2025
Felix Mikus,Armando Rubio Ramos,Hiral Shah et al.
Felix Mikus et al.
Microbial eukaryotes remain understudied despite their critical ecological importance, with the exception of a few established models. They are often small, difficult to culture, and resistant to standard labeling and imaging techniques. He...
Olivia V Goldman,Alexandra E DeFoe,Yanyan Qi et al.
Olivia V Goldman et al.
The female Aedes aegypti mosquito's remarkable ability to hunt humans and transmit pathogens relies on her unique biology. Here, we present the Aedes aegypti Mosquito Cell Atlas, a comprehensive single-nucleus RNA sequencing dataset of more...
Jiashuo Zheng,Marcus Conrad
Jiashuo Zheng
In this issue of Cell, Han et al. find that tumor cells metastasizing to the bone marrow hijack macrophages to seize iron from red blood cells. This metabolic plunder thereby fuels tumor progression while contributing to anemia. ...