In vivo transcriptomic, functional, circuit-based, and translational analyses of enteric neurons [0.03%]
肠神经元的体内转录组、功能、回路和转化分析
Claire J Millett,James J Shaver,Bernadette Bracken et al.
Claire J Millett et al.
Enteric neurons (ENs) are interwoven into the gastrointestinal (GI) tract, where they integrate local and external information to coordinate gut function across diverse cell types. Since EN dysfunction underlies the pathophysiology of multi...
Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses [0.03%]
mRNA疫苗的不同成分协同指导有效的生发中心反应
Diana Castaño,Emily Bettini,Binod Kumar et al.
Diana Castaño et al.
Nucleoside-modified messenger RNA (mRNA) vaccines elicit protective antibodies through their ability to promote T follicular helper (Tfh) cell differentiation. The lipid nanoparticles (LNPs) of mRNA vaccines possess inherent adjuvant activi...
HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion [0.03%]
黑色素瘤细胞通过输出人类白细胞抗原来诱骗细胞毒性T细胞以促进免疫逃逸
Yoav Chemla,Orit Itzhaki,Stav Melamed et al.
Yoav Chemla et al.
While melanoma cells often express a high burden of mutated proteins, the infiltration of reactive T cells rarely results in tumor-eradicating immunity. We discovered that large extracellular vesicles, known as melanosomes, secreted by mela...
The neutrophil collective [0.03%]
中性粒细胞集体行为
Iván Ballesteros,Andrés Hidalgo
Iván Ballesteros
More than a century after their discovery, neutrophils continue to puzzle immunologists. Their remarkable migratory, cytotoxic, phagocytic, and degranulating capacities gave rise to the traditional perception that they are dedicated microbe...
Are ultrasensitive ctDNA assays ready for clinical use in early-stage NSCLC? [0.03%]
超灵敏ctDNA检测在早期NSCLC中临床应用的准备就绪了吗？
Sam Khan,Janice J N Li,Natasha B Leighl
Sam Khan
Disease recurrence in early-stage non-small cell lung cancer (NSCLC) remains a persistent clinical challenge, underscoring the need for better prognostic biomarkers. In this preview, we highlight the clinical implications of ultrasensitive ...
Sensitized mast cells for targeted drug delivery and augmented cancer immunotherapy [0.03%]
用于靶向药物输送和增强癌症免疫治疗的敏化肥大细胞
Yan Xu,Xiaoge Zhang,Xiao Han et al.
Yan Xu et al.
Cell-mediated drug-delivery systems have garnered significant attention for their potential to boost therapeutic efficacy in cancer treatment. Here, we engineered immunoglobulin E (IgE)-sensitized mast cells (IgE-MCs) to achieve antigen-gui...
Multimodal AI generates virtual population for tumor microenvironment modeling [0.03%]
多模态AI生成肿瘤微环境建模的虚拟人群
Jeya Maria Jose Valanarasu,Hanwen Xu,Naoto Usuyama et al.
Jeya Maria Jose Valanarasu et al.
The tumor immune microenvironment (TIME) critically impacts cancer progression and immunotherapy response. Multiplex immunofluorescence (mIF) is a powerful imaging modality for deciphering TIME, but its applicability is limited by high cost...
Sung Ryul Choi,Thorsten B Blum,Matteo Giono et al.
Sung Ryul Choi et al.
Microtubules have long been recognized as upstream mediators of intracellular signaling, but the mechanisms underlying this fundamental function remain elusive. Here, we identify the structural basis by which microtubules regulate the guani...
Biomaterial-minimalistic photoactivated bioprinting of cell-dense tissues [0.03%]
用于密集细胞组织光激活生物打印的生物材料极简主义方法
Mian Wang,Wanlu Li,Jin Hao et al.
Mian Wang et al.
Conventional hydrogel-based bioprinting methods often suffer from insufficient cell densities, which may limit crucial cell-cell interactions and impair overall tissue functions. Here, we present an approach that modifies cell membranes wit...
Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks [0.03%]
裸盖菇素诱发皮层网络的活动依赖性重塑
Quan Jiang,Ling-Xiao Shao,Shenqin Yao et al.
Quan Jiang et al.
Psilocybin holds promise as a treatment for mental illnesses. One dose of psilocybin induces structural remodeling of dendritic spines in the medial frontal cortex in mice. The dendritic spines would be innervated by presynaptic neurons, bu...