Encoding and decoding selectivity and promiscuity in the human chemokine-GPCR interaction network [0.03%]
人类趋化因子-G蛋白偶联受体相互作用网络中选择性和泛选择性编码和解码
Andrew B Kleist,Martyna Szpakowska,Lindsay J Talbot et al.
Andrew B Kleist et al.
In humans, selective and promiscuous interactions between 46 secreted chemokine ligands and 23 cell surface chemokine receptors of the G-protein-coupled receptor (GPCR) family form a complex network to coordinate cell migration. While chemo...
Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias [0.03%]
融合突变剪接因子的白血病中的错拼变异新抗原及同源T细胞受体
Won Jun Kim,Edie I Crosse,Emma De Neef et al.
Won Jun Kim et al.
Mutations in RNA splicing factors are prevalent across cancers and generate recurrently mis-spliced mRNA isoforms. Here, we identified a series of bona fide neoantigens translated from highly stereotyped splicing alterations promoted by neo...
Hypothalamic PNOC/NPY neurons constitute mediators of leptin-controlled energy homeostasis [0.03%]
下丘脑PNOC/NPY神经元构成能量稳态中瘦素控制的介导因素
Marie H Solheim,Sima Stroganov,Weiyi Chen et al.
Marie H Solheim et al.
Leptin acts in the brain to suppress appetite, yet the responsible neurocircuitries underlying leptin's anorectic effect are incompletely defined. Prepronociceptin (PNOC)-expressing neurons mediate diet-induced hyperphagia and weight gain i...
Transcriptional regulation by PHGDH drives amyloid pathology in Alzheimer's disease [0.03%]
PHGDH的转录调控驱动阿尔茨海默病淀粉样蛋白病理学发展
Junchen Chen,Fatemeh Hadi,Xingzhao Wen et al.
Junchen Chen et al.
Virtually all individuals aged 65 or older develop at least early pathology of Alzheimer's disease (AD), yet most lack disease-causing mutations in APP, PSEN, or MAPT, and many do not carry the APOE4 risk allele. This raises questions about...
The establishment of nuclear organization in mouse embryos is orchestrated by multiple epigenetic pathways [0.03%]
表观遗传途径共同调控小鼠胚胎核型建立
Mrinmoy Pal,Tamas Schauer,Adam Burton et al.
Mrinmoy Pal et al.
The folding of the genome in the 3D nuclear space is fundamental for regulating all DNA-related processes. The association of the genome with the nuclear lamina into lamina-associated domains (LADs) represents the earliest feature of nuclea...
A type 1 immune-stromal cell network mediates disease tolerance against intestinal infection [0.03%]
一类I型免疫-基质细胞网络介导肠道感染的疾病忍耐力
Susan Westfall,Maria E Gentile,Tayla M Olsen et al.
Susan Westfall et al.
Type 1 immunity mediates host defense through pathogen elimination, but whether this pathway also impacts tissue function is unknown. Here, we demonstrate that rapid induction of interferon γ (IFNγ) signaling coordinates a multicellular r...
Jingying Zhang,Bing Wang,Haoran Xu et al.
Jingying Zhang et al.
Rice tillering is an important agronomic trait regulated by plant genetic and environmental factors. However, the role and mechanism of the root microbiota in modulating rice tillering have not been explored. Here, we examined the root micr...
A cognitive map for value-guided choice in the ventromedial prefrontal cortex [0.03%]
腹内侧前额叶皮层的价值引导选择认知地图
Sebastijan Veselic,Timothy H Muller,Elena Gutierrez et al.
Sebastijan Veselic et al.
The prefrontal cortex (PFC) is crucial for economic decision-making. However, how PFC value representations facilitate flexible decisions remains unknown. We reframe economic decision-making as a navigation process through a cognitive map o...
Yiming Han,Xiaoye Liu,Shaoqi Qu et al.
Yiming Han et al.
Epithelial tissues serve as the first line of host against bacterial infections. The self-organization of epithelial tissues continuously adapts to the architecture and mechanics of microenvironments, thereby dynamically impacting the initi...
Yaozhen Chen,Shouwen Chen,Zhixin Liu et al.
Yaozhen Chen et al.
The canonical complement-mediated lysis of mature red blood cells (RBCs) leads to severe pathogenesis. However, inhibition strategies targeting complement are not always as efficient as expected, indicating that unknown mechanisms are await...