Felix Mikus,Armando Rubio Ramos,Hiral Shah et al.
Felix Mikus et al.
Microbial eukaryotes remain understudied despite their critical ecological importance, with the exception of a few established models. They are often small, difficult to culture, and resistant to standard labeling and imaging techniques. He...
Olivia V Goldman,Alexandra E DeFoe,Yanyan Qi et al.
Olivia V Goldman et al.
The female Aedes aegypti mosquito's remarkable ability to hunt humans and transmit pathogens relies on her unique biology. Here, we present the Aedes aegypti Mosquito Cell Atlas, a comprehensive single-nucleus RNA sequencing dataset of more...
Jiashuo Zheng,Marcus Conrad
Jiashuo Zheng
In this issue of Cell, Han et al. find that tumor cells metastasizing to the bone marrow hijack macrophages to seize iron from red blood cells. This metabolic plunder thereby fuels tumor progression while contributing to anemia. ...
Vanessa Sancho-Shimizu
Vanessa Sancho-Shimizu
Saturation genome editing meets functional phenotyping to turn sequencing ambiguity into actionable diagnoses. Copyright © 2025 Elsevier Inc. All rights...
Bacterial tubular networks channel carbohydrates in insect endosymbiosis [0.03%]
细菌管状网络在昆虫内共生中输送碳水化合物
Séverine Balmand,Camille Rivard,Sergio Peignier et al.
Séverine Balmand et al.
Symbiosis is widespread in nature and plays a fundamental role in organism adaptation and evolution. In nutritional endosymbiosis, host cells accommodate intracellular bacteria and act as a "metabolic factory," requiring extensive metabolic...
George Q Daley
George Q Daley
Shuai He,Chun-Ling Luo,Tao Luo et al.
Shuai He et al.
The second trimester of pregnancy is a pivotal stage in human immune system development. Utilizing single-cell RNA sequencing and T cell receptor sequencing, we profiled 2,868,420 immune cells from 321 samples across 23 organs, including ad...
Unveiling conformation-selective regulation of the norepinephrine transporter [0.03%]
解开去甲肾上腺素转运蛋白的构象选择性调节机制
Heng Zhang,Tianwei Zhang,Dingyan Wang et al.
Heng Zhang et al.
The norepinephrine transporter (NET) plays a crucial role in synaptic neurotransmission and is implicated in major depression and attention-deficit/hyperactivity disorders, yet our understanding of its allosteric, conformation-selective reg...
Protein restriction reprograms the multi-organ proteomic landscape of mouse aging [0.03%]
蛋白质限制重塑了小鼠衰老过程中的多器官蛋白质组景观
Tian Lu,Yuting Xie,Yingrui Wang et al.
Tian Lu et al.
Population aging is accelerating, yet the multi-organ aging process and the geroprotective effects of dietary protein restriction (PR) remain poorly understood. Here, we conducted comprehensive proteomic analyses on 41 mouse tissues during ...
Cancer cells co-opt an inter-organ neuroimmune circuit to escape immune surveillance [0.03%]
癌细胞劫持器官间神经免疫回路以逃避免疫监控
Yu Zhang,Yibo Guo,Zheqi Liu et al.
Yu Zhang et al.
Whether and how cancer exploits distant organs to escape immune surveillance remains largely unknown. Using clinical data from head and neck squamous cell carcinoma (HNSCC) patients and three murine oral cancer models, we find that cancer c...