Image-based inference of tumor cell trajectories enables large-scale cancer progression analysis [0.03%]
基于图像的肿瘤细胞轨迹推理可实现大规模癌症进展分析
Yang Liu,Ling Cai,Ruichen Rong et al.
Yang Liu et al.
Current approaches to estimating cell trajectories, tumor progression dynamics, and cell population diversity of tumor microenvironment often depend on single-cell RNA sequencing, which is costly and resource intensive. To address this limi...
CMOS-compatible flash-gated thyristor-based neuromorphic module with small area and low energy consumption for in-memory computing [0.03%]
一种基于闪存触发晶闸管的小型化低能耗存储内计算兼容类脑模块
Jonghyun Ko,Jiseong Im,Jangsaeng Kim et al.
Jonghyun Ko et al.
In-memory computing (IMC) is a technology that enables efficient analog vector-matrix multiplication (VMM). This field has been extensively researched to overcome the performance bottlenecks associated with traditional von Neumann architect...
Temporally programmed STING nanoadjuvant delivery unlocks synergistic chemotherapy-induced antitumor immunity [0.03%]
时空编程的STING纳米佐剂递送解锁协同化疗抗肿瘤免疫反应
Zimeng Yang,Hengzhi Liu,Shuo Li et al.
Zimeng Yang et al.
Stimulator of interferon genes (STING) agonists have attracted notable attention for their potent immune activation capabilities. However, their clinical application is hindered by systemic toxicity and delivery inefficiencies. We addressed...
Suyasha Roy,Min Ren,Peng Li et al.
Suyasha Roy et al.
Interleukin-2 (IL-2) regulates immune homeostasis by fine-tuning the balance between effector and regulatory T (Treg) cells. To identify regulators of IL-2 signaling, we performed genome-wide CRISPR-knockout screening in IL-2-dependent cell...
AI-powered skin spectral imaging enables instant sepsis diagnosis and outcome prediction in critically ill patients [0.03%]
基于人工智能的皮肤光谱成像技术实现危重患者的瞬时诊断和预后预测
Silvia Seidlitz,Katharina Hölzl,Ayca von Garrel et al.
Silvia Seidlitz et al.
With sepsis remaining a leading cause of mortality, early identification of patients with sepsis and those at high risk of death is a challenge of high socioeconomic importance. Given the potential of hyperspectral imaging (HSI) to monitor ...
Observational Study
Science advances. 2025 Jul 18;11(29):eadw1968. DOI:10.1126/sciadv.adw1968 2025
Insights into the spool-like architecture and infection strategy of an enveloped archaeal virus [0.03%]
关于包膜古菌病毒纺锤形结构及其感染策略的见解
Haonan Zhang,Haina Wang,Yan Li et al.
Haonan Zhang et al.
Archaeal viruses are well known for their diverse morphologies and extreme stability. Here, we used cryo-electron tomography to analyze the structure of Sulfolobus ellipsoid virus 1 (SEV1), an archaeal virus with an ellipsoidal shape and a ...
Xiao Wu,Jianxi Zhu,Hongmei Yang et al.
Xiao Wu et al.
In the deep biosphere, where surface-derived substrates are depleted, microbial communities rely on redox pairs generated through water-rock reactions to sustain metabolism. A notable example of this is the production of hydrogen gas (H2) a...
Harnessing tissue-derived mitochondria-rich extracellular vesicles (Ti-mitoEVs) to boost mitochondrial biogenesis for regenerative medicine [0.03%]
利用组织衍生的富含线粒体的细胞外囊泡促进线粒体生物发生以用于再生医学
Peng Lou,Xiyue Zhou,Yimeng Zhang et al.
Peng Lou et al.
Mitochondrial damage is a critical pathological factor in various forms of tissue injury, and specific therapies with high biosafety are desirable. Inspired by the natural role of extracellular vesicles (EVs) in regulating mitochondrial met...
NRBP1 pseudokinase binds to and activates the WNK pathway in response to osmotic stress [0.03%]
NRBP1 假激酶通过结合并激活渗透压应激反应的 WNK 通路发挥功能
Ramchandra V Amnekar,Toby Dite,Pawel Lis et al.
Ramchandra V Amnekar et al.
WNK family kinases are regulated by osmotic stress and control ion homeostasis by activating SPAK and OXSR1 kinases. Using a proximity labeling approach, we found that osmotic stress promotes the association of WNK1 with the NRBP1 pseudokin...
Aphid effectors suppress plant immunity via recruiting defense proteins to processing bodies [0.03%]
飞虱效应因子通过将防御蛋白募集到加工体抑制植物免疫反应
Qun Liu,Anna C M Neefjes,Archana Singh et al.
Qun Liu et al.
Aphids are small insects that have developed specialized mouthparts and effector proteins to establish long-term relationships with plants. The peach-potato aphid Myzus persicae is a generalist, feeding on many plant species and capable of ...