CHI3L1/YKL-40 signaling inhibits neurogenesis in models of Alzheimer's disease [0.03%]
CHI3L1/YKL-40信号抑制阿尔茨海默病模型中的神经发生作用
Xin Yang,Wei Jiang,Yuhan Li et al.
Xin Yang et al.
CHI3L1/YKL-40 is an astrocyte-secreted glycoprotein recognized as a biomarker of CNS inflammation and implicated in Alzheimer's disease (AD) cognitive decline. However, its precise pathological role remains unclear. Here, we investigate CHI...
Role of d-serine in intestinal ROS accumulation after sleep deprivation [0.03%]
睡眠剥夺后d-丝氨酸在肠道ROS聚集中的作用
Feng Zheng,Shuai Liu,Tian Wei et al.
Feng Zheng et al.
Prolonged sleep deprivation (SD) results in increased accumulation of reactive oxygen species (ROS) in gut, although the underlying mechanisms remain to be elucidated. This study identifies d-serine as a crucial regulator of gut ROS during ...
Manuel A Florez,Bing Q Li,David R Shelly et al.
Manuel A Florez et al.
The factors controlling the spatial distribution and temporal evolution of earthquake swarms in volcanic systems remain unclear. We leverage leading-edge deep learning algorithms and a detailed three-dimensional velocity model to construct ...
Acoustic technologies for the orchestration of cellular functions for therapeutic applications [0.03%]
声学技术在细胞功能治疗应用中的作用调控方面的作用
Ye He,Jianping Xia,John D H Mai et al.
Ye He et al.
Mechanical forces constantly stimulate cellular functions and influence their response behaviors. Similar to how an orchestra's music synchronizes an audience, acoustic technologies have emerged as precise, contact-free tools to study cellu...
Ternary Schottky-p-n heterojunction strategy for enhancing photothermal dry reforming of methane [0.03%]
用于增强甲烷光热干重整的三元肖特基- p-n异质结策略
Qingqing Zhang,Ziyu Chen,Yutao Ye et al.
Qingqing Zhang et al.
Breaking the trade-off between activity and stability in catalysts for dry reforming of methane has long remained a huge challenge. Here, we demonstrate a ternary Schottky-p-n (TSPN) heterojunction strategy based on Ni-NiO-Sr2Nb2O7 (NiOx/SN...
Quancheng Liu,Weijie Liu,Yuechen Jia et al.
Quancheng Liu et al.
Topological order in photonics, defined by pseudo-spin degrees of freedom, is traditionally static. By contrast, a unique quantum effect is that measurements alter system states. The convergence of these foundational concepts-measurement an...
Nicotinamide boosts oocyte quantity and quality by promoting N4-acetylation modification in lupus mice [0.03%]
尼克酸通过促进N-乙酰化修饰提高狼疮小鼠卵母细胞数量和质量
Yun Xie,Chuanchuan Zhou,Qi Guo et al.
Yun Xie et al.
Patients with systemic lupus erythematosus (SLE) often have decreased fertility. Gene translation is crucial to oocyte meiosis and development. However, it remains unclear how SLE affects this process. Here, we used single-cell transcriptom...
Proteolytic-resistant self-assembling peptide nanofibers combat specific bacterial infections via trap and kill [0.03%]
耐蛋白酶的自组装肽纳米纤维通过捕获和杀死的方式对抗特定细菌感染
Weikang Yu,Mengyi Zhao,Xu Guo et al.
Weikang Yu et al.
The rise in global antibiotic resistance highlights the urgent need for effective antimicrobial agents. Antimicrobial peptides (AMPs) offer a potential solution to combat bacterial resistance. However, key challenges remain in addressing th...
Seismic imaging reveals a strain-partitioned sliver and nascent megathrust at an incipient subduction zone in the northeast Pacific [0.03%]
地震成像揭示了东北太平洋初始俯冲带中应变分区的微地块和新生的大规模逆断层区
Collin C Brandl,Lindsay L Worthington,Emily C Roland et al.
Collin C Brandl et al.
The Queen Charlotte plate boundary (QCPB), a transform separating the Pacific and North American plates, accommodates ~55 millimeters per year of motion, is a source of large earthquakes in the northeast Pacific, and may be a modern site of...
Architecture mechanics mediated osteogenic progression in bone regeneration of artificial scaffolds [0.03%]
人工骨移植物支架的结构力学介导的成骨过程分析
Si-Yu Long,Ya-Jun Fu,Zheng-Min Zhang et al.
Si-Yu Long et al.
Scaffold architecture exerts a considerable influence on the osteogenic effect through stress transmission, as the deformation of scaffolds alters the mechanical microenvironment of cells adhering to scaffold surface. Despite extensive rese...