APOE+ macrophages and POSTN+CAFs form immune-exclusion niche driving immunotherapy resistance in clear-cell renal carcinoma [0.03%]
APOE+巨噬细胞和POSTN+癌相关成纤维细胞形成排除免疫治疗的免疫排斥生态位，驱动透明细胞肾细胞癌产生耐药性
Qintao Ge,Shengdong Ge,Zhongyuan Wang et al.
Qintao Ge et al.
Tumor immune barriers (TIBs) are spatially organized stromal-immune niches that restrict lymphocyte entry. To explain persistent immune-checkpoint blockade (ICB) resistance in clear cell renal cell carcinoma (ccRCC), we mapped TIBs and defi...
Zhengcai Ma,Juan Li,Xiaoduo Li et al.
Zhengcai Ma et al.
Metabolic dysfunction-associated steatohepatitis (MASH) is a prevalent and life-threatening liver disease with limited effective therapies, necessitating the urgent identification of previously unidentified molecular targets and effective p...
Periodic extreme rainfall in a warmer climate due to stronger convectively coupled waves [0.03%]
变暖气候下强耦合对流波导致的极端降水周期性事件增多
Heng Quan,Yi Zhang,Guy Dagan et al.
Heng Quan et al.
Tropical regions may experience periodic extreme precipitation and suffer from associated periodic deluges in a warmer climate. Recent studies conducted small-domain (around 100 kilometers by 100 kilometers) atmospheric model simulations an...
Experimental violation of a Bell-like causal inequality in a photonic quantum switch [0.03%]
贝尔因果不等式的光子量子开关实验违反实验
Dengke Qu,Quan Lin,Lei Xiao et al.
Dengke Qu et al.
Indefinite causal order can be realized by a quantum switch, yet its experimental certification has so far relied on assumptions about the devices. A device-independent verification of indefinite causal order would show, from the observed c...
Neural competition between prefrontal and auditory cortex constrains novel sound strategy learning [0.03%]
前额叶和听觉皮层之间的神经竞争限制了新型声音策略的学习
Kai Lu,Kelvin T Wong,Chengcheng J Yang et al.
Kai Lu et al.
In nature, animals learn to replace predisposed behaviors with new strategies, yet the neural constraints on these transitions are unclear. Using an ethological search task in mice, we reveal medial prefrontal cortical (mPFC) neural correla...
Zahra Basiri,Alessandro Tomasino,Gabriel Jülg et al.
Zahra Basiri et al.
Tunable lasers are essential for optical communication, spectroscopy, and precision sensing, where fast and stable wavelength control is required. Conventional tuning approaches rely on either current or temperature tuning, mechanical actua...
T cell-nanodrug conjugates synchronize vascular normalization and immune activation for solid tumor therapy [0.03%]
T细胞-纳米药物偶联物同步血管正常化和免疫激活用于实体瘤治疗
Xin Yang,Ye Su,Xiaoyun Ye et al.
Xin Yang et al.
Adoptive T cell therapy requires T cells to infiltrate vascular tissues and preserve immune function. In solid tumor treatment, however, the surrounding microenvironment produces abnormal vasculature that impedes T cell infiltration. An app...
3D genome organization in tissue regeneration involves long-range chromatin loops [0.03%]
组织再生中的三维基因组组织涉及长程染色质环化
Palmira Llorens-Giralt,Carlos Camilleri-Robles,Leo Zuber et al.
Palmira Llorens-Giralt et al.
The three-dimensional (3D) organization of the genome plays a fundamental role in gene expression regulation, yet how changes in genome architecture influence transcriptional responses during tissue regeneration remains poorly understood. H...
Tomonari Matsuo,Iris Hordijk,Lucy Amissah et al.
Tomonari Matsuo et al.
Succession is a foundational concept in ecology, describing changes in populations, communities, and ecosystems over time following a disturbance. Predicting successional pathways is challenging because of high spatiotemporal variability. H...
Global distribution and amplitudes of internal solitary waves revealed by SWOT [0.03%]
SWOT揭示的内部孤立波的全球分布及振幅特征
Xudong Zhang,Yinfei Zhou,Xiaochen Wang et al.
Xudong Zhang et al.
Internal solitary waves (ISWs) are powerful underwater disturbances that can vertically displace water by more than 200 meters, driving ocean mixing and affecting offshore engineering. Yet, their global distributions and vertical imprints r...