Assessing the risk of diseases with epidemic and pandemic potential in a changing world [0.03%]
评估一个变化中的世界中具有大流行潜力的疾病的危险性
Angela Fanelli,Alessandro Cescatti,Juan-Carlos Ciscar et al.
Angela Fanelli et al.
How do human activities contribute to the emergence of zoonotic diseases that can lead to epidemics and pandemics? Our analysis of common drivers of the World Health Organization's priority diseases suggests that climate conditions, includi...
A ventral pallidal glutamatergic aversive network encodes abstinence from and reexposure to cocaine [0.03%]
腹侧苍白球谷氨酸类厌恶网络编码可卡因的戒断和重新接触事件
Liran A Levi,Kineret Inbar,Esti Tseiger et al.
Liran A Levi et al.
Relapse to drugs of abuse can occur after long periods of abstinence. The ventral pallidum (VP) is central to drug addiction, and its glutamatergic neurons (VPGlu), whose activation drives aversion, inhibit drug seeking. However, it remains...
Flexible, nonfused sulfone functionalized polymer with enhanced active site access for photocatalytic sacrificial hydrogen evolution [0.03%]
一种柔性砜基官能团聚合物光催化剂用于提升析氢反应活性位点的可达性
Tse-Fu Huang,Kuei-Jhong Lin,Ying-Rang Zhuang et al.
Tse-Fu Huang et al.
The fused sulfone unit has been a key building block for hydrogen evolution photocatalysts for 9 years but still faces the challenge of a poor water/polymer interface due to its rigid structure. This work introduces nonfused, flexible sulfu...
A fossilized ventral ganglion reveals a chaetognath affinity for Cambrian nectocaridids [0.03%]
一件头盖化石揭示了刺胞动物门-nectocaridids之间的联系
Jakob Vinther,Luke A Parry,Mirinae Lee et al.
Jakob Vinther et al.
Nectocaridids are enigmatic Palaeozoic animals with a controversial phylogenetic position. Previous hypotheses have placed them in their own phylum, chordates, molluscs (specifically cephalopods), or radiodont panarthropods. We describe her...
Donghyeon Kang,Byung-Joon Park,Joon-Ha Hwang et al.
Donghyeon Kang et al.
Wireless power transfer-based neuromodulation has emerged as a promising alternative to battery-powered implants. However, its practical application is hindered by limited therapeutic efficacy resulting from low power transfer efficiency, s...
Eliane Seraina Meier,Alexander Indermaur,Eva Knop
Eliane Seraina Meier
Human-induced global change may cause the sixth mass extinction of species. The moderate success of patch-scale biodiversity conservation measures has led to the concept of creating biodiversity-friendly landscapes. However, these landscape...
Observations of a splitting ocean cyclone resulting in subduction of surface waters [0.03%]
关于海洋气旋分裂导致海表层海水沉降的观测结果
Leo Middleton,Weiguang Wu,T M Shaun Johnston et al.
Leo Middleton et al.
Earth's oceans contain large numbers of cyclonic eddies, 10 to 25 kilometers in diameter and unresolved in climate simulations. However, we lack observations of these features due to their small size and fast evolution. Here, we present in ...
Obtuse-angled separation of chiral resonances with planar asymmetry-induced tunability of quality factors [0.03%]
基于平面不对称的品质因子可调的手性共振尖锐分离
Minsu Jeong,Jihae Lee,Seokwoo Kim et al.
Minsu Jeong et al.
Photonic crystal (PhC) supports Bloch resonances that confine electromagnetic energy within the subwavelength thickness and enable polarization modulation through their intrinsic mode states. If a PhC generates chiral resonances, then it ca...
Engineering hybrid nanoparticles for targeted codelivery of triptolide and CYP3A4-siRNA against pulmonary metastatic melanoma [0.03%]
工程化杂合纳米颗粒用于三联递送三尖杉碱和CYP3A4-siRNA治疗肺转移性黑色素瘤研究
Yongwei Gu,Aixue Li,Yuanye Zeng et al.
Yongwei Gu et al.
Pulmonary metastatic melanoma (PMM) is an aggressive malignancy with limited response and rapid resistance to clinical chemotherapy, radiotherapy, immunotherapy, and biological therapies. Here, we developed a targeted biomimetic drug delive...
Neuropeptide Y neurons surrounding the locus coeruleus inhibit noradrenergic system activity to reduce anxiety [0.03%]
围绕蓝斑的神经肽Y神经元通过抑制去甲肾上腺素系统活性来缓解焦虑
Danai Riga,Karlijn L Kooij,Kelly Rademakers et al.
Danai Riga et al.
Adaptive responses to challenging environments depend on optimal function of the locus coeruleus (LC), the brain's main source of noradrenaline and primary mediator of the initial stress response. Combining functional circuit dissection and...