The microenvironment dictates glyco-immune surveillance via HSF1-mediated metabolism [0.03%]
微环境通过HSF1介导的代谢决定糖免疫监视
Kevin M Tharp,Sangwoo Park,Greg A Timblin et al.
Kevin M Tharp et al.
Altered glucose metabolism is an auspicious feature of solid tumors, but is it an intrinsic property of tumor cells or a metabolic adaptation to the tumor microenvironment? Using normal epithelial cells cultured in a physiological culture m...
Gaseous liquid nitrogen-assisted cryo-printing strategies for challenging volumetric anisotropic tissues fabrication [0.03%]
用于制造具有挑战性的体积各向异性组织的气体液氮辅助冷冻印刷策略
Zhiqiang Gao,Wanlu Li,Zeyu Luo et al.
Zhiqiang Gao et al.
Engineering physiologically relevant anisotropic tissues remains a major challenge due to limitations in replicating native structural cues across complex geometries. Here, we developed a cryogenic extrusion bioprinting platform by precisel...
Mengmeng Niu,Peng-Jie Guo,Yicheng Ma et al.
Mengmeng Niu et al.
Correlated and topological phases often coexist or compete in van der Waals materials, yet achieving an electrically switchable and reversible conversion between them remains a substantial challenge. Such control is crucial for understandin...
Uncovering PFAS and halogenated chemicals using nontargeted analysis and the PFAS IMplementer for mass spectrometry (PIMMS) [0.03%]
利用非目标分析和PFAS质谱实施程序(PIMMS)揭示PFAS和卤素化合物
Gregory P Kudzin,James N Dodds,Erin S Baker
Gregory P Kudzin
Per- and polyfluoroalkyl substances (PFASs) are synthetic chemicals of considerable epidemiological concern. While targeted liquid chromatography (LC)-tandem mass spectrometry (MS/MS) methods are established for legacy PFAS, emerging replac...
Qiang Gao,Gabriele Berruto,Khanh Duy Nguyen et al.
Qiang Gao et al.
Flat electronic bands enable fascinating emergent phenomena such as superconductivity and charge orders. A prevailing approach to realizing flat bands is to engineer lattice geometric constraints in twisted or kagome-like materials. An alte...
Direct visualization of RNA virus and evaluation of drug effect in living cells by catalytically transformable DNA cube [0.03%]
催化转换DNA立方体在活细胞内直接可视化RNA病毒和评估药物作用
Jiajia Liu,Qiming Yan,Hongbo Qin et al.
Jiajia Liu et al.
In situ visualization of viral RNA in living cells is critical for understanding infection dynamics and evaluating antiviral responses, yet offline methods such as polymerase chain reaction are incompatible with real-time analysis. Here, a ...
Formation of tertiary lymphoid structures drives Parkin antitumor immunity [0.03%]
Parkin抗肿瘤免疫促进三级淋巴组织的形成
Michela Perego,Andrew V Kossenkov,Jagadish C Ghosh et al.
Michela Perego et al.
Mitochondria activate immunity, but the role in cancer is unknown. Here, we report that transgenic expression of Parkin, a regulator of mitochondrial fitness, induces inflammation and interferon (IFN) gene signatures, suppresses prostate ca...
Decoding the chemical space of fast-ion conductors via a descriptor-guided transfer learning framework [0.03%]
基于描述符引导的迁移学习框架探索快速离子导体化学空间
Zhilong Wang,Fengqi You
Zhilong Wang
Fast-ion conductors (FICs) are key components for next-generation high-performance batteries, yet predicting ion mobility remains challenging because of the unclear transport mechanisms. This difficulty is further compounded by experimental...
Holly V Moeller,Erica Lasek-Nesselquist,Zachary L Reitz et al.
Holly V Moeller et al.
Stable acquisitions of metabolism, such as the endosymbiotic incorporation of eukaryotic chloroplasts, are thought to proceed through mechanisms that increase the genetic repertoire of the host and allow for vertical integration of new meta...
Ribosomal protein bL27 protects translating ribosomes from tmRNA-SmpB [0.03%]
核糖体蛋白bL27保护翻译中的核糖体免受tmRNA-SmpB的影响
Divyasorubini Seerpatham,George Wanes,Chathuri Pathirage et al.
Divyasorubini Seerpatham et al.
Bacterial ribosomal protein bL27 is universally conserved, and its amino terminus is adjacent to the peptidyl transfer center, yet its roles in translation remain unclear. Combining genetics, biochemistry, and molecular dynamics, we show th...