Bacterial enzyme-responsive hydrogels for triggered delivery of antibiotics to infected wounds [0.03%]
Akram Abbasi,Alec McCall,Zhaowei Jiang et al.
Akram Abbasi et al.
Wound infections are becoming increasingly difficult to treat due to rising antibiotic-resistant bacteria. β-Lactamase-producing bacteria are among the most common pathogens implicated in these infections. Here, we report a bacterial enzym...
Ultrasensitive soft vibration sensors based on atomically thin metal dichalcogenide ribbon networks [0.03%]
Chengyi Xu,Xufan Li,Lukas Felix Michalek et al.
Chengyi Xu et al.
The rapid progress of artificial intelligence (AI) and the internet of things (IoT) has driven growing demand for high-performance, skin-compatible vibration sensors capable of capturing subtle physiological and environmental signals. Low-d...
Membrane-associated Rhes-Slc4a7 complex orchestrates tunneling nanotube formation and mutant Huntingtin spread [0.03%]
Sunayana Dagar,Alexandra Fernandez,Uri Nimrod Ramírez-Jarquín et al.
Sunayana Dagar et al.
Tunneling nanotubes (TNTs) are membranous structures that mediate intercellular transfer of proteins, including the pathogenic mutant Huntingtin (mHTT) protein in Huntington disease (HD). We previously identified the ras homolog enriched in...
Dengue infection elicits skin tissue-resident and circulating CD8+ T cells associated with protection from hospitalization [0.03%]
Noor Zayanah Hamis,Justin Sg Ooi,Ka-Wai Cheung et al.
Noor Zayanah Hamis et al.
Dengue is spreading globally, and there is urgent need to define immune correlates of protection for this disease. Dengue infection first occurs in the skin following the bite of an infected mosquito; however, knowledge of host immune respo...
Conformational dynamics of SARS-CoV-2 spike on a membrane reveals the allosteric effects of furin cleavage and the D614G mutation [0.03%]
Sophie R Shoemaker,Megan Luo,Kim-Marie A Dam et al.
Sophie R Shoemaker et al.
By combining hydrogen-deuterium exchange monitored by mass spectrometry (HDX-MS) with the ability of enveloped virus-like particles (eVLPs) to display full-length native-like severe acute respiratory syndrome coronavirus 2 spike protein, we...
H James Choi,Teresa W Lo,Kevin J Cutler et al.
H James Choi et al.
Protein expression levels optimize cell fitness: Too low an expression level of essential proteins will slow growth by compromising essential processes, whereas overexpression slows growth by increasing the metabolic load. This trade-off na...
HfO2-based memristive synapses with asymmetrically extended p-n heterointerfaces for highly energy-efficient neuromorphic hardware [0.03%]
Babak Bakhit,Xiao Xie,Simon M Fairclough et al.
Babak Bakhit et al.
The escalating energy consumption of existing artificial intelligence hardware has become a serious global issue that demands immediate action. Neuromorphic computing offers promises to drastically reduce this footprint. Here, we introduce ...
Steven Henikoff,Jorja G Henikoff
Steven Henikoff
microRNAs are ~22-nucleotide RNAs processed from primary transcripts and exported from the nucleus to repress gene expression by base-pairing to mRNAs. Unexpectedly, we find that the highest levels of RNA polymerase II (Pol II) at human mic...
Transcriptional readthrough precedes alternative splicing programs triggered in CML cells by imatinib [0.03%]
Paulina Podszywałow-Bartnicka,Morgan Shine,Jing Lin et al.
Paulina Podszywałow-Bartnicka et al.
Cellular stresses regulate transcriptional readthrough, whereby RNA polymerase II elongates past a gene's polyadenylation cleavage site without RNA cleavage. Readthrough has been reported in several cancer types. Here, we use long-read sequ...
Zihua Chai,Zeyu Gao,Mengqi Wang et al.
Zihua Chai et al.
The rapid development of the Internet of Things and the digital information era has intensified the demand for secure hardware and information systems. Physical unclonable functions (PUFs) provide a hardware-based approach by exploiting fab...