Natural noncoding pumilio variants retune value-coding interneurons to bias Drosophila oviposition decisions [0.03%]
天然非编码pumilio变体通过调节价值编码中间神经元来偏向果蝇产卵决定
Dorsa Motevalli,Robert Alfredson,Sydney Fogleman et al.
Dorsa Motevalli et al.
How natural regulatory genetic variation creates innate biases in economic decisions through modifying circuit structure and function is rarely explored. Here, we trace this link in a simple value-based decision in Drosophila: where to ovip...
Uniaxial spin texture in a superconducting electron gas revealed by exchange interactions [0.03%]
交换相互作用揭示出超导电子气中的一维自旋构型
Junyi Yang,Changjiang Liu,Xianjing Zhou et al.
Junyi Yang et al.
Two-dimensional (2D) superconductors with spin-textured Fermi surfaces can be a platform for realizing unconventional pairing states and are of substantial interest in the context of quantum information science and superconducting spintroni...
The pleuroparenchymal fibroelastosis atlas reveals aberrant cell states and their zonation as an alternate roadmap to lung fibrosis [0.03%]
肺纤维化pleuroparenchymal fibroelastosis图谱揭示了异常细胞状态及其区带化作为替代的肺纤维化路线图
Jannik Ruwisch,Aurélie Cazes,Lena M Leiber et al.
Jannik Ruwisch et al.
Pleuroparenchymal fibroelastosis (PPFE) is a progressive interstitial lung disease (ILD) with defining histology of intra-alveolar fibrosis with septal elastosis (AFE), suggesting unique cellular disease processes. Here, we present a binati...
Symmetric instability drives exchange between surface and bottom waters in a coastal front [0.03%]
对称不稳定驱动沿海锋面表层水与底层水交换
Mareike Körner,Jesse M Cusack,Jonathan Nash et al.
Mareike Körner et al.
The coastal ocean in the northern Gulf of Mexico is highly productive and socioeconomically important. Here, stratification can inhibit vertical exchange, with consequences for ecosystem health and hypoxia. Previous work emphasized the role...
Protein language models accurately predict polymorphic peptide-modulated NK cell receptor-HLA class I interaction strengths [0.03%]
蛋白质语言模型可准确预测多形肽调节的自然杀伤细胞受体-I类主要组织相容性复合体相互作用强度
Abdallah AlShafey,Madeline Nelson,Mubasher Hassan et al.
Abdallah AlShafey et al.
Killer-cell immunoglobulin-like receptors (KIRs) are key determinants of natural killer cell function and are associated with the outcomes of infective, inflammatory, and neoplastic diseases. They form a polymorphic family of activating and...
A unified mechanism for tubulin cofactors catalyzing α/β-tubulin biogenesis and degradation [0.03%]
角蛋白辅因子催化α/β-角蛋白生物发生和降解的统一机制
Aryan Taheri,Md Ashaduzzaman,Vishv Gill et al.
Aryan Taheri et al.
Microtubules polymerize from cytoplasmic pools of soluble αβ-tubulin heterodimers that support diverse cellular functions. The tubulin cofactors, TBCC, TBCD, and TBCE and the Arl2 GTPase, form TBC-DEG assemblies that regulate the assembly...
Ampere-level furfurylamine electrosynthesis enabled by high-density atomic copper sites and a well-engineered electrolysis reactor [0.03%]
高密度原子态铜位点和优化电解槽助力安培级呋喃胺电合成
Weiliang Zhou,Qihua Huo,Shuai Qi et al.
Weiliang Zhou et al.
Furfurylamine is an essential feedstock for diverse agrochemicals and pharmaceuticals; however, industrial-scale thermochemical furfurylamine production is plagued by high energy consumption and considerable greenhouse gas emissions. Here, ...
Hydrogen-carbon doubly superionic conduits of carbonic acids in planetary ices [0.03%]
行星冰中碳酸的氢碳双超离子导体通道
Jun Deng,Huiyang Gou,Qingyang Hu
Jun Deng
Recent astronomical observations show that carbon dioxide (CO2) is widespread on planetary bodies, often coexisting with water (H2O). Crystalline carbonic acid (H2CO3), produced from CO2-H2O interactions, has been predicted and synthesized ...
RAB5c orchestrates LC3-associated phagocytosis to promote microbicidal function of macrophages [0.03%]
RAB5c通过调控LC3相关吞噬作用促进巨噬细胞的杀菌功能
Edismauro Garcia Freitas-Filho,Isabella Zaidan,Daniel Leonardo Alzamora-Terrel et al.
Edismauro Garcia Freitas-Filho et al.
Noncanonical conjugation of ATG8 proteins, including LC3, to single membranes implicates the autophagy machinery in cell functions unrelated to metabolic stress. One such pathway is LC3-associated phagocytosis (LAP), which aids in phagosome...
Spatial reorganization of object representations in high-level visual cortex distinguishes working memory from perception [0.03%]
高级视觉皮层中的物体表征空间重组使工作记忆区别于感知
Wanru Li,Jia Yang,Pinglei Bao
Wanru Li
The visual system balances veridical object perception with flexible visual working memory (VWM), both engaging high-level visual regions. However, how these competing demands shape object-selective cortex (OSC) representations remains uncl...