Photothermal catalysis versus thermal catalysis: A palladium-catalyzed intermolecular three-component C─H 1,3- N, O-difunctionalization [0.03%]
He-Yuan Bai,Kai Tang,Zi-Hao Li et al.
He-Yuan Bai et al.
Although transition metal-catalyzed C─H activation has notably advanced C─H functionalization, achieving highly selective C─H difunctionalization remains a substantial challenge. Current C─H difunctionalization strategies remain largely...
Kavan Gor,Eva Maria Geissen,Olivier Duss
Kavan Gor
RNA structure starts forming cotranscriptionally as the nascent RNA emerges from the RNA polymerase and is dynamically modulated by cellular factors. How individual RNA conformations, out of an ensemble of RNA molecules, relate to function ...
Regulation of sodium/calcium homeostasis by BacNav gene therapy rescues cardiac dysfunction in chronic heart failure [0.03%]
Tianyu Wu,Yongwu Li,Robin M Perelli et al.
Tianyu Wu et al.
Despite continued progress, therapies to augment contractile function and prevent arrhythmias in patients with heart failure remain limited. Here, we present a two-pronged gene therapy approach that simultaneously augments peak Na+ current ...
Haoze Sun,Gabriel Alkuino,Yinding Chi et al.
Haoze Sun et al.
Mechanical metamaterials achieve multistep, programmable responses through sequential deformation driven by snapping instabilities, yet these sequences are typically governed by unavoidable imperfections, resulting in random and uncontrolla...
A reconfigurable dielectric elastomer actuator via phase-transitional ferrofluid enables sustainable operation [0.03%]
Yun Hyeok Lee,Seung Won Moon,Min-Gyu Lee et al.
Yun Hyeok Lee et al.
Dielectric elastomer actuators (DEAs) are promising soft transducers capable of rapid and precise actuation. However, their conventional architecture for efficient actuation confines DEAs in predesigned operational modes, leading to limited...
A unified ab initio theory of spin-phonon relaxation and decoherence uncovers fast dephasing in magnetic molecules [0.03%]
Alessandro Lunghi
Alessandro Lunghi
Spin-phonon interactions are known to drive magnetic relaxation in solid-state systems but are generally overlooked as a contribution to spin decoherence through dephasing. Here, we extend quantum master equations to account for coherence t...
Aleksandra Dagunts,Hayden Adoff,Brandon Novy et al.
Aleksandra Dagunts et al.
A critical homeostatic mechanism for regulating G protein-coupled receptor (GPCR) activity is agonist-induced GPCR endocytosis and trafficking to the lysosome for proteolytic down-regulation. The mu opioid receptor (MOR) is a notable exampl...
Jin Zhang,Tian Wei,Yong-Wei Xiong et al.
Jin Zhang et al.
Recently, the perspective of paternal origin has emerged, yet its role in motor disorders remains unclear. Here, using Drosophila and murine models, we demonstrated that following paternal environmental heavy metal stress, offspring from mu...
Sugarcane streak mosaic virus P1 protein targets the BES1 transcription factor to subvert DAMP-triggered immunity in plant [0.03%]
Zhen He,Xiaolong Deng,Haoyu Chen et al.
Zhen He et al.
Sugarcane streak mosaic virus (SCSMV) is the major cause of sugarcane mosaic disease. Its P1 protein (P1SCSMV) is crucial for pathogenesis, but how it disrupts plant immunity remains unclear. Here, we found that P1SCSMV directly binds to th...
Atmospheric transport and deposition of PFAS in East Antarctica: Evidence from snow transect measurements and a multidecadal record [0.03%]
Xiaotong Li,Minmin Hou,Su Jiang et al.
Xiaotong Li et al.
The occurrence of per- and polyfluoroalkyl substances (PFAS) in Antarctica has been previously reported; however, the mechanisms of their inland penetration and the interplay between their depositional histories and interhemispheric transpo...