Efficacy and safety of KN026, a bispecific anti-HER2 antibody, in combination with KN046, an anti-CTLA4/PD-L1 antibody, in patients with advanced HER2-positive nonbreast cancer: a combined analysis of a phase Ib and a phase II study [0.03%]
KN026（一种双特异性抗HER2抗体）与KN046（一种抗CTLA4/PD-L1抗体）联用治疗晚期HER2阳性非乳腺癌患者的疗效和安全性：一项Ib期和II期研究的联合分析
Dan Liu,Jifang Gong,Jian Li et al.
Dan Liu et al.
To evaluate the efficacy and safety of KN026, a novel bispecific HER2 (ECD2 and ECD4) antibody, plus KN046, a PD-L1, and CTLA4 bispecific antibody, in patients with advanced HER2-positive solid tumors. We conducted two sequentially designed...
Massively parallel interrogation of human functional variants modulating cancer immunosurveillance [0.03%]
大规模并行检测人类功能变异调节癌症免疫监视
Ying Liu,Yongshuo Liu,Xuran Niu et al.
Ying Liu et al.
Anti-PD-1/PD-L1 immune checkpoint blockade (ICB) therapy has revolutionized clinical cancer treatment, while abnormal PD-L1 or HLA-I expression in patients can significantly impact the therapeutic efficacy. Somatic mutations in cancer cells...
Cytosolic nucleic acid sensing as driver of critical illness: mechanisms and advances in therapy [0.03%]
细胞质核酸感应作为驱动重症的机制及其治疗进展
Zhaorong Chen,Rayk Behrendt,Lennart Wild et al.
Zhaorong Chen et al.
Nucleic acids from both self- and non-self-sources act as vital danger signals that trigger immune responses. Critical illnesses such as acute respiratory distress syndrome, sepsis, trauma and ischemia lead to the aberrant cytosolic accumul...
Photodynamic gel-bombs enhance tumor penetration and downstream synergistic therapies [0.03%]
光动力凝胶炸弹可提高肿瘤渗透性及下游联合治疗效果
Xiaole Bai,Fanliang Meng,Xuejiao Wang et al.
Xiaole Bai et al.
Nanoparticle-based drug delivery system remains a significant challenge in the current treatment of solid tumors, primarily due to their limited penetration capabilities. Herein, we successfully engineer photodynamic gel-bombs (DCM@OPR) cap...
Monocyte-lineage tumor infiltration predicts immunoradiotherapy response in advanced pretreated soft-tissue sarcoma: phase 2 trial results [0.03%]
单核细胞系肿瘤浸润预测晚期治疗前软组织肉瘤的免疫放射治疗反应：二期试验结果
Antonin Levy,Daphné Morel,Matthieu Texier et al.
Antonin Levy et al.
Immunoradiotherapy holds promise for improving outcomes in patients with advanced solid tumors, including in soft-tissue sarcoma (STS). However, the ideal combination of treatment modalities remains to be determined, and reliable biomarkers...
Systemic lupus erythematosus: updated insights on the pathogenesis, diagnosis, prevention and therapeutics [0.03%]
系统性红斑狼疮：发病机理、诊断、预防和治疗的最新见解
Xiaofeng Dai,Yuting Fan,Xing Zhao
Xiaofeng Dai
Systemic lupus erythematosus (SLE) is a chronic inflammatory illness with heterogeneous clinical manifestations covering multiple organs. Diversified types of medications have been shown effective for alleviating SLE syndromes, ranging from...
Targeting tumor-intrinsic S100 calcium-binding protein A1 augments antitumor immunity and potentiates immunotherapy efficacy [0.03%]
靶向肿瘤内在的S100钙结合蛋白A1可增强抗肿瘤免疫并提高免疫治疗疗效
Yufeng Guo,Rui Wan,Jianchun Duan et al.
Yufeng Guo et al.
Immune checkpoint blockade (ICB) has revolutionized cancer treatment, but the therapeutic response is highly heterogeneous, which highlights the necessity for developing predictive biomarkers and overcoming ICB resistance. Cancer cell-intri...
PD-1 antibody camrelizumab plus apatinib and SOX as first-line treatment in patients with AFP-producing gastric or gastro-esophageal junction adenocarcinoma (CAP 06): a multi-center, single-arm, phase 2 trial [0.03%]
抗PD-1抗体卡瑞利珠单抗联合阿帕替尼和SOX作为AFP阳性胃或胃食管结合部腺癌患者一线治疗（CAP 06）：一项多中心、单臂、二期试验
Yakun Wang,Jialin Lu,Xiaoyi Chong et al.
Yakun Wang et al.
Alpha-fetoprotein-producing gastric or gastro-esophageal junction (AFP-G/GEJ) cancer, a rare gastric cancer subtype, exhibits increased angiogenesis and more immunosuppression than non-AFP-G/GEJ cancer. The potential benefits of anti-angiog...
Tina Kos,Dieter Saur
Tina Kos
Enhancer transcription profiling reveals an enhancer RNA-driven ferroptosis and new therapeutic opportunities in prostate cancer [0.03%]
增强子转录谱分析揭示了前列腺癌中由增强子RNA驱动的铁死亡及新的治疗机会
Sheng Ma,Zixian Wang,Zezhong Xiong et al.
Sheng Ma et al.
Enhancer RNAs (eRNAs), a subclass of non-coding RNAs transcribed from enhancer regions, have emerged as critical regulators of gene expression; however, their functional roles in prostate cancer remain largely unexplored. In this study, we ...