Immunological synapse: structures, molecular mechanisms and therapeutic implications in disease [0.03%]
免疫突触：结构、分子机制及其在疾病治疗中的应用
Zheng Chao,Qi Mei,Chunguang Yang et al.
Zheng Chao et al.
The immunological synapse (IS) serves as the fundamental architectural framework for direct interactions and secretory crosstalk between immune cells, as well as between immune cells and other cells. Its dysregulation is thought to be a key...
AAV for gene therapy drives a nephrotoxic response via NFκB in kidney organoids [0.03%]
腺相关病毒载体基因治疗通过NFκB诱导肾脏类器官发生肾毒性反应
Navin Gupta,Ke Zhang,Venkata Sabbisetti et al.
Navin Gupta et al.
Yichu Fu,Binhan Wang,Aqu Alu et al.
Yichu Fu et al.
Immunosenescence refers to the abnormal activation or dysfunction of the immune system as people age. Inflammaging is a typical pathological inflammatory state associated with immunosenescence and is characterized by excessive expression of...
Finotonlimab (PD-1 inhibitor) plus bevacizumab (bevacizumab biosimilar) as first-tier therapy for late-stage hepatocellular carcinoma: a randomized phase 2/3 trial [0.03%]
派姆利尤单抗联合贝伐珠单抗作为晚期肝细胞癌一线治疗的疗效：一项随机II/III期试验
Chuanhua Zhao,Yanqiao Zhang,Gang Wang et al.
Chuanhua Zhao et al.
We aimed to assess the tolerability and efficacy of finotonlimab (an anti-programmed cell death protein-1 antibody) in combination with SCT510, a bevacizumab biosimilar, versus sorafenib in unresectable advanced HCC. This randomized phase 2...
Novel atypical G protein-coupled receptor (GPCR)-arrestin complexes: a structural snapshot of the barcode hypothesis [0.03%]
新型非典型G蛋白偶联受体(GPCR)- Arrestin复合物：条形码假说的结构快照
Jenny C Filor,Edda S F Matthees,Carsten Hoffmann
Jenny C Filor
Islet environment and development of type 1 diabetes in the biobreeding rat model [0.03%]
生物繁殖大鼠模型中的胰岛环境与1型糖尿病的发展关系研究
Patricia Recio-López,Per-Olof Berggren,Montserrat Visa Majoral et al.
Patricia Recio-López et al.
Cancer stem cells: landscape, challenges and emerging therapeutic innovations [0.03%]
癌症干细胞：研究概览、面临的挑战及新兴治疗策略创新发展方向展望
Haksoo Lee,Byeongsoo Kim,Junhyeong Park et al.
Haksoo Lee et al.
Cancer stem cells (CSCs) constitute a highly plastic and therapy-resistant cell subpopulation within tumors that drives tumor initiation, progression, metastasis, and relapse. Their ability to evade conventional treatments, adapt to metabol...
mTOR inhibition sensitizes T-ALL cells to Venetoclax through engagement of the integrated stress response [0.03%]
mTOR抑制通过整合应激反应使T-急性淋巴细胞白血病细胞对维奈克拉敏感化
Loredana Urso,Irene Bertazzolo,Alberto Corradin et al.
Loredana Urso et al.
Hongxiang Du,Tianhan Xu,Sihui Yu et al.
Hongxiang Du et al.
Mitochondria are dynamic organelles that are essential for cellular energy generation, metabolic regulation, and signal transduction. Their structural complexity enables adaptive responses to diverse physiological demands. In cancer, mitoch...
Targeting AKR1B1 inhibits metabolic reprogramming to reverse systemic therapy resistance in hepatocellular carcinoma [0.03%]
靶向AKR1B1抑制代谢重编程以逆转肝细胞癌的全身治疗耐药性
Qi Wang,Juan Liu,Ming Yang et al.
Qi Wang et al.
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, and resistance to systemic therapies remains a significant clinical challenge. This study investigated the mechanisms by which metabolic reprogramming contribute...