Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy [0.03%]
运动诱导的微生物代谢物通过促进免疫治疗效果来增强CD8 T细胞抗肿瘤免疫力
Catherine M Phelps,Nathaniel B Willis,Tingting Duan et al.
Catherine M Phelps et al.
Exercise improves immune checkpoint inhibitor (ICI) efficacy in cancers such as melanoma; however, the mechanisms through which exercise mediates this antitumor effect remain obscure. Here, we identify that the gut microbiota plays a critic...
Modeling the vertebrate regulatory sequence landscape by UUATAC-seq and deep learning [0.03%]
UUATAC-seq和深度学习建模脊椎动物调控序列图谱
Xiaoping Han,Hanyu Wu,Xueyi Wang et al.
Xiaoping Han et al.
The regulatory sequences of vertebrate genomes remain incompletely understood. To address this, we developed an ultra-throughput, ultra-sensitive single-nucleus assay for transposase-accessible chromatin using sequencing (UUATAC-seq) protoc...
Structures of the measles virus polymerase complex with non-nucleoside inhibitors and mechanism of inhibition [0.03%]
携带非核苷抑制剂的麻疹病毒复制酶复合体结构及抑制机制研究
Yiru Wang,Lixia Zhao,Yi Zhang et al.
Yiru Wang et al.
The measles virus (MeV), a highly contagious non-segmented negative-sense RNA virus in the Paramyxoviridae family, causes millions of infections annually, with no approved antivirals available. The viral polymerase complex, comprising the l...
Advancing protein evolution with inverse folding models integrating structural and evolutionary constraints [0.03%]
基于结构和进化约束的逆向折叠模型推动蛋白质进化
Hongyuan Fei,Yunjia Li,Yijing Liu et al.
Hongyuan Fei et al.
Protein engineering enables artificial protein evolution through iterative sequence changes, but current methods often suffer from low success rates and limited cost effectiveness. Here, we present AI-informed constraints for protein engine...
A natural gene on-off system confers field thermotolerance for grain quality and yield in rice [0.03%]
水稻田间高温抗性自然基因开关型调控系统可保护籽粒品质和产量
Wei Li,Ke Yang,Chaofan Hu et al.
Wei Li et al.
Published Erratum
Cell. 2025 Jul 3:S0092-8674(25)00744-5. DOI:10.1016/j.cell.2025.06.041 2025
Recessive epistasis of a synonymous mutation confers cucumber domestication through epitranscriptomic regulation [0.03%]
同义突变通过表转录调控制约黄瓜驯化
Tongxu Xin,Zhen Zhang,Yueying Zhang et al.
Tongxu Xin et al.
Synonymous mutations, once known as "silent" mutations, are increasingly attracting the interest of biologists. Although they may affect transcriptional or post-transcriptional processes, their impact on biological traits remains under-inve...
Development of clinically viable non-muscle myosin II small molecule inhibitors [0.03%]
临床可行的非肌肉肌球蛋白II小分子抑制剂的研发
Laszlo Radnai,Erica J Young,Carlos Kikuti et al.
Laszlo Radnai et al.
Non-muscle myosin II (NMII), a molecular motor that regulates critical processes such as cytokinesis and neuronal plasticity, has substantial therapeutic potential. However, translating this potential to in vivo use has been hampered by a l...
Proximity between LAG-3 and the T cell receptor guides suppression of T cell activation and autoimmunity [0.03%]
LAG-3与T细胞受体的距离指导T细胞激活和自身免疫的抑制作用
Jasper Du,Hui Chen,Jia You et al.
Jasper Du et al.
Therapeutically targeting pathogenic T cells in autoimmune diseases has been challenging. Although LAG-3, an inhibitory checkpoint receptor specifically expressed on activated T cells, is known to bind to major histocompatibility complex cl...
Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids [0.03%]
中胚层和内胚叶的共开发使得能够在肺和肠道类器官中实现组织特异性血管化
Yifei Miao,Nicole M Pek,Cheng Tan et al.
Yifei Miao et al.
The vasculature and mesenchyme exhibit distinct organ-specific characteristics adapted to local physiological needs, shaped by microenvironmental and cell-cell interactions from early development. To recapitulate this entire process, we co-...
Deconstructing the intercellular interactome in vascular dementia with focal ischemia for therapeutic applications [0.03%]
血管性痴呆伴局灶性缺血的细胞间相互作用网络的解析及其治疗应用
Min Tian,Riki Kawaguchi,Yang Shen et al.
Min Tian et al.
Vascular dementia (VaD), the second-leading cause of dementia, is primarily a white matter ischemic disease with no direct therapies. Cell-cell interactions within lesion sites dictate disease progression or repair. To elucidate key interce...