Plant cell wall-plasma membrane attachments mediate stress resilience through cellulose synthase complexes and remorins [0.03%]
细胞壁-质膜连接通过胞质素复合体和remorin介导胁迫抗逆性
Yue Rui,Magda Zaoralová,William P Dwyer et al.
Yue Rui et al.
The outer cell surface of an organism is the frontline for detecting and responding to environmental stimuli. In plants, this interface consists of the plasma membrane that lies beneath the cell wall and remains associated with it through a...
Explosive cytotoxicity of ruptoblasts bridges hormone surveillance and immune defense [0.03%]
裂细胞爆破解开了激素监视与免疫防御之间的桥梁作用
Chew Chai,Eliya Sultan,Souradeep R Sarkar et al.
Chew Chai et al.
Current understanding of cytotoxic immunity is shaped by hematopoietic-derived cells-T cells, natural killer cells, and neutrophils. Here, we identify "ruptoblasts," a previously unknown cytotoxic glandular cell type in regenerative planari...
Physiological brain clearance architecture revealed by neuronal protein tracing [0.03%]
神经蛋白追踪揭示生理脑清除结构
Yuichi Chayama,Nalini R Rao,Daniela Perla et al.
Yuichi Chayama et al.
The brain must efficiently clear protein waste to maintain homeostasis, yet physiological drainage pathways remain poorly defined. Standard tracer injection approaches may not reflect endogenous efflux. Here, we develop a non-invasive genet...
Yanxin Li,Zhongqiu Li,Yong She et al.
Yanxin Li et al.
The human meninges are essential regulators of central nervous system (CNS) development and homeostasis. However, a comprehensive spatiotemporal characterization of the cellular and molecular dynamics during human meninges development is cu...
Fronto-insular circuit mechanisms of accelerated intermittent theta burst stimulation [0.03%]
加速间歇θ爆发刺激的 frontal-insular 回路机制
Shane B Johnson,Devin Rocks,Laura Chalençon et al.
Shane B Johnson et al.
Published Erratum
Cell. 2026 May 29:S0092-8674(26)00580-5. DOI:10.1016/j.cell.2026.05.021 2026
A causal link between autoantibodies and neurological symptoms in long COVID [0.03%]
长新冠患者自身抗体与神经症状之间存在因果关系
Keyla Santos Guedes de Sá,Julio Silva,Rafael Bayarri-Olmos et al.
Keyla Santos Guedes de Sá et al.
Acute SARS-CoV-2 infection triggers the de novo production of diverse, functional autoantibodies (AABs) that remain elevated in long COVID (LC), but their pathogenic role remains unclear. Using tissue-based immunofluorescence, ELISA, human ...
Jinlong Y Lu,William B Tu,Shuai Ma et al.
Jinlong Y Lu et al.
Aging is characterized by the loss of tissue homeostasis, traditionally captured by the hallmarks of aging, yet how these hallmarks integrate to drive organismal decline remains unresolved. We propose mesenchymal drift, a process in which c...
B cells just got a workout [0.03%]
B细胞锻炼一下
Maria E Moreno-Fernandez,Senad Divanovic
Maria E Moreno-Fernandez
In this issue of Cell, Mao et al. reveal that B cells play an unexpected, immune-independent role in exercise physiology by facilitating multi-organ communication. Secreting TGF-β1, they transcriptionally reprogram hepatic glutamine metabo...
Autoantibodies in long COVID: A mechanistic foothold in a heterogeneous disease [0.03%]
长期新冠中的自身抗体：在异质性疾病中寻找机制切入点
Emma C Wall,Alex G Richter
Emma C Wall
Long COVID is a heterogeneous, multi-system disease that poses challenges for patients, health systems, and economies. Two papers in Cell and Cell Reports Medicine from independent groups suggest that autoantibodies in a subset of long COVI...
Per Uhlén
Per Uhlén
Two studies in this issue of Cell, by Bintu et al. and Brann et al., overturn the long-standing zonal model of olfactory receptor organization. Using image-based spatial transcriptomics, they reveal that receptors occupy reproducible positi...