ALDH7A1 protects against ferroptosis by generating membrane NADH and regulating FSP1 [0.03%]
醛脱氢酶7家族成员A1通过产生膜NADH和调节FSP1来对抗铁死亡防护作用
Jia-Shu Yang,Andrew J Morris,Koki Kamizaki et al.
Jia-Shu Yang et al.
Ferroptosis is a form of cell death due to iron-induced lipid peroxidation. Ferroptosis suppressor protein 1 (FSP1) protects against this death by generating antioxidants, which requires nicotinamide adenine dinucleotide, reduced form (NADH...
Precision proteogenomics reveals pan-cancer impact of germline variants [0.03%]
精准的蛋白质基因组学揭示了胚系变异的肿瘤通用影响规律
Fernanda Martins Rodrigues,Nadezhda V Terekhanova,Kathleen J Imbach et al.
Fernanda Martins Rodrigues et al.
We investigate the impact of germline variants on cancer patients' proteomes, encompassing 1,064 individuals across 10 cancer types. We introduced an approach, "precision peptidomics," mapping 337,469 coding germline variants onto peptides ...
Integrator loss leads to dsRNA formation that triggers the integrated stress response [0.03%]
整合子丢失导致dsRNA形成从而触发整合应激反应
Apoorva Baluapuri,Nicole ChenCheng Zhao,Ryan J Marina et al.
Apoorva Baluapuri et al.
Integrator (INT) is a metazoan-specific complex that targets promoter-proximally paused RNA polymerase II (RNAPII) for termination, preventing immature RNAPII from entering gene bodies and functionally attenuating transcription of stress-re...
A two-step self-pollination mechanism maximizes fertility in Brassicaceae [0.03%]
白花囊泡的两步自花粉机制可使其受精能力最大化
Pu Liu,Xin Quan,Zihan Song et al.
Pu Liu et al.
Self-pollination in self-compatible plant species often occurs prior to flower opening. By tracking the temporal progress of pollination in Arabidopsis, we observed that pollen predominantly targets the lateral region of the stigma in unope...
An Arabidopsis single-nucleus atlas decodes leaf senescence and nutrient allocation [0.03%]
拟南芥单细胞核图谱解析叶片衰老和营养再分配机制
Xing Guo,Yichuan Wang,Caiyao Zhao et al.
Xing Guo et al.
With rapid advancements in single-cell RNA sequencing (scRNA-seq) technologies, exploration of the systemic coordination of critical physiological processes has entered a new era. Here, we generated a comprehensive Arabidopsis single-nucleu...
Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity [0.03%]
工程改造TCR控制的模糊逻辑至CAR-T细胞可提高治疗特异性
Taisuke Kondo,François X P Bourassa,Sooraj Achar et al.
Taisuke Kondo et al.
Chimeric antigen receptor (CAR) T cell immunotherapy represents a breakthrough in the treatment of hematological malignancies, but poor specificity has limited its applicability to solid tumors. By contrast, natural T cells harboring T cell...
Extracellular respiration is a latent energy metabolism in Escherichia coli [0.03%]
胞外呼吸是大肠杆菌的潜在能量代谢方式
Biki Bapi Kundu,Jayanth Krishnan,Richard Szubin et al.
Biki Bapi Kundu et al.
Diverse microbes utilize redox shuttles to exchange electrons with their environment through mediated extracellular electron transfer (EET), supporting anaerobic survival. Although mediated EET has been leveraged for bioelectrocatalysis for...
Extensive N4 cytosine methylation is essential for Marchantia sperm function [0.03%]
N4 岛状胞嘧啶甲基化对地钱精子功能至关重要
James Walker,Jingyi Zhang,Yalin Liu et al.
James Walker et al.
N4-methylcytosine (4mC) is an important DNA modification in prokaryotes, but its relevance and even its presence in eukaryotes have been mysterious. Here we show that spermatogenesis in the liverwort Marchantia polymorpha involves two waves...
Engineered nucleocytosolic vehicles for loading of programmable editors [0.03%]
用于装载可编程编辑器的工程化核质运输载体
Julian Geilenkeuser,Niklas Armbrust,Emily Steinmaßl et al.
Julian Geilenkeuser et al.
Advanced gene editing methods have accelerated biomedical discovery and hold great therapeutic promise, but safe and efficient delivery of gene editors remains challenging. In this study, we present a virus-like particle (VLP) system featur...
Fast, accurate, and versatile data analysis platform for the quantification of molecular spatiotemporal signals [0.03%]
快速、准确且功能强大的数据分析平台，用于量化分子时空信号
Xuelong Mi,Alex Bo-Yuan Chen,Daniela Duarte et al.
Xuelong Mi et al.
Optical recording of intricate molecular dynamics is becoming an indispensable technique for biological studies, accelerated by the development of new or improved biosensors and microscopy technology. This creates major computational challe...