Cancer immunology data engine reveals secreted AOAH as a potential immunotherapy [0.03%]
癌症免疫数据引擎揭示分泌AOAH作为潜在的免疫疗法
Lanqi Gong,Jie Luo,Emily Yang et al.
Lanqi Gong et al.
Secreted proteins are central mediators of intercellular communications and can serve as therapeutic targets in diverse diseases. The ∼1,903 human genes encoding secreted proteins are difficult to study through common genetic approaches. T...
Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures [0.03%]
全面的人类蛋白质组谱图跨越50年寿命揭示了衰老轨迹和特征
Yingjie Ding,Yuesheng Zuo,Bin Zhang et al.
Yingjie Ding et al.
Proteins are the cornerstone of life. However, the proteomic blueprint of aging across human tissues remains uncharted. Here, we present a comprehensive proteomic and histological analysis of 516 samples from 13 human tissues spanning five ...
Human interpretable grammar encodes multicellular systems biology models to democratize virtual cell laboratories [0.03%]
人类可解释的语法规则编码多细胞系统生物学模型以实现虚拟细胞实验室的大众化
Jeanette A I Johnson,Daniel R Bergman,Heber L Rocha et al.
Jeanette A I Johnson et al.
Cells interact as dynamically evolving ecosystems. While recent single-cell and spatial multi-omics technologies quantify individual cell characteristics, predicting their evolution requires mathematical modeling. We propose a conceptual fr...
Tornike Mamuladze,Tiago H Zaninelli,Leon C D Smyth et al.
Tornike Mamuladze et al.
Cerebrospinal fluid (CSF) flow is essential for brain homeostasis, and its disruption is implicated in neurodegenerative and neuroinflammatory diseases. Arachnoid cuff exit (ACE) points, anatomical discontinuities in the arachnoid mater aro...
A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis [0.03%]
一项关于颅骨-大脑轴的新发现或有助中风后减少大脑炎症反应
Ruchita Kothari,Mostafa W Abdulrahim,Hyun Jong Oh et al.
Ruchita Kothari et al.
The immune environment surrounding the brain plays a fundamental role in monitoring signs of injury. Insults, including ischemic stroke, can disrupt this balance and incite an exaggerated inflammatory response, yet the underlying mechanism ...
Unmasking the Denisovans [0.03%]
揭秘丹尼索瓦人
Vanessa Villalba-Mouco,Arev Pelin Sümer
Vanessa Villalba-Mouco
The Harbin cranium, linked to Denisovans via mitochondrial DNA, broadens their known range and provides the first insights into Denisovan morphology. This discovery highlights the potential of biomolecular analysis from nontraditional sourc...
The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment [0.03%]
揭示顶体虫生存所需的宿主基因组及其代谢依赖性以寻求治疗手段
N Bishara Marzook,Ok-Ryul Song,Lotta Baumgärtel et al.
N Bishara Marzook et al.
Cryptosporidium is a leading cause of diarrheal disease, yet little is known regarding the infection cell biology of this intracellular intestinal parasite. To this end, we implemented an arrayed genome-wide CRISPR-Cas9 knockout screen to m...
Structure of gut microbial glycolipid modulates host inflammatory response [0.03%]
肠道微生物甘油糖脂结构调节宿主炎症反应
Hyoung-Soo Cho,Ji-Sun Yoo,Xinyang Song et al.
Hyoung-Soo Cho et al.
Commensals are constantly shaping the host's immunological landscape. Lipopolysaccharides found in gram-negative microbes have a terminal lipid A in their outer membrane. Here, we report that structural variations in symbiotic lipid A lead ...
SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress [0.03%]
SPIDR 实现了RNA-蛋白质相互作用的多重映射，并揭示了细胞应激条件下选择性翻译抑制的机制
Erica Wolin,Jimmy K Guo,Mario R Blanco et al.
Erica Wolin et al.
RNA-binding proteins (RBPs) regulate all stages of the mRNA life cycle, yet current methods generally map RNA targets of RBPs one protein at a time. To overcome this limitation, we developed SPIDR (split-and-pool identification of RBP targe...
Procr+ chondroprogenitors sense mechanical stimuli to govern articular cartilage maintenance and regeneration [0.03%]
力学生物学感应在关节软骨维持和再生中的作用
Qiaoling Zhu,Feng Yin,Jiachen Qin et al.
Qiaoling Zhu et al.
Protein C receptor+ (Procr+) cells were identified as stem or progenitor cells in multiple adult tissues. However, whether mechanical stimuli fine-tune their activation and differentiation remain unknown. Here, we found rare Procr+ cells in...