Rational design of Gi-biased CB1 agonist with reduced side effects [0.03%]
一种偏向Gi型的人大麻素受体激动剂的设计合成及其活性评价
Yu-Ying Liao,Jinxin Che,Yun-Tao Gao et al.
Yu-Ying Liao et al.
The cannabinoid receptor 1 (CB1) has emerged as a promising candidate for next-generation non-opioid therapies. However, the development of therapeutics targeting CB1 has been consistently hindered by significant adverse effects. Here, thro...
Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia [0.03%]
泛素连接酶COP1通过降解小胶质细胞中的c/EBPβ抑制神经炎症作用
Ada Ndoja,Rohit Reja,Seung-Hye Lee et al.
Ada Ndoja et al.
Published Erratum
Cell. 2026 Apr 7:S0092-8674(26)00391-0. DOI:10.1016/j.cell.2026.04.002 2026
Clemens Hinterleitner,Hailey V Goldberg,Domhnall McHugh et al.
Clemens Hinterleitner et al.
Cellular senescence is a conserved stress-responsive program defined by durable proliferative arrest and extensive remodeling of chromatin, metabolism, intercellular signaling, and immune interactions. Initially described as a barrier to un...
Wenqiang Liu,Paul D Pang,Catherine A Wu et al.
Wenqiang Liu et al.
Traditional animal-based drug discovery has high failure rates, prompting the search for and adoption of human-centered new approach methodologies (NAMs). Rapid advances in stem cell-, organoid-, and in silico-based NAMs, supported by evolv...
Xiaozhi Fu
Xiaozhi Fu
Artificial intelligence has rapidly advanced molecular science, yet progress has largely unfolded through specialized models tailored to specific tasks. In this issue of Cell, Peng et al. introduce PocketXMol, a unified 3D generative framew...
Lijing Chang,Zhen Xu,Purong Deng et al.
Lijing Chang et al.
Nicotine, tobacco's addictive and potent insecticidal alkaloid, has shaped human history, agriculture, and the plants that produce it. However, the enzymatic steps and reaction mechanisms involved in nicotine biosynthesis remain elusive. He...
Robin Caire,Roberta Bordo,Francesca Zanconato et al.
Robin Caire et al.
The tissue-level processes underpinning metastatic outgrowth remain unclear. We combined single-cell RNA sequencing, spatial transcriptomics, and AI-supported 3D imaging in human breast cancer with functional investigations in mice to uncov...
R Manley,R Woodhams,T J Arrowsmith et al.
R Manley et al.
Many viruses can switch between lytic replication and dormancy (or lysogeny). It was recently discovered that some viruses that infect bacteria (known as bacteriophage or phage) employ peptide-based ("arbitrium") communication systems to op...
Francisca Gallego-Del-Sol,Daniel Sin,Cora Chmielowska et al.
Francisca Gallego-Del-Sol et al.
Arbitrium is a communication system that helps bacteriophages to decide between lysis and lysogeny through secreted peptides. In this system, the arbitrium communication peptide (AimP) binds its cognate arbitrium receptor (AimR) to repress ...
Yu He,James S H Bae,Elżbieta Nowak et al.
Yu He et al.
Although kinase activators hold significant therapeutic promise, their development remains challenging and rarely achieved. Here, we report the discovery of direct small-molecule activators of p21-activated kinase-1 (PAK1), a key regulator ...