Dynamic prediction of HIV-related incomplete immune reconstitution: A multicenter, large cohort study using advanced joint modeling [0.03%]
HIV相关性不完全免疫重建的动态预测：一项多中心大样本队列研究，采用先进的联合分析模型
Fang Liu,Hanxi Zhang,Xi Wang et al.
Fang Liu et al.
Incomplete immune reconstitution (IIR) is a serious complication affecting 10 to 40% of people living with HIV (PLWH) despite effective antiretroviral therapy, leading to increased morbidity and mortality. Current risk prediction models rel...
Multicenter Study
Science advances. 2026 Aug 7;12(32):eaeb2781. DOI:10.1126/sciadv.aeb2781 2026
Emergent cooperative superstructures via order-disorder kinetics in molecular intercalation superlattices [0.03%]
分子插层超晶格中有序无序转变动力学诱导的协同超结构
Taiga Ueda,Hideki Matsuoka,Shungo Aoyagi et al.
Taiga Ueda et al.
Molecular intercalation superlattices, formed by inserting organic molecules into van der Waals crystals, create inorganic-organic hybrid interfaces that have enabled a variety of emergent phenomena. Traditionally, the intercalated molecule...
Leveraging IGF signaling to improve the spatial organization and regenerative potential of iPSC-derived vascularized liver organoids [0.03%]
利用IGF信号传导改善诱导多能干细胞来源的血管化肝类器官的空间组织和再生潜能
Da-Hyun Kim,Yongju Lee,Min-Ji Kim et al.
Da-Hyun Kim et al.
Liver tissue engineering offers a promising alternative for end-stage liver disease, yet the recreation of functional vasculature remains a major bottleneck to clinical translation. Here, we developed vascularized liver organoids by integra...
Development of a structurally distinct TopBP1 inhibitor that enhances PARP blockade and reverses osimertinib resistance [0.03%]
开发一种结构上独特的TopBP1抑制剂，可增强PARP阻断并逆转奥希替尼耐药性
Fang-Tsyr Lin,Shwu-Jiuan Lin,Kang Liu et al.
Fang-Tsyr Lin et al.
Therapeutic resistance remains a major challenge in cancer treatment, driven by compensatory signaling and stress response pathways that sustain tumor survival. Topoisomerase IIβ-binding protein 1 (TopBP1), a multifunctional scaffold prote...
Unlock lasing in two-dimensional metal halide perovskites by tuning ns2 lone pairs [0.03%]
通过调节ns2孤对实现二维金属卤化物钙钛矿激光发射解锁
Xinyu Li,Mingyuan Li,Shixuan Zheng et al.
Xinyu Li et al.
Despite the proliferation of lasing reports in three-dimensional (3D) lead halide perovskites, robust lasing in their single-layer two-dimensional (2D) counterparts, (LA)2PbX4 (LA = spacer cation; X = halide), has remained elusive. Here, we...
What is happening at the atomic level during the seed-mediated growth of copper on gold? [0.03%]
种子介导的铜在金表面生长过程中的原子尺度研究
Yanzi Yan,Kei Kwan Li,Xintong Huang et al.
Yanzi Yan et al.
Bimetallic nanocrystals obtained via seed-mediated growth are typically analyzed using conventional electron microscopy and many interesting features at the atomic level are often missed. Here we report the seed-mediated growth of copper (C...
Multi-component gradients in 3D host frameworks enabled stack-type zinc plating/stripping for highly durable aqueous Zn-ion batteries [0.03%]
三维主体框架中多组分梯度实现堆叠式锌电镀/剥离助力长效水系锌离子电池
Jingjie Sun,Tianyu Shen,Mingyue Zhang et al.
Jingjie Sun et al.
Developing dendrite-free zinc metal anodes with high durability poses a great challenge for aqueous zinc-ion batteries. Herein, we propose an in situ constructed 3D restrained host frameworks with multi-component gradients that induces a co...
SARS-CoV-2 nucleocapsid induces hyperinflammation and vascular leakage through the Toll-like receptor signaling axis in macrophages [0.03%]
SARS-CoV-2核蛋白通过巨噬细胞Toll样受体信号轴诱导过度炎症和血管渗漏
Zhenlan Yao,Pablo A Alvarez,Carolina Chavez et al.
Zhenlan Yao et al.
A substantial proportion of hospitalized COVID-19 patients require ICU admission, often associated with an imbalance between antiviral responses and inflammatory signaling leading to uncontrolled cytokine secretion. The SARS-CoV-2 nucleocap...
Quantitative reconstruction of the Yiwu Jurassic Forest in Northwest China and high forest productivity in the Middle Jurassic [0.03%]
中国西北義烏侏羅紀森林的定量重建及中侏罗世高森林生产力
Xu-Dong Gou,Yun Guo,Tao Zhao et al.
Xu-Dong Gou et al.
Forests constitute the dominant terrestrial ecosystems and play a critical role in global carbon cycling. However, the changing structure and function of forests through geological time remain poorly understood due to the scarcity of in sit...
Shane Stoeber,Hengye Chen,Ruo-Wen Chen et al.
Shane Stoeber et al.
Nucleosomes present a major barrier to transcription factor (TF) binding. However, a subgroup of TFs known as pioneer factors (PFs) can recognize motifs covered by nucleosomes and initiate chromatin opening. PFs also bind nucleosomal substr...