A motoneuron discharge-driven interface realizing simultaneous and proportional control of prosthetics in end-users [0.03%]
一种基于运动神经元放电的假肢同步比例控制接口系统
Chen Chen,Ruye Guo,Dongxuan Li et al.
Chen Chen et al.
Accurate decoding of movement intent from muscle signals is essential for dexterous prosthetic control. While motoneuron discharge decomposition provides a promising approach, most studies are confined to proof-of-concept demonstrations due...
A NHEJ1 mutator allele influencing germline mutation rates sex-specifically in humans [0.03%]
一个NHEJ1等位基因通过性别特异性影响人类生殖系突变率
Kun Wu,Jiuhong Nan,Haoxuan Liu
Kun Wu
Germline mutations play a pivotal role in evolution and are the primary cause of hereditary diseases in humans. Although interpopulation and interspecific variations in the mutation rate and spectrum are observed, their underlying genetic b...
Transient receptor potential vanilloid 2 functions as a directional driver for hepoxilin A3-mediated neutrophil migration [0.03%]
瞬时受体电位香草素通道2作为白细胞三烯介导的中性粒细胞迁移的方向驱动因素发挥作用
Claudia Feriotti,Regino Mercado-Lubo,Merran Bryford et al.
Claudia Feriotti et al.
Neutrophil migration involves a dynamic balance of chemoattractant and inhibitory signals. We previously identified hepoxilin A3 (HxA3) as a potent chemoattractant that directs neutrophil migration across intestinal epithelia and showed tha...
Indirect pathway neurons in the tail of the striatum regulate inhibitory control over sensory driven behavior [0.03%]
纹状体尾部的间接通路神经元调控感觉驱动行为的抑制控制
Sarah M Ferrigno,Evan Iliakis,Nathan Zhang et al.
Sarah M Ferrigno et al.
Inhibitory control, the ability to withhold action in certain contexts, is behaviorally essential. Disrupted inhibitory control is linked to various neuropsychiatric symptoms, making it critical to understand the underlying neural basis. We...
ZMAT3 alleviates cell death in Fanconi anemia via adaptation of sphingolipid metabolism [0.03%]
ZMAT3通过适应鞘脂代谢缓解Fanconi贫血症细胞死亡
Maeva Loock,Blandine Lucchini,Emmanuelle Latour et al.
Maeva Loock et al.
Fanconi anemia (FA) is characterized by defective DNA repair and chronic p53 activation, predisposing to acute myeloid leukemia through persistent genomic instability. The molecular adaptations enabling cell survival under chronic stress re...
Satellite observations reveal underestimation of CO2 emissions in Africa and the Middle East [0.03%]
卫星观测显示非洲和中东地区的二氧化碳排放量被低估
Xiaojuan Lin,Ronald van der A,Jos de Laat et al.
Xiaojuan Lin et al.
Africa and the Middle East contribute significantly to global fossil fuel production, yet the associated carbon emissions from these extraction and processing activities remain insufficiently reported. The current reporting is not only dela...
A lab-on-a-silicon-chip platform for all-electrical antibiotic susceptibility tests with a sample-to-results time within 20 minutes [0.03%]
一种实验室芯片平台，用于抗生素敏感性测试，可在20分钟内实现从样品到结果的全电化测试
Zheqiang Xu,Victoria C Nolan,Yingtao Yu et al.
Zheqiang Xu et al.
Rapid antibiotic susceptibility tests (ASTs) are essential for quick selection of effective drugs to treat infections at an early stage. However, the most widely used phenotypic ASTs in clinical practice often require 24 to 48 hours of pre-...
Cohesin and NuRD antagonistically drive alternative neuronal fates via PLZF transcription factors [0.03%]
共hesin和NuRD通过PLZF转录因子拮抗驱动神经元的分化命运
Dongyeop Lee,Takashi Hirose,H Robert Horvitz
Dongyeop Lee
Diverse genetic and epigenetic factors cooperate to specify cellular fates during development. Establishing these fates is especially critical in the nervous system, which comprises diverse neuronal cell types. How genomic architecture inte...
Mitochondrial control of amino acid catabolism by a fasting-inducible mitochondrial carrier [0.03%]
由饥饿诱导的线粒体转运蛋白控制氨基酸分解代谢
Satoshi Oikawa,Tadashi Yamamuro,Hiroshi Nishida et al.
Satoshi Oikawa et al.
Metabolic adaptation to nutrient deprivation requires coordinated control of mitochondrial anaplerosis and cataplerosis; however, how metabolite flux across the mitochondrial membrane is regulated during fasting remains less defined. Here, ...
Structural mechanism of histone H2A.Z exchange by human SRCAP-CFDP1 holoenzyme [0.03%]
SRCAP-CFDP1全酶介导组蛋白H2A.Z置换的分子机制研究
Giho Park,Carl Wu,Robert K Louder
Giho Park
The conserved yeast SWR1 and human SRCAP chromatin remodeling complexes catalyze exchange of nucleosomal histone H2A for H2A.Z, but the underlying mechanism has remained obscure. Here, we show that histone exchange by SRCAP requires the tra...