Gut dysbiosis conveys psychological stress to activate LRP5/β-catenin pathway promoting cancer stemness [0.03%]
肠道菌群失调通过传递心理压力激活LRP5/β-连环蛋白通路从而促进癌症干性
Bai Cui,Huandong Luo,Bin He et al.
Bai Cui et al.
Psychological stress causes gut microbial dysbiosis and cancer progression, yet how gut microbiota determines psychological stress-induced tumor development remains unclear. Here we showed that psychological stress promotes breast tumor gro...
Advance in peptide-based drug development: delivery platforms, therapeutics and vaccines [0.03%]
基于肽类的药物研发进展：传递系统，治疗药物和疫苗
Wenjing Xiao,Wenjie Jiang,Zheng Chen et al.
Wenjing Xiao et al.
The successful approval of peptide-based drugs can be attributed to a collaborative effort across multiple disciplines. The integration of novel drug design and synthesis techniques, display library technology, delivery systems, bioengineer...
Metaplastic epithelial cells: origination from stem cells and promotion of intestinal inflammation [0.03%]
间变上皮细胞：起源于干细胞并促进肠道炎症
Tim Holland,Jochen Mattner
Tim Holland
Ultra-high dose rate radiotherapy overcomes radioresistance in head and neck squamous cell carcinoma [0.03%]
超高速率放射疗法克服了头颈部鳞状细胞癌的放疗抵抗性
Hong-Shuai Li,Ruo Tang,Hua-Shan Shi et al.
Hong-Shuai Li et al.
Radiotherapy (RT) resistance in head and neck squamous cell carcinoma (HNSCC) significantly hampers local control and patient prognosis. This study investigated the efficacy and molecular mechanisms of high-energy X-ray-based ultra-high dos...
Engineered mitochondria in diseases: mechanisms, strategies, and applications [0.03%]
疾病相关的工程线粒体：机制、策略及应用
Mingyang Li,Limin Wu,Haibo Si et al.
Mingyang Li et al.
Mitochondrial diseases represent one of the most prevalent and debilitating categories of hereditary disorders, characterized by significant genetic, biological, and clinical heterogeneity, which has driven the development of the field of e...
Neoleukin-2/15-armored CAR-NK cells sustain superior therapeutic efficacy in solid tumors via c-Myc/NRF1 activation [0.03%]
通过c-Myc/NRF1激活，新白细胞介素-2/15装甲CAR-NK细胞在实体瘤中维持卓越的治疗效果
Jianhua Luo,Meng Guo,Mingyan Huang et al.
Jianhua Luo et al.
Adoptive transfer of chimeric antigen receptor (CAR)-modified natural killer (NK) cells represents a transformative approach that has significantly advanced clinical outcomes in patients with malignant hematological conditions. However, the...
Safety, pharmacokinetics and efficacy of HA121-28 in patients with advanced solid tumors and RET fusion-positive non-small-cell lung cancer: a multicenter, open-label, single-arm phase 1/2 trial [0.03%]
HA121-28在晚期实体瘤和RET融合阳性非小细胞肺癌患者中的安全性，药代动力学和疗效：一项多中心，开放标签，单臂的1/2期试验
Dan-Yun Ruan,Wen-Wen Huang,Yongsheng Li et al.
Dan-Yun Ruan et al.
HA121-28, a promising multikinase inhibitor, mainly targets rearranged during transfection (RET) fusions and selectively targets vascular endothelial growth factor receptor-2, endothelial growth factor receptor, and fibroblast growth factor...
A recombinant protein vaccine induces protective immunity against SARS-CoV-2 JN.1 and XBB-lineage subvariants [0.03%]
重组蛋白疫苗诱导对SARS-CoV-2 JN.1和XBB谱系亚变异株的保护性免疫反应
Jingyun Yang,Weiqi Hong,Huashan Shi et al.
Jingyun Yang et al.
The emergence of XBB- and JN.1-lineages with remarkable immune evasion characteristics have led to rises in breakthrough infections within populations. In addition, the unfavorable impacts of immune imprinting, stemming from continuous expo...
Invasion and metastasis in cancer: molecular insights and therapeutic targets [0.03%]
癌症中的侵袭和转移：分子见解与治疗靶点
Yongxing Li,Fengshuo Liu,Qingjin Cai et al.
Yongxing Li et al.
The progression of malignant tumors leads to the development of secondary tumors in various organs, including bones, the brain, liver, and lungs. This metastatic process severely impacts the prognosis of patients, significantly affecting th...