Exploratory phase II trial of an anti-PD-1 antibody camrelizumab combined with a VEGFR-2 inhibitor apatinib and chemotherapy as a neoadjuvant therapy for triple-negative breast cancer (NeoPanDa03): efficacy, safety and biomarker analysis [0.03%]
卡瑞利珠单抗联合阿帕替尼和化疗新辅助治疗三阴性乳腺癌的探索性Ⅱ期研究（NeoPanDa03）：疗效、安全性及生物标志物分析
Xiaoxiao Liu,Chunying Zhuang,Lei Liu et al.
Xiaoxiao Liu et al.
Chemotherapy serves as the primary therapeutic approach for triple-negative breast cancer (TNBC), yet its efficacy remains unsatisfactory. This study was a single-arm, open-label, single-center clinical trial (NCT05447702) involving patient...
Aberrant Notch-signaling promotes tumor angiogenesis in esophageal squamous-cell carcinoma [0.03%]
诺特信号异常可促进食道鳞状细胞癌的肿瘤血管生成
Cainan Li,Pujie Wu,Xiaoting Xie et al.
Cainan Li et al.
Esophageal squamous-cell carcinoma (ESCC) is one of the most common gastrointestinal cancers in China, characterized by high malignancy and poor prognosis. Nowadays, the therapeutic options for this cancer are very limited. Notch-signaling ...
Differential expression pattern of CC chemokine receptor 7 guides precision treatment of hepatocellular carcinoma [0.03%]
C趋化因子受体7的差异表达模式引导肝细胞癌的精准治疗
Jie Qin,Qianyi Gong,Cheng Zhou et al.
Jie Qin et al.
The treatment of hepatocellular carcinoma (HCC) faces challenges of low response rates to targeted drugs and immune checkpoint inhibitors, which are influenced by complicated microenvironment of HCC. In this study, the complex tumor microen...
Phosphoglycerate dehydrogenase stabilizes protein kinase C delta type mRNA to promote hepatocellular carcinoma progression [0.03%]
磷酸甘油酸脱氢酶稳定蛋白激酶C delta型mRNA以促进肝细胞癌进展
Bin Cheng,Pai Peng,Shi Chen et al.
Bin Cheng et al.
Metabolic reprogramming not only reshapes cellular bioenergetics but also profoundly influences RNA metabolism through metabolite signaling and the RNA-binding activities of metabolic enzymes. Emerging evidence highlights that certain metab...
Correction: Clinical investigation on nebulized human umbilical cord MSC-derived extracellular vesicles for pulmonary fibrosis treatment [0.03%]
关于人脐带间充质干细胞来源外泌体治疗肺纤维化临床研究的更正公告
Meng Li,Huaping Huang,Xiaofei Wei et al.
Meng Li et al.
Targeting epigenetic regulators as a promising avenue to overcome cancer therapy resistance [0.03%]
表观遗传调控因子在克服癌症治疗耐药方面颇具潜力
Jiawei Song,Ping Yang,Canting Chen et al.
Jiawei Song et al.
Cancer remains one of the leading health threats globally, with therapeutic resistance being a long-standing challenge across chemotherapy, radiotherapy, targeted therapy, and immunotherapy. In recent years, the association between epigenet...
Phosphorylated Toll-like receptor 3 nuclear translocation in cancer cell promotes metastasis and chemoresistance [0.03%]
泛素化修饰的TLR3通过介导核转移促进肿瘤进展和化疗耐药
Zixin Wang,Yan Gu,Yanfang Liu et al.
Zixin Wang et al.
Aberrant expression and subcellular location of innate sensors in cancer cells, such as Toll-like receptors (TLRs), correlates with pro-tumoral inflammation and cancer progression, but the mechanism is still largely unknown. Deciphering the...
Comprehensive genomic and transcriptomic analyses reveal prognostic stratification for esophageal squamous cell carcinoma [0.03%]
泛基因组和转录组分析揭示了食管鳞状细胞癌的预后分类
Jian Gao,Qiming Wang,Fangqiu Fu et al.
Jian Gao et al.
Recent large-scale multi-omics studies have characterized the heterogeneity of esophageal squamous cell carcinoma (ESCC), but inconsistent clinical management has hindered the identification of prognostic markers and patient stratification....
Bat organoid platform: revolutionizing zoonotic virus research and pandemic preparedness [0.03%]
蝙蝠器官模型平台：革新人畜共患病病毒研究和大流行病应对措施
Young-Ho Park,Sun-Uk Kim,Taeho Kwon
Young-Ho Park
DDX39B K63-linked ubiquitination mediated by TRIM28 promotes NSCLC metastasis by enhancing ECAD lysosomal degradation [0.03%]
TRIM28介导的DDX39B K63连接泛素化通过增强ECAD溶酶体降解促进非小细胞肺癌转移
Hang Yuan,Qin Li,Liang Li et al.
Hang Yuan et al.
Metastasis is a leading cause of treatment failure and high mortality in non-small cell lung cancer (NSCLC). Recently, we demonstrated that DEAD box helicase 39B (DDX39B) was upregulated and activated metabolic reprogramming in colorectal c...