New liposidomycin congeners produced by Streptomyces sp. TMPU-20A065, anti-Mycobacterium avium complex agents with therapeutic efficacy in a silkworm infection model [0.03%]
丝状杆菌TMPU-20A065产生新型脂糖肽类利索西菌素类似物，对鸟类分枝杆菌复合体具有体内抗菌活性
Akiho Yagi,Mayu Fujiwara,Mayu Sato et al.
Akiho Yagi et al.
Three new liposidomycin congeners (1, 2, and 4), together with 14 known liposidomycins (3 and 5-17), were isolated from the culture broth of Streptomyces sp. TMPU-20A065 as anti-Mycobacterium avium complex agents. The structures of liposido...
Benastatin K, a chlorinated benastatin-related antibiotic from Streptomyces sp. HGTA384 [0.03%]
来自HGTA384链霉菌的氯化苯他stinK抗生素
Teppei Kawahara,Kanako Saita,Rika Iwamoto et al.
Teppei Kawahara et al.
Benastatin K (1), a new chlorinated benastatin derivative, was isolated from the culture broth of the actinomycete Streptomyces sp. HGTA384. The structure of 1 was determined on the basis of spectroscopic analysis, including 1D and 2D NMR, ...
Crowdsourcing for mining new fungal sources for addressing the need for novel antibiotics against multidrug resistant pathogens [0.03%]
crowdsourcing：挖掘新的真菌来源以应对多药耐药病原体的新抗生素需求
T S Suryanarayanan
T S Suryanarayanan
There are a limited number of new antibiotics to manage the health crisis caused by the evolution and spread of antimicrobial resistant (AMR) bacteria including multidrug resistant (MDR), extensively drug-resistant (XDR) and pan-drug-resist...
A new polycyclic tetramate macrolactam from Allostreptomyces RD068384: stereochemistry and antifungal potential [0.03%]
来自放线菌Allostreptomyces RD068384的多环四肽大环内酰胺：立体化学和抗真菌潜力
Marwa Elsbaey,Yuki Samaru,Engy Elekhnawy et al.
Marwa Elsbaey et al.
A new polycyclic tetramate macrolactam designated allostreptamide (1), together with four known congeners, were isolated from the culture extract of Allostreptomyces RD068384. The planar structure of the new compound was elucidated through ...
New polycyclic tetramate macrolactams with antimycobacterial activity produced by marine-derived Streptomyces sp. KKMA-0239 [0.03%]
由海洋来源的链霉菌KKMA-0239产生的具有抗分枝杆菌活性的新多环四肽大环内酰胺类化合物
Satoru Shigeno,Miyu Kadowaki,Kenichiro Nagai et al.
Satoru Shigeno et al.
During our screening for anti-mycobacterial agents against Mycobacterium avium complex (MAC), two new polycyclic tetramate macrolactams (PTMs), named hydroxycapsimycin (1) and brokamycin (2), were isolated along with the known PTM, ikarugam...
Actinomycetospora termitidis sp. nov., an insect-derived actinomycete isolated from termite (Odontotermes formosanus) [0.03%]
来源于白蚁（Odontotermes formosanus）的昆虫来源放线菌 Actinomycetospora termitidis 新种
Khomsan Supong,Nantawan Niemhom,Chanwit Suriyachadkun et al.
Khomsan Supong et al.
Strain Odt1-22T, an insect-derived actinomycete was isolated from a termite (Odontotermes formosanus) that was collected from Chanthaburi province, Thailand. Strain Odt1-22T was aerobic, Gram-stain-positive, and produced bud-like spore chai...
Tumescenamide C, a cyclic lipodepsipeptide from Streptomyces sp. KUSC_F05, exerts antimicrobial activity against the scab-forming actinomycete Streptomyces scabiei [0.03%]
链霉菌孢子链霉菌KUSC_F05产生的肿瘤塞尼amide C具有抗微生物作用
Kensuke Kaneko,Marika Mieda,Yulu Jiang et al.
Kensuke Kaneko et al.
The antimicrobial activity of tumescenamide C against the scab-forming S. scabiei NBRC13768 was confirmed with a potent IC50 value (1.5 μg/mL). Three tumescenamide C-resistant S. scabiei strains were generated to compare their gene variant...
Three new phthalide derivatives from culture broth of Dentipellis fragilis and their cytotoxic activities [0.03%]
三种来自齿孔薄革菌培养物的新的酞衍生物及其细胞毒性作用
Dae-Won Ki,Dae-Cheol Choi,Yeong-Seon Won et al.
Dae-Won Ki et al.
Three new phthalide derivatives (1‒3) together with two known compounds, erinaceolactone B (4) and hericerin III (5), were isolated from the culture broth of Dentipellis fragilis. The chemical structures of 1‒5 were determined by analyses...
Okichromanone, a new antiviral chromanone from a marine-derived Microbispora [0.03%]
来源于海洋来源Microbispora的抗病毒化合物奥基克洛曼酮奥基克罗曼酮结构修改及活性改善研究
Marwa Elsbaey,Takahiro Jomori,Junichi Tanaka et al.
Marwa Elsbaey et al.
Okichromanone (1), a new chromanone, was isolated from the culture extract of a sponge-derived actinomycete Microbispora, along with known 1-hydroxyphenazine (2). Compound 1 was elucidated to exist as a mixture of two isomeric structures (1...
Uncovering the potentiality of quinazoline derivatives against Pseudomonas aeruginosa with antimicrobial synergy and SAR analysis [0.03%]
基于抗菌协同和药效团关系分析的喹唑啉类衍生物对抗绿脓杆菌活性的研究
Rakshit Manhas,Arti Rathore,Ujwal Havelikar et al.
Rakshit Manhas et al.
Antimicrobial resistance has emerged as a covert global health crisis, posing a significant threat to humanity. If left unaddressed, it is poised to become the foremost cause of mortality worldwide. Among the multitude of resistant bacteria...