Haruo Ikeda,Junko Hashimoto,Ikuko Kozone et al.
Haruo Ikeda et al.
New technology for the derivatization of thioamide ribosomally synthesized and post-translationally modified peptide (RiPP) compounds we previously developed was optimized for the derivatization of thiostrepton metabolites. These optimized ...
Luteoagmacins A and B, new antimicrobial agmatine derivatives from a hot spring water-derived Luteococcus sp [0.03%]
来源于热泉的红硫细菌的新抗菌胍衍生物卢提奥麻灵A和B
Shotaro Hoshino,Emiko Nagai,Hisayuki Komaki et al.
Shotaro Hoshino et al.
Two new agmatine derivatives, luteoagmacins A (1) and B (2), were isolated from the culture extract of the hot spring water-associated actinomycete Luteococcus sp. RD000023. The chemical structures of 1 and 2 were elucidated by spectroscopi...
A N-methylated antimicrobial peptide targets the fructose transporter FruA of Staphylococcus aureus [0.03%]
N-甲基化抗菌肽针对金黄色葡萄球菌果糖转运蛋白FruA
Qi Liu,Yaxuan Li,Zhichen Jiang et al.
Qi Liu et al.
Antimicrobial peptides (AMPs) represent promising alternatives to conventional antibiotics, but their therapeutic application is often hindered by suboptimal stability and poorly defined mechanisms of action. To overcome these limitations, ...
Discovery of new α-pyrone derivative with α-glucosidase inhibitory activity from the fungus Acremonium persicinum [0.03%]
来源于真菌Acremonium persicinum的α-糖苷酶抑制剂新结构α-吡酮衍生物的发现
Yu Tu,Baodan Zhang,Meiyan Bao et al.
Yu Tu et al.
One new α-pyrone derivative, acremopyrone A (1) was isolated from the soil-derived fungus Acremonium persicinum 3.2858. The structure of 1 was elucidated by comprehensive spectroscopic analysis including nuclear magnetic resonance (NMR) an...
Allantopyrone A promotes cross-linking of ubiquitin-specific protease 5 (USP5) and inhibits its deubiquitinase activity by targeting distinct domains [0.03%]
黄烷酮衍生物allantopyrone A通过靶向不同结构域促进泛素特异性蛋白酶5的交联并抑制其去泛素化活性
Chiharu Okuda,Seito Tokumori,Nhat Thi Vu et al.
Chiharu Okuda et al.
Allantopyrone A is an α-pyrone metabolite produced by the plant endophytic fungus Allantophomopsis lycopodina KS-97. We previously demonstrated that allantopyrone A decreased the abundance of many components of 26S proteasome fractions whi...
Actinomycetospora lichenicola sp. nov., a rare actinomycete isolated from the crustose lichen Arthonia leioplacella [0.03%]
来源于地衣Arthonia leioplacella的链霉菌Actinomycetospora lichenicola sp. nov.
Cholticha Meepara,Achiraya Somphong,Chanwit Suriyachadkun et al.
Cholticha Meepara et al.
A Gram-positive actinomycete, designated strain C-140ᵀ, was isolated from the crustose lichen Arthonia leioplacella collected in Thailand. A polyphasic taxonomic study demonstrated that the strain represents a member of the genus Actinomyc...
Bortezomib exhibited bacteriostatic activity and pro-inflammatory effect against Mycoplasma pneumoniae [0.03%]
硼替佐米对肺炎支原体具有杀菌和促炎作用
Zhikun Zhang,Yixuan Mao,Xiu Wang et al.
Zhikun Zhang et al.
Mycoplasma pneumoniae (MP) is an important respiratory pathogen. Growth inhibition and regulation of inflammation in lung are key to the treatment of MP infections. Bortezomib, a proteinase inhibitor, was found to possess both functions in ...
Pheophorbide a from Acrotrema agastyamalayanum: A potent antibiofilm agent targeting Proteus mirabilis [0.03%]
采自Acrotrema agastyamalayanum的叶绿素衍生物甲酰胆碱A：一种针对奇异变形杆菌的高效抗菌膜剂
R Remya Babu,Nagaraja Ingaladal,P Anjumol et al.
R Remya Babu et al.
The antibiofilm potential of the hexane extract of the rare and endangered endemic plant Acrotrema agastyamalayanum was determined against Proteus mirabilis. The biofilm-inhibitory activity of the hexane extract was evaluated by crystal vio...
Tsukubacyclinone, a novel angucyclinone compound with anti-inflammatory activity in synovial cell line SW982, produced by Streptomyces sp. K21-0141 [0.03%]
Tsukubacyclinone，一种由链霉菌K21-0141产生的具有抗炎活性的新型角 cyclinone 类化合物
Fumito Iizuka,Kentaro Uchida,Yuta Kikuchi et al.
Fumito Iizuka et al.
Streptomyces species are prolific producers of structurally diverse secondary metabolites with a broad spectrum of biological activities. In this study, we isolated a novel angucyclinone compound, tsukubacyclinone (1), from the culture brot...
Macrolide antibiotic action, resistance, and tolerance, and approaches to improve their activity against Gram-negative bacteria [0.03%]
大环内酯类抗生素的作用、抗性及耐受性及其改善其对革兰氏阴性菌活性的策略
Umar A Aulia,Seyi Jung,Lily I Kronenberg et al.
Umar A Aulia et al.
Macrolide antibiotics inhibit bacterial translation and are characterized by the presence of a macrocyclic lactone ring. First discovered as natural products of Streptomyces species, the potency of macrolide antibiotics against a diverse sw...