Andrés M Caraballo-Rodríguez,Andrés Cumsille,Sarolt Magyari et al.
Andrés M Caraballo-Rodríguez et al.
Actinomycetes have been a cornerstone species for the discovery of bioactive natural products with applications in pharmacotherapy and biotechnology. To expand the experimental evidence of their biosynthetic potential, we collected liquid-c...
Minhui Ji,Qianqian Liu,Ling Liu
Minhui Ji
A new indole diketopiperazine penichrysogenone A (1), and two new natural products 4-(N-benzoyl-N-hydroxyamino)-butyric acid (2) and 2-acetamido-N-benzyl-2-(ethylamino)acetamide (3), together with 10 known compounds (4-13) were isolated fro...
Yi Yang,Takahiro Mori
Yi Yang
Lincomycin A and celesticetin are representative members of the lincosamide class of clinically used antibiotics produced by Streptomyces species. Their distinctive chemical architectures arise from atypical biosynthetic gene clusters that ...
Thiofrenomycins, new kalafungin-type pyranonaphthoquinone skeleton with sulfide linkage from Streptomyces sp. MM863L-181F9 [0.03%]
来源于链霉菌MM863L-181F9的新咔拉fungin类硫化物桥式吡喃萘醌骨架抗菌化合物硫分罗霉素类化合物
Tomoyuki Kimura,Yoshimasa Ishizaki,Maya Umekita et al.
Tomoyuki Kimura et al.
Neisseria gonorrhoeae is the bacterium that causes gonorrhea, and multidrug resistance is becoming progressively more severe in many countries. Therefore, limited drugs are available for treatment. It is predicted that further drug resistan...
Multidrug-resistant Klebsiella pneumoniae and Klebsiella oxytoca isolated from backyard broiler chickens and their contacts with antimicrobial resistance genes of Klebsiella pneumoniae [0.03%]
我国活禽市场销售的肉鸡及其携带的条件致病菌肺炎克雷伯氏菌和oxytoca Klebsiella的耐药性研究及基因分析
Shimaa El Baz,Abdelfattah H Eladl,Reham A El-Shafei et al.
Shimaa El Baz et al.
The objective of this study was to investigate the prevalence and phenotypic identification of antimicrobial resistance of K. pneumoniae and K. oxytoca recovered from backyard broiler chickens and their human contacts. The serotypes and gen...
Genome mining-driven discovery of enzymes catalyzing stereodivergent transformations [0.03%]
基因组数据挖掘驱动的催化立体多样性转化的酶的发现
Jiayi Yu,Richiro Ushimaru
Jiayi Yu
Natural products provide privileged scaffolds for drug discovery, yet their stereochemical complexity often exceeds the limits of synthetic chemistry. Genome mining has emerged as a transformative strategy to uncover cryptic biosynthetic ge...
Microbial unusual gene clusters without prominent core enzymes: natural products, biosynthesis and genome mining [0.03%]
微生物罕见基因簇的无核心酶特征：天然产物、生物合成和基因组挖掘
Yu-Jing Zeng,Yi-Feng Ye,Xu-Ming Mao
Yu-Jing Zeng
Natural products (NPs) from bacteria and fungi have contributed substantially to human health and life. They have particularly attracted attention due to their intriguing bioactivity and complex structures. Biosynthetic gene clusters (BGCs)...
Correction: Litchficin, a germination inhibitory acyloin from a halophilic Gram-positive bacterium of the genus Litchfieldia [0.03%]
纠错：Litchficin是一种来源于嗜盐芽抱杆菌属（Litchfieldia）细菌的发芽抑制剂酰醇素
Md Mehebub Al Raji,Naoya Oku,Toshihiko Nogawa et al.
Md Mehebub Al Raji et al.
Published Erratum
The Journal of antibiotics. 2025 Nov 12. DOI:10.1038/s41429-025-00882-z 2025
Antibacterial activity and mechanism of optimized THPA conjugated dipeptides against methicillin-resistant Staphylococcus aureus [0.03%]
优化的THPA偶联双肽类化合物对耐甲氧西林金黄色葡萄球菌抗菌活性及机制研究
Arti Rathore,Beenish Rashid,Aminur Rahman Sarkar et al.
Arti Rathore et al.
Despite decades of investigation, multidrug-resistant bacterial resistance has become the leading health concern globally related to MRSA infections, where conventional antibiotics have failed in this race. However, the development of short...
Reversion of multidrug resistance in clinical isolates of Escherichia coli using non-steroidal anti-inflammatory drugs (NSAIDs) [0.03%]
非甾体抗炎药物逆转大肠杆菌临床分离株的多药耐药性
Amina Hayat,Aalia Khanem,Ikram Ullah et al.
Amina Hayat et al.
Antibiotics have transformed the treatment of bacterial infections, but their efficacy is increasingly threatened by antimicrobial resistance (AMR). Resistance mechanisms, such as target site modification, efflux pumps, and porin loss, nece...