Taxonomic characterization of Kribbella broussonetiae sp. nov., a novel rare actinomycete isolated from the rhizosphere soil of Broussonetia papyrifera [0.03%]
来源于构树根际土壤的罕见放线菌Kribbella broussonetiae sp. nov. 的分类表征
Ming-Yue Li,Yan Xiao,Jian Gao
Ming-Yue Li
A novel rare actinomycete strain, WER1T, was isolated from rhizosphere soil of Broussonetia papyrifera collected from Xiangtan City, Hunan province, China. Strain WER1T contained LL-diaminopimelic acid as the diagnostic diamino acid in the ...
Two new diastereomeric sterigmatocystin derivatives from the culture broth of Hypomyces sp [0.03%]
来自Hypomyces菌株培养液的两种新的几何异构体 Sterigmatocystin 衍生物
Yongkuk Lee,Dae-Cheol Choi,Dae-Won Ki et al.
Yongkuk Lee et al.
Two new sterigmatocystin derivatives, named hyposterigmatocystin A and B (1 and 2), and three known compounds, 3a,12c-dihydro-8,12c-dihydroxy-6-methoxy-7H-furo[3',2':4,5]furo[2,3-c]xanthen-7-one (3), sterigmatocystin (4), and secosterigmato...
Biological profiling of structurally diverse LEGO-LPPOs reveals differences in antibacterial activity, cytocompatibility, and in vivo tolerability [0.03%]
结构多样的LEGO-LPPOs的生物特征分析揭示了其抗菌活性、细胞相容性和体内耐受性之间的差异
Jana Sabová,Kateřina Bogdanová,Renata Večeřová et al.
Jana Sabová et al.
Lipophosphonoxins represent a promising class of membrane-active antimicrobial agents with potential relevance for skin-targeted antimicrobial applications. Antibacterial activity of a panel of LEGO-lipophosphonoxin (LEGO-LPPO) compounds wa...
Reimagining antimicrobial resistance: AI-driven predictive epidemiology and the C-AMRE framework for next-generation antibiotic discovery [0.03%]
重新构想抗菌素耐药性：人工智能驱动的预测流行病学和下一代抗生素发现的C-AMRE框架
Ashutosh Patil,Mangesh Jadhav,Ujban Hussain et al.
Ashutosh Patil et al.
Antimicrobial Resistance (AMR) has evolved from a clinically observed phenomenon into a complex, dynamic, and partially predictable evolutionary process. Traditional approaches centered on phenotypic detection and retrospective surveillance...
Haruo Ikeda,Junko Hashimoto,Ikuko Kozone et al.
Haruo Ikeda et al.
New technology for the derivatization of thioamide ribosomally synthesized and post-translationally modified peptide (RiPP) compounds we previously developed was optimized for the derivatization of thiostrepton metabolites. These optimized ...
Luteoagmacins A and B, new antimicrobial agmatine derivatives from a hot spring water-derived Luteococcus sp [0.03%]
来源于热泉的红硫细菌的新抗菌胍衍生物卢提奥麻灵A和B
Shotaro Hoshino,Emiko Nagai,Hisayuki Komaki et al.
Shotaro Hoshino et al.
Two new agmatine derivatives, luteoagmacins A (1) and B (2), were isolated from the culture extract of the hot spring water-associated actinomycete Luteococcus sp. RD000023. The chemical structures of 1 and 2 were elucidated by spectroscopi...
A N-methylated antimicrobial peptide targets the fructose transporter FruA of Staphylococcus aureus [0.03%]
N-甲基化抗菌肽针对金黄色葡萄球菌果糖转运蛋白FruA
Qi Liu,Yaxuan Li,Zhichen Jiang et al.
Qi Liu et al.
Antimicrobial peptides (AMPs) represent promising alternatives to conventional antibiotics, but their therapeutic application is often hindered by suboptimal stability and poorly defined mechanisms of action. To overcome these limitations, ...
Discovery of new α-pyrone derivative with α-glucosidase inhibitory activity from the fungus Acremonium persicinum [0.03%]
来源于真菌Acremonium persicinum的α-糖苷酶抑制剂新结构α-吡酮衍生物的发现
Yu Tu,Baodan Zhang,Meiyan Bao et al.
Yu Tu et al.
One new α-pyrone derivative, acremopyrone A (1) was isolated from the soil-derived fungus Acremonium persicinum 3.2858. The structure of 1 was elucidated by comprehensive spectroscopic analysis including nuclear magnetic resonance (NMR) an...
Allantopyrone A promotes cross-linking of ubiquitin-specific protease 5 (USP5) and inhibits its deubiquitinase activity by targeting distinct domains [0.03%]
黄烷酮衍生物allantopyrone A通过靶向不同结构域促进泛素特异性蛋白酶5的交联并抑制其去泛素化活性
Chiharu Okuda,Seito Tokumori,Nhat Thi Vu et al.
Chiharu Okuda et al.
Allantopyrone A is an α-pyrone metabolite produced by the plant endophytic fungus Allantophomopsis lycopodina KS-97. We previously demonstrated that allantopyrone A decreased the abundance of many components of 26S proteasome fractions whi...
Actinomycetospora lichenicola sp. nov., a rare actinomycete isolated from the crustose lichen Arthonia leioplacella [0.03%]
来源于地衣Arthonia leioplacella的链霉菌Actinomycetospora lichenicola sp. nov.
Cholticha Meepara,Achiraya Somphong,Chanwit Suriyachadkun et al.
Cholticha Meepara et al.
A Gram-positive actinomycete, designated strain C-140ᵀ, was isolated from the crustose lichen Arthonia leioplacella collected in Thailand. A polyphasic taxonomic study demonstrated that the strain represents a member of the genus Actinomyc...