Rare distribution of butenolide-type signaling molecules among Streptomyces strains and functional importance as inducing factors for secondary metabolite production in Streptomyces rochei 7434AN4 [0.03%]
土霉素产生菌链霉菌ROCHEI 7434AN4中布泰内酸型信号分子的分布及诱导活性研究
Asahi Hirata,Miho Sumiyoshi,Hazuki Fujita et al.
Asahi Hirata et al.
Streptomyces rochei 7434AN4 produces two structurally unrelated polyketide antibiotics, lankacidin (LC) and lankamycin (LM), and their biosynthesis is tightly controlled by 2,3-disubstituted butenolide-type signaling molecules SRB1 and SRB2...
Micrococcins from Peribacillus sp. KDM594; efficacy against vancomycin-resistant enterococci and drug metabolism in a silkworm model [0.03%]
KDM594分枝杆菌微球菌素的产生及其对耐万古霉素肠球菌的有效性以及蚕模型中的药物代谢研究
Akiho Yagi,Mayu Sato,Katsuki Kikuchi et al.
Akiho Yagi et al.
The screening of antibiotics derived from microbial resources to combat vancomycin-resistant enterococci (VRE) revealed that a culture of marine-derived Peribacillus sp. KDM594 exhibited significant therapeutic efficacy in an infected in vi...
New antimicrobial butanolides from a deep sea-derived fungus Aspergillus tabacinus LW82 [0.03%]
由深海可可毛霉菌LW82分离得到的新型抗菌并四苯醇类化合物
Yu Tu,Jinxin Zhang,Lei Cai et al.
Yu Tu et al.
Two new butanolides asperbutanolides A (1) and B (2), and a new fatty acid derivative omphalotol C (3), along with 5 known compounds were isolated from the ethyl acetate (EtOAc) crude extract of the deep-sea-derived fungus Aspergillus tabac...
Ólafur S Andrésson,Douglas E Berg,Patrice Courvalin et al.
Ólafur S Andrésson et al.
Survival strategies of imipenem-resistant P. aeruginosa: a comparative analysis of surface-bound biofilms and unbound aggregates [0.03%]
碳青霉烯耐药铜绿假单胞菌的生存策略：黏附生物被膜与游离细胞的比较研究
Mahwish Saleem,Mona Siddiqui,Hafiza Noor Ul Huda et al.
Mahwish Saleem et al.
This study investigated imipenem-resistant Pseudomonas aeruginosa (P. aeruginosa) isolates recovered from various ready-to-eat food items. Isolates were identified as P. aeruginosa based on growth on selective P-Pseudomonas media and confir...
"Global divide in carbapenem resistance and hypervirulence of Klebsiella pneumonia: comparing trends in India and developed nations"- a comprehensive review [0.03%]
“印度与发达国家肺炎克雷伯菌碳青霉烯耐药性及高毒力流行趋势的差异”——全面综述一篇
Saloni V Koli,Snehal V Mali,Jisha Geevarghese
Saloni V Koli
The global health problem of carbapenem-resistant and hypervirulent Klebsiella pneumoniae (CRKP) is exacerbated by the lack of effective treatments and increasing resistance. This study compares the clinical impact, resistance mechanisms, a...
The antirheumatic drug sulfasalazine ameliorates acute renal failure (ARF) induced by polymyxin B [0.03%]
抗风湿药物磺胺吡唑能改善多粘菌素B引起的急性肾功能衰竭(ARF)
Kohei Otani,Tomohiro Kagi,Takuya Noguchi et al.
Kohei Otani et al.
Polymyxin B (PMB) is a polypeptide antibiotic active against multidrug-resistant bacteria, including multidrug-resistant Pseudomonas aeruginosa (MDRP). However, PMB frequently initiates serious acute renal failure (ARF). Our recent study de...
New oligomycin derivatives inhibit anchorage-independent growth of pancreatic cancer cells [0.03%]
新寡霉素衍生物可抑制胰腺癌细胞的贴壁独立生长
Daisuke Tatsuda,Masahide Amemiya,Chisato Nosaka et al.
Daisuke Tatsuda et al.
Cancer stem cells (CSCs) play a crucial role in cancer progression, recurrence, and therapy resistance through their abilities to self-renew, differentiate, and evade treatment. Disrupting the interaction between CSCs and their tumor microe...
A novel clotrimazole selenium nano-composite for combating deep dermal Candida albicans infections and virulence genes [0.03%]
一种新型克霉唑硒纳米复合材料对抗深部皮肤白色念珠菌感染和毒力基因的作用
Rana Eshimy,Ahmed I El-Batal,Farag M Mosallam
Rana Eshimy
Traditional antifungal drugs are ineffective against multidrug-resistant Candida infections. The goal of this work is the preparation of Clotrimazole Selenium Nano-composite (CZ-Se-NC) suspension and CZ-Se-NC-gel for combating clotrimazole-...
Isolation and synthesis of a new cyclic tetrapeptide from marine-associated Bacillus sp. and its bacterial biofilm formation inhibitory activity [0.03%]
一种来源于海洋芽孢杆菌的新环状四肽的分离与合成及其抑制细菌生物被膜活性的研究
Shuaiqi Ma,Shixin Li,Li Song et al.
Shuaiqi Ma et al.
A new cyclic tetrapeptide named Cereusitin B (1), along with a number of known cyclic dipeptides was isolated from the fermentation broth of a marine-associated Bacillus sp. I-2. The structure of Cereusitin B, cyclo-(L-phenylalanyl-trans-4-...