The Journal of antibiotics. 2025 Jun 9. doi: 10.1038/s41429-025-00836-5 Q22.72025

New antimicrobial butanolides from a deep sea-derived fungus Aspergillus tabacinus LW82

由深海可可毛霉菌LW82分离得到的新型抗菌并四苯醇类化合物翻译改进

Yu Tu¹, Jinxin Zhang^{1 2}, Lei Cai^{1 2}, Ling Liu^{3 4}

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作者单位

¹ State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

² University of Chinese Academy of Sciences, Beijing, China.

³ State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. liul@im.ac.cn.

⁴ University of Chinese Academy of Sciences, Beijing, China. liul@im.ac.cn.

DOI: 10.1038/s41429-025-00836-5 PMID: 40490501

摘要中英对照阅读

Two new butanolides asperbutanolides A (1) and B (2), and a new fatty acid derivative omphalotol C (3), along with 5 known compounds were isolated from the ethyl acetate (EtOAc) crude extract of the deep-sea-derived fungus Aspergillus tabacinus LW82 guided by OSMAC (One Strain Many Compounds) strategy. The structural elucidation and absolute configuration determination of these compounds were achieved by comprehensive spectroscopic analysis, including nucl... ...点击完成人机验证后继续浏览

从深海来源的曲霉菌LW82（Aspergillus tabacinus LW82）的乙酸乙酯粗提物中，通过OSMAC（一种多化合物策略）引导，分离出了两种新的丁内酯asperbutanolides A (1) 和 B (2)，以及一种新的脂肪酸衍生物omphalotol C (3)，同时还发现了5种已知化合物。这些化合物的结构解析和绝对构型确定是通过核磁共振（NMR）、高分辨率电喷雾离子化质谱（HRESIMS）和[Rh₂(OCOCF₃)₄]诱导的电子圆二色性（ECD）实验等综合光谱分析完成的。化合物1对假单胞菌Pseudomonas syringae pv. Lachrymans表现出抗菌活性，最小抑菌浓度（MIC）值为64 μg/ml。此外，化合物6对Cryptococcus gattii R265和3284G14两种真菌显示出显著的抗真菌效果，其MIC值均为8 μg/ml，与抗真菌药物氟康唑相当。

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期刊名：Journal of antibiotics

缩写：J ANTIBIOT

ISSN：0021-8820

e-ISSN：1881-1469

IF/分区：2.7/Q2

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New antimicrobial butanolides from a deep sea-derived fungus Aspergillus tabacinus LW82

由深海可可毛霉菌LW82分离得到的新型抗菌并四苯醇类化合物翻译改进

Indole diketopiperazine alkaloids from the deep-sea-derived fungus Aspergillus sp. FS445

来源于深海优势霉菌FS445的吲哚二肽生物碱类化合物

Cytotoxic Nitrogenated Azaphilones from the Deep-Sea-Derived Fungus Chaetomium globosum MP4-S01-7

由深海来源的真菌Chaetomium globosum MP4-S01-7产生的细胞毒氮杂菲酮类化合物

Cytotoxic Thiodiketopiperazine Derivatives from the Deep Sea-Derived Fungus Epicoccum nigrum SD-388

来源于深海内生菌Epicoccum nigrum SD-388的细胞毒噻二酮类茋衍生物

Unstable Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus Cladosporium sphaerospermum EIODSF 008

来自深海丛梗孢霉(EIODSF 008)的四种不稳定的四甲酸衍生物

Punicesterones A-G, polyhydroxylated mycoecdysteroids from the deep-sea-derived fungus Aspergillus puniceus SCSIO z021

深海真菌SCSIO z021来源的多羟基蜕皮甾酮类化合物Punicesterones A-G

Sorbicillamines A-E, nitrogen-containing sorbicillinoids from the deep-sea-derived fungus Penicillium sp. F23-2

来自深海分离的曲霉属真菌F23-2的抗肿瘤化合物sorbicillamine A-E及其结构类似物氮杂sorbicillinoid类化合物

Penithoketone and Penithochromones A-L, Polyketides from the Deep-Sea-Derived Fungus Penicillium thomii YPGA3

来自海洋真菌Penicillium thomii YPGA3的聚酮化合物Penithoketone和Penithochromones A-L

Xanthones and Quinolones Derivatives Produced by the Deep-Sea-Derived Fungus Penicillium sp. SCSIO Ind16F01

来源于深海真菌Penicillium sp. SCSIO Ind16F01的xanthone和喹唑啉衍生物

Two new meroterpenoids and two new monoterpenoids from the deep sea-derived fungus Penicillium sp. YPGA11

一种深海来源的棒曲霉酵素YPGA11中新倍半萜及单萜类化合物

New antimicrobial butanolides from a deep sea-derived fungus Aspergillus tabacinus LW82

由深海可可毛霉菌LW82分离得到的新型抗菌并四苯醇类化合物 翻译改进

Indole diketopiperazine alkaloids from the deep-sea-derived fungus Aspergillus sp. FS445

来源于深海优势霉菌FS445的吲哚二肽生物碱类化合物

Cytotoxic Nitrogenated Azaphilones from the Deep-Sea-Derived Fungus Chaetomium globosum MP4-S01-7

由深海来源的真菌Chaetomium globosum MP4-S01-7产生的细胞毒氮杂菲酮类化合物

Cytotoxic Thiodiketopiperazine Derivatives from the Deep Sea-Derived Fungus Epicoccum nigrum SD-388

来源于深海内生菌Epicoccum nigrum SD-388的细胞毒噻二酮类茋衍生物

Unstable Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus Cladosporium sphaerospermum EIODSF 008

来自深海丛梗孢霉(EIODSF 008)的四种不稳定的四甲酸衍生物

Punicesterones A-G, polyhydroxylated mycoecdysteroids from the deep-sea-derived fungus Aspergillus puniceus SCSIO z021

深海真菌SCSIO z021来源的多羟基蜕皮甾酮类化合物Punicesterones A-G

Sorbicillamines A-E, nitrogen-containing sorbicillinoids from the deep-sea-derived fungus Penicillium sp. F23-2

来自深海分离的曲霉属真菌F23-2的抗肿瘤化合物sorbicillamine A-E及其结构类似物氮杂sorbicillinoid类化合物

Penithoketone and Penithochromones A-L, Polyketides from the Deep-Sea-Derived Fungus Penicillium thomii YPGA3

来自海洋真菌Penicillium thomii YPGA3的聚酮化合物Penithoketone和Penithochromones A-L

Xanthones and Quinolones Derivatives Produced by the Deep-Sea-Derived Fungus Penicillium sp. SCSIO Ind16F01

来源于深海真菌Penicillium sp. SCSIO Ind16F01的xanthone和喹唑啉衍生物

Two new meroterpenoids and two new monoterpenoids from the deep sea-derived fungus Penicillium sp. YPGA11

一种深海来源的棒曲霉酵素YPGA11中新倍半萜及单萜类化合物

由深海可可毛霉菌LW82分离得到的新型抗菌并四苯醇类化合物翻译改进