Review The Journal of antibiotics. 2025 Jun 3. doi: 10.1038/s41429-025-00833-8 Q22.72025
"Global divide in carbapenem resistance and hypervirulence of Klebsiella pneumonia: comparing trends in India and developed nations"- a comprehensive review
“印度与发达国家肺炎克雷伯菌碳青霉烯耐药性及高毒力流行趋势的差异”——全面综述一篇 翻译改进
Saloni V Koli 1, Snehal V Mali 1, Jisha Geevarghese 2
作者单位 +展开
作者单位
DOI: 10.1038/s41429-025-00833-8 PMID: 40461635
摘要 中英对照阅读
耐碳青霉烯类和高毒力肺炎克雷伯菌（CRKP）的全球健康问题因缺乏有效的治疗手段以及不断增加的抗药性而加剧。本研究比较了工业化国家和新兴国家中CR-hvKP的临床影响、抗药机制及流行情况，分析了来自各国数据库的300篇论文，并从中挑选出70篇进行进一步的研究。该研究重点考察了携带毒力基因（rmpA、aerobactin、yersiniabactin）和碳青霉烯酶基因（blaKPC、blaNDM、blaOXA-12）的CRKP和hvKP菌株的有效性治疗、临床结果、抗药机制及流行情况。分析结果显示，β-内酰胺酶基因如blaOXA-48（占研究的25%）、blaKPC（占30%）以及blaNDM（占45%）是肺炎克雷伯菌株耐碳青霉烯类的主要原因。在印度，CR-hvKP的抗药率范围为4.4%至100%，该地区的情况尤为严重。临床结果令人担忧：住院患者的死亡率为30%-60%，病死率达到高达90%。研究强调了质粒介导的抗性、免疫逃避机制以及生物膜增强的发展如何促进CR-hvKP的病理生理学，使得治疗更加困难。迫切需要采取行动来对抗CR-hvKP并减轻其对临床影响的巨大破坏力，因为印度的情况比发达国家更为严重。
© 2025. 作者保留独家许可给日本抗生素研究协会的权利。
相关内容
-
Convergence of carbapenem-resistance and hypervirulence in Klebsiella pneumoniae
碳青霉烯耐药性与条件致病菌肺炎克雷伯菌毒力的汇聚趋势
Liang Chen
The Lancet. Infectious diseases. 2018 Jan;18(1):2-3.
-
Hypervirulence Markers Among Non-ST11 Strains of Carbapenem- and Multidrug-Resistant Klebsiella pneumoniae Isolated From Patients With Bloodstream Infections
从感染鲍曼不动杆菌血流感染患者中鉴定出碳青霉烯耐药及多重耐药非ST258型序列型菌株的高毒力标志物
Ping Shen et al.
Frontiers in microbiology. 2020 Jun 18:11:1199.
-
A global perspective on the convergence of hypervirulence and carbapenem resistance in Klebsiella pneumoniae
肺炎克雷伯菌泛耐碳氢酶烯和高毒力融合的全球性观点
Peng Lan et al.
Journal of global antimicrobial resistance. 2021 Jun:25:26-34.
-
Convergent Klebsiella pneumoniae strains belonging to a sequence type 307 outbreak clone combine cefiderocol and carbapenem resistance with hypervirulence
具序列型307爆发克隆特征的新德里金属蛋白酶碳青霉烯酶产生肺炎克雷伯菌的耐药性及高毒力特征分析
Katharina Schaufler et al.
Emerging microbes & infections. 2023 Dec;12(2):2271096.
-
Detection and analysis of different interactions between resistance mechanisms and carbapenems in clinical isolates of Klebsiella pneumoniae
耐药机制与碳青霉烯类抗生素不同作用方式的检测及分析——克氏肺炎菌株临床分离实例分析
Tanise Vendruscolo Dalmolin et al.
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]. 2017 Jul-Sep;48(3):493-498.
-
Characterization, Antibiotic Susceptibility, and Clonal Analysis of Carbapenem-Resistant Klebsiella pneumoniae From Different Clinical Cases
来自不同临床病例的耐碳青霉烯类药物肺炎克雷伯菌的特征、抗生素敏感性及谱型分析
Zanan M Taha
Cureus. 2024 Oct 19;16(10):e71889.
-
"Superbugs" with hypervirulence and carbapenem resistance in Klebsiella pneumoniae: the rise of such emerging nosocomial pathogens in China
肺炎克雷伯菌超广谱耐药和高毒力“超级细菌”在中国医院的出现和发展
Danni Pu et al.
Science bulletin. 2023 Nov 15;68(21):2658-2670.
-
Carbapenem Resistance Caused by High-Level Expression of OXA-663 β-Lactamase in an OmpK36-Deficient Klebsiella pneumoniae Clinical Isolate
由于OmpK36缺乏而由OXA-663β-内酰胺酶高表达引起的肺炎克雷伯菌临床分离株的碳青霉烯耐药性
Peijun Ma et al.
Antimicrobial agents and chemotherapy. 2018 Oct 24;62(11):e01281-18.
-
Reduced susceptibility to carbapenems in Klebsiella pneumoniae clinical isolates associated with plasmid-mediated beta-lactamase production and OmpK36 porin deficiency
产碳青霉烯酶和OmpK36孔蛋白缺陷介导的肺炎克雷伯菌临床分离株对碳青霉烯类药物的低敏感性
Xuan Ding Wang et al.
Journal of medical microbiology. 2009 Sep;58(Pt 9):1196-1202.
