Comparison of two human cell-based in vitro eye hazard assessment methods: the cytotoxicity test for evaluation of eye irritation (CEI) and the OECD 492B method [0.03%]
两种基于原代人细胞的体外眼损伤评估方法比较：用于眼部刺激评价的眼部细胞毒性试验（CEI）与OECD 492B方法
Daniel Krakowian,Przemysław Żemła,Dominika Gądarowska et al.
Daniel Krakowian et al.
Lately, we have developed a cytotoxicity test for evaluation of eye irritation (CEI), which is able to classify a substance as serious eye damage, eye irritant or not requiring classification. The OECD 492B method can also classify substanc...
A human-relevant epithelial-fibroblast co-culture platform for integrated analysis of PHMG-HCl-induced pulmonary fibrogenic responses [0.03%]
一种与人类相关的上皮-成纤维细胞共培养平台用于系统分析PHMG-HCl诱导的肺纤维化反应
Hee Sung Hwang,Min Ju Kim,Ju Hee Lee et al.
Hee Sung Hwang et al.
Polyhexamethylene guanidine hydrochloride (PHMG-HCl) is a fibrogenic chemical associated with severe pulmonary injury, however, human-relevant in vitro systems capable of mechanistically evaluating fibrogenic responses remain limited. Pulmo...
Current perspectives on the in vitro cytotoxic effects of tebuconazole, imidacloprid, and microplastics: A comprehensive review [0.03%]
тебуконазول、imidacloprid和微塑料在体外毒性效应的最新研究观点：综述性文章
David Silva Alexandre,Evaldo Luiz Gaeta Espíndola,Cassiana Carolina Montagner et al.
David Silva Alexandre et al.
In vitro ecotoxicological approaches have gained relevance as alternative methods to investigate cellular mechanisms underlying the toxicity of environmental contaminants. This review systematically analyzed studies from the last 25 years e...
Carboxylesterase 2 as a potential molecular target for long-chain perfluoroalkyl carboxylic acids [0.03%]
长链全氟羧酸的潜在分子靶标：羧酸酯酶2
Francisco Alejandro Lagunas-Rangel
Francisco Alejandro Lagunas-Rangel
Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a broad and chemically diverse class of synthetic compounds widely used in industrial applications and consumer products. Human exposure to PFAS is widespread and occurs through multi...
Antileishmanial activity, cytotoxicity, and immunomodulatory effects of a naphthoquinone derivative [0.03%]
萘醌衍生物的抗利什曼病活性，细胞毒性和免疫调节作用
Jhennifer S Martins,Paulline P M S Leal,Bianca S Anjos et al.
Jhennifer S Martins et al.
This study evaluated the antileishmanial activity, toxicity, and immunomodulatory effects of the synthetic compound IM4, derived from β-lapachone. In promastigote forms, IM4 showed IC50 values of 4.82 ± 0.11 μg/mL for L. infantum and 15....
In-vitro study and in-vivo zebrafish model to minimize the toxic effects of implant (CoCrMo particles) by antioxidants [0.03%]
抗氧化剂的体外和活体斑马鱼实验以减少植入物（CoCrMo颗粒）的毒性效应
Sowmya Gurusamy Kamaraj,Amber Lopez,Hemalatha Kanniyappan et al.
Sowmya Gurusamy Kamaraj et al.
Total hip replacement (THR) is the standard of care for end-stage hip joint disorders; however, corrosion of THR components and the resulting release of metal ions and particles can lead to tissue microenvironmental toxicity. This study exa...
ESTIV 2024: The application of new approach methodologies (NAMs) in drug discovery and drug and chemical safety assessment [0.03%]
ESTIV 2024：新方法学(NAMs)在药物发现及药品和化学品安全评估中的应用
Helena Kandárová,Markéta Dvořáková,Benoît Maisonneuve
Helena Kandárová
SiO2 dust induces the transformation of lung fibroblasts to myofibroblasts by activating the S1P-RhoA-YAP signaling pathway [0.03%]
二氧化硅粉尘通过激活S1P-RhoA-YAP信号通路诱导肺成纤维细胞转分化为肌成纤维细胞
Hualing Zhang,Fangcai Huang,Lan Guan et al.
Hualing Zhang et al.
Silicosis, a prevalent and severe form of pneumoconiosis, is characterized by silicotic nodule formation and extensive pulmonary fibrosis. Caused by prolonged inhalation of free silica (SiO₂) dust, its pathogenesis involves complex regulat...
1,25-Dihydroxyvitamin D3 attenuates TGF-β1-induced airway remodeling in asthma by inhibiting IL-33 mediated by the ERK1/2 signaling pathway [0.03%]
1,25-二羟基维生素D3通过抑制ERK1 / 2信号通路介导的IL-33减轻哮喘中TGF-β1诱导的气道重塑作用
Liyuan Liu,Dongjie Li,Jiajie Duan et al.
Liyuan Liu et al.
Airway remodeling is a central pathological feature of asthma, while 1,25-dihydroxyvitamin D₃ (1,25(OH)₂D₃) has known immunomodulatory and anti-fibrotic properties. And transforming growth factor-β1 (TGF-β1) plays a core role in induci...
Corrigendum to "Validation of a new 3D epidermis model for the SENS-IS assay to evaluate skin sensitization potency of chemicals" [Toxicol In Vitro, 106 (2025) 106039] [0.03%]
“新型3D表皮模型的验证，用于评估化学品致皮肤敏化潜能的SENS-IS试验”一文的勘误(毒性学与 vitro, 106 (2025) 106039)
Françoise Cottrez,Elodie Boitel,Essia Sahli et al.
Françoise Cottrez et al.