Liposomal nanoparticles containing adenosine triphosphate targeted by heart-specific peptide ligands as antidotes for aluminum phosphide poisoning in isolated rat cardiomyocyte cell line [0.03%]
心肌细胞系中特异性富集ATP的载药脂质体用于治疗磷化铝中毒的研究
Roghayeh Jahani,Hamidreza Mohammadi,Mohammad Seyedabadi et al.
Roghayeh Jahani et al.
Aluminum phosphide (ALP) poisoning remains a critical challenge because of the limited number of treatment options. ALP disrupts the electron transport chain, causing ATP depletion, oxidative stress, and cytotoxicity. This study developed i...
Metabolic stability and effects of microsomal enzymes on the activity of the sonic hedgehog pathway inhibitor piperonyl butoxide [0.03%]
pipernyl但氧对声波刺猬信号通路抑制作用及代谢稳定性与微粒体酶的作用研究
Kenneth S Rivera-González,Cameron O Scarlett,Robert J Lipinski
Kenneth S Rivera-González
The pesticide synergist piperonyl butoxide (PBO) is a methylenedioxy compound used in many pesticide formulations. Previous studies identified PBO as an inhibitor of the Sonic hedgehog (Shh) signaling pathway and linked prenatal PBO exposur...
Effects of heated tobacco products and conventional cigarettes on oxidative stress and inflammation in alveolar macrophages [0.03%]
加热烟草产品和常规卷烟对肺泡巨噬细胞氧化应激和炎症的影响
Ok Joo Sul,Hye Won Choi,Seo Hee Park et al.
Ok Joo Sul et al.
Oxidative stress in macrophages is a major factor contributing to smoking-induced chronic respiratory diseases. However, the oxidative stress induced by heat-not-burn tobacco products (HTP) and conventional cigarettes (3R4F) in macrophages ...
Tributyltin propionate and tributyltin salicylate represent novel RXR ligands: Effects on transcriptional activity of thyroid hormone receptor and vitamin D3 receptor [0.03%]
三正丁基锡丙酸酯和三正丁基锡水杨酸盐是新颖的RXR配体：对甲状腺激素受体和维生素D3受体转录活性的影响
Dana Macejova,Jakub Kollar,Zdenek Dvorak et al.
Dana Macejova et al.
Several organometallic trialkyltins or triaryltins are known to act as retinoid X receptor (RXR) agonists, which were also reported to exert eminent cytotoxic properties. In the present study, binding properties of tributyltin propionate (T...
First toxicity profile of aminoindane-based new psychoactive substances: 2-aminoindane (2-AI, CAS: 2975-41-9) and N-Methyl-2-aminoindane (NM-2-AI, CAS: 24445-44-1) - comprehensive prediction of toxicological endpoints important from clinical and forensic perspective using in silico multi- approach [0.03%]
首个人工合成大麻素类精神活性物质2-氨基茚（2-AI）及其甲基衍生物N-甲基-2-氨基茚（NM-2AI）的毒性谱分析：从临床及法医毒理学角度预测其重要毒性终点的多学科计算毒理学研究
Kamil Jurowski,Adrian Frydrych
Kamil Jurowski
This study provides the first toxicity profile of two aminoindane-based new psychoactive substances (NPS): 2-aminoindane (2-AI) and N-methyl-2-aminoindane (NM-2-AI), using a multi-method in silico approach. Tools including Percepta, ProTox ...
The pesticide fungicide difenoconazole modulates the biophysical properties of sodium channel Nav1.5 [0.03%]
杀菌剂difenoconazole调节钠通道Nav1.5的生物物理性质
V Fogaça-Santos,F S Alcântara,Conceição Mrl et al.
V Fogaça-Santos et al.
Difenoconazole (DIF) is a widely used fungicide in agriculture, but it is unknown if it can modulate the excitability of the heart tissue. Thus, we investigated the acute effect of DIF on the electrical properties of heart tissue, with a pa...
Collaborative evaluation of in silico predictions for high throughput toxicokinetics [0.03%]
高通量毒代动力学的计算机预测联合评价方法研究进展
John Wambaugh,Nisha Sipes,Gilberto Padilla Mercado et al.
John Wambaugh et al.
High throughput toxicokinetic (HTTK) methods address chemical risk assessment data gaps but require chemical-specific values that can be obtained by in vitro measurements or in silico models. In this study, seven quantitative structure prop...
Binding of plutonium and americium to small molecular weight ligands favors their paracellular transfer across lung epithelium in vitro [0.03%]
钚和镅与小分子量配体结合有利于其通过体外肺上皮的旁细胞转运
G Drouet,A Bourgois,K Devilliers et al.
G Drouet et al.
Pulmonary absorption is a critical step in the time-dependent processes governing actinide biodistribution and toxicity following internal contamination by inhalation. The current study was undertaken to investigate on a simple in vitro Cal...
Synergistic and divergent effects of dietary sugars on hepatocyte viability and steatosis [0.03%]
膳食糖类物质对肝细胞存活率和脂肪变性作用的协同效应与相异效应
Ajay Kumar,Garhima Arora,Deepika Kumari et al.
Ajay Kumar et al.
Our study explores the effects of glucose, fructose, and sucrose on hepatocyte health, focusing on cell viability and lipid accumulation. Hepatocyte cells (HepG2) were exposed to a range of concentrations of glucose, fructose and sucrose, b...
Toxicity assessment of 6PPD-quinone in human lung cells: Insights from BEAS-2B and A549 cell lines [0.03%]
6PPD醌对人肺细胞毒性的评估：BEAS-2B和A549细胞系的见解
Saja Damdam,Blake Hunnie,Parker Jones et al.
Saja Damdam et al.
N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine-quinone (6PPD-Q), an environmental transformation product of the rubber tire antioxidant 6PPD, is increasingly detected in urban environments, yet its impact on human health. This study inv...