Polyethylene glycol encapsulation enhances phytol-induced oxidative stress, mitochondrial dysfunction and apoptotic death in oral carcinoma cells [0.03%]
聚乙二醇封装增强PHYTL诱导的口腔癌细胞氧化应激、线粒体功能障碍和凋亡死亡
M Padmapriya,R Rajathi
M Padmapriya
Oral carcinoma is an aggressive cancer characterized by significant morbidity and limited treatment alternatives due to drug resistance and systemic toxicity. The study investigates phytol (PYT), for its unexplored anticancer efficacy again...
7,8-Dihydroxyflavone attenuates etoposide-induced genotoxicity in cardiomyocytes via a biphasic, p53-dependent mechanism [0.03%]
7,8-二羟基黄酮通过依赖p53的双相机制缓解依托泊苷诱导的心肌细胞遗传毒性
Yuwei Hu,Qiujie Li,Shaoxuan Zhang et al.
Yuwei Hu et al.
Etoposide (ETO) is an anticancer drug that inhibits topoisomerase II but also causes cellular senescence. 7,8-Dihydroxyflavone (7,8-DHF), a small-molecule tropomyosin receptor kinase B agonist, has demonstrated cardioprotective effects in m...
A targeted lipidomics workflow for high-throughput phenotyping and mechanism-based in vitro hepatotoxicity studies [0.03%]
一种用于高通量表型和基于机制的体外肝毒性研究的靶向脂质组学工作流程
Tzu-Hsin Yen,Chander K Negi,Courtney Sakolish et al.
Tzu-Hsin Yen et al.
Animal-based toxicity testing is limited in throughput and mechanistic characterization, underscoring the need for cell-based approaches. Incorporating molecular readouts, such as lipidomics, can enhance the translational relevance of cell-...
Dose-dependent cytotoxicity and modulation of catabolic cytokine expression by teicoplanin in human articular chondrocytes [0.03%]
茶利霉素对人关节软骨细胞的剂量依赖性细胞毒作用及对分解代谢细胞因子表达的调节作用
Chang-Chin Wu,Chen-Chie Wang,Chih-Yung Chiang et al.
Chang-Chin Wu et al.
Intra-articular administration of teicoplanin is a cost-effective therapeutic strategy for septic arthritis. Although teicoplanin has been reported to induce cytotoxicity in multiple cell types, the effects on human articular chondrocytes r...
Transcriptomic analysis identifies key genes and mechanisms involved in dibutyl phthalate-induced alteration in hepatic stellate cells [0.03%]
转录组分析鉴定出邻苯二甲酸二丁酯诱导的肝星状细胞改变的关键基因和机制
Eun-A Ko,Sung-Cherl Jung,Hyang-Ae Lee et al.
Eun-A Ko et al.
Dibutyl phthalate (DBP) is a widely used phthalate plasticizer and endocrine disruptor implicated in hepatic injury and fibrosis. However, its direct impact on hepatic stellate cells (HSCs) remains insufficiently characterized. In this stud...
SENP2 participates in DBP-induced oxidative stress injury via mediating Nrf2 de-SUMOylation [0.03%]
SENP2通过介导Nrf2去SUMO化参与DBP诱导的氧化应激损伤
Xingyu Wu,Lixin Mao,Yang Jie et al.
Xingyu Wu et al.
Exposure to Di-n-butyl phthalate (DBP) is associated with congenital and acquired defects in the male reproductive system, and DBP-induced oxidative stress plays a critical role in this process. The activation of the Nrf2 antioxidant pathwa...
Inflammatory activation and MAPK signaling mediate fumonisin B1-induced myocardial dysfunction [0.03%]
炎症活化和MAPK信号转导介导的伏马菌素B1诱导的心肌功能障碍
Liezhong Chen,Guojun Zhou,Chanlin Fang et al.
Liezhong Chen et al.
Fumonisin B1 (FB1) poses serious health concerns to human health. In this research, the cardiotoxic effects of FB1 were comprehensively evaluated through in vitro experiments using H9C2 cardiomyocytes and in vivo assays utilizing zebrafish....
Microbiota-derived Indole-3-propionic acid improves FFA-induced liver injury in an in vitro model of nonalcoholic fatty liver disease by activating PINK1/parkin-mediated mitophagy [0.03%]
微生物衍生的吲哚-3-丙酸通过激活PINK1/parkin介导的线粒体自噬改善非酒精性脂肪肝病体外模型中FFA诱导的肝脏损伤
Qilin Liu,Dahai Wu,Linhua Teng et al.
Qilin Liu et al.
Background: Non-alcoholic fatty liver disease (NAFLD) is a growing global health concern, and its pathology is associated with impaired hepatic mitochondrial function and disrupted mitophagy. Emerging evidence highlights ...
Integrating multi-organ cytokine responses with CTD and AOP-based knowledge to identify disease-relevant hazard signals: A case study of CMIT/MIT [0.03%]
基于多器官细胞因子响应、CTD和AOP知识的整合以识别疾病相关危害信号：CMIT/MIT 的案例研究
Keon Kang,Nivedita Chatterjee,Filipa Lebre et al.
Keon Kang et al.
Assessment of chemical-induced toxicity has traditionally relied on single-endpoint measurements that provide limited mechanistic resolution for organ-specific disease outcomes. This limitation is particularly evident for CMIT/MIT (chlorome...
PM2.5 exposure impairs mitochondrial function and myocardial contractility in cardiac organoids via the Sirt3/Mdh2 pathway [0.03%]
暴露于PM2.5通过Sirt3/Mdh2途径损害心脏器官样结构的线粒体功能和心肌收缩力
Li Tian,Jiahui Li,Jianong Lv et al.
Li Tian et al.
Ambient fine particulate matter (PM2.5) is a leading global environmental risk factor for cardiovascular disease. Although PM2.5 exposure is known to lead to mitochondrial dysfunction, the precise metabolic mechanisms underlying this effect...