Role of CD163 in the mechanism of hydrophilic silica nanoparticle-induced pulmonary fibrosis [0.03%]
CD163在亲水性二氧化硅纳米粒子诱导的肺纤维化机制中的作用
Chaoya Ma,Yaotang Deng,Xiao Zhang et al.
Chaoya Ma et al.
Objective: Silicosis, a progressive pulmonary fibrosis caused by silica dust exposure, remains a global occupational health threat, particularly with the rising use of nano-silica (nano-SiO₂) in industries. This study ai...
Conditioned medium from 1-nitropyrene induced THP-1 foam cells promotes pro-tumorigenesis in lung epithelial cells [0.03%]
1-硝基荧蒽诱导的训练体外培养液可促进泡沫细胞向肿瘤表型转化
Ankita Bagde,Atul Katarkar,K Krishnamurthi
Ankita Bagde
Diesel exhaust (DE) is a major environmental pollutant containing fine particulate matter and polycyclic aromatic hydrocarbons (PAHs). Among its constituents, 1-nitropyrene (1NP) is a recognized surrogate marker of DE. Although 1NP is known...
Chemical characterisation and cytotoxic analysis of an electronic cigarette and heated tobacco product compared to a conventional cigarette in human lung cell lines [0.03%]
与传统卷烟相比，电子烟和加热不燃烧烟草产品的人类肺细胞系中的化学特征及细胞毒性分析
Gregory Rankin,Håkan Wingfors,Linda Öberg et al.
Gregory Rankin et al.
The use of electronic nicotine delivery systems, such as e-cigarettes and heated tobacco products (HTPs), is increasing, but knowledge of their short and long-term toxicological effects remains limited. Here, aerosols generated from an e-ci...
Using a reconstructed human vaginal epithelium to assess irritation: A proof-of-concept study supporting regulatory qualification of the method for use with personal lubricants [0.03%]
使用重建的人类阴道上皮评估刺激作用：一项概念验证研究，支持该方法用于个人润滑剂的监管认定
Jessica Perrin,Gertrude-Emilia Costin,Seyoum Ayehunie et al.
Jessica Perrin et al.
Consumers tend to think of personal lubricants as personal care products or cosmetics that are not tested using animals, but the regulatory classification and hence the testing requirements for these products vary by country. For example, i...
Vitamin E acetate and its aerosol activate aryl hydrocarbon receptor signaling and exacerbate inflammation in human U937-derived macrophages [0.03%]
乙酰左旋维生素E及其气溶胶激活人U937源性巨噬细胞中的芳香烃受体信号并加重炎症反应
Xiaohan Li,Andrea Rossi,Thomas Haarmann-Stemmann et al.
Xiaohan Li et al.
In 2019, a number of patients were hospitalized after the use of electronic cigarettes and displayed acute lung injuries. Such injury was categorized as e-cigarette or vaping associated lung injury (EVALI). Among these patients, Vitamin E a...
Effects of cyanobacterial metabolites and their mixtures on biomarkers of oxidative stress in RTgill-W1 cells [0.03%]
蓝藻代谢产物及其混合物对RTgill-W1细胞氧化应激生物标志物的影响
Adam Bownik,Barbara Pawlik-Skowrońska
Adam Bownik
The aim of our investigation was to determine the effects of seven cyanobacterial metabolites microcystin-LR (MC-LR), anabaenopeptin-A (ANA-A), cylindrospermopsin (CYL), anabaenopeptin-B (ANA-B) aeruginosin 98 A (AER-A), aeruginosin 98B (AE...
Dual effects of metformin and resveratrol on compromising viability of endometrial cancer cells [0.03%]
二甲双胍和白藜芦醇联合使用对子宫内膜癌细胞活力的影响
Henrique Leal de Oliveira,Sara Hartke,Victória Borgmann A de Souza et al.
Henrique Leal de Oliveira et al.
Raising of mitogenic and anti-apoptotic agents - such as insulin, insulin-like growth factor type 1, and estrogen - during obesity and diabetes mellitus (types 1 and 2) favors the endometrial cancer (EC) development. Metformin, commonly use...
Diesel exhaust nanoparticles: Cellular adaptation in lung epithelial and fibroblast cells - An in vitro study [0.03%]
柴油尾气纳米颗粒对人体肺上皮细胞和纤维母细胞的体外研究
Gabriel Martínez-Razo,Ruth Angélica Lezama,Armando Vega-López et al.
Gabriel Martínez-Razo et al.
Diesel exhaust particles (DEnP) represent a major urban air pollutant with known adverse effects on human health, yet detailed cellular interactions at the nanoscale are poorly understood. This study aims to elucidate the cellular responses...
Barriergel formulations and coated gloves to reduce skin permeation of nicotine and protect against green tobacco sickness [0.03%]
屏障凝胶配方和涂布手套可减少尼古丁的皮肤渗透并预防烟草病
Abhay U Andar,Youcheng Liu,Dana C Hammell et al.
Abhay U Andar et al.
Tobacco harvesting workers may have high levels of skin exposure to nicotine that can lead to green tobacco sickness. Current exposure reduction methods are often infeasible. The purpose of this work was to develop and evaluate the effectiv...
Interactions of neocryptotanshinone and human cytochrome P450 in silico and in vitro [0.03%]
基于新型丹参茋类成分新隐丹参素与人肝微粒体CYP450的药物相互作用研究
Xiu Chen,Xiaoyi Pan,Jieping Zhao et al.
Xiu Chen et al.
Neocryptotanshinone (NCTS), an ingredient of Salviae Miltiorrhizae Radix et Rhizoma, is a promising compound for development since it exhibits various pharmacological effects including hypoglycemic and anti-inflammatory activities. In this ...