XANTHINE OXIDOREDUCTASE IN DIGESTIVE DISEASES: A CONTEXT-DEPENDENT REDOX SWITCH LINKING INFLAMMATION, METABOLISM AND CARCINOGENESIS [0.03%]
消化系统疾病中的黄嘌呤氧化还原酶：一个与炎症、代谢和癌变相关的条件依赖性红氧转换开关
Maria Giulia Battelli,Massimo Bortolotti,Andrea Bolognesi et al.
Maria Giulia Battelli et al.
Xanthine oxidoreductase (XOR) is a molybdenum-containing enzyme that catalyzes the final steps of purine catabolism, generating uric acid and, under specific conditions, reactive oxygen species (ROS) and reactive nitrogen species. Due to it...
N-acetylcysteine regulates the endoplasmic reticulum stress response in CEP-like chondrocytes exposed to proinflammatory cytokines [0.03%]
N-乙酰半胱氨酸调节暴露于促炎细胞因子的类软骨细胞样软骨细胞中内质网应力反应
Laura González-Blanco,Mariam Farrag,Verónica Sierra et al.
Laura González-Blanco et al.
Background: Intervertebral disc degeneration (IVDD) is characterized by chronic inflammation and redox imbalance, which compromise cartilage endplate (CEP) cells and essential organelles such as the endoplasmic reticulum ...
Se-methylselenocysteine induces NRF2-ATF4 stress signaling and ferroptosis-associated remodeling in pancreatic cancer [0.03%]
硒甲基硒代半胱氨酸诱导NRF2-ATF4应激信号通路和铁死亡相关重塑在胰腺癌中的作用研究
Mehran Ghaderi,Joakim Dillner,Mikael Björnstedt et al.
Mehran Ghaderi et al.
Pancreatic ductal adenocarcinoma (PDAC) is characterized by profound resistance to therapy, driven in part by its capacity to adapt to oxidative, metabolic, and proteotoxic stress. In this study, we investigated how the redox-active seleniu...
Crosstalk Between Mitophagy and Metabolism in Cancer: Mechanisms and Therapeutic Opportunities [0.03%]
癌症中线粒体自噬与代谢的串扰：机制和治疗机会
Jingyi Cheng,Ting Xiao,Zhangui Tang et al.
Jingyi Cheng et al.
Mitophagy is a highly selective autophagic process that eliminates dysfunctional mitochondria to enforce stringent cellular quality control, acting as a context-dependent modulator of stress adaptation in cancer cells. Concurrently, to thri...
CKLF1 Upregulation Exacerbates Secondary Brain Injury after Intracerebral Hemorrhage by Promoting Neuronal Ferroptosis and Oxidative Stress [0.03%]
CKLF1上调通过促进神经元铁死亡和氧化应激加重脑出血后的继发性脑损伤
Shangwen Yang,Yupei Liu,Xinyi Zhang et al.
Shangwen Yang et al.
Background: Secondary brain injury (SBI) following spontaneous intracerebral hemorrhage (ICH) is a critical determinant of neurological outcome. It is closely associated with neuronal death, and inflammatory responses. Ho...
The utility of FRET/FLIM-based bioassays for monitoring Nrf2 activation in single live cells [0.03%]
基于FRET/FLIM的生物测定法在单个活细胞中监测Nrf2激活方面的效用
Dina Dikovskaya,Albena T Dinkova-Kostova
Dina Dikovskaya
The Kelch-like ECH-associated protein 1 - Nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) partnership is vital for protection against oxidative stress, and its dysregulation has been linked to the pathogenesis of numerous chronic d...
Semaglutide ameliorates traumatic sepsis-induced cardiac injury by activating the March5-ACSL4 axis to suppress ferroptosis [0.03%]
司美格鲁肽通过激活March5-ACSL4轴抑制铁死亡从而改善创伤性脓毒症诱导的心脏损伤
Baisheng Sun,Lingxin Liu,He Zhang et al.
Baisheng Sun et al.
Post-traumatic septic myocardial dysfunction (PT-SIMD) is a life-threatening condition with high mortality and no specific treatment. Ferroptosis, an iron-dependent regulated cell death pathway driven by lipid peroxidation, has been implica...
Iron accumulation drives radiation-induced proctopathy via VDR/YAP signaling [0.03%]
铁沉积通过VDR/YAP信号传导驱动放射诱导的结肠炎
Xueyan Li,Wenzhi Tu,Yong Liu
Xueyan Li
Radiation proctopathy is a severe dose-limiting complication of pelvic radiotherapy that lacks effective interventions. Here, we investigate whether iron accumulation contributes to radiation-induced rectal fibrosis and elucidate the underl...
Succinylation of TAGLN2 at K40 drives lipid oxidative stress resistance and TMZ chemoresistance via redox reprogramming in Glioblastoma [0.03%]
胶质母细胞瘤中TAGLN2的K40琥珀酰化通过氧化还原重构驱动脂质氧化应激抵抗和TMZ耐药性
Wanyao Meng,Yayun Feng,Yuanyuan Huang et al.
Wanyao Meng et al.
Temozolomide (TMZ) resistance constitutes a primary cause of clinical treatment failure in glioblastoma (GBM). Targeting oxidative cell death to reverse glioma chemoresistance has emerged as a promising novel therapeutic strategy, whereas t...
Edaravone Attenuates Carbonyl-Stress-Driven ApoA-I Carboxymethylation and Macrophage Cholesterol-Handling Dysfunction in Diabetic Atherosclerosis [0.03%]
依达拉奉减轻糖尿病动脉粥样硬化中羰基应激驱动的载脂蛋白a-i碳甲基化和巨噬细胞胆固醇处理功能障碍
Hao-Cheng Ma,Yong-Xuan Xu,Zhuo-Rui Zhang et al.
Hao-Cheng Ma et al.
Diabetes increases atherosclerotic risk significantly, yet the molecular mechanisms linking diabetes-associated carbonyl stress to HDL dysfunction remain insufficiently defined. This study delineated a glyoxal-ApoA-I pathway in diabetes-ass...